Cancer CRCdb

TF information

TF name:	STAT3
TF family:	STAT
Ensembl gene ID:	ENSG00000168610
Ensembl protein ID:	ENSP00000373923, ENSP00000264657, ENSP00000467000, ENSP00000467985, ENSP00000384943
Entrez gene ID:	6774

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of STAT3 in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_02_166	Cell line	Mammary Gland	HCC1954_Parental	0.848
Sample_02_228	Cell line	Oesophagus	KYSE510	0.65144454799627

STAT3 distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name
Sample_02_166	Mammary Gland	Cell line	HCC1954_Parental

STAT3 distribution in all CRCs

Genomic distribution of SEs associated with STAT3

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Mutation of STAT3

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of STAT3

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr17	40485919	40485919	A	T	exonic	STAT3	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr17	40478196	40478196	C	T	exonic	STAT3	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr17	40490754	40490754	T	C	exonic	STAT3	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr17	40476753	40476753	T	C	exonic	STAT3	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	40476865	40476865	C	A	splicing	STAT3	splicing	UCEC\|1\|248\|0.00403
-	chr17	40485746	40485746	G	A	exonic	STAT3	nonsynonymous	DLBC\|1\|48\|0.02083,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	40474513	40474513	C	G	splicing	STAT3	splicing	SKCM\|1\|368\|0.00272
-	chr17	40489876	40489876	C	-	splicing	STAT3	unknown	UCS\|1\|57\|0.01754
-	chr17	40498617	40498617	G	A	exonic	STAT3	synonymous	SKCM\|1\|368\|0.00272
-	chr17	40497585	40497585	C	T	exonic	STAT3	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr17	40476996	40476996	C	T	exonic	STAT3	synonymous	BLCA\|1\|396\|0.00253,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	40489864	40489864	G	-	exonic	STAT3	stopgain	PAAD\|1\|185\|0.00541
-	chr17	40500461	40500461	C	A	exonic	STAT3	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr17	40474489	40474489	C	T	exonic	STAT3	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr17	40491337	40491337	C	T	exonic	STAT3	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr17	40469241	40469241	G	A	exonic	STAT3	synonymous	UCEC\|1\|248\|0.00403
-	chr17	40478180	40478180	G	A	exonic	STAT3	nonsynonymous	PCPG\|2\|184\|0.01087
-	chr17	40498618	40498618	T	A	exonic	STAT3	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr17	40475149	40475149	G	T	exonic	STAT3	synonymous	LUAD\|1\|543\|0.00184
-	chr17	40468916	40468916	C	G	exonic	STAT3	synonymous	LUAD\|1\|543\|0.00184
rs763754846	chr17	40481601	40481601	C	T	exonic	STAT3	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs146817483	chr17	40475346	40475346	G	A	exonic	STAT3	synonymous	SKCM\|1\|368\|0.00272
-	chr17	40475063	40475063	T	C	exonic	STAT3	nonsynonymous	DLBC\|1\|48\|0.02083
rs751536580	chr17	40474481	40474481	G	A	exonic	STAT3	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	40500452	40500452	A	T	exonic	STAT3	nonsynonymous	LIHC\|1\|373\|0.00268
rs869312890	chr17	40491346	40491346	G	A	exonic	STAT3	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr17	40485756	40485756	G	A	exonic	STAT3	synonymous	UCEC\|1\|248\|0.00403
-	chr17	40475064	40475064	C	T	exonic	STAT3	nonsynonymous	CESC\|1\|194\|0.00515
-	chr17	40475303	40475303	A	G	exonic	STAT3	nonsynonymous	LUAD\|2\|543\|0.00368
-	chr17	40481633	40481633	G	-	exonic	STAT3	frameshift	LUAD\|1\|543\|0.00184
-	chr17	40478169	40478169	C	T	exonic	STAT3	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr17	40476777	40476777	G	A	exonic	STAT3	stopgain	PRAD\|1\|499\|0.00200
-	chr17	40500481	40500481	G	C	exonic	STAT3	synonymous	CESC\|2\|194\|0.01031
-	chr17	40481653	40481653	A	C	exonic	STAT3	nonsynonymous	PRAD\|2\|499\|0.00401,UCS\|1\|57\|0.01754
-	chr17	40478182	40478182	G	A	exonic	STAT3	synonymous	SKCM\|1\|368\|0.00272
-	chr17	40500461	40500461	C	T	exonic	STAT3	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs749583802	chr17	40481429	40481429	T	C	exonic	STAT3	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr17	40490751	40490751	C	T	exonic	STAT3	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr17	40476813	40476813	C	T	exonic	STAT3	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	40475062	40475063	TT	-	exonic	STAT3	frameshift	DLBC\|1\|48\|0.02083,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	40467771	40467771	G	A	exonic	STAT3	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr17	40483543	40483543	C	A	exonic	STAT3	synonymous	SKCM\|1\|368\|0.00272
-	chr17	40498610	40498610	G	A	exonic	STAT3	stopgain	UCEC\|1\|248\|0.00403
-	chr17	40476866	40476866	T	G	splicing	STAT3	splicing	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr17	40474448	40474448	A	G	exonic	STAT3	synonymous	PRAD\|1\|499\|0.00200
-	chr17	40481576	40481576	T	C	exonic	STAT3	nonsynonymous	BRCA\|1\|982\|0.00102,LIHC\|1\|373\|0.00268,LUAD\|1\|543\|0.00184
-	chr17	40474479	40474479	G	A	exonic	STAT3	nonsynonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr17	40500474	40500474	G	C	exonic	STAT3	nonsynonymous	TGCT\|1\|155\|0.00645
-	chr17	40500443	40500443	C	T	exonic	STAT3	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
rs759225787	chr17	40489799	40489799	C	T	exonic	STAT3	synonymous	UCEC\|1\|248\|0.00403
rs376080249	chr17	40481782	40481782	G	A	exonic	STAT3	synonymous	SKCM\|1\|368\|0.00272
-	chr17	40475330	40475330	C	A	exonic	STAT3	nonsynonymous	DLBC\|1\|48\|0.02083
-	chr17	40474455	40474455	G	C	exonic	STAT3	stopgain	LUSC\|1\|178\|0.00562
rs113994137	chr17	40481441	40481441	C	T	exonic	STAT3	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr17	40477031	40477031	T	C	exonic	STAT3	nonsynonymous	PRAD\|1\|499\|0.00200
-	chr17	40474477	40474477	T	C	exonic	STAT3	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr17	40467768	40467768	-	G	exonic	STAT3	frameshift	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr17	40475068	40475068	G	C	exonic	STAT3	nonsynonymous	DLBC\|1\|48\|0.02083
-	chr17	40481604	40481604	T	C	exonic	STAT3	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr17	40489793	40489793	G	A	exonic	STAT3	synonymous	SKCM\|1\|368\|0.00272
-	chr17	40485988	40485988	A	T	exonic	STAT3	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr17	40483494	40483494	C	T	exonic	STAT3	nonsynonymous	LUAD\|3\|543\|0.00552
-	chr17	40476748	40476748	T	A	exonic	STAT3	synonymous	LUAD\|1\|543\|0.00184
-	chr17	40481591	40481591	G	A	exonic	STAT3	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr17	40475078	40475078	C	T	exonic	STAT3	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr17	40498702	40498702	G	C	exonic	STAT3	nonsynonymous	OV\|1\|469\|0.00213
-	chr17	40485969	40485969	A	G	exonic	STAT3	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr17	40475322	40475322	G	T	exonic	STAT3	synonymous	UCEC\|1\|248\|0.00403
-	chr17	40489528	40489528	G	T	exonic	STAT3	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	40498592	40498592	G	T	exonic	STAT3	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr17	40474419	40474419	T	A	exonic	STAT3	nonsynonymous	DLBC\|1\|48\|0.02083,HNSC\|1\|512\|0.00195
-	chr17	40474470	40474470	T	C	exonic	STAT3	nonsynonymous	DLBC\|1\|48\|0.02083
-	chr17	40474485	40474485	G	A	exonic	STAT3	nonsynonymous	PRAD\|1\|499\|0.00200
-	chr17	40475291	40475291	G	A	exonic	STAT3	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr17	40481588	40481588	G	A	exonic	STAT3	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr17	40468893	40468893	A	G	exonic	STAT3	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr17	40491335	40491335	C	A	exonic	STAT3	synonymous	ESCA\|1\|185\|0.00541
-	chr17	40485979	40485979	C	A	exonic	STAT3	nonsynonymous	PRAD\|1\|499\|0.00200
-	chr17	40476790	40476790	G	A	exonic	STAT3	synonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr17	40498730	40498730	C	T	exonic	STAT3	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr17	40498622	40498622	G	A	exonic	STAT3	stopgain	SKCM\|1\|368\|0.00272
