Cancer CRCdb

TF information

TF name:	EGR1
TF family:	zf-C2H2
Ensembl gene ID:	ENSG00000120738
Ensembl protein ID:	ENSP00000239938
Entrez gene ID:	1958

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of EGR1 in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_02_228	Cell line	Oesophagus	KYSE510	0.58713886300093
Sample_02_242	Cell line	Colon	V481	0.052265589950651

EGR1 distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name
Sample_02_228	Oesophagus	Cell line	KYSE510

EGR1 distribution in all CRCs

Genomic distribution of SEs associated with EGR1

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Mutation of EGR1

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of EGR1

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr5	137801607	137801607	G	C	exonic	EGR1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr5	137803195	137803195	G	A	exonic	EGR1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr5	137802653	137802653	C	T	exonic	EGR1	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr5	137803283	137803283	A	G	exonic	EGR1	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr5	137803056	137803056	C	G	exonic	EGR1	synonymous	LUAD\|1\|543\|0.00184
-	chr5	137801480	137801480	G	A	exonic	EGR1	synonymous	BRCA\|1\|982\|0.00102
-	chr5	137802977	137802977	G	A	exonic	EGR1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr5	137803366	137803366	G	T	exonic	EGR1	stopgain	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr5	137801456	137801456	C	G	exonic	EGR1	synonymous	LIHC\|1\|373\|0.00268
-	chr5	137802757	137802757	C	T	exonic	EGR1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs558452520	chr5	137801553	137801553	C	T	exonic	EGR1	synonymous	DLBC\|1\|48\|0.02083
-	chr5	137803616	137803616	C	T	exonic	EGR1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr5	137803554	137803554	C	A	exonic	EGR1	synonymous	BLCA\|1\|396\|0.00253
-	chr5	137803217	137803217	G	A	exonic	EGR1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr5	137801498	137801498	C	T	exonic	EGR1	synonymous	BLCA\|1\|396\|0.00253
-	chr5	137802688	137802688	G	A	exonic	EGR1	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr5	137803563	137803563	C	T	exonic	EGR1	synonymous	SKCM\|1\|368\|0.00272
-	chr5	137802702	137802702	A	C	exonic	EGR1	synonymous	BRCA\|1\|982\|0.00102
-	chr5	137801685	137801686	AG	-	exonic	EGR1	frameshift	PAAD\|7\|185\|0.03784
rs750013399	chr5	137802597	137802597	C	T	exonic	EGR1	synonymous	SKCM\|2\|368\|0.00543
-	chr5	137801591	137801591	G	C	exonic	EGR1	nonsynonymous	DLBC\|1\|48\|0.02083
-	chr5	137802696	137802696	G	T	exonic	EGR1	nonsynonymous	PAAD\|1\|185\|0.00541
rs538748263	chr5	137801568	137801568	C	A	exonic	EGR1	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr5	137801684	137801684	C	G	exonic	EGR1	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr5	137803326	137803326	C	T	exonic	EGR1	synonymous	BRCA\|1\|982\|0.00102
-	chr5	137802678	137802682	CTCCG	-	exonic	EGR1	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs149170181	chr5	137801526	137801526	T	C	exonic	EGR1	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr5	137801567	137801568	GC	-	exonic	EGR1	frameshift	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr5	137802686	137802686	C	T	exonic	EGR1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr5	137801710	137801710	A	C	exonic	EGR1	nonsynonymous	SARC\|1\|247\|0.00405
-	chr5	137802545	137802545	G	T	exonic	EGR1	nonsynonymous	BLCA\|1\|396\|0.00253
rs775787059	chr5	137803250	137803250	G	A	exonic	EGR1	nonsynonymous	ACC\|1\|90\|0.01111
rs746692720	chr5	137803131	137803131	-	C	exonic	EGR1	frameshift	BRCA\|2\|982\|0.00204,COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,KIPAN\|8\|799\|0.01001,KIRC\|8\|451\|0.01774,STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr5	137803097	137803097	G	A	exonic	EGR1	nonsynonymous	COADREAD\|1\|489\|0.00204,OV\|1\|469\|0.00213,READ\|1\|122\|0.00820
-	chr5	137802637	137802637	C	G	exonic	EGR1	nonsynonymous	PRAD\|1\|499\|0.00200
-	chr5	137803396	137803396	C	T	exonic	EGR1	nonsynonymous	CESC\|1\|194\|0.00515
-	chr5	137803578	137803578	G	A	exonic	EGR1	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr5	137803249	137803249	C	T	exonic	EGR1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr5	137803725	137803725	G	A	exonic	EGR1	synonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr5	137802740	137802740	C	A	exonic	EGR1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr5	137803450	137803450	T	-	exonic	EGR1	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr5	137801512	137801512	G	A	exonic	EGR1	nonsynonymous	CESC\|1\|194\|0.00515
-	chr5	137801523	137801523	C	G	exonic	EGR1	nonsynonymous	OV\|1\|469\|0.00213
-	chr5	137803130	137803130	C	T	exonic	EGR1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr5	137802956	137802956	C	T	exonic	EGR1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr5	137802588	137802588	G	A	exonic	EGR1	stopgain	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr5	137801471	137801471	G	A	exonic	EGR1	synonymous	CESC\|1\|194\|0.00515
