TF information

TF name: NFATC4
TF family: RHD
Ensembl gene ID: ENSG00000100968
Ensembl protein ID: ENSP00000451284, ENSP00000450733, ENSP00000451224, ENSP00000450590, ENSP00000451183, ENSP00000451395, ENSP00000451151, ENSP00000396788, ENSP00000452270, ENSP00000450686, ENSP00000450810, ENSP00000451502, ENSP00000452349, ENSP00000388910, ENSP00000451454, ENSP00000388668
Entrez gene ID: 4776
Database name Link Database name Link
NCBI Gene: Genecards:
Uniprot: Wikipedia:
Cosmic 3D: Geneontology:
CCLE:

Frequency of NFATC4 in all biosamples
Sample ID Biosample type Tissue type Biosample name TF Frequency
Sample_02_095Cell lineMammary GlandMDA-MB-4680.4147859922179
Sample_02_096Cell lineMammary GlandZR-75-1_10.96739130434783
Sample_02_220Cell lineBrainBE2C_10.15384615384615
Sample_02_228Cell lineOesophagusKYSE5100.19757688723206
Sample_02_304Cell lineNeuroblastomaN2060.20923913043478
Sample_02_319Cell lineNeuroblastomaNB-EBc10.16763005780347
Sample_02_338Cell lineNeuroblastomaBE20.11764705882353

NFATC4 distribution in samples’ most representative CRC
Sample ID Tissue type Biosample type Biosample name
Sample_02_096Mammary GlandCell lineZR-75-1_1

NFATC4 distribution in all CRCs
Biosample type
Biosample name
Sample ID

Genomic distribution of SEs associated with NFATC4
Download

Mutation of NFATC4
Database name Link
gnomAD: gnomAD
ExAC: ExAC
ICGC:
Database name Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of NFATC4

rsID Chr Start Stop Ref Alt Gene_region Gene_symble Effect TCGA_Occurrence
rs763157014chr142484244624842446CTexonicNFATC4nonsynonymous HNSC|1|512|0.00195
-chr142483939824839398CTexonicNFATC4nonsynonymous SKCM|1|368|0.00272
-chr142484687824846878CGexonicNFATC4nonsynonymous BRCA|1|982|0.00102
-chr142484585324845853CTexonicNFATC4nonsynonymous SKCM|1|368|0.00272
-chr142484180924841809GTexonicNFATC4nonsynonymous TGCT|1|155|0.00645
-chr142484529924845299TGexonicNFATC4nonsynonymous KIPAN|1|799|0.00125,KIRC|1|451|0.00222
rs779918597chr142484587724845877CTexonicNFATC4nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr142483923124839231TCexonicNFATC4synonymous LUAD|1|543|0.00184
-chr142484363624843636CTexonicNFATC4nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
rs147125766chr142484566624845666CTexonicNFATC4synonymous UCEC|1|248|0.00403
-chr142484490824844908TAexonicNFATC4nonsynonymous LIHC|1|373|0.00268
-chr142483979524839795CTexonicNFATC4synonymous SKCM|1|368|0.00272
-chr142484355524843563CCCCAGGTG-exonicNFATC4nonframeshift STAD|1|395|0.00253,STES|1|395|0.00253
-chr142483979724839797TCexonicNFATC4nonsynonymous UCEC|1|248|0.00403
-chr142484688324846883CTexonicNFATC4nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr142483932624839326GTexonicNFATC4nonsynonymous BLCA|1|396|0.00253
-chr142484570824845708AGexonicNFATC4synonymous HNSC|1|512|0.00195
-chr142484299824842998GTexonicNFATC4nonsynonymous LUAD|1|543|0.00184
-chr142483967524839675AGexonicNFATC4synonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr142484295024842950CAexonicNFATC4synonymous LUSC|1|178|0.00562
-chr142484568124845681CTexonicNFATC4synonymous SKCM|1|368|0.00272
rs144789611chr142484257024842570CTexonicNFATC4nonsynonymous SKCM|1|368|0.00272
-chr142483894424838944CTexonicNFATC4nonsynonymous PAAD|1|185|0.00541
-chr142483763024837630G-exonicNFATC4frameshift PRAD|1|499|0.00200
-chr142484249424842494GAexonicNFATC4nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr142484565624845656CTexonicNFATC4nonsynonymous CESC|1|194|0.00515
rs750979890chr142483958224839582CTexonicNFATC4synonymous SKCM|1|368|0.00272
rs756648728chr142484552424845524CTexonicNFATC4nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr142484354124843541CTexonicNFATC4nonsynonymous BLCA|1|396|0.00253
-chr142484588224845882GAexonicNFATC4synonymous BRCA|1|982|0.00102
rs762964789chr142484297024842970CTexonicNFATC4synonymous GBMLGG|1|820|0.00122,LGG|1|530|0.00189
-chr142483941524839415TCexonicNFATC4nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
rs752364673chr142484600524846005GAexonicNFATC4synonymous LUAD|1|543|0.00184
-chr142484589224845892CTexonicNFATC4nonsynonymous SKCM|1|368|0.00272
-chr142483897124838971CTexonicNFATC4nonsynonymous GBM|1|290|0.00345,GBMLGG|1|820|0.00122
rs756073934chr142484179224841792GAexonicNFATC4nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
rs778408359chr142484291224842912CTexonicNFATC4nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr142484168724841687CTexonicNFATC4stopgain BLCA|1|396|0.00253
rs772343312chr142484295024842950CTexonicNFATC4nonsynonymous GBMLGG|1|820|0.00122,LGG|1|530|0.00189
-chr142484687924846879CTexonicNFATC4nonsynonymous BRCA|1|982|0.00102
-chr142483916324839163GAexonicNFATC4nonsynonymous THCA|1|504|0.00198
-chr142483880024838800C-exonicNFATC4frameshift STAD|1|395|0.00253,STES|1|395|0.00253
-chr142484560124845601C-exonicNFATC4frameshift COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr142483946124839461GAexonicNFATC4nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
rs751744912chr142483909024839090-GexonicNFATC4frameshift STAD|1|395|0.00253,STES|1|395|0.00253
rs138954014chr142484180124841801GAexonicNFATC4nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr142484241424842414TCexonicNFATC4nonsynonymous LUAD|1|543|0.00184
rs775517670chr142484295124842951GAexonicNFATC4nonsynonymous LUSC|1|178|0.00562
-chr142483924024839240CAexonicNFATC4synonymous UCEC|1|248|0.00403
