Cancer CRCdb

TF information

TF name:	TGIF1
TF family:	Homeobox
Ensembl gene ID:	ENSG00000177426
Ensembl protein ID:	ENSP00000339631, ENSP00000450025, ENSP00000383031, ENSP00000327959, ENSP00000385206, ENSP00000449287, ENSP00000449973, ENSP00000446838, ENSP00000384970, ENSP00000447747, ENSP00000449501, ENSP00000449531, ENSP00000448121, ENSP00000384133, ENSP00000449580, ENSP00000483499
Entrez gene ID:	7050

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of TGIF1 in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_01_001	Cell line	Prostate	22Rv1	0.37772397094431
Sample_01_046	Cell line	Mammary Gland	MCF-7	0.4
Sample_01_059	Cell line	Lung	PC-9	0.86666666666667
Sample_02_006	Other	Cervical	cervical-cancer_parental	0.5
Sample_02_007	Other	Cervical	cervical-cancer_vector	0.06953642384106
Sample_02_021	Cell line	Colon	V429	0.58345344479677
Sample_02_069	Cell line	Brain	SF268	0.52671755725191
Sample_02_080	Cell line	Lung	Calu-3	0.45454545454545
Sample_02_095	Cell line	Mammary Gland	MDA-MB-468	0.66770428015564
Sample_02_096	Cell line	Mammary Gland	ZR-75-1_1	0.28260869565217
Sample_02_114	Cell line	Mammary Gland	CAL51	0.39195979899497
Sample_02_164	Cell line	Lung	H2087_Parental	0.41666666666667
Sample_02_166	Cell line	Mammary Gland	HCC1954_Parental	0.536
Sample_02_168	Cell line	Prostate	LNCaP	0.3574144486692
Sample_02_181	Cell line	Human melanoma	COLO679	0.81013333333333
Sample_02_182	Cell line	Human melanoma	LOX-IMVI	0.50574712643678
Sample_02_183	Cell line	Skin	SKMEL2	0.58974358974359
Sample_02_184	Cell line	Skin	SKMEL30	0.73633440514469
Sample_02_195	Cell line	Stomach	OCUM1	1
Sample_02_219	Cell line	Mammary Gland	MDA-MB-231	0.57843137254902
Sample_02_228	Cell line	Oesophagus	KYSE510	0.70829450139795
Sample_02_236	Cell line	Colon	V206	0.48654244306418
Sample_02_237	Cell line	Colon	V389	0.49085219952144
Sample_02_241	Cell line	Colon	V456	0.43905191873589
Sample_02_242	Cell line	Colon	V481	0.63811446516696
Sample_02_258	Other	Lung	NCI-H1299_EGFP-NEO_reporter_cells_DMSO	0.14444444444444
Sample_02_268	Cell line	Kidney	A-498	0.42089717555843
Sample_02_280	Cell line	Mammary Gland	SUM159_DMSO_24h	0.38333333333333
Sample_02_285	Cell line	Liver	HuH7_untreat	0.29268292682927
Sample_02_307	Cell line	Neuroblastoma	SJNB12	0.056338028169014
Sample_02_308	Cell line	Neuroblastoma	SJNB1	0.0625
Sample_02_317	Cell line	Neuroblastoma	GICAN	0.081081081081081
Sample_02_322	Cell line	Colon	Caco-2	0.38627187079408
Sample_02_323	Cell line	Colon	RKO	1
Sample_02_354	Cell line	Colon	Colo205	0.42342342342342
Sample_02_355	Cell line	Colon	HCT15	0.625
Sample_02_356	Cell line	Colon	Sw480	0.40645161290323
Sample_02_358	Cell line	Colon	LS180	0.71129541864139
Sample_02_359	Cell line	Colon	Colo741	0.46084337349398
Sample_02_361	Cell line	Colon	HT29_DMSO	0.52743362831858
Sample_02_395	Cell line	Mammary Gland	BT-549	0.33230769230769
Sample_02_404	Cell line	Mammary Gland	ZR-75-1_2	0.40287769784173
Sample_02_413	Tissue	Brain	GBM_2493	0.34615384615385
Sample_02_424	Cell line	Colon	SW620	0.81159420289855