-	chr17	40481599	40481599	G	T	exonic	STAT3	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr17	40475298	40475298	G	A	exonic	STAT3	synonymous	SKCM\|1\|368\|0.00272
-	chr17	40497666	40497666	G	A	exonic	STAT3	nonsynonymous	UCEC\|1\|248\|0.00403
rs769031989	chr17	40474482	40474482	T	A	exonic	STAT3	nonsynonymous	DLBC\|1\|48\|0.02083,LIHC\|2\|373\|0.00536
-	chr17	40486045	40486045	G	C	exonic	STAT3	nonsynonymous	BLCA\|2\|396\|0.00505
-	chr17	40467764	40467764	C	G	exonic	STAT3	stoploss	CESC\|1\|194\|0.00515
-	chr17	40485735	40485735	C	T	exonic	STAT3	synonymous	SKCM\|1\|368\|0.00272
-	chr17	40475084	40475084	C	G	exonic	STAT3	nonsynonymous	PRAD\|1\|499\|0.00200
-	chr17	40481601	40481601	C	A	exonic	STAT3	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr17	40481654	40481654	A	T	exonic	STAT3	nonsynonymous	BRCA\|1\|982\|0.00102
rs113512148	chr17	40485908	40485908	C	G	splicing	STAT3	splicing	LUAD\|1\|543\|0.00184
-	chr17	40476842	40476842	G	A	exonic	STAT3	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr17	40485957	40485957	G	A	exonic	STAT3	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr17	40468879	40468879	G	-	exonic	STAT3	frameshift	COAD\|3\|367\|0.00817,COADREAD\|3\|489\|0.00613
-	chr17	40476848	40476848	G	A	exonic	STAT3	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr17	40474456	40474456	A	G	exonic	STAT3	nonsynonymous	LUAD\|1\|543\|0.00184
rs147202525	chr17	40467787	40467787	C	T	exonic	STAT3	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	40474378	40474378	G	A	exonic	STAT3	nonsynonymous	UCEC\|1\|248\|0.00403
rs747639500	chr17	40474420	40474420	C	A	exonic	STAT3	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	40497602	40497602	A	G	exonic	STAT3	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr17	40483533	40483533	G	A	exonic	STAT3	nonsynonymous	SKCM\|1\|368\|0.00272
rs779733888	chr17	40485938	40485938	G	A	exonic	STAT3	synonymous	COAD\|2\|367\|0.00545,COADREAD\|2\|489\|0.00409
-	chr17	40498586	40498586	-	TGCT	splicing	STAT3	unknown	BLCA\|1\|396\|0.00253
-	chr17	40481573	40481573	A	-	exonic	STAT3	stopgain	LUAD\|1\|543\|0.00184
-	chr17	40489554	40489554	C	A	exonic	STAT3	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	40485740	40485740	C	A	exonic	STAT3	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr17	40500471	40500471	A	G	exonic	STAT3	nonsynonymous	UCEC\|1\|248\|0.00403
rs868859792	chr17	40498723	40498723	G	A	exonic	STAT3	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189,LUAD\|1\|543\|0.00184,PAAD\|3\|185\|0.01622,PRAD\|1\|499\|0.00200
-	chr17	40468877	40468877	G	A	exonic	STAT3	synonymous	BRCA\|2\|982\|0.00204
-	chr17	40474352	40474352	G	T	exonic	STAT3	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr17	40481436	40481436	T	C	exonic	STAT3	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr17	40468908	40468908	C	T	exonic	STAT3	nonsynonymous	PAAD\|1\|185\|0.00541
rs373256669	chr17	40474352	40474352	G	A	exonic	STAT3	synonymous	SKCM\|1\|368\|0.00272
-	chr17	40468878	40468878	-	G	exonic	STAT3	frameshift	KIPAN\|2\|799\|0.00250,KIRC\|2\|451\|0.00443
rs146184566	chr17	40498635	40498635	C	T	exonic	STAT3	synonymous	DLBC\|1\|48\|0.02083,UCEC\|1\|248\|0.00403
-	chr17	40474506	40474506	G	A	exonic	STAT3	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr17	40481467	40481467	C	A	exonic	STAT3	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr17	40483492	40483492	G	A	exonic	STAT3	synonymous	ESCA\|1\|185\|0.00541
-	chr17	40475133	40475133	G	A	exonic	STAT3	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr17	40476788	40476788	G	T	exonic	STAT3	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr17	40486033	40486033	G	A	exonic	STAT3	nonsynonymous	HNSC\|1\|512\|0.00195,UCEC\|1\|248\|0.00403
-	chr17	40474406	40474406	G	A	exonic	STAT3	synonymous	LUAD\|1\|543\|0.00184