rs377116679chr142484167824841678CTexonicNFATC4synonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr142484574024845740CTexonicNFATC4nonsynonymous SKCM|1|368|0.00272
-chr142483878224838782GAexonicNFATC4nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
rs748592990chr142484526524845265CTexonicNFATC4nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr142484583624845836CTexonicNFATC4nonsynonymous ESCA|1|185|0.00541
-chr142484292924842929CGexonicNFATC4nonsynonymous LUAD|1|543|0.00184
-chr142484301324843013GAexonicNFATC4nonsynonymous PAAD|1|185|0.00541
rs766194904chr142484251524842515GAexonicNFATC4nonsynonymous BLCA|1|396|0.00253
-chr142484360024843600GTexonicNFATC4nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr142483878924838789CAexonicNFATC4nonsynonymous OV|1|469|0.00213
-chr142483890224838902G-exonicNFATC4frameshift ESCA|1|185|0.00541
-chr142484563924845639CAexonicNFATC4stopgain BRCA|1|982|0.00102
-chr142483980024839800GAexonicNFATC4nonsynonymous SKCM|1|368|0.00272
-chr142483907624839076GAexonicNFATC4nonsynonymous PAAD|1|185|0.00541
-chr142483927824839278GAexonicNFATC4stopgain SKCM|1|368|0.00272
-chr142483922624839226CTexonicNFATC4nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr142484354524843545CAexonicNFATC4synonymous LIHC|1|373|0.00268
rs752964036chr142484586024845860CTexonicNFATC4nonsynonymous SKCM|1|368|0.00272
-chr142484589924845899CTexonicNFATC4nonsynonymous SKCM|1|368|0.00272
-chr142484295924842959GAexonicNFATC4nonsynonymous BLCA|1|396|0.00253,CESC|1|194|0.00515
-chr142484173824841738CTexonicNFATC4nonsynonymous ESCA|1|185|0.00541
-chr142484570024845700GTexonicNFATC4nonsynonymous OV|1|469|0.00213
rs756375882chr142483873824838738GAexonicNFATC4nonsynonymous LUSC|1|178|0.00562
-chr142484249524842495CTexonicNFATC4nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
rs755808600chr142483946324839463CAexonicNFATC4nonsynonymous LUAD|1|543|0.00184
-chr142483633424836334CGexonicNFATC4nonsynonymous BRCA|1|982|0.00102
-chr142483761424837614C-exonicNFATC4frameshift BRCA|1|982|0.00102,COAD|2|367|0.00545,COADREAD|2|489|0.00409
rs776150453chr142484572624845726CAexonicNFATC4synonymous BRCA|1|982|0.00102
-chr142483632024836320CTexonicNFATC4synonymous BLCA|1|396|0.00253
-chr142483970124839701GTexonicNFATC4nonsynonymous LUAD|1|543|0.00184
-chr142484243124842431GAexonicNFATC4nonsynonymous SKCM|1|368|0.00272
-chr142484582624845826CTexonicNFATC4nonsynonymous GBM|1|290|0.00345,GBMLGG|1|820|0.00122
-chr142484586824845868-CexonicNFATC4frameshift COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr142483627324836273CTexonicNFATC4nonsynonymous HNSC|1|512|0.00195
-chr142483881024838810CTexonicNFATC4nonsynonymous SKCM|1|368|0.00272
-chr142484165924841659ACexonicNFATC4synonymous TGCT|1|155|0.00645
-chr142483925924839259CAexonicNFATC4synonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr142484561924845619CAexonicNFATC4nonsynonymous HNSC|1|512|0.00195
-chr142484172724841727GTexonicNFATC4nonsynonymous LIHC|1|373|0.00268
-chr142483637724836377TAexonicNFATC4nonsynonymous UCS|1|57|0.01754
-chr142484686624846866CAexonicNFATC4nonsynonymous BRCA|1|982|0.00102
-chr142484591624845916CTexonicNFATC4nonsynonymous HNSC|2|512|0.00391
-chr142483971724839717GAexonicNFATC4synonymous SKCM|2|368|0.00543
-chr142484490424844904CTexonicNFATC4stopgain COADREAD|1|489|0.00204,READ|1|122|0.00820
-chr142484568224845682CGexonicNFATC4nonsynonymous THCA|1|504|0.00198
-chr142483944924839449CTexonicNFATC4nonsynonymous ESCA|1|185|0.00541
-chr142484523724845237CTexonicNFATC4synonymous KIPAN|1|799|0.00125,KIRC|1|451|0.00222
-chr142484356924843569CAexonicNFATC4synonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr142483895324838953CTexonicNFATC4nonsynonymous DLBC|1|48|0.02083
-chr142484592624845926CTexonicNFATC4nonsynonymous SKCM|1|368|0.00272
rs372741212chr142484302824843028GAexonicNFATC4nonsynonymous LUAD|1|543|0.00184
-chr142484599424845994GTexonicNFATC4stopgain LUAD|1|543|0.00184
-chr142483896924838969CGexonicNFATC4nonsynonymous CESC|1|194|0.00515
-chr142483872624838726CTexonicNFATC4nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr142483631324836313ACexonicNFATC4nonsynonymous BRCA|1|982|0.00102
-chr142484527524845275G-exonicNFATC4frameshift LUAD|1|543|0.00184
-chr142483639724836397GTexonicNFATC4nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr142484613924846139AGexonicNFATC4nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr142483959824839598CTexonicNFATC4nonsynonymous UCEC|1|248|0.00403
-chr142483634724836347ACexonicNFATC4synonymous BRCA|1|982|0.00102
-chr142484241924842419AGexonicNFATC4nonsynonymous KIPAN|1|799|0.00125,KIRC|1|451|0.00222
-chr142483972524839725GAexonicNFATC4nonsynonymous LUAD|1|543|0.00184
-chr142484294424842944GAexonicNFATC4nonsynonymous BRCA|1|982|0.00102
-chr142484572524845725GTexonicNFATC4nonsynonymous LUAD|1|543|0.00184
rs747615604chr142483919024839190GAexonicNFATC4nonsynonymous THCA|1|504|0.00198
-chr142484180524841805TCexonicNFATC4nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr142484306024843060GAexonicNFATC4synonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr142484312624843126G-intronicNFATC4unknown UCEC|2|248|0.00806
rs762172509chr142484174524841745AGexonicNFATC4nonsynonymous SKCM|1|368|0.00272
-chr142484527524845275GAexonicNFATC4nonsynonymous UCEC|1|248|0.00403
-chr142484584924845849-CexonicNFATC4frameshift KIPAN|1|799|0.00125,KIRC|1|451|0.00222
-chr142483971424839714GAexonicNFATC4synonymous LUAD|1|543|0.00184
-chr142483898524838985GAexonicNFATC4synonymous CESC|1|194|0.00515
-chr142483915924839159CTexonicNFATC4synonymous GBMLGG|1|820|0.00122,LGG|1|530|0.00189
-chr142484573824845738C-exonicNFATC4frameshift BRCA|2|982|0.00204
-chr142484561124845611CTexonicNFATC4nonsynonymous LIHC|1|373|0.00268
-chr142484299324842993GAexonicNFATC4nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr142483970224839702AGexonicNFATC4synonymous SKCM|1|368|0.00272
-chr142484353624843536GTexonicNFATC4nonsynonymous PAAD|1|185|0.00541
-chr142484573924845739CTexonicNFATC4nonsynonymous SKCM|1|368|0.00272
-chr142484584024845840CTexonicNFATC4synonymous SKCM|1|368|0.00272
-chr142483958324839583CTexonicNFATC4nonsynonymous SKCM|1|368|0.00272
-chr142484520524845205GAexonicNFATC4nonsynonymous SKCM|2|368|0.00543
-chr142484489124844891GAexonicNFATC4synonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr142484603424846034GAexonicNFATC4nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
rs200059234chr142483949924839499CTexonicNFATC4nonsynonymous SKCM|1|368|0.00272
-chr142483919324839193GAexonicNFATC4nonsynonymous GBMLGG|1|820|0.00122,LGG|1|530|0.00189
-chr142484173224841732CAexonicNFATC4nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr142483941024839410GAexonicNFATC4nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr142483928024839280ATexonicNFATC4nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
rs368665121chr142484607424846074GAexonicNFATC4synonymous UCEC|1|248|0.00403
-chr142483978824839788GTexonicNFATC4nonsynonymous UCEC|1|248|0.00403
-chr142483887324838873CTexonicNFATC4nonsynonymous UCEC|1|248|0.00403
rs372002281chr142484297524842975GAexonicNFATC4nonsynonymous PAAD|1|185|0.00541,SKCM|1|368|0.00272
-chr142483946424839464GAexonicNFATC4nonsynonymous GBMLGG|1|820|0.00122,LGG|1|530|0.00189,THYM|1|123|0.00813
rs755075807chr142484564024845640GAexonicNFATC4nonsynonymous LIHC|2|373|0.00536
-chr142483956424839564CAexonicNFATC4synonymous LUAD|1|543|0.00184
-chr142484704024847040TAUTR3NFATC4unknown BRCA|1|982|0.00102
-chr142483973024839730GAexonicNFATC4nonsynonymous KIPAN|1|799|0.00125,KIRC|1|451|0.00222
-chr142483953824839538CTexonicNFATC4nonsynonymous LUAD|1|543|0.00184
-chr142483980124839801GAsplicingNFATC4splicing SKCM|1|368|0.00272
-chr142483878424838784TCexonicNFATC4synonymous UCEC|1|248|0.00403
-chr142483882324838823GAexonicNFATC4synonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204

Disease information of NFATC4
TF_name Disease_name Disease_class Disease_semantic_type TF_disease_source

Pathway associated with NFATC4
pathway_ID pathway_name pathway_source gene_number edge_number
pathway0000259 Axon guidance mediated by netrin panther 30 253
pathway0000695 ErbB2/ErbB3 signaling events pid 41 404
pathway0002609 B cell receptor signaling pathway kegg 70 856
pathway0002786 Hs_MicroRNAs_in_cardiomyocyte_hypertrophy_WP1544_89794 wikipathways 29 113
pathway0002865 Hs_Brain-Derived_Neurotrophic_Factor_(BDNF)_signaling_pathway_WP2380_89803 wikipathways 80 623

Go term information of NFATC4
GO_term_name GO_term_type TF_name
GO_NEGATIVE_REGULATION_OF_NEURON_DIFFERENTIATION BP NFATC4
GO_SMOOTH_MUSCLE_CELL_DIFFERENTIATION BP NFATC4
GO_REGULATION_OF_DENDRITE_MORPHOGENESIS BP NFATC4
GO_CELLULAR_RESPONSE_TO_LITHIUM_ION BP NFATC4
GO_NEGATIVE_REGULATION_OF_DENDRITE_MORPHOGENESIS BP NFATC4
GO_CALCIUM_MEDIATED_SIGNALING BP NFATC4
GO_REGULATION_OF_CHROMATIN_BINDING BP NFATC4
GO_POSITIVE_REGULATION_OF_TUMOR_NECROSIS_FACTOR_SUPERFAMILY_CYTOKINE_PRODUCTION BP NFATC4
GO_NEGATIVE_REGULATION_OF_PROTEIN_BINDING BP NFATC4
GO_PATTERNING_OF_BLOOD_VESSELS BP NFATC4
GO_NEGATIVE_REGULATION_OF_DENDRITE_DEVELOPMENT BP NFATC4
GO_BLOOD_VESSEL_MORPHOGENESIS BP NFATC4
GO_RESPONSE_TO_UV BP NFATC4
GO_CELLULAR_RESPONSE_TO_RADIATION BP NFATC4
GO_RESPONSE_TO_LITHIUM_ION BP NFATC4
GO_TUBE_MORPHOGENESIS BP NFATC4
GO_GENERATION_OF_PRECURSOR_METABOLITES_AND_ENERGY BP NFATC4
GO_REGULATION_OF_PRI_MIRNA_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER BP NFATC4
GO_INOSITOL_PHOSPHATE_MEDIATED_SIGNALING BP NFATC4
GO_REGULATION_OF_SYNAPSE_MATURATION BP NFATC4
GO_TRANSCRIPTION_FACTOR_ACTIVITY_RNA_POLYMERASE_II_CORE_PROMOTER_PROXIMAL_REGION_SEQUENCE_SPECIFIC_BINDING MF NFATC4
GO_PEROXISOME_PROLIFERATOR_ACTIVATED_RECEPTOR_BINDING MF NFATC4
GO_CORE_PROMOTER_PROXIMAL_REGION_DNA_BINDING MF NFATC4

Survival analysis of NFATC4



Calculate the hazards ratio based on Cox PH Model.
Add the 95% CI as dotted line.

Expression of NFATC4