Cancer CRCdb

TF information

TF name:	NFIB
TF family:	CTF/NFI
Ensembl gene ID:	ENSG00000147862
Ensembl protein ID:	ENSP00000475362, ENSP00000490945, ENSP00000380711, ENSP00000490020, ENSP00000380705, ENSP00000370340, ENSP00000490762, ENSP00000370321, ENSP00000496424, ENSP00000475813, ENSP00000490864, ENSP00000370311, ENSP00000489634, ENSP00000442888, ENSP00000490588, ENSP00000380709
Entrez gene ID:	4781

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of NFIB in all biosamples

Download

Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_02_007	Other	Cervical	cervical-cancer_vector	0.0099337748344371
Sample_02_021	Cell line	Colon	V429	0.13865667339291
Sample_02_095	Cell line	Mammary Gland	MDA-MB-468	0.39027237354086
Sample_02_164	Cell line	Lung	H2087_Parental	0.15
Sample_02_166	Cell line	Mammary Gland	HCC1954_Parental	0.056
Sample_02_182	Cell line	Human melanoma	LOX-IMVI	0.089080459770115
Sample_02_220	Cell line	Brain	BE2C_1	0.012820512820513
Sample_02_228	Cell line	Oesophagus	KYSE510	0.084808946877912
Sample_02_237	Cell line	Colon	V389	0.012589729431253
Sample_02_254	Cell line	Neuroblastoma	IMR5-75	0.029411764705882
Sample_02_258	Other	Lung	NCI-H1299_EGFP-NEO_reporter_cells_DMSO	0.082222222222222
Sample_02_268	Cell line	Kidney	A-498	0.072549381576518
Sample_02_296	Cell line	Neuroblastoma	CLB-BER-Lud	0.03672532517215
Sample_02_298	Cell line	Neuroblastoma	CLB-GA	0.027397260273973
Sample_02_299	Cell line	Neuroblastoma	CLB-MA	0.0047961630695444
Sample_02_303	Cell line	Neuroblastoma	LAN1	0.057142857142857
Sample_02_307	Cell line	Neuroblastoma	SJNB12	0.014084507042254
Sample_02_308	Cell line	Neuroblastoma	SJNB1	0.015625
Sample_02_309	Cell line	Neuroblastoma	SJNB6	0.004739336492891
Sample_02_310	Cell line	Neuroblastoma	SJNB8	0.00065530799475754
Sample_02_311	Cell line	Neuroblastoma	SK-N-AS	0.012987012987013
Sample_02_312	Cell line	Neuroblastoma	SK-N-BE_2-C	0.01063829787234
Sample_02_313	Cell line	Neuroblastoma	SK-N-DZ	0.0038610038610039
Sample_02_314	Cell line	Neuroblastoma	SK-N-FI	0.0061728395061728
Sample_02_316	Cell line	Neuroblastoma	CHP212	0.0054945054945055
Sample_02_318	Cell line	Neuroblastoma	NB69	0.0078125
Sample_02_319	Cell line	Neuroblastoma	NB-EBc1	0.011560693641618
Sample_02_338	Cell line	Neuroblastoma	BE2	0.014705882352941
Sample_02_395	Cell line	Mammary Gland	BT-549	0.26937062937063
Sample_02_404	Cell line	Mammary Gland	ZR-75-1_2	0.35251798561151
Sample_02_413	Tissue	Brain	GBM_2493	0.13736263736264

NFIB distribution in samples’ most representative CRC

Download

Sample ID	Tissue type	Biosample type	Biosample name
Sample_02_095	Mammary Gland	Cell line	MDA-MB-468

