Cancer CRCdb

TF information

TF name:	KLF3
TF family:	zf-C2H2
Ensembl gene ID:	ENSG00000109787
Ensembl protein ID:	ENSP00000261438
Entrez gene ID:	51274

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of KLF3 in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_02_021	Cell line	Colon	V429	0.73450562121649
Sample_02_114	Cell line	Mammary Gland	CAL51	0.17085427135678
Sample_02_191	Cell line	Stomach	SNU719	0.42857142857143
Sample_02_204	Cell line	Stomach	IM95	0.22727272727273
Sample_02_205	Tissue	Stomach	Gastric_Primary_Sample_T	0.45185185185185
Sample_02_228	Cell line	Oesophagus	KYSE510	0.36160298229264
Sample_02_236	Cell line	Colon	V206	0.38509316770186
Sample_02_237	Cell line	Colon	V389	0.54422970734401
Sample_02_241	Cell line	Colon	V456	0.38600451467269
Sample_02_242	Cell line	Colon	V481	0.52111773376915
Sample_02_258	Other	Lung	NCI-H1299_EGFP-NEO_reporter_cells_DMSO	0.26222222222222
Sample_02_285	Cell line	Liver	HuH7_untreat	0.57142857142857
Sample_02_307	Cell line	Neuroblastoma	SJNB12	0.15492957746479
Sample_02_308	Cell line	Neuroblastoma	SJNB1	0.125
Sample_02_354	Cell line	Colon	Colo205	0.16216216216216
Sample_02_358	Cell line	Colon	LS180	0.21484992101106
Sample_02_361	Cell line	Colon	HT29_DMSO	0.52389380530973

KLF3 distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name
Sample_02_021	Colon	Cell line	V429
Sample_02_191	Stomach	Cell line	SNU719
Sample_02_237	Colon	Cell line	V389
Sample_02_242	Colon	Cell line	V481
Sample_02_285	Liver	Cell line	HuH7_untreat
Sample_02_361	Colon	Cell line	HT29_DMSO

