Cancer CRCdb

TF information

TF name:	FOXQ1
TF family:	Fork_head
Ensembl gene ID:	ENSG00000164379
Ensembl protein ID:	ENSP00000296839
Entrez gene ID:	94234

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of FOXQ1 in all biosamples

Download

Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_02_021	Cell line	Colon	V429	0.84433554338426
Sample_02_187	Cell line	Stomach	KATOIII	0.66666666666667
Sample_02_191	Cell line	Stomach	SNU719	0.42857142857143
Sample_02_196	Cell line	Stomach	NCC59	0.21428571428571
Sample_02_197	Cell line	Stomach	SNU1750	0.33333333333333
Sample_02_199	Cell line	Stomach	KATO3	0.66666666666667
Sample_02_204	Cell line	Stomach	IM95	0.63636363636364
Sample_02_205	Tissue	Stomach	Gastric_Primary_Sample_T	0.82962962962963
Sample_02_208	Cell line	Stomach	YCC3	1
Sample_02_219	Cell line	Mammary Gland	MDA-MB-231	0.049019607843137
Sample_02_227	Cell line	Oesophagus	TE7	0.32
Sample_02_228	Cell line	Oesophagus	KYSE510	0.13793103448276
Sample_02_241	Cell line	Colon	V456	0.36343115124153
Sample_02_280	Cell line	Mammary Gland	SUM159_DMSO_24h	0.21666666666667
Sample_02_285	Cell line	Liver	HuH7_untreat	0.27526132404181
Sample_02_322	Cell line	Colon	Caco-2	0.36877523553163
Sample_02_356	Cell line	Colon	Sw480	0.5741935483871
Sample_02_358	Cell line	Colon	LS180	0.34399684044234
Sample_02_361	Cell line	Colon	HT29_DMSO	0.37345132743363
Sample_02_424	Cell line	Colon	SW620	0.72463768115942

FOXQ1 distribution in samples’ most representative CRC

Download

Sample ID	Tissue type	Biosample type	Biosample name
Sample_02_021	Colon	Cell line	V429
Sample_02_187	Stomach	Cell line	KATOIII
Sample_02_191	Stomach	Cell line	SNU719
Sample_02_199	Stomach	Cell line	KATO3
Sample_02_204	Stomach	Cell line	IM95
Sample_02_205	Stomach	Tissue	Gastric_Primary_Sample_T
Sample_02_208	Stomach	Cell line	YCC3
Sample_02_227	Oesophagus	Cell line	TE7
Sample_02_361	Colon	Cell line	HT29_DMSO
Sample_02_424	Colon	Cell line	SW620