NFIB distribution in all CRCs

Genomic distribution of SEs associated with NFIB

Download

Mutation of NFIB

Download

Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of NFIB

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr9	14307385	14307385	T	-	exonic	NFIB	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,KIPAN\|2\|799\|0.00250,KIRC\|2\|451\|0.00443
-	chr9	14307284	14307284	C	A	exonic	NFIB	nonsynonymous	KIPAN\|2\|799\|0.00250,KIRC\|2\|451\|0.00443
-	chr9	14113035	14113035	A	G	exonic	NFIB	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr9	14120485	14120485	T	C	exonic	NFIB	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr9	14307058	14307058	G	T	exonic	NFIB	synonymous	LUSC\|1\|178\|0.00562
-	chr9	14146806	14146806	G	C	exonic	NFIB	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr9	14120603	14120603	G	C	exonic	NFIB	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr9	14146709	14146709	T	C	exonic	NFIB	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr9	14313500	14313500	G	A	exonic	NFIB	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr9	14307010	14307010	-	A	exonic	NFIB	frameshift	LUAD\|1\|543\|0.00184
-	chr9	14120446	14120446	G	A	exonic	NFIB	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr9	14146751	14146751	C	G	exonic	NFIB	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr9	14307412	14307412	C	T	exonic	NFIB	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr9	14155894	14155894	T	A	splicing	NFIB	splicing	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr9	14307000	14307000	C	T	exonic	NFIB	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr9	14307195	14307195	C	T	exonic	NFIB	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,UCEC\|1\|248\|0.00403
-	chr9	14307434	14307434	C	T	exonic	NFIB	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr9	14307498	14307498	C	T	exonic	NFIB	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
rs545983563	chr9	14307409	14307409	C	T	exonic	NFIB	synonymous	PAAD\|1\|185\|0.00541
-	chr9	14307166	14307166	C	T	exonic	NFIB	stopgain	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr9	14146797	14146797	G	T	exonic	NFIB	synonymous	HNSC\|1\|512\|0.00195
-	chr9	14307139	14307139	C	G	exonic	NFIB	synonymous	BRCA\|1\|982\|0.00102
-	chr9	14307337	14307337	C	T	exonic	NFIB	synonymous	SKCM\|1\|368\|0.00272
rs747872784	chr9	14150186	14150186	G	A	exonic	NFIB	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr9	14307175	14307177	GTC	-	exonic	NFIB	nonframeshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr9	14146730	14146730	A	G	exonic	NFIB	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr9	14155846	14155846	T	G	exonic	NFIB	synonymous	UCEC\|1\|248\|0.00403
rs770325375	chr9	14307364	14307364	G	A	exonic	NFIB	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr9	14307015	14307015	A	C	exonic	NFIB	nonsynonymous	DLBC\|1\|48\|0.02083
-	chr9	14307214	14307214	C	A	exonic	NFIB	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr9	14307521	14307521	T	C	splicing	NFIB	splicing	LUSC\|1\|178\|0.00562
-	chr9	14125636	14125636	T	A	exonic	NFIB	nonsynonymous	ESCA\|2\|185\|0.01081
-	chr9	14146719	14146719	A	T	exonic	NFIB	synonymous	LUAD\|1\|543\|0.00184
-	chr9	14307382	14307382	T	A	exonic	NFIB	synonymous	LUSC\|1\|178\|0.00562
-	chr9	14155855	14155855	G	T	exonic	NFIB	nonsynonymous	BLCA\|2\|396\|0.00505
rs762726429	chr9	14146711	14146711	C	T	exonic	NFIB	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr9	14307321	14307321	G	A	exonic	NFIB	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr9	14307164	14307164	C	T	exonic	NFIB	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr9	14307439	14307439	T	A	exonic	NFIB	synonymous	LUAD\|1\|543\|0.00184
-	chr9	14120612	14120612	G	A	exonic	NFIB	stopgain	UCEC\|1\|248\|0.00403
-	chr9	14307200	14307200	C	A	exonic	NFIB	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr9	14120551	14120551	G	C	exonic	NFIB	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr9	14116247	14116247	C	T	exonic	NFIB	synonymous	CESC\|1\|194\|0.00515
-	chr9	14307186	14307186	G	A	exonic	NFIB	stopgain	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs371408383	chr9	14146701	14146701	G	A	exonic	NFIB	synonymous	LUAD\|1\|543\|0.00184
-	chr9	14150231	14150231	G	-	exonic	NFIB	frameshift	LUAD\|1\|543\|0.00184
-	chr9	14125696	14125696	G	A	exonic	NFIB	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr9	14125655	14125655	C	T	exonic	NFIB	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr9	14150223	14150223	C	A	exonic	NFIB	stopgain	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr9	14150259	14150259	T	C	exonic	NFIB	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr9	14120548	14120548	G	A	exonic	NFIB	nonsynonymous	UCEC\|1\|248\|0.00403
rs368309534	chr9	14150263	14150263	C	T	exonic	NFIB	synonymous	HNSC\|1\|512\|0.00195,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr9	14179741	14179741	C	T	exonic	NFIB	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr9	14307393	14307393	C	T	exonic	NFIB	nonsynonymous	BLCA\|1\|396\|0.00253
rs370563581	chr9	14307296	14307296	C	T	exonic	NFIB	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr9	14307185	14307185	C	A	exonic	NFIB	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
rs563322451	chr9	14307196	14307196	G	A	exonic	NFIB	synonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr9	14146769	14146769	C	T	exonic	NFIB	nonsynonymous	SKCM\|1\|368\|0.00272
rs765968906	chr9	14307111	14307111	C	T	exonic	NFIB	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr9	14088266	14088266	G	A	exonic	NFIB	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr9	14307161	14307161	A	C	exonic	NFIB	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr9	14125722	14125722	C	-	exonic	NFIB	frameshift	HNSC\|1\|512\|0.00195
-	chr9	14307309	14307309	G	A	exonic	NFIB	nonsynonymous	UCEC\|1\|248\|0.00403,UCS\|1\|57\|0.01754
-	chr9	14150255	14150255	G	A	exonic	NFIB	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr9	14120462	14120462	G	A	exonic	NFIB	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr9	14146736	14146736	G	C	exonic	NFIB	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr9	14307176	14307176	T	C	exonic	NFIB	nonsynonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr9	14146714	14146714	C	-	exonic	NFIB	frameshift	SKCM\|1\|368\|0.00272
-	chr9	14120611	14120611	C	T	exonic	NFIB	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr9	14113047	14113047	C	T	exonic	NFIB	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr9	14150218	14150218	G	A	exonic	NFIB	synonymous	UCEC\|1\|248\|0.00403
-	chr9	14116325	14116325	T	A	exonic	NFIB	synonymous	TGCT\|1\|155\|0.00645
rs772662135	chr9	14307244	14307244	C	T	exonic	NFIB	synonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr9	14179764	14179765	CC	-	exonic	NFIB	frameshift	LUAD\|1\|543\|0.00184
-	chr9	14313493	14313493	G	A	exonic	NFIB	synonymous	BLCA\|1\|396\|0.00253
-	chr9	14150145	14150145	T	C	exonic	NFIB	nonsynonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
rs773837618	chr9	14307440	14307440	C	T	exonic	NFIB	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr9	14307370	14307370	C	T	exonic	NFIB	synonymous	LUAD\|1\|543\|0.00184
-	chr9	14125766	14125766	C	A	splicing	NFIB	splicing	PRAD\|1\|499\|0.00200
-	chr9	14120501	14120501	G	A	exonic	NFIB	nonsynonymous	SARC\|1\|247\|0.00405
-	chr9	14120531	14120531	G	A	exonic	NFIB	nonsynonymous	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr9	14150265	14150265	C	A	splicing	NFIB	splicing	LUAD\|2\|543\|0.00368

