Cancer CRCdb

TF information

TF name:	KLF5
TF family:	zf-C2H2
Ensembl gene ID:	ENSG00000102554
Ensembl protein ID:	ENSP00000366915, ENSP00000440407
Entrez gene ID:	688

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of KLF5 in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_02_021	Cell line	Colon	V429	0.97290285384837
Sample_02_080	Cell line	Lung	Calu-3	0.54545454545455
Sample_02_114	Cell line	Mammary Gland	CAL51	0.39195979899497
Sample_02_195	Cell line	Stomach	OCUM1	1
Sample_02_196	Cell line	Stomach	NCC59	0.78571428571429
Sample_02_199	Cell line	Stomach	KATO3	0.33333333333333
Sample_02_203	Cell line	Stomach	YCC21	0.66666666666667
Sample_02_204	Cell line	Stomach	IM95	0.45454545454545
Sample_02_205	Tissue	Stomach	Gastric_Primary_Sample_T	0.41481481481481
Sample_02_208	Cell line	Stomach	YCC3	0.875
Sample_02_227	Cell line	Oesophagus	TE7	0.96
Sample_02_228	Cell line	Oesophagus	KYSE510	1
Sample_02_236	Cell line	Colon	V206	1
Sample_02_237	Cell line	Colon	V389	0.97110252162709
Sample_02_242	Cell line	Colon	V481	0.72963532653977
Sample_02_322	Cell line	Colon	Caco-2	0.99865410497981
Sample_02_354	Cell line	Colon	Colo205	1
Sample_02_355	Cell line	Colon	HCT15	0.83928571428571
Sample_02_358	Cell line	Colon	LS180	0.93127962085308
Sample_02_361	Cell line	Colon	HT29_DMSO	1
Sample_02_424	Cell line	Colon	SW620	1

KLF5 distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name
Sample_02_021	Colon	Cell line	V429
Sample_02_195	Stomach	Cell line	OCUM1
Sample_02_196	Stomach	Cell line	NCC59
Sample_02_204	Stomach	Cell line	IM95
Sample_02_208	Stomach	Cell line	YCC3
Sample_02_227	Oesophagus	Cell line	TE7
Sample_02_228	Oesophagus	Cell line	KYSE510
Sample_02_236	Colon	Cell line	V206
Sample_02_237	Colon	Cell line	V389
Sample_02_242	Colon	Cell line	V481
Sample_02_322	Colon	Cell line	Caco-2
Sample_02_354	Colon	Cell line	Colo205
Sample_02_355	Colon	Cell line	HCT15
Sample_02_358	Colon	Cell line	LS180
Sample_02_361	Colon	Cell line	HT29_DMSO
Sample_02_424	Colon	Cell line	SW620