rs202122132	chr5	137802687	137802687	C	T	exonic	EGR1	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs780315115	chr5	137802865	137802865	G	A	exonic	EGR1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr5	137803660	137803660	G	A	exonic	EGR1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr5	137803292	137803292	C	T	exonic	EGR1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr5	137803747	137803747	C	T	exonic	EGR1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr5	137803153	137803153	G	A	exonic	EGR1	nonsynonymous	PRAD\|1\|499\|0.00200
-	chr5	137802588	137802588	G	T	exonic	EGR1	nonsynonymous	ACC\|1\|90\|0.01111,TGCT\|1\|155\|0.00645
-	chr5	137802624	137802624	G	C	exonic	EGR1	synonymous	BRCA\|1\|982\|0.00102
-	chr5	137801538	137801538	G	A	exonic	EGR1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr5	137802793	137802793	G	A	exonic	EGR1	nonsynonymous	LUAD\|2\|543\|0.00368
rs137878468	chr5	137802589	137802589	C	T	exonic	EGR1	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
rs200476410	chr5	137803521	137803521	G	A	exonic	EGR1	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr5	137803118	137803118	G	A	exonic	EGR1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr5	137801548	137801548	C	A	exonic	EGR1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr5	137802964	137802964	G	A	exonic	EGR1	nonsynonymous	LUAD\|1\|543\|0.00184
rs201207618	chr5	137803632	137803632	G	A	exonic	EGR1	synonymous	PRAD\|1\|499\|0.00200
-	chr5	137803417	137803417	G	A	exonic	EGR1	nonsynonymous	HNSC\|2\|512\|0.00391
-	chr5	137803019	137803019	C	T	exonic	EGR1	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr5	137803517	137803517	C	A	exonic	EGR1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr5	137803193	137803193	C	T	exonic	EGR1	nonsynonymous	CESC\|1\|194\|0.00515
-	chr5	137803189	137803189	C	T	exonic	EGR1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr5	137803314	137803314	C	T	exonic	EGR1	synonymous	PRAD\|1\|499\|0.00200
-	chr5	137802462	137802462	C	T	exonic	EGR1	synonymous	SKCM\|1\|368\|0.00272
-	chr5	137801495	137801495	G	A	exonic	EGR1	synonymous	UCEC\|1\|248\|0.00403
-	chr5	137803620	137803620	G	A	exonic	EGR1	synonymous	UCEC\|1\|248\|0.00403
-	chr5	137802543	137802543	C	T	exonic	EGR1	synonymous	KIPAN\|2\|799\|0.00250,KIRC\|2\|451\|0.00443
-	chr5	137803141	137803141	G	A	exonic	EGR1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr5	137801634	137801635	AG	-	exonic	EGR1	frameshift	PAAD\|12\|185\|0.06486
-	chr5	137803304	137803304	C	T	exonic	EGR1	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr5	137803132	137803132	C	-	exonic	EGR1	frameshift	COAD\|4\|367\|0.01090,COADREAD\|4\|489\|0.00818,PAAD\|1\|185\|0.00541,STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr5	137802675	137802676	CT	-	exonic	EGR1	frameshift	COAD\|2\|367\|0.00545,COADREAD\|2\|489\|0.00409
-	chr5	137801586	137801586	C	A	exonic	EGR1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr5	137802862	137802862	G	A	exonic	EGR1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr5	137802531	137802531	C	T	exonic	EGR1	synonymous	UCEC\|1\|248\|0.00403
-	chr5	137803327	137803327	G	A	exonic	EGR1	nonsynonymous	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr5	137803293	137803293	C	T	exonic	EGR1	synonymous	SKCM\|1\|368\|0.00272
-	chr5	137802972	137802972	G	A	exonic	EGR1	synonymous	SKCM\|1\|368\|0.00272
-	chr5	137803261	137803261	C	T	exonic	EGR1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|2\|489\|0.00409,READ\|1\|122\|0.00820
-	chr5	137803764	137803764	T	C	exonic	EGR1	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr5	137803019	137803019	C	A	exonic	EGR1	nonsynonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr5	137802542	137802542	G	A	exonic	EGR1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr5	137803316	137803316	A	T	exonic	EGR1	nonsynonymous	HNSC\|1\|512\|0.00195
rs753338388	chr5	137802694	137802694	C	T	exonic	EGR1	stopgain	SKCM\|1\|368\|0.00272
-	chr5	137802682	137802682	G	A	exonic	EGR1	nonsynonymous	ESCA\|1\|185\|0.00541,KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222,PRAD\|1\|499\|0.00200
-	chr5	137802542	137802542	G	T	exonic	EGR1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr5	137803102	137803102	C	T	exonic	EGR1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr5	137803577	137803577	C	T	exonic	EGR1	nonsynonymous	BLCA\|1\|396\|0.00253,LUSC\|1\|178\|0.00562
-	chr5	137803157	137803157	G	T	exonic	EGR1	nonsynonymous	TGCT\|1\|155\|0.00645
-	chr5	137802445	137802445	G	C	splicing	EGR1	splicing	HNSC\|1\|512\|0.00195
-	chr5	137803494	137803494	C	T	exonic	EGR1	synonymous	SKCM\|1\|368\|0.00272
-	chr5	137803753	137803753	A	G	exonic	EGR1	nonsynonymous	PAAD\|1\|185\|0.00541