KLF3 distribution in all CRCs

Genomic distribution of SEs associated with KLF3

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Mutation of KLF3

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of KLF3

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr4	38696528	38696528	G	T	splicing	KLF3	splicing	ESCA\|1\|185\|0.00541
-	chr4	38691484	38691484	C	T	exonic	KLF3	stopgain	HNSC\|1\|512\|0.00195
-	chr4	38696452	38696452	A	G	exonic	KLF3	nonsynonymous	UCEC\|1\|248\|0.00403
rs761105610	chr4	38696378	38696378	C	T	exonic	KLF3	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs761153626	chr4	38690414	38690414	G	A	exonic	KLF3	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr4	38698856	38698856	T	G	exonic	KLF3	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr4	38698754	38698754	G	A	exonic	KLF3	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr4	38691454	38691454	C	-	exonic	KLF3	frameshift	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr4	38690565	38690565	G	T	exonic	KLF3	synonymous	LUAD\|2\|543\|0.00368
-	chr4	38690303	38690303	G	A	exonic	KLF3	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr4	38698868	38698868	G	A	exonic	KLF3	nonsynonymous	COAD\|2\|367\|0.00545,COADREAD\|2\|489\|0.00409
-	chr4	38696400	38696400	G	T	exonic	KLF3	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr4	38690502	38690502	C	T	exonic	KLF3	synonymous	CESC\|1\|194\|0.00515
-	chr4	38690459	38690459	-	A	exonic	KLF3	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,ESCA\|1\|185\|0.00541
-	chr4	38698843	38698843	G	C	exonic	KLF3	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr4	38696384	38696384	T	C	exonic	KLF3	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr4	38690448	38690448	C	A	exonic	KLF3	synonymous	ESCA\|1\|185\|0.00541
-	chr4	38698711	38698711	C	T	exonic	KLF3	nonsynonymous	BLCA\|1\|396\|0.00253
rs140456976	chr4	38690577	38690577	C	T	exonic	KLF3	synonymous	SKCM\|1\|368\|0.00272
rs201591446	chr4	38690508	38690508	G	A	exonic	KLF3	synonymous	SKCM\|1\|368\|0.00272
-	chr4	38698729	38698729	G	T	exonic	KLF3	stopgain	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr4	38691425	38691425	G	T	exonic	KLF3	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr4	38690278	38690278	G	A	exonic	KLF3	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr4	38691419	38691419	C	T	exonic	KLF3	nonsynonymous	OV\|1\|469\|0.00213
rs142916199	chr4	38696385	38696385	C	T	exonic	KLF3	synonymous	DLBC\|1\|48\|0.02083
-	chr4	38691479	38691479	C	T	exonic	KLF3	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr4	38691388	38691388	A	-	exonic	KLF3	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr4	38698705	38698705	G	T	exonic	KLF3	stopgain	CESC\|1\|194\|0.00515
rs530847522	chr4	38682297	38682297	C	T	exonic	KLF3	synonymous	UCEC\|1\|248\|0.00403
-	chr4	38698737	38698737	C	T	exonic	KLF3	synonymous	UCEC\|1\|248\|0.00403
-	chr4	38696400	38696400	G	C	exonic	KLF3	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr4	38696483	38696483	A	G	exonic	KLF3	nonsynonymous	THYM\|1\|123\|0.00813
-	chr4	38690220	38690220	T	G	exonic	KLF3	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr4	38690460	38690460	A	-	exonic	KLF3	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,ESCA\|2\|185\|0.01081,STAD\|6\|395\|0.01519,STES\|6\|395\|0.01519
rs150818202	chr4	38690369	38690369	C	A	exonic	KLF3	stopgain	HNSC\|1\|512\|0.00195
-	chr4	38690514	38690514	C	T	exonic	KLF3	synonymous	SKCM\|1\|368\|0.00272
-	chr4	38691351	38691351	A	G	exonic	KLF3	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr4	38696436	38696436	-	A	exonic	KLF3	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr4	38690438	38690438	T	C	exonic	KLF3	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr4	38682284	38682284	C	T	exonic	KLF3	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr4	38682250	38682250	C	A	exonic	KLF3	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr4	38698768	38698768	A	G	exonic	KLF3	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr4	38682252	38682252	C	T	exonic	KLF3	synonymous	BLCA\|1\|396\|0.00253
rs199559194	chr4	38690515	38690515	A	G	exonic	KLF3	nonsynonymous	DLBC\|1\|48\|0.02083
rs373502495	chr4	38690343	38690343	G	A	exonic	KLF3	synonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr4	38698823	38698823	A	G	exonic	KLF3	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr4	38690342	38690342	C	T	exonic	KLF3	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr4	38690482	38690482	C	T	exonic	KLF3	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr4	38698861	38698861	A	G	exonic	KLF3	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr4	38698837	38698837	C	T	exonic	KLF3	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr4	38690670	38690670	A	C	exonic	KLF3	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr4	38690408	38690408	C	G	exonic	KLF3	stopgain	HNSC\|1\|512\|0.00195
-	chr4	38698816	38698816	G	A	exonic	KLF3	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr4	38691487	38691487	G	A	exonic	KLF3	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr4	38691476	38691476	C	T	exonic	KLF3	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr4	38691387	38691387	-	A	exonic	KLF3	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr4	38696529	38696529	T	C	splicing	KLF3	splicing	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr4	38690547	38690547	G	A	exonic	KLF3	synonymous	ESCA\|1\|185\|0.00541
-	chr4	38691475	38691475	-	C	exonic	KLF3	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,GBMLGG\|1\|820\|0.00122,KIPAN\|5\|799\|0.00626,KIRC\|5\|451\|0.01109,LGG\|1\|530\|0.00189,LUAD\|4\|543\|0.00737,STAD\|3\|395\|0.00759,STES\|3\|395\|0.00759
-	chr4	38690545	38690545	C	T	exonic	KLF3	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr4	38690456	38690456	C	T	exonic	KLF3	nonsynonymous	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr4	38696416	38696416	G	A	exonic	KLF3	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr4	38690413	38690413	C	A	exonic	KLF3	synonymous	UCEC\|1\|248\|0.00403
-	chr4	38698844	38698844	A	G	exonic	KLF3	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr4	38690331	38690331	A	T	exonic	KLF3	synonymous	LUAD\|1\|543\|0.00184
-	chr4	38691476	38691476	C	-	exonic	KLF3	frameshift	COAD\|2\|367\|0.00545,COADREAD\|2\|489\|0.00409,PAAD\|7\|185\|0.03784,STAD\|8\|395\|0.02025,STES\|8\|395\|0.02025
rs754796742	chr4	38690382	38690382	G	A	exonic	KLF3	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs777382745	chr4	38698797	38698797	C	G	exonic	KLF3	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr4	38690447	38690447	C	T	exonic	KLF3	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr4	38696440	38696440	C	T	exonic	KLF3	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,UCEC\|1\|248\|0.00403
-	chr4	38691456	38691456	C	T	exonic	KLF3	synonymous	LUSC\|1\|178\|0.00562
-	chr4	38696516	38696516	G	T	exonic	KLF3	nonsynonymous	TGCT\|1\|155\|0.00645

Disease information of KLF3

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source

Pathway associated with KLF3

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number

Go term information of KLF3

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GO_term_name	GO_term_type	TF_name

Survival analysis of KLF3

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of KLF3

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)