TGIF1 distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name
Sample_01_001	Prostate	Cell line	22Rv1
Sample_01_059	Lung	Cell line	PC-9
Sample_02_006	Cervical	Other	cervical-cancer_parental
Sample_02_021	Colon	Cell line	V429
Sample_02_069	Brain	Cell line	SF268
Sample_02_095	Mammary Gland	Cell line	MDA-MB-468
Sample_02_114	Mammary Gland	Cell line	CAL51
Sample_02_166	Mammary Gland	Cell line	HCC1954_Parental
Sample_02_181	Human melanoma	Cell line	COLO679
Sample_02_182	Human melanoma	Cell line	LOX-IMVI
Sample_02_183	Skin	Cell line	SKMEL2
Sample_02_184	Skin	Cell line	SKMEL30
Sample_02_195	Stomach	Cell line	OCUM1
Sample_02_219	Mammary Gland	Cell line	MDA-MB-231
Sample_02_228	Oesophagus	Cell line	KYSE510
Sample_02_236	Colon	Cell line	V206
Sample_02_242	Colon	Cell line	V481
Sample_02_268	Kidney	Cell line	A-498
Sample_02_323	Colon	Cell line	RKO
Sample_02_355	Colon	Cell line	HCT15
Sample_02_358	Colon	Cell line	LS180
Sample_02_359	Colon	Cell line	Colo741
Sample_02_361	Colon	Cell line	HT29_DMSO
Sample_02_424	Colon	Cell line	SW620

TGIF1 distribution in all CRCs

Genomic distribution of SEs associated with TGIF1

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Mutation of TGIF1

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of TGIF1

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr18	3452058	3452058	C	T	exonic	TGIF1	synonymous	SKCM\|1\|368\|0.00272
rs121909069	chr18	3457604	3457604	C	T	exonic	TGIF1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr18	3452101	3452101	T	-	exonic	TGIF1	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr18	3456572	3456572	-	T	exonic	TGIF1	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr18	3456474	3456474	G	T	exonic	TGIF1	nonsynonymous	OV\|1\|469\|0.00213
-	chr18	3456550	3456550	C	-	exonic	TGIF1	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr18	3457449	3457449	T	G	exonic	TGIF1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr18	3456474	3456474	G	-	exonic	TGIF1	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr18	3457371	3457371	C	-	exonic	TGIF1	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr18	3457635	3457635	G	T	exonic	TGIF1	synonymous	KIPAN\|2\|799\|0.00250,KIRC\|2\|451\|0.00443
-	chr18	3457802	3457802	C	-	exonic	TGIF1	frameshift	UCEC\|1\|248\|0.00403
-	chr18	3447754	3447754	A	G	exonic	TGIF1	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr18	3457889	3457889	C	T	exonic	TGIF1	nonsynonymous	TGCT\|1\|155\|0.00645
-	chr18	3457415	3457415	G	T	exonic	TGIF1	nonsynonymous	BRCA\|1\|982\|0.00102
rs776816609	chr18	3452168	3452168	C	T	exonic	TGIF1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr18	3451995	3451995	C	T	exonic	TGIF1	synonymous	UCEC\|1\|248\|0.00403
-	chr18	3447749	3447749	G	A	exonic	TGIF1	synonymous	CHOL\|1\|35\|0.02857
-	chr18	3456381	3456381	G	C	exonic	TGIF1	nonsynonymous	CESC\|1\|194\|0.00515,HNSC\|1\|512\|0.00195
-	chr18	3452011	3452011	G	A	exonic	TGIF1	nonsynonymous	TGCT\|1\|155\|0.00645
-	chr18	3457753	3457753	T	-	exonic	TGIF1	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr18	3451994	3451994	G	A	exonic	TGIF1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr18	3457714	3457714	G	C	exonic	TGIF1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr18	3452124	3452124	C	A	exonic	TGIF1	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr18	3457547	3457547	C	A	exonic	TGIF1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr18	3451984	3451984	C	G	exonic	TGIF1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr18	3457843	3457843	G	A	exonic	TGIF1	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
rs751011709	chr18	3452341	3452341	G	C	exonic	TGIF1	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr18	3452158	3452158	C	A	exonic	TGIF1	nonsynonymous	HNSC\|1\|512\|0.00195
rs765309909	chr18	3451989	3451989	G	A	exonic	TGIF1	synonymous	DLBC\|1\|48\|0.02083
-	chr18	3456685	3456685	A	G	intronic	TGIF1	unknown	ESCA\|1\|185\|0.00541
-	chr18	3456442	3456442	G	A	exonic	TGIF1	nonsynonymous	LUSC\|1\|178\|0.00562
rs371311801	chr18	3456426	3456426	G	A	exonic	TGIF1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr18	3456358	3456358	T	G	exonic	TGIF1	nonsynonymous	CESC\|1\|194\|0.00515
rs749217690	chr18	3456507	3456507	C	G	exonic	TGIF1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr18	3457365	3457365	-	T	exonic	TGIF1	frameshift	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr18	3457387	3457387	C	G	exonic	TGIF1	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr18	3452189	3452189	C	T	exonic	TGIF1	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr18	3457419	3457419	G	A	exonic	TGIF1	synonymous	SKCM\|1\|368\|0.00272
rs11571510	chr18	3452223	3452223	T	-	exonic	TGIF1	frameshift	ACC\|2\|90\|0.02222,COAD\|10\|367\|0.02725,COADREAD\|15\|489\|0.03067,GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189,LUAD\|2\|543\|0.00368,LUSC\|1\|178\|0.00562,READ\|5\|122\|0.04098,SKCM\|1\|368\|0.00272
rs764201714	chr18	3457732	3457732	G	A	exonic	TGIF1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr18	3452225	3452225	C	T	exonic	TGIF1	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr18	3452353	3452353	C	T	exonic	TGIF1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr18	3456483	3456483	C	A	exonic	TGIF1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr18	3456578	3456578	G	T	exonic	TGIF1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr18	3457825	3457825	C	T	exonic	TGIF1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr18	3457782	3457782	-	C	exonic	TGIF1	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr18	3447755	3447755	A	C	exonic	TGIF1	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr18	3457581	3457581	G	A	exonic	TGIF1	synonymous	UCEC\|1\|248\|0.00403
-	chr18	3452062	3452062	C	T	exonic	TGIF1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr18	3457483	3457483	T	C	exonic	TGIF1	nonsynonymous	SARC\|1\|247\|0.00405
-	chr18	3456665	3456665	C	G	intronic	TGIF1	unknown	BLCA\|1\|396\|0.00253
-	chr18	3456494	3456494	G	T	exonic	TGIF1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr18	3456404	3456418	TCCCTTGGACCTTTC	-	exonic	TGIF1	nonframeshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs8098291	chr18	3452262	3452262	C	T	exonic	TGIF1	synonymous	DLBC\|1\|48\|0.02083
-	chr18	3457644	3457644	T	C	exonic	TGIF1	synonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr18	3456512	3456512	C	A	exonic	TGIF1	stopgain	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr18	3457641	3457641	C	A	exonic	TGIF1	stopgain	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204