Disease information of EGR1

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
EGR1	Anoxemia	C23	Sign or Symptom	CTD_human
EGR1	Anoxia	C23	Pathologic Function	CTD_human
EGR1	Autoimmune Diseases	C20	Disease or Syndrome	CTD_human
EGR1	Brain Ischemia	C10;C14	Disease or Syndrome	CTD_human
EGR1	Cholangitis	C06	Disease or Syndrome	CTD_human
EGR1	Cholestasis	C06	Disease or Syndrome	CTD_human
EGR1	Intrahepatic Cholestasis	C06	Disease or Syndrome	CTD_human
EGR1	Cocaine Abuse	C25;F03	Mental or Behavioral Dysfunction	CTD_human
EGR1	Hydronephrosis	C12;C13	Disease or Syndrome	CTD_human
EGR1	Inflammation	C23	Pathologic Function	CTD_human
EGR1	Ischemia	C23	Pathologic Function	CTD_human
EGR1	Lung Neoplasms	C04;C08	Neoplastic Process	CTD_human
EGR1	Mesothelioma	C04	Neoplastic Process	CTD_human
EGR1	Prostatic Neoplasms	C04;C12	Neoplastic Process	CTD_human
EGR1	Reperfusion Injury	C14;C23	Injury or Poisoning	CTD_human
EGR1	Schizophrenia	F03	Mental or Behavioral Dysfunction	PSYGENET
EGR1	Juvenile-Onset Still Disease	C05;C17;C20	Disease or Syndrome	CTD_human
EGR1	Cocaine-Related Disorders	C25;F03	Mental or Behavioral Dysfunction	CTD_human
EGR1	Hypoxia	C23	Pathologic Function	CTD_human
EGR1	Malignant neoplasm of lung	C04;C08	Neoplastic Process	CTD_human
EGR1	Malignant neoplasm of prostate	C04;C12	Neoplastic Process	CTD_human
EGR1	Cocaine Dependence	C25;F03	Mental or Behavioral Dysfunction	CTD_human
EGR1	Hypoxemia	C23	Finding	CTD_human
EGR1	Bipolar I disorder		Mental or Behavioral Dysfunction	PSYGENET
EGR1	Cerebral Ischemia	C10;C14	Disease or Syndrome	CTD_human
EGR1	Juvenile arthritis	C05;C17;C20	Disease or Syndrome	CTD_human
EGR1	Juvenile psoriatic arthritis	C05;C17;C20	Disease or Syndrome	CTD_human