KLF5 distribution in all CRCs

Genomic distribution of SEs associated with KLF5

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Mutation of KLF5

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of KLF5

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr13	73636640	73636640	C	T	exonic	KLF5	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr13	73636030	73636030	C	G	exonic	KLF5	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr13	73649898	73649901	ATCG	-	exonic	KLF5	frameshift	LIHC\|1\|373\|0.00268
-	chr13	73636093	73636093	T	C	exonic	KLF5	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr13	73636135	73636135	G	T	exonic	KLF5	nonsynonymous	OV\|1\|469\|0.00213
-	chr13	73636262	73636262	G	A	exonic	KLF5	synonymous	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr13	73636601	73636601	G	A	exonic	KLF5	nonsynonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr13	73636639	73636639	C	A	exonic	KLF5	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr13	73636669	73636669	G	T	exonic	KLF5	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr13	73636396	73636396	C	T	exonic	KLF5	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr13	73636204	73636204	C	G	exonic	KLF5	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr13	73636553	73636553	G	A	exonic	KLF5	synonymous	BLCA\|1\|396\|0.00253
-	chr13	73636411	73636411	-	G	exonic	KLF5	frameshift	BLCA\|1\|396\|0.00253
-	chr13	73636360	73636360	-	C	exonic	KLF5	frameshift	BLCA\|1\|396\|0.00253
-	chr13	73636638	73636638	C	T	exonic	KLF5	nonsynonymous	LUAD\|2\|543\|0.00368,UCS\|1\|57\|0.01754
-	chr13	73649905	73649905	G	C	exonic	KLF5	nonsynonymous	LUAD\|1\|543\|0.00184,LUSC\|2\|178\|0.01124
-	chr13	73636244	73636244	C	A	exonic	KLF5	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr13	73649937	73649937	C	A	exonic	KLF5	synonymous	THCA\|1\|504\|0.00198
-	chr13	73636162	73636162	A	G	exonic	KLF5	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr13	73636260	73636260	A	G	exonic	KLF5	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr13	73636148	73636148	-	AT	exonic	KLF5	frameshift	BLCA\|1\|396\|0.00253
-	chr13	73636195	73636195	C	-	exonic	KLF5	frameshift	PAAD\|1\|185\|0.00541
-	chr13	73636656	73636656	T	G	exonic	KLF5	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr13	73636199	73636199	G	T	exonic	KLF5	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr13	73636681	73636683	AAG	-	exonic	KLF5	nonframeshift	BLCA\|2\|396\|0.00505
rs774556061	chr13	73636401	73636401	C	T	exonic	KLF5	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr13	73636667	73636668	AA	-	exonic	KLF5	frameshift	COAD\|2\|367\|0.00545,COADREAD\|2\|489\|0.00409
-	chr13	73649902	73649902	G	T	exonic	KLF5	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr13	73636804	73636804	C	G	exonic	KLF5	nonsynonymous	BLCA\|1\|396\|0.00253
rs772237443	chr13	73636580	73636580	G	A	exonic	KLF5	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr13	73636501	73636501	C	T	exonic	KLF5	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr13	73636112	73636112	T	G	exonic	KLF5	synonymous	LUSC\|1\|178\|0.00562
-	chr13	73636582	73636582	C	T	exonic	KLF5	nonsynonymous	SKCM\|2\|368\|0.00543
-	chr13	73649903	73649903	A	G	exonic	KLF5	nonsynonymous	BLCA\|1\|396\|0.00253,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr13	73636341	73636341	G	A	exonic	KLF5	nonsynonymous	CESC\|1\|194\|0.00515
-	chr13	73649892	73649892	C	G	exonic	KLF5	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr13	73636106	73636106	C	T	exonic	KLF5	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr13	73636462	73636462	C	G	exonic	KLF5	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr13	73636372	73636372	T	C	exonic	KLF5	nonsynonymous	PRAD\|1\|499\|0.00200
-	chr13	73636671	73636671	C	T	exonic	KLF5	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr13	73636578	73636578	A	G	exonic	KLF5	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr13	73636462	73636462	C	A	exonic	KLF5	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr13	73636861	73636861	G	-	exonic	KLF5	frameshift	SARC\|1\|247\|0.00405
-	chr13	73636790	73636790	A	-	exonic	KLF5	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr13	73649902	73649902	G	A	exonic	KLF5	nonsynonymous	BLCA\|2\|396\|0.00505
rs778424957	chr13	73636332	73636332	G	A	exonic	KLF5	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr13	73636730	73636730	A	-	exonic	KLF5	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr13	73636562	73636562	G	A	exonic	KLF5	synonymous	CESC\|1\|194\|0.00515
-	chr13	73636580	73636580	G	T	exonic	KLF5	nonsynonymous	OV\|1\|469\|0.00213
-	chr13	73636172	73636172	-	T	exonic	KLF5	frameshift	BLCA\|2\|396\|0.00505
-	chr13	73636253	73636253	G	T	exonic	KLF5	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr13	73636330	73636330	C	T	exonic	KLF5	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr13	73636410	73636410	C	T	exonic	KLF5	stopgain	BLCA\|1\|396\|0.00253
-	chr13	73636323	73636323	C	A	exonic	KLF5	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr13	73636402	73636402	C	T	exonic	KLF5	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr13	73636761	73636761	A	T	exonic	KLF5	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs760764157	chr13	73649892	73649892	C	T	exonic	KLF5	synonymous	BLCA\|1\|396\|0.00253
rs375892924	chr13	73636032	73636032	C	G	exonic	KLF5	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr13	73636639	73636639	C	T	exonic	KLF5	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr13	73636518	73636518	G	A	exonic	KLF5	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr13	73636282	73636282	C	T	exonic	KLF5	nonsynonymous	ACC\|1\|90\|0.01111,LUSC\|1\|178\|0.00562
-	chr13	73636642	73636642	C	A	exonic	KLF5	nonsynonymous	BLCA\|1\|396\|0.00253
rs778406638	chr13	73636832	73636832	C	A	exonic	KLF5	synonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr13	73636180	73636180	C	A	exonic	KLF5	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr13	73636362	73636362	A	-	exonic	KLF5	frameshift	BLCA\|1\|396\|0.00253
-	chr13	73650024	73650024	A	G	exonic	KLF5	stoploss	LIHC\|1\|373\|0.00268
-	chr13	73649860	73649860	A	G	exonic	KLF5	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr13	73636016	73636016	G	C	exonic	KLF5	nonsynonymous	BLCA\|1\|396\|0.00253
rs767950381	chr13	73649880	73649880	C	T	exonic	KLF5	synonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189,UCEC\|1\|248\|0.00403
-	chr13	73649905	73649905	G	A	exonic	KLF5	nonsynonymous	BLCA\|1\|396\|0.00253,CESC\|1\|194\|0.00515,LUAD\|2\|543\|0.00368
-	chr13	73636090	73636090	C	T	exonic	KLF5	nonsynonymous	BLCA\|2\|396\|0.00505
rs747783347	chr13	73636220	73636220	C	G	exonic	KLF5	nonsynonymous	LUAD\|1\|543\|0.00184
rs748275920	chr13	73636549	73636549	C	T	exonic	KLF5	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr13	73636126	73636137	TACCTTACAGTA	-	exonic	KLF5	nonframeshift	HNSC\|1\|512\|0.00195
-	chr13	73636025	73636025	G	C	exonic	KLF5	synonymous	HNSC\|1\|512\|0.00195
-	chr13	73649881	73649881	G	T	exonic	KLF5	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr13	73636078	73636078	G	T	exonic	KLF5	nonsynonymous	CESC\|1\|194\|0.00515
-	chr13	73636358	73636358	C	T	exonic	KLF5	synonymous	BLCA\|1\|396\|0.00253
-	chr13	73636695	73636695	C	T	exonic	KLF5	stopgain	SKCM\|2\|368\|0.00543