Disease information of STAT3

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
STAT3	Adenocarcinoma	C04	Neoplastic Process	CTD_human
STAT3	Arthritis, Adjuvant-Induced	C05	Experimental Model of Disease	CTD_human
STAT3	Atherosclerosis	C14	Disease or Syndrome	CTD_human
STAT3	Autoimmune Diseases	C20	Disease or Syndrome	CTD_human
STAT3	Malignant neoplasm of breast	C04;C17	Neoplastic Process	CTD_human
STAT3	Carcinoma	C04	Neoplastic Process	CTD_human
STAT3	Malignant tumor of colon	C04;C06	Neoplastic Process	CTD_human
STAT3	Non-Small Cell Lung Carcinoma	C04;C08	Neoplastic Process	CTD_human
STAT3	Squamous cell carcinoma	C04	Neoplastic Process	CTD_human
STAT3	Neoplastic Cell Transformation	C04;C23	Neoplastic Process	CTD_human
STAT3	Brain Ischemia	C10;C14	Disease or Syndrome	CTD_human
STAT3	Uterine Cervical Neoplasm	C04;C13	Neoplastic Process	CTD_human
STAT3	Ulcerative Colitis	C06	Disease or Syndrome	CTD_human
STAT3	Colonic Neoplasms	C04;C06	Neoplastic Process	CTD_human
STAT3	Craniosynostosis	C05;C16	Disease or Syndrome	GENOMICS_ENGLAND
STAT3	Depressive disorder	F03	Mental or Behavioral Dysfunction	PSYGENET
STAT3	Diabetes Mellitus, Insulin-Dependent	C18;C19;C20	Disease or Syndrome	CTD_human
STAT3	Fever	C23	Sign or Symptom	CTD_human
STAT3	Fibrosis	C23	Pathologic Function	CTD_human
STAT3	Cardiomegaly	C14;C23	Finding	CTD_human
STAT3	Hepatitis, Chronic	C06	Disease or Syndrome	CTD_human
STAT3	Hepatoma, Morris	C04;C06	Experimental Model of Disease; Neoplastic Process	CTD_human
STAT3	Hepatoma, Novikoff	C04;C06	Experimental Model of Disease; Neoplastic Process	CTD_human
STAT3	Inflammation	C23	Pathologic Function	CTD_human
STAT3	Leukemia, Myelocytic, Acute	C04	Neoplastic Process	CTD_human
STAT3	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	C04;C15;C20	Neoplastic Process	CTD_human
STAT3	Leukemia, T-Cell	C04;C15;C20	Neoplastic Process	CTD_human
STAT3	Adult T-Cell Lymphoma/Leukemia	C04;C15;C20	Neoplastic Process	CTD_human
STAT3	Liver neoplasms	C04;C06	Neoplastic Process	CTD_human
STAT3	Liver Neoplasms, Experimental	C04;C06	Experimental Model of Disease; Neoplastic Process	CTD_human
STAT3	Lymphatic Metastasis	C04;C23	Neoplastic Process	CTD_human
STAT3	Malignant neoplasm of stomach	C04;C06	Neoplastic Process	CTD_human
STAT3	Animal Mammary Neoplasms	C04;C22	Neoplastic Process	CTD_human
STAT3	Mammary Neoplasms, Experimental	C04	Experimental Model of Disease; Neoplastic Process	CTD_human
STAT3	Medulloblastoma	C04	Neoplastic Process	CTD_human
STAT3	Memory Disorders	C10;C23;F01	Mental or Behavioral Dysfunction	CTD_human
STAT3	Acute Myeloid Leukemia, M1	C04	Neoplastic Process	CTD_human
STAT3	Neoplasm Metastasis	C04;C23	Neoplastic Process	CTD_human
STAT3	Pustulosis of Palms and Soles	C17	Disease or Syndrome	CTD_human
STAT3	Pancreatic Neoplasm	C04;C06;C19	Neoplastic Process	CTD_human
STAT3	Precancerous Conditions	C04	Neoplastic Process	CTD_human
STAT3	Cardiomyopathies, Primary	C14	Disease or Syndrome	CTD_human