Pathway associated with EGR1

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number
pathway0000187	AP-1 transcription factor network	pid	71	659
pathway0000343	Calcineurin-regulated NFAT-dependent transcription in lymphocytes	pid	50	304
pathway0000634	Downstream signaling in na�ve CD8+ T cells	pid	69	708
pathway0000692	ErbB1 downstream signaling	pid	105	1597
pathway0000916	Glucocorticoid receptor regulatory network	pid	85	876
pathway0001180	Interferon alpha/beta signaling	reactome	67	378
pathway0001825	Regulation of Androgen receptor activity	pid	54	338
pathway0002036	Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)	pid	80	1068
pathway0002037	Signaling events mediated by PRL	pid	23	78
pathway0002339	Trk receptor signaling mediated by PI3K and PLC-gamma	pid	36	303
pathway0002340	Trk receptor signaling mediated by the MAPK pathway	pid	34	175
pathway0002596	Cell adhesion molecules (CAMs)	kegg	133	672
pathway0002643	Prion diseases	kegg	34	110
pathway0002707	Hs_Thyroid_Stimulating_Hormone_(TSH)_signaling_pathway_WP2032_89823	wikipathways	28	79
pathway0002750	Hs_Serotonin_Receptor_4-6-7_and_NR3C_Signaling_WP734_74438	wikipathways	15	37
pathway0002760	Hs_Oncostatin_M_Signaling_Pathway_WP2374_73668	wikipathways	44	408

Go term information of EGR1

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GO_term_name	GO_term_type	TF_name
GO_POSITIVE_REGULATION_OF_METANEPHROS_DEVELOPMENT	BP	EGR1
GO_MUSCLE_ORGAN_DEVELOPMENT	BP	EGR1
GO_CELLULAR_RESPONSE_TO_INTERLEUKIN_1	BP	EGR1
GO_REGULATION_OF_PROTEIN_SUMOYLATION	BP	EGR1
GO_POSITIVE_REGULATION_OF_NEURON_DIFFERENTIATION	BP	EGR1
GO_POSITIVE_REGULATION_OF_KIDNEY_DEVELOPMENT	BP	EGR1
GO_CELLULAR_RESPONSE_TO_GAMMA_RADIATION	BP	EGR1
GO_REGULATION_OF_WNT_SIGNALING_PATHWAY	BP	EGR1
GO_REGULATION_OF_CELL_PROLIFERATION_INVOLVED_IN_KIDNEY_DEVELOPMENT	BP	EGR1
GO_REGULATION_OF_KIDNEY_DEVELOPMENT	BP	EGR1
GO_GLOMERULUS_DEVELOPMENT	BP	EGR1
GO_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_IN_RESPONSE_TO_HYPOXIA	BP	EGR1
GO_REGULATION_OF_GLOMERULUS_DEVELOPMENT	BP	EGR1
GO_RESPONSE_TO_CARBOHYDRATE	BP	EGR1
GO_INTERLEUKIN_1_MEDIATED_SIGNALING_PATHWAY	BP	EGR1
GO_RESPONSE_TO_BMP	BP	EGR1
GO_RENAL_SYSTEM_VASCULATURE_DEVELOPMENT	BP	EGR1
GO_REGULATION_OF_METANEPHROS_DEVELOPMENT	BP	EGR1
GO_RESPONSE_TO_GAMMA_RADIATION	BP	EGR1
GO_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_IN_RESPONSE_TO_STRESS	BP	EGR1
GO_SKELETAL_MUSCLE_CELL_DIFFERENTIATION	BP	EGR1
GO_FEEDING_BEHAVIOR	BP	EGR1
GO_REGULATION_OF_VASCULATURE_DEVELOPMENT	BP	EGR1
GO_HISTONE_ACETYLTRANSFERASE_BINDING	MF	EGR1

Survival analysis of EGR1

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of EGR1

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)