Disease information of KLF5

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
KLF5	Malignant neoplasm of urinary bladder	C04;C12;C13	Neoplastic Process	CTD_human
KLF5	Bladder Neoplasm	C04;C12;C13	Neoplastic Process	CTD_human
KLF5	Squamous cell carcinoma	C04	Neoplastic Process	CTD_human
KLF5	Pancreatic Neoplasm	C04;C06;C19	Neoplastic Process	CTD_human
KLF5	Schizophrenia	F03	Mental or Behavioral Dysfunction	PSYGENET
KLF5	Adenocarcinoma of lung (disorder)	C04;C08	Neoplastic Process	CTD_human
KLF5	Malignant neoplasm of pancreas	C04;C06;C19	Neoplastic Process	CTD_human
KLF5	Colorectal Cancer	C04;C06	Neoplastic Process	UNIPROT
KLF5	Neointima	C23	Acquired Abnormality	CTD_human
KLF5	Neointima Formation	C23	Pathologic Function	CTD_human

Pathway associated with KLF5

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number
pathway0002302	Transcriptional regulation of white adipocyte differentiation	reactome	79	1522
pathway0002758	Hs_TGF-beta_Receptor_Signaling_WP560_90187	wikipathways	28	32

Go term information of KLF5

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GO_term_name	GO_term_type	TF_name
GO_MUSCLE_ORGAN_DEVELOPMENT	BP	KLF5
GO_EPITHELIAL_CELL_DEVELOPMENT	BP	KLF5
GO_POSITIVE_REGULATION_OF_FAT_CELL_DIFFERENTIATION	BP	KLF5
GO_INTESTINAL_EPITHELIAL_CELL_DEVELOPMENT	BP	KLF5
GO_INTESTINAL_EPITHELIAL_CELL_DIFFERENTIATION	BP	KLF5
GO_COLUMNAR_CUBOIDAL_EPITHELIAL_CELL_DEVELOPMENT	BP	KLF5
GO_REGULATION_OF_MICROVILLUS_ORGANIZATION	BP	KLF5
GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER	BP	KLF5
GO_REGULATION_OF_CELL_PROJECTION_ASSEMBLY	BP	KLF5
GO_SKELETAL_MUSCLE_CELL_DIFFERENTIATION	BP	KLF5
GO_MICROVILLUS_ORGANIZATION	BP	KLF5
GO_TRANSCRIPTIONAL_ACTIVATOR_ACTIVITY_RNA_POLYMERASE_II_CORE_PROMOTER_PROXIMAL_REGION_SEQUENCE_SPECIFIC_BINDING	MF	KLF5

Survival analysis of KLF5

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of KLF5

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)