STAT3	Prostatic Neoplasms	C04;C12	Neoplastic Process	CTD_human
STAT3	Psoriasis	C17	Disease or Syndrome	CTD_human
STAT3	Reperfusion Injury	C14;C23	Injury or Poisoning	CTD_human
STAT3	Myocardial Diseases, Secondary	C14	Disease or Syndrome	CTD_human
STAT3	Stomach Neoplasms	C04;C06	Neoplastic Process	CTD_human
STAT3	T-Cell Lymphoma	C04;C15;C20	Neoplastic Process	CTD_human
STAT3	Experimental Hepatoma	C04;C06	Experimental Model of Disease; Neoplastic Process	CTD_human
STAT3	Juvenile-Onset Still Disease	C05;C17;C20	Disease or Syndrome	CTD_human
STAT3	Chronic Persistent Hepatitis	C06	Disease or Syndrome	CTD_human
STAT3	Adenocarcinoma, Basal Cell	C04	Neoplastic Process	CTD_human
STAT3	Adenocarcinoma, Oxyphilic	C04	Neoplastic Process	CTD_human
STAT3	Carcinoma, Cribriform	C04	Neoplastic Process	CTD_human
STAT3	Carcinoma, Granular Cell	C04	Neoplastic Process	CTD_human
STAT3	Adenocarcinoma, Tubular	C04	Neoplastic Process	CTD_human
STAT3	Anaplastic carcinoma	C04	Neoplastic Process	CTD_human
STAT3	Carcinoma, Spindle-Cell	C04	Neoplastic Process	CTD_human
STAT3	Undifferentiated carcinoma	C04	Neoplastic Process	CTD_human
STAT3	Carcinomatosis	C04	Neoplastic Process	CTD_human
STAT3	Diabetes, Autoimmune	C18;C19;C20	Disease or Syndrome	CTD_human
STAT3	Medullomyoblastoma	C04	Neoplastic Process	CTD_human
STAT3	Ki-1+ Anaplastic Large Cell Lymphoma	C04;C15;C20	Neoplastic Process	CTD_human
STAT3	Memory impairment	C10;C23;F01	Mental or Behavioral Dysfunction	CTD_human
STAT3	Congenital diaphragmatic hernia	C16;C23	Disease or Syndrome	CTD_human
STAT3	Middle Cerebral Artery Syndrome	C10;C14	Disease or Syndrome	CTD_human
STAT3	Congenital hernia of foramen of Morgagni	C16;C23	Congenital Abnormality	CTD_human
STAT3	Congenital hernia of foramen of Bochdalek	C16;C23	Congenital Abnormality	CTD_human
STAT3	Childhood Medulloblastoma	C04	Neoplastic Process	CTD_human
STAT3	Adult Medulloblastoma	C04	Neoplastic Process	CTD_human
STAT3	Condition, Preneoplastic	C04	Neoplastic Process	CTD_human
STAT3	Atrophic	C23	Pathologic Function	CTD_human
STAT3	Brittle diabetes	C18;C19;C20	Disease or Syndrome	CTD_human
STAT3	Malignant neoplasm of liver	C04;C06	Neoplastic Process	CTD_human
STAT3	Malignant neoplasm of pancreas	C04;C06;C19	Neoplastic Process	CTD_human
STAT3	Malignant neoplasm of prostate	C04;C12	Neoplastic Process	CTD_human
STAT3	Hematologic Neoplasms	C04;C15	Neoplastic Process	GENOMICS_ENGLAND
STAT3	Chronic active hepatitis	C06	Disease or Syndrome	CTD_human
STAT3	Cryptogenic Chronic Hepatitis	C06	Disease or Syndrome	CTD_human
STAT3	Breast Carcinoma	C04;C17	Neoplastic Process	CTD_human
STAT3	Middle Cerebral Artery Thrombosis	C10;C14	Disease or Syndrome	CTD_human
STAT3	Middle Cerebral Artery Occlusion	C10;C14	Acquired Abnormality	CTD_human
STAT3	Infarction, Middle Cerebral Artery	C10;C14	Disease or Syndrome	CTD_human
STAT3	Desmoplastic Medulloblastoma	C04	Neoplastic Process	CTD_human
