TF information
| TF name: | ZBTB7A |
| TF family: | ZBTB |
| Ensembl gene ID: | ENSG00000178951 |
| Ensembl protein ID: | ENSP00000471865, ENSP00000471865, ENSP00000323670, ENSP00000323670 |
| Entrez gene ID: | 51341 |
| Database name | Link | Database name | Link |
| NCBI Gene: |  |
Genecards: |  |
| Uniprot: |  |
Wikipedia: |  |
| Cosmic 3D: |  |
Geneontology: |  |
| CCLE: |  |
Frequency of ZBTB7A in all biosamples
| Sample ID | Biosample type | Tissue type | Biosample name | TF Frequency |
|---|---|---|---|---|
| Sample_01_022 | Cell line | Prostate | C4-2B | 0.071428571428571 |
| Sample_02_205 | Tissue | Stomach | Gastric_Primary_Sample_T | 0.088888888888889 |
| Sample_02_219 | Cell line | Mammary Gland | MDA-MB-231 | 0.23529411764706 |
| Sample_02_228 | Cell line | Oesophagus | KYSE510 | 0.040074557315937 |
| Sample_02_236 | Cell line | Colon | V206 | 0.12215320910973 |
| Sample_02_237 | Cell line | Colon | V389 | 0.028897478372906 |
| Sample_02_241 | Cell line | Colon | V456 | 0.12076749435666 |
| Sample_02_280 | Cell line | Mammary Gland | SUM159_DMSO_24h | 0.033333333333333 |
| Sample_02_285 | Cell line | Liver | HuH7_untreat | 0.055749128919861 |
| Sample_02_354 | Cell line | Colon | Colo205 | 0.12012012012012 |
| Sample_02_355 | Cell line | Colon | HCT15 | 0.16071428571429 |
| Sample_02_356 | Cell line | Colon | Sw480 | 0.12903225806452 |
| Sample_02_358 | Cell line | Colon | LS180 | 0.068720379146919 |
| Sample_02_413 | Tissue | Brain | GBM_2493 | 0.049450549450549 |
| Sample_02_424 | Cell line | Colon | SW620 | 0.18840579710145 |
ZBTB7A distribution in samples’ most representative CRC
| Sample ID | Tissue type | Biosample type | Biosample name |
|---|
ZBTB7A distribution in all CRCs
Genomic distribution of SEs associated with ZBTB7A
Genomic distribution of SEs associated with TF
Figure legend:
Genomic distribution of SEs associated with TF: It can roughly understand the genomic regions of SEs associated with TF, and help to carry out the next analysis, such as knocking down the experiment.
What is important information?
The yellow box can be thought of as the common genomic regions that regulates the SEs associated with TF. For example, if a knockdown experiment is performed on this region, then theoretically, the expression of the TF will be greatly reduced.
| Database name | Link |
|---|---|
| Cosmic: |  |
| Cosmic cell lines: |  |
| Depmap: |  |
TCGA somatic mutations and clinical variants of ZBTB7A
| rsID | Chr | Start | Stop | Ref | Alt | Gene_region | Gene_symble | Effect | TCGA_Occurrence |
|---|---|---|---|---|---|---|---|---|---|
| - | chr19 | 4053996 | 4053996 | C | T | exonic | ZBTB7A | nonsynonymous | CHOL|1|35|0.02857 |
| - | chr19 | 4047803 | 4047803 | C | T | exonic | ZBTB7A | nonsynonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr19 | 4054877 | 4054877 | G | A | exonic | ZBTB7A | synonymous | HNSC|1|512|0.00195 |
| - | chr19 | 4048234 | 4048234 | T | G | exonic | ZBTB7A | nonsynonymous | STAD|2|395|0.00506,STES|2|395|0.00506 |
| rs770961493 | chr19 | 4048101 | 4048101 | G | A | exonic | ZBTB7A | synonymous | UCEC|1|248|0.00403 |
| - | chr19 | 4054106 | 4054107 | CT | - | exonic | ZBTB7A | frameshift | SKCM|1|368|0.00272 |