Disease information of NFIB

Download

TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
NFIB	Adenoid Cystic Carcinoma	C04	Neoplastic Process	CTD_human

Pathway associated with NFIB

Download

pathway_ID	pathway_name	pathway_source	gene_number	edge_number
pathway0000824	FOXA1 transcription factor network	pid	45	204
pathway0001926	RNA Polymerase III Abortive And Retractive Initiation	reactome	41	663
pathway0001931	RNA Polymerase III Transcription Termination	reactome	23	245
pathway0002757	Hs_Pathways_Affected_in_Adenoid_Cystic_Carcinoma_WP3651_89271	wikipathways	27	108

Go term information of NFIB

Download

GO_term_name	GO_term_type	TF_name
GO_NEGATIVE_REGULATION_OF_EPITHELIAL_CELL_PROLIFERATION	BP	NFIB
GO_LUNG_EPITHELIUM_DEVELOPMENT	BP	NFIB
GO_GLAND_MORPHOGENESIS	BP	NFIB
GO_SALIVARY_GLAND_DEVELOPMENT	BP	NFIB
GO_LUNG_CELL_DIFFERENTIATION	BP	NFIB
GO_SKELETAL_SYSTEM_DEVELOPMENT	BP	NFIB
GO_NEURON_PROJECTION_DEVELOPMENT	BP	NFIB
GO_NEGATIVE_REGULATION_OF_DNA_BINDING	BP	NFIB
GO_REGULATION_OF_EPITHELIAL_CELL_PROLIFERATION	BP	NFIB
GO_NEGATIVE_REGULATION_OF_STEM_CELL_PROLIFERATION	BP	NFIB
GO_REGULATION_OF_MESENCHYMAL_CELL_PROLIFERATION	BP	NFIB
GO_GLIOGENESIS	BP	NFIB
GO_REGULATION_OF_DNA_BINDING	BP	NFIB
GO_CHONDROCYTE_DIFFERENTIATION	BP	NFIB
GO_EXOCRINE_SYSTEM_DEVELOPMENT	BP	NFIB
GO_TUBE_DEVELOPMENT	BP	NFIB
GO_CENTRAL_NERVOUS_SYSTEM_PROJECTION_NEURON_AXONOGENESIS	BP	NFIB
GO_CONNECTIVE_TISSUE_DEVELOPMENT	BP	NFIB
GO_RESPIRATORY_SYSTEM_DEVELOPMENT	BP	NFIB
GO_CELL_MORPHOGENESIS_INVOLVED_IN_NEURON_DIFFERENTIATION	BP	NFIB
GO_CENTRAL_NERVOUS_SYSTEM_NEURON_DEVELOPMENT	BP	NFIB
GO_REGULATION_OF_PRI_MIRNA_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER	BP	NFIB
GO_EPITHELIAL_CELL_DIFFERENTIATION	BP	NFIB
GO_CENTRAL_NERVOUS_SYSTEM_NEURON_AXONOGENESIS	BP	NFIB
GO_RNA_POLYMERASE_II_TRANSCRIPTION_COREPRESSOR_ACTIVITY	MF	NFIB
GO_TRANSCRIPTIONAL_ACTIVATOR_ACTIVITY_RNA_POLYMERASE_II_TRANSCRIPTION_REGULATORY_REGION_SEQUENCE_SPECIFIC_BINDING	MF	NFIB

Survival analysis of NFIB

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of NFIB

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)