STAT3	Age-Related Memory Disorders	C10;C23;F01	Mental or Behavioral Dysfunction	CTD_human
STAT3	Memory Disorder, Semantic	C10;C23;F01	Mental or Behavioral Dysfunction	CTD_human
STAT3	Memory Disorder, Spatial	C10;C23;F01	Mental or Behavioral Dysfunction	CTD_human
STAT3	Memory Loss	C10;C23;F01	Sign or Symptom	CTD_human
STAT3	Middle Cerebral Artery Embolus	C10;C14	Disease or Syndrome	CTD_human
STAT3	Left Middle Cerebral Artery Infarction	C10;C14	Disease or Syndrome	CTD_human
STAT3	Embolic Infarction, Middle Cerebral Artery	C10;C14	Disease or Syndrome	CTD_human
STAT3	Thrombotic Infarction, Middle Cerebral Artery	C10;C14	Disease or Syndrome	CTD_human
STAT3	Right Middle Cerebral Artery Infarction	C10;C14	Disease or Syndrome	CTD_human
STAT3	Cardiomyopathies	C14	Disease or Syndrome	CTD_human
STAT3	Cerebral Ischemia	C10;C14	Disease or Syndrome	CTD_human
STAT3	ovarian neoplasm	C04;C13;C19	Neoplastic Process	CTD_human
STAT3	Arthritis, Collagen-Induced	C05	Experimental Model of Disease	CTD_human
STAT3	Arthritis, Experimental	C05	Experimental Model of Disease	CTD_human
STAT3	Malignant neoplasm of ovary	C04;C13;C19	Neoplastic Process	CTD_human
STAT3	Squamous cell carcinoma of the head and neck	C04	Neoplastic Process	CTD_human
STAT3	Mammary Carcinoma, Animal	C04;C22	Neoplastic Process	CTD_human
STAT3	Mammary Neoplasms, Human	C04;C17	Neoplastic Process	CTD_human
STAT3	Melanotic medulloblastoma	C04	Neoplastic Process	CTD_human
STAT3	Cardiac Hypertrophy	C14;C23	Pathologic Function	CTD_human
STAT3	Mammary Neoplasms	C04;C17	Neoplastic Process	CTD_human
STAT3	Atherogenesis	C14	Pathologic Function	CTD_human
STAT3	Cirrhosis	C23	Disease or Syndrome	CTD_human
STAT3	Hereditary Diffuse Gastric Cancer	C04;C06	Neoplastic Process	CTD_human
STAT3	DIABETES MELLITUS, PERMANENT NEONATAL	C18;C19	Disease or Syndrome	ORPHANET
STAT3	Copper-Overload Cirrhosis	C06;C10;C16;C18	Disease or Syndrome	CTD_human
STAT3	Acute Myeloid Leukemia (AML-M2)	C04	Neoplastic Process	CTD_human
STAT3	T-Cell Large Granular Lymphocyte Leukemia	C04;C15;C20	Neoplastic Process	CGI
STAT3	Hyper-Immunoglobulin E Syndrome, Autosomal Recessive	C15;C20	Disease or Syndrome	CTD_human
STAT3	Hyper-Immunoglobulin E Syndrome, Autosomal Dominant	C15;C20	Disease or Syndrome	CTD_human;ORPHANET;UNIPROT
STAT3	Hyper-Ige Recurrent Infection Syndrome, Autosomal Dominant	C15;C20	Disease or Syndrome	CTD_human;ORPHANET;UNIPROT
STAT3	Juvenile arthritis	C05;C17;C20	Disease or Syndrome	CTD_human
STAT3	Juvenile psoriatic arthritis	C05;C17;C20	Disease or Syndrome	CTD_human
STAT3	Diabetes Mellitus, Ketosis-Prone	C18;C19;C20	Disease or Syndrome	CTD_human
STAT3	Job Syndrome	C15;C20	Disease or Syndrome	CTD_human;ORPHANET;UNIPROT
STAT3	AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 1		Disease or Syndrome	CTD_human;ORPHANET;UNIPROT
STAT3	cervical cancer	C04;C13	Neoplastic Process	CTD_human
STAT3	Familial M?ni?re disease		Disease or Syndrome	GENOMICS_ENGLAND