| - | chr19 | 4054697 | 4054697 | G | A | exonic | ZBTB7A | synonymous | UCEC|1|248|0.00403 |
| - | chr19 | 4047820 | 4047820 | C | T | exonic | ZBTB7A | nonsynonymous | BLCA|1|396|0.00253 |
| - | chr19 | 4048123 | 4048123 | G | A | exonic | ZBTB7A | nonsynonymous | SKCM|1|368|0.00272 |
| - | chr19 | 4053968 | 4053968 | C | T | splicing | ZBTB7A | splicing | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr19 | 4054745 | 4054756 | CTCGAGGTACTC | - | exonic | ZBTB7A | nonframeshift | - |
| - | chr19 | 4055153 | 4055153 | C | T | exonic | ZBTB7A | synonymous | BRCA|1|982|0.00102 |
| - | chr19 | 4054074 | 4054074 | A | T | exonic | ZBTB7A | nonsynonymous | BLCA|1|396|0.00253 |
| - | chr19 | 4054867 | 4054867 | C | T | exonic | ZBTB7A | nonsynonymous | UVM|1|80|0.01250 |
| - | chr19 | 4054211 | 4054211 | C | A | exonic | ZBTB7A | nonsynonymous | PRAD|1|499|0.00200 |
| - | chr19 | 4047985 | 4047985 | G | A | exonic | ZBTB7A | nonsynonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| rs773321856 | chr19 | 4047794 | 4047794 | G | A | exonic | ZBTB7A | nonsynonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr19 | 4054174 | 4054174 | G | T | exonic | ZBTB7A | nonsynonymous | GBMLGG|1|820|0.00122,LGG|1|530|0.00189 |
| - | chr19 | 4048230 | 4048230 | C | T | exonic | ZBTB7A | synonymous | BLCA|1|396|0.00253 |
| - | chr19 | 4054881 | 4054881 | G | A | exonic | ZBTB7A | nonsynonymous | SKCM|1|368|0.00272 |
| - | chr19 | 4055075 | 4055075 | C | T | exonic | ZBTB7A | synonymous | BLCA|1|396|0.00253 |
| rs560721320 | chr19 | 4054985 | 4054985 | G | A | exonic | ZBTB7A | synonymous | SKCM|1|368|0.00272 |
| - | chr19 | 4054874 | 4054874 | C | T | exonic | ZBTB7A | synonymous | BRCA|1|982|0.00102 |
| - | chr19 | 4055085 | 4055085 | C | T | exonic | ZBTB7A | nonsynonymous | LIHC|1|373|0.00268 |
| - | chr19 | 4054046 | 4054046 | G | A | exonic | ZBTB7A | synonymous | GBMLGG|1|820|0.00122,LGG|1|530|0.00189 |
| rs756558497 | chr19 | 4047941 | 4047941 | C | T | exonic | ZBTB7A | nonsynonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr19 | 4054919 | 4054919 | C | A | exonic | ZBTB7A | synonymous | CESC|1|194|0.00515 |
| - | chr19 | 4047778 | 4047778 | T | A | exonic | ZBTB7A | nonsynonymous | LUAD|1|543|0.00184 |
| - | chr19 | 4048019 | 4048019 | G | A | exonic | ZBTB7A | nonsynonymous | BLCA|1|396|0.00253 |
| - | chr19 | 4054988 | 4054988 | G | A | exonic | ZBTB7A | synonymous | PRAD|1|499|0.00200 |
| - | chr19 | 4055191 | 4055191 | G | A | exonic | ZBTB7A | nonsynonymous | SKCM|1|368|0.00272 |
| rs77059506 | chr19 | 4054833 | 4054833 | G | A | exonic | ZBTB7A | nonsynonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr19 | 4055065 | 4055065 | T | C | exonic | ZBTB7A | nonsynonymous | STAD|2|395|0.00506,STES|2|395|0.00506 |
| rs749935719 | chr19 | 4054708 | 4054708 | - | G | exonic | ZBTB7A | frameshift | CESC|1|194|0.00515 |
| - | chr19 | 4054600 | 4054607 | CGGCCACG | - | exonic | ZBTB7A | frameshift | SKCM|1|368|0.00272 |
| - | chr19 | 4054020 | 4054020 | T | C | exonic | ZBTB7A | nonsynonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr19 | 4054254 | 4054254 | G | A | exonic | ZBTB7A | nonsynonymous | LUSC|1|178|0.00562 |
| - | chr19 | 4054997 | 4054997 | G | C | exonic | ