Cancer CRCdb

TF information

TF name:	FOSL2
TF family:	TF_bZIP
Ensembl gene ID:	ENSG00000075426
Ensembl protein ID:	ENSP00000264716, ENSP00000368939, ENSP00000396497
Entrez gene ID:	2355

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of FOSL2 in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_01_046	Cell line	Mammary Gland	MCF-7	0.6
Sample_02_006	Other	Cervical	cervical-cancer_parental	0.5
Sample_02_021	Cell line	Colon	V429	0.30959930815797
Sample_02_069	Cell line	Brain	SF268	0.41221374045802
Sample_02_095	Cell line	Mammary Gland	MDA-MB-468	0.17898832684825
Sample_02_161	Cell line	Brain	U87	0.6
Sample_02_164	Cell line	Lung	H2087_Parental	0.5
Sample_02_166	Cell line	Mammary Gland	HCC1954_Parental	0.312
Sample_02_179	Cell line	Urinary bladder	T24	0.19540229885057
Sample_02_182	Cell line	Human melanoma	LOX-IMVI	0.26436781609195
Sample_02_191	Cell line	Stomach	SNU719	0.21428571428571
Sample_02_196	Cell line	Stomach	NCC59	1
Sample_02_197	Cell line	Stomach	SNU1750	0.44444444444444
Sample_02_199	Cell line	Stomach	KATO3	1
Sample_02_204	Cell line	Stomach	IM95	0.31818181818182
Sample_02_205	Tissue	Stomach	Gastric_Primary_Sample_T	0.40740740740741
Sample_02_208	Cell line	Stomach	YCC3	0.75
Sample_02_219	Cell line	Mammary Gland	MDA-MB-231	0.79411764705882
Sample_02_220	Cell line	Brain	BE2C_1	0.15384615384615
Sample_02_227	Cell line	Oesophagus	TE7	0.76
Sample_02_228	Cell line	Oesophagus	KYSE510	0.32339235787512
Sample_02_236	Cell line	Colon	V206	0.42650103519669
Sample_02_237	Cell line	Colon	V389	0.43942573163998
Sample_02_241	Cell line	Colon	V456	0.27539503386005
Sample_02_242	Cell line	Colon	V481	0.16157149266167
Sample_02_267	Cell line	Kidney	786-O	0.8
Sample_02_268	Cell line	Kidney	A-498	0.28281336533136
Sample_02_280	Cell line	Mammary Gland	SUM159_DMSO_24h	0.45833333333333
Sample_02_317	Cell line	Neuroblastoma	GICAN	0.28378378378378
Sample_02_318	Cell line	Neuroblastoma	NB69	0.328125
Sample_02_322	Cell line	Colon	Caco-2	0.18169582772544
Sample_02_338	Cell line	Neuroblastoma	BE2	0.14705882352941
Sample_02_354	Cell line	Colon	Colo205	0.31381381381381
Sample_02_356	Cell line	Colon	Sw480	0.083870967741935
Sample_02_358	Cell line	Colon	LS180	0.2480252764613
Sample_02_361	Cell line	Colon	HT29_DMSO	0.20353982300885
Sample_02_395	Cell line	Mammary Gland	BT-549	0.1172027972028
Sample_02_413	Tissue	Brain	GBM_2493	0.06043956043956
Sample_02_430	Cell line	Kidney	12364284	0.26785714285714

FOSL2 distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name
Sample_02_021	Colon	Cell line	V429
Sample_02_069	Brain	Cell line	SF268
Sample_02_161	Brain	Cell line	U87
Sample_02_182	Human melanoma	Cell line	LOX-IMVI
Sample_02_196	Stomach	Cell line	NCC59
Sample_02_199	Stomach	Cell line	KATO3
Sample_02_205	Stomach	Tissue	Gastric_Primary_Sample_T
Sample_02_208	Stomach	Cell line	YCC3
Sample_02_219	Mammary Gland	Cell line	MDA-MB-231
Sample_02_227	Oesophagus	Cell line	TE7
Sample_02_237	Colon	Cell line	V389
Sample_02_267	Kidney	Cell line	786-O
Sample_02_280	Mammary Gland	Cell line	SUM159_DMSO_24h

FOSL2 distribution in all CRCs

Genomic distribution of SEs associated with FOSL2

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Mutation of FOSL2

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of FOSL2

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr2	28635007	28635007	C	G	exonic	FOSL2	nonsynonymous	UCEC\|1\|248\|0.00403
rs143327177	chr2	28634930	28634930	G	T	exonic	FOSL2	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr2	28635091	28635091	G	-	exonic	FOSL2	frameshift	LIHC\|1\|373\|0.00268
-	chr2	28616622	28616622	C	G	exonic	FOSL2	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr2	28635083	28635083	G	A	exonic	FOSL2	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr2	28627127	28627127	C	T	exonic	FOSL2	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr2	28634913	28634913	T	A	exonic	FOSL2	synonymous	UCEC\|1\|248\|0.00403
-	chr2	28635106	28635106	G	C	exonic	FOSL2	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr2	28627123	28627123	C	T	exonic	FOSL2	synonymous	SKCM\|1\|368\|0.00272
rs763475600	chr2	28635103	28635103	G	A	exonic	FOSL2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs773239010	chr2	28634933	28634933	C	T	exonic	FOSL2	nonsynonymous	SKCM\|1\|368\|0.00272
rs768637618	chr2	28627206	28627206	G	A	exonic	FOSL2	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr2	28631726	28631726	T	G	exonic	FOSL2	nonsynonymous	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr2	28634937	28634949	CCCAGCCCCTGGG	-	exonic	FOSL2	frameshift	HNSC\|1\|512\|0.00195
-	chr2	28634856	28634860	GAAGG	-	exonic	FOSL2	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs375020008	chr2	28627104	28627104	G	A	exonic	FOSL2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr2	28627100	28627100	C	A	exonic	FOSL2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr2	28634820	28634820	G	C	exonic	FOSL2	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr2	28634949	28634949	-	T	exonic	FOSL2	frameshift	BLCA\|1\|396\|0.00253
-	chr2	28627094	28627094	C	A	exonic	FOSL2	nonsynonymous	ACC\|1\|90\|0.01111
-	chr2	28631696	28631696	G	A	exonic	FOSL2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr2	28635086	28635086	T	G	exonic	FOSL2	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr2	28635026	28635026	C	T	exonic	FOSL2	nonsynonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr2	28634862	28634863	GA	-	exonic	FOSL2	frameshift	BLCA\|1\|396\|0.00253
-	chr2	28635000	28635000	A	T	exonic	FOSL2	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr2	28627145	28627145	C	T	exonic	FOSL2	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr2	28631707	28631707	C	T	exonic	FOSL2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr2	28627079	28627079	A	G	exonic	FOSL2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr2	28634796	28634796	G	T	splicing	FOSL2	splicing	PAAD\|1\|185\|0.00541
-	chr2	28635275	28635275	C	T	exonic	FOSL2	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr2	28635208	28635208	T	C	exonic	FOSL2	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr2	28634937	28634937	-	CAG	exonic	FOSL2	nonframeshift	HNSC\|1\|512\|0.00195
-	chr2	28634939	28634951	CAGCCCCTGGGCT	-	exonic	FOSL2	frameshift	HNSC\|1\|512\|0.00195
-	chr2	28635076	28635076	C	-	exonic	FOSL2	frameshift	BLCA\|1\|396\|0.00253
-	chr2	28635187	28635187	C	T	exonic	FOSL2	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr2	28635177	28635177	C	T	exonic	FOSL2	synonymous	SKCM\|1\|368\|0.00272
rs747349464	chr2	28627159	28627159	C	T	exonic	FOSL2	synonymous	SKCM\|1\|368\|0.00272
-	chr2	28634925	28634928	GCGC	-	exonic	FOSL2	frameshift	LUSC\|1\|178\|0.00562
-	chr2	28634997	28634997	G	C	exonic	FOSL2	synonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
rs112541505	chr2	28627027	28627027	C	T	exonic	FOSL2	synonymous	BLCA\|1\|396\|0.00253,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr2	28634914	28634922	AGCCCCGAG	-	exonic	FOSL2	nonframeshift	HNSC\|1\|512\|0.00195
-	chr2	28627022	28627022	A	G	exonic	FOSL2	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr2	28627144	28627144	C	T	exonic	FOSL2	synonymous	HNSC\|1\|512\|0.00195
rs143327177	chr2	28634930	28634930	G	A	exonic	FOSL2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr2	28635081	28635081	C	T	exonic	FOSL2	synonymous	CESC\|1\|194\|0.00515
rs199613963	chr2	28627119	28627119	G	T	exonic	FOSL2	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr2	28634865	28634866	GG	-	exonic	FOSL2	frameshift	COAD\|2\|367\|0.00545,COADREAD\|2\|489\|0.00409
-	chr2	28631719	28631719	G	A	exonic	FOSL2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,OV\|1\|469\|0.00213
-	chr2	28627176	28627176	T	G	exonic	FOSL2	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr2	28627033	28627033	C	T	exonic	FOSL2	synonymous	SKCM\|1\|368\|0.00272
-	chr2	28635012	28635012	G	A	exonic	FOSL2	synonymous	BRCA\|1\|982\|0.00102
-	chr2	28634924	28634924	-	C	exonic	FOSL2	frameshift	HNSC\|1\|512\|0.00195
-	chr2	28616645	28616645	C	G	exonic	FOSL2	nonsynonymous	CESC\|1\|194\|0.00515
-	chr2	28635285	28635285	C	T	exonic	FOSL2	synonymous	SKCM\|1\|368\|0.00272
-	chr2	28626994	28626994	T	C	exonic	FOSL2	synonymous	UCS\|1\|57\|0.01754
-	chr2	28635280	28635280	G	A	exonic	FOSL2	nonsynonymous	SKCM\|1\|368\|0.00272
rs767171135	chr2	28631669	28631669	G	A	exonic	FOSL2	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr2	28635251	28635251	G	T	exonic	FOSL2	nonsynonymous	UCEC\|1\|248\|0.00403
rs773347086	chr2	28635192	28635192	C	T	exonic	FOSL2	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr2	28635065	28635065	C	G	exonic	FOSL2	nonsynonymous	CESC\|1\|194\|0.00515
-	chr2	28634949	28634949	-	C	exonic	FOSL2	frameshift	BLCA\|1\|396\|0.00253
-	chr2	28635205	28635205	G	C	exonic	FOSL2	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr2	28627222	28627222	-	C	exonic	FOSL2	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr2	28635135	28635135	G	A	exonic	FOSL2	synonymous	LUAD\|1\|543\|0.00184
-	chr2	28626989	28626989	A	G	exonic	FOSL2	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr2	28635199	28635199	G	C	exonic	FOSL2	nonsynonymous	OV\|1\|469\|0.00213
-	chr2	28635229	28635229	T	G	exonic	FOSL2	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr2	28631654	28631654	G	A	exonic	FOSL2	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr2	28635284	28635284	C	T	exonic	FOSL2	nonsynonymous	SKCM\|1\|368\|0.00272
rs200360785	chr2	28635174	28635174	C	T	exonic	FOSL2	synonymous	SKCM\|1\|368\|0.00272
-	chr2	28631664	28631664	G	C	exonic	FOSL2	synonymous	HNSC\|1\|512\|0.00195
-	chr2	28634831	28634831	T	C	exonic	FOSL2	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr2	28627122	28627122	C	A	exonic	FOSL2	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr2	28631709	28631709	G	T	exonic	FOSL2	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr2	28631704	28631704	C	T	exonic	FOSL2	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr2	28631710	28631710	G	C	exonic	FOSL2	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr2	28616605	28616605	C	T	exonic	FOSL2	synonymous	BLCA\|1\|396\|0.00253
-	chr2	28634812	28634813	GA	-	exonic	FOSL2	frameshift	ESCA\|1\|185\|0.00541
-	chr2	28634797	28634797	G	T	exonic	FOSL2	stopgain	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr2	28634950	28634950	C	T	exonic	FOSL2	synonymous	SKCM\|1\|368\|0.00272