Disease information of TGIF1

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
TGIF1	Neoplasm Invasiveness	C04;C23	Pathologic Function	CTD_human
TGIF1	Arhinencephaly	C05;C10;C16	Congenital Abnormality	CTD_human
TGIF1	Holoprosencephaly	C05;C10;C16	Congenital Abnormality	CTD_human;GENOMICS_ENGLAND
TGIF1	Lobar Holoprosencephaly	C05;C10;C16	Congenital Abnormality	CTD_human;ORPHANET
TGIF1	Alobar Holoprosencephaly	C05;C10;C16	Congenital Abnormality	CTD_human;ORPHANET
TGIF1	Semilobar Holoprosencephaly	C05;C10;C16	Congenital Abnormality	CTD_human;ORPHANET
TGIF1	HOLOPROSENCEPHALY 4 (disorder)	C05;C10;C16	Disease or Syndrome	CTD_human;UNIPROT
TGIF1	Intellectual Disability	C10;C23;F01;F03	Mental or Behavioral Dysfunction	GENOMICS_ENGLAND

Pathway associated with TGIF1

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number
pathway0000631	Downregulation of SMAD2/3:SMAD4 transcriptional activity	reactome	23	145
pathway0002069	SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	reactome	32	197
pathway0002812	Hs_Sudden_Infant_Death_Syndrome_(SIDS)_Susceptibility_Pathways_WP706_86078	wikipathways	33	60
pathway0002853	Hs_TGF-beta_Signaling_Pathway_WP366_90028	wikipathways	67	576

Go term information of TGIF1

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GO_term_name	GO_term_type	TF_name
GO_RESPONSE_TO_GROWTH_FACTOR	BP	TGIF1
GO_CO_SMAD_BINDING	MF	TGIF1
GO_TRANSCRIPTION_FACTOR_ACTIVITY_RNA_POLYMERASE_II_CORE_PROMOTER_PROXIMAL_REGION_SEQUENCE_SPECIFIC_BINDING	MF	TGIF1
GO_CORE_PROMOTER_PROXIMAL_REGION_DNA_BINDING	MF	TGIF1

Survival analysis of TGIF1

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of TGIF1

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)