Pathway associated with STAT3

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number
pathway0000226	Association of TriC/CCT with target proteins during biosynthesis	reactome	39	324
pathway0000323	BMP2 signaling pathway(through Smad) ( TGF-beta_BMP Diagram(MolecularVariation) )	inoh	13	47
pathway0000633	Downstream signal transduction	reactome	29	307
pathway0000688	EPO signaling pathway(JAK2 STAT1 STAT3 STAT5) ( EPO signaling pathway(JAK2 STAT1 STAT3 STAT5) )	inoh	12	59
pathway0000695	ErbB2/ErbB3 signaling events	pid	41	404
pathway0000899	Gene expression of SOCS by STAT dimer ( JAK-STAT pathway and regulation pathway Diagram )	inoh	14	66
pathway0000900	Gene expression of SOCS1 by STAT dimer ( JAK-STAT pathway and regulation pathway Diagram )	inoh	8	29
pathway0000901	Gene expression of SOCS3 by STAT dimer ( JAK-STAT pathway and regulation pathway Diagram )	inoh	8	29
pathway0000966	GMCSF-mediated signaling events	pid	38	413
pathway0000976	Growth hormone receptor signaling	reactome	24	171
pathway0001081	IFN alpha signaling pathway(JAK1 TYK2 STAT1 STAT3) ( IFN alpha signaling(JAK1 TYK2 STAT1 STAT2 STAT3) )	inoh	19	91
pathway0001083	IFN alpha signaling pathway(JAK1 TYK2 STAT3) ( IFN alpha signaling(JAK1 TYK2 STAT1 STAT2 STAT3) )	inoh	18	73
pathway0001102	IL-10 signaling pathway(JAK1 TYK2 STAT3) ( IL-10 signaling(JAK1 TYK2 STAT3) )	inoh	6	16
pathway0001106	IL-23 signaling pathway(JAK2 TYK2 STAT3 STAT4) ( IL-23 signaling(JAK2 TYK2 STAT3 STAT4) )	inoh	6	17
pathway0001111	IL-6 signaling pathway(JAK1 JAK2 STAT3) ( IL-6 signaling(JAK1 JAK2 STAT3) )	inoh	6	19
pathway0001112	IL-7	netpath	28	203
pathway0001117	IL12 signaling mediated by STAT4	pid	33	229
pathway0001123	IL23-mediated signaling events	pid	37	345
pathway0001124	IL27-mediated signaling events	pid	26	217
pathway0001131	IL6-mediated signaling events	pid	48	426
pathway0001135	IL9	netpath	24	200
pathway0001188	Interleukin-6 signaling	reactome	11	57
pathway0001228	JAK/STAT signaling pathway	panther	15	87
pathway0001279	LIF signaling pathway ( LIF signaling(JAK1 JAK2 STAT3) )	inoh	10	29
pathway0001516	Notch-mediated HES/HEY network	pid	48	337
pathway0001701	POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	reactome	13	36
pathway0002010	Signaling by cytosolic FGFR1 fusion mutants	reactome	18	77
pathway0002022	Signaling by Leptin	reactome	11	48
pathway0002030	Signaling by SCF-KIT	reactome	37	402
pathway0002038	Signaling events mediated by PTP1B	pid	53	577
pathway0002040	Signaling events mediated by TCPTP	pid	40	361
pathway0002301	Transcriptional regulation of pluripotent stem cells	reactome	28	184
pathway0002355	TSLP	netpath	24	159
pathway0002668	Acute myeloid leukemia	kegg	53	562
pathway0002682	Hs_Interferon_type_I_signaling_pathways_WP585_85198	wikipathways	35	246
pathway0002700	Hs_Signaling_of_Hepatocyte_Growth_Factor_Receptor_WP313_79946	wikipathways	15	18
pathway0002712	Hs_Leptin_signaling_pathway_WP2034_89856	wikipathways	37	264
pathway0002717	Hs_Hepatitis_C_and_Hepatocellular_Carcinoma_WP3646_88640	wikipathways	36	226
pathway0002718	Hs_Interleukin-11_Signaling_Pathway_WP2332_79525	wikipathways	17	80
pathway0002735	Hs_PDGF_Pathway_WP2526_82681	wikipathways	12	44
pathway0002746	Hs_Dopaminergic_Neurogenesis_WP2855_87239	wikipathways	19	37
pathway0002760	Hs_Oncostatin_M_Signaling_Pathway_WP2374_73668	wikipathways	44	408
pathway0002761	Hs_Amino_Acid_metabolism_WP3925_90737	wikipathways	6	3
pathway0002772	Hs_Vitamin_B12_Metabolism_WP1533_85340	wikipathways	33	122
pathway0002781	Hs_ESC_Pluripotency_Pathways_WP3931_91005	wikipathways	13	20
pathway0002786	Hs_MicroRNAs_in_cardiomyocyte_hypertrophy_WP1544_89794	wikipathways	29	113
pathway0002810	Hs_Regulation_of_Microtubule_Cytoskeleton_WP2038_90889	wikipathways	38	161
pathway0002829	Hs_Kit_receptor_signaling_pathway_WP304_78799	wikipathways	46	510
pathway0002837	Hs_IL-5_Signaling_Pathway_WP127_78498	wikipathways	35	321
pathway0002844	Hs_IL-2_Signaling_Pathway_WP49_91243	wikipathways	33	332
pathway0002858	Hs_IL-6_signaling_pathway_WP364_89832	wikipathways	26	174
pathway0002861	Hs_RalA_downstream_regulated_genes_WP2290_79988	wikipathways	9	12
pathway0002864	Hs_IL-4_Signaling_Pathway_WP395_89828	wikipathways	41	397
pathway0002865	Hs_Brain-Derived_Neurotrophic_Factor_(BDNF)_signaling_pathway_WP2380_89803	wikipathways	80	623
pathway0002871	Hs_IL-3_Signaling_Pathway_WP286_78583	wikipathways	35	403
pathway0002873	Hs_Notch_Signaling_Pathway_WP61_78592	wikipathways	16	52
pathway0002879	Hs_IL-9_Signaling_Pathway_WP22_79264	wikipathways	11	49