Disease information of FOSL2

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
FOSL2	Glioblastoma	C04	Neoplastic Process	CTD_human
FOSL2	Lung Neoplasms	C04;C08	Neoplastic Process	CTD_human
FOSL2	Juvenile-Onset Still Disease	C05;C17;C20	Disease or Syndrome	CTD_human
FOSL2	Malignant neoplasm of lung	C04;C08	Neoplastic Process	CTD_human
FOSL2	Giant Cell Glioblastoma	C04	Neoplastic Process	CTD_human
FOSL2	Glioblastoma Multiforme	C04	Neoplastic Process	CTD_human
FOSL2	Juvenile arthritis	C05;C17;C20	Disease or Syndrome	CTD_human
FOSL2	Juvenile psoriatic arthritis	C05;C17;C20	Disease or Syndrome	CTD_human

Pathway associated with FOSL2

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number
pathway0000187	AP-1 transcription factor network	pid	71	659
pathway0000895	Gene expression of IL2 by AP-1 ( CD4 T cell receptor signaling (JNK cascade) )	inoh	5	10
pathway0000896	Gene expression of IL2 by AP-1 ( CD4 T cell receptor signaling )	inoh	5	10
pathway0001230	JNK cascade ( CD4 T cell receptor signaling (JNK cascade) )	inoh	12	48
pathway0001231	JNK cascade ( CD4 T cell receptor signaling )	inoh	10	35
pathway0002392	Validated transcriptional targets of AP1 family members Fra1 and Fra2	pid	37	165
pathway0002393	Validated transcriptional targets of deltaNp63 isoforms	pid	47	101

Go term information of FOSL2

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GO_term_name	GO_term_type	TF_name
GO_POSITIVE_REGULATION_OF_FIBROBLAST_PROLIFERATION	BP	FOSL2
GO_KERATINOCYTE_DIFFERENTIATION	BP	FOSL2
GO_REGULATION_OF_FIBROBLAST_PROLIFERATION	BP	FOSL2
GO_EPITHELIAL_CELL_DIFFERENTIATION	BP	FOSL2
GO_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_ACTIVITY_SEQUENCE_SPECIFIC_DNA_BINDING	MF	FOSL2

Survival analysis of FOSL2

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of FOSL2

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)