FOXQ1 distribution in all CRCs

Genomic distribution of SEs associated with FOXQ1

Download

Mutation of FOXQ1

Download

Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of FOXQ1

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr6	1313357	1313357	T	C	exonic	FOXQ1	synonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr6	1313368	1313368	G	T	exonic	FOXQ1	synonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr6	1313599	1313599	G	T	exonic	FOXQ1	synonymous	LUAD\|1\|543\|0.00184
-	chr6	1313343	1313343	C	A	exonic	FOXQ1	stopgain	BLCA\|1\|396\|0.00253
-	chr6	1313402	1313402	T	-	exonic	FOXQ1	frameshift	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr6	1313374	1313374	C	T	exonic	FOXQ1	synonymous	BLCA\|1\|396\|0.00253
rs770819384	chr6	1313402	1313402	T	C	exonic	FOXQ1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	1313520	1313520	G	A	exonic	FOXQ1	stopgain	BLCA\|1\|396\|0.00253
-	chr6	1313375	1313376	AA	-	exonic	FOXQ1	frameshift	BLCA\|2\|396\|0.00505
-	chr6	1313312	1313312	A	C	exonic	FOXQ1	nonsynonymous	CESC\|1\|194\|0.00515
rs9502889	chr6	1313117	1313117	A	C	exonic	FOXQ1	nonsynonymous	ACC\|2\|90\|0.02222
-	chr6	1313386	1313386	C	T	exonic	FOXQ1	synonymous	BLCA\|1\|396\|0.00253
rs780504140	chr6	1313285	1313285	C	T	exonic	FOXQ1	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr6	1313296	1313296	-	C	exonic	FOXQ1	frameshift	BLCA\|1\|396\|0.00253
-	chr6	1313539	1313539	C	T	exonic	FOXQ1	synonymous	HNSC\|1\|512\|0.00195
-	chr6	1313345	1313345	G	A	exonic	FOXQ1	nonsynonymous	TGCT\|1\|155\|0.00645
-	chr6	1313791	1313791	C	-	exonic	FOXQ1	frameshift	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr6	1313401	1313401	C	G	exonic	FOXQ1	synonymous	TGCT\|1\|155\|0.00645
-	chr6	1313560	1313560	G	T	exonic	FOXQ1	synonymous	LIHC\|1\|373\|0.00268
-	chr6	1313384	1313384	C	T	exonic	FOXQ1	nonsynonymous	PAAD\|1\|185\|0.00541
rs9502890	chr6	1313121	1313121	A	C	exonic	FOXQ1	nonsynonymous	ACC\|2\|90\|0.02222
-	chr6	1313369	1313369	G	A	exonic	FOXQ1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr6	1313536	1313536	-	A	exonic	FOXQ1	frameshift	BLCA\|1\|396\|0.00253
-	chr6	1313531	1313531	C	T	exonic	FOXQ1	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr6	1313398	1313398	C	A	exonic	FOXQ1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr6	1313344	1313344	G	T	exonic	FOXQ1	synonymous	THCA\|1\|504\|0.00198
-	chr6	1313297	1313297	C	-	exonic	FOXQ1	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	1313480	1313480	C	G	exonic	FOXQ1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr6	1313343	1313343	C	T	exonic	FOXQ1	nonsynonymous	BLCA\|3\|396\|0.00758
-	chr6	1313255	1313255	-	C	exonic	FOXQ1	frameshift	BLCA\|1\|396\|0.00253
-	chr6	1313596	1313596	C	T	exonic	FOXQ1	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs768720637	chr6	1313290	1313290	G	A	exonic	FOXQ1	synonymous	HNSC\|1\|512\|0.00195
-	chr6	1313513	1313526	AACTACTGGATGCT	-	exonic	FOXQ1	frameshift	PAAD\|1\|185\|0.00541
-	chr6	1313481	1313481	T	C	exonic	FOXQ1	nonsynonymous	LUAD\|1\|543\|0.00184
rs566840319	chr6	1313378	1313378	G	A	exonic	FOXQ1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr6	1313422	1313422	G	A	exonic	FOXQ1	synonymous	PRAD\|1\|499\|0.00200
rs78460560	chr6	1313078	1313078	G	A	exonic	FOXQ1	nonsynonymous	ACC\|2\|90\|0.02222
-	chr6	1313801	1313801	G	A	exonic	FOXQ1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr6	1313436	1313436	C	T	exonic	FOXQ1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr6	1313563	1313563	C	G	exonic	FOXQ1	synonymous	BLCA\|1\|396\|0.00253
-	chr6	1313320	1313320	C	G	exonic	FOXQ1	synonymous	BLCA\|1\|396\|0.00253
-	chr6	1313527	1313527	C	G	exonic	FOXQ1	synonymous	HNSC\|2\|512\|0.00391
-	chr6	1313391	1313391	G	A	exonic	FOXQ1	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr6	1313431	1313431	C	A	exonic	FOXQ1	synonymous	BLCA\|1\|396\|0.00253

Disease information of FOXQ1

Download

TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
FOXQ1	Malignant neoplasm of breast	C04;C17	Neoplastic Process	CTD_human
FOXQ1	Breast Carcinoma	C04;C17	Neoplastic Process	CTD_human
FOXQ1	Mammary Neoplasms, Human	C04;C17	Neoplastic Process	CTD_human
FOXQ1	Mammary Neoplasms	C04;C17	Neoplastic Process	CTD_human

Pathway associated with FOXQ1

Download

pathway_ID	pathway_name	pathway_source	gene_number	edge_number

Go term information of FOXQ1

Download

GO_term_name	GO_term_type	TF_name
GO_EPIDERMIS_MORPHOGENESIS	BP	FOXQ1
GO_TISSUE_MORPHOGENESIS	BP	FOXQ1
GO_SKIN_EPIDERMIS_DEVELOPMENT	BP	FOXQ1
GO_MOLTING_CYCLE	BP	FOXQ1
GO_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_ACTIVITY_SEQUENCE_SPECIFIC_DNA_BINDING	MF	FOXQ1

Survival analysis of FOXQ1

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of FOXQ1

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)