Go term information of STAT3

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GO_term_name	GO_term_type	TF_name
GO_SOMATIC_STEM_CELL_POPULATION_MAINTENANCE	BP	STAT3
GO_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT_PROTEIN	BP	STAT3
GO_RESPONSE_TO_ESTRADIOL	BP	STAT3
GO_NEGATIVE_REGULATION_OF_CELLULAR_CATABOLIC_PROCESS	BP	STAT3
GO_NEGATIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS	BP	STAT3
GO_POSITIVE_REGULATION_OF_NOTCH_SIGNALING_PATHWAY	BP	STAT3
GO_CYTOKINE_MEDIATED_SIGNALING_PATHWAY	BP	STAT3
GO_POSITIVE_REGULATION_OF_STAT_CASCADE	BP	STAT3
GO_REGULATION_OF_NUCLEOTIDE_CATABOLIC_PROCESS	BP	STAT3
GO_POSITIVE_REGULATION_OF_NUCLEOSIDE_METABOLIC_PROCESS	BP	STAT3
GO_AGING	BP	STAT3
GO_RESPONSE_TO_ENDOGENOUS_STIMULUS	BP	STAT3
GO_REGULATION_OF_NUCLEOSIDE_METABOLIC_PROCESS	BP	STAT3
GO_EYE_PHOTORECEPTOR_CELL_DIFFERENTIATION	BP	STAT3
GO_REGULATION_OF_BEHAVIOR	BP	STAT3
GO_REGULATION_OF_FEEDING_BEHAVIOR	BP	STAT3
GO_REGULATION_OF_MULTICELLULAR_ORGANISM_GROWTH	BP	STAT3
GO_NEGATIVE_REGULATION_OF_NUCLEOSIDE_METABOLIC_PROCESS	BP	STAT3
GO_EATING_BEHAVIOR	BP	STAT3
GO_CELLULAR_RESPONSE_TO_GROWTH_HORMONE_STIMULUS	BP	STAT3
GO_CELLULAR_RESPONSE_TO_HORMONE_STIMULUS	BP	STAT3
GO_REGULATION_OF_PEPTIDYL_TYROSINE_PHOSPHORYLATION	BP	STAT3
GO_ACUTE_INFLAMMATORY_RESPONSE	BP	STAT3
GO_RESPONSE_TO_GROWTH_HORMONE	BP	STAT3
GO_POSITIVE_REGULATION_OF_PRI_MIRNA_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER	BP	STAT3
GO_REGULATION_OF_NEURON_MIGRATION	BP	STAT3
GO_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS	BP	STAT3
GO_ASTROCYTE_DIFFERENTIATION	BP	STAT3
GO_STAT_CASCADE	BP	STAT3
GO_INFLAMMATORY_RESPONSE	BP	STAT3
GO_JAK_STAT_CASCADE_INVOLVED_IN_GROWTH_HORMONE_SIGNALING_PATHWAY	BP	STAT3
GO_REGULATION_OF_NOTCH_SIGNALING_PATHWAY	BP	STAT3
GO_NEGATIVE_REGULATION_OF_CARBOHYDRATE_METABOLIC_PROCESS	BP	STAT3
GO_POSITIVE_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT3_PROTEIN	BP	STAT3
GO_RESPONSE_TO_INTERLEUKIN_6	BP	STAT3
GO_POSTTRANSCRIPTIONAL_GENE_SILENCING	BP	STAT3
GO_PHOTORECEPTOR_CELL_DIFFERENTIATION	BP	STAT3
GO_POSITIVE_REGULATION_OF_PEPTIDYL_TYROSINE_PHOSPHORYLATION	BP	STAT3
GO_ENERGY_HOMEOSTASIS	BP	STAT3
GO_REGULATION_OF_NEURON_DEATH	BP	STAT3
GO_REGULATION_OF_HYDROGEN_PEROXIDE_METABOLIC_PROCESS	BP	STAT3
GO_NEGATIVE_REGULATION_OF_NUCLEOTIDE_CATABOLIC_PROCESS	BP	STAT3
GO_NEGATIVE_REGULATION_OF_COFACTOR_METABOLIC_PROCESS	BP	STAT3
GO_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS	BP	STAT3
GO_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT3_PROTEIN	BP	STAT3
GO_CELLULAR_RESPONSE_TO_INTERLEUKIN_6	BP	STAT3
GO_CELLULAR_RESPONSE_TO_LEPTIN_STIMULUS	BP	STAT3
GO_REGULATION_OF_COFACTOR_METABOLIC_PROCESS	BP	STAT3
GO_FEEDING_BEHAVIOR	BP	STAT3
GO_REGULATION_OF_PRI_MIRNA_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER	BP	STAT3
GO_REGULATION_OF_POSTTRANSCRIPTIONAL_GENE_SILENCING	BP	STAT3
GO_REGULATION_OF_MEMBRANE_PERMEABILITY	BP	STAT3
GO_NEGATIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_BIOSYNTHETIC_PROCESS	BP	STAT3
GO_REGULATION_OF_CARBOHYDRATE_CATABOLIC_PROCESS	BP	STAT3
GO_GENE_SILENCING_BY_RNA	BP	STAT3
GO_TEMPERATURE_HOMEOSTASIS	BP	STAT3
GO_REGULATION_OF_GENE_SILENCING	BP	STAT3
GO_REGULATION_OF_SKELETAL_MUSCLE_CELL_PROLIFERATION	BP	STAT3
GO_RESPONSE_TO_LEPTIN	BP	STAT3
GO_ACUTE_PHASE_RESPONSE	BP	STAT3
GO_NEGATIVE_REGULATION_OF_CELL_PROLIFERATION	BP	STAT3
GO_EYE_MORPHOGENESIS	BP	STAT3
GO_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_COMPLEX	CC	STAT3
GO_NUCLEAR_TRANSCRIPTION_FACTOR_COMPLEX	CC	STAT3
GO_TRANSCRIPTION_FACTOR_ACTIVITY_DIRECT_LIGAND_REGULATED_SEQUENCE_SPECIFIC_DNA_BINDING	MF	STAT3
GO_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_ACTIVITY_SEQUENCE_SPECIFIC_DNA_BINDING	MF	STAT3
GO_RNA_POLYMERASE_II_REPRESSING_TRANSCRIPTION_FACTOR_BINDING	MF	STAT3
GO_GLUCOCORTICOID_RECEPTOR_BINDING	MF	STAT3
GO_TRANSCRIPTIONAL_ACTIVATOR_ACTIVITY_RNA_POLYMERASE_II_CORE_PROMOTER_PROXIMAL_REGION_SEQUENCE_SPECIFIC_BINDING	MF	STAT3
GO_STEROID_HORMONE_RECEPTOR_BINDING	MF	STAT3
GO_CCR_CHEMOKINE_RECEPTOR_BINDING	MF	STAT3
GO_CHEMOKINE_RECEPTOR_BINDING	MF	STAT3
GO_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_BINDING	MF	STAT3
GO_STRUCTURE_SPECIFIC_DNA_BINDING	MF	STAT3

Survival analysis of STAT3

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of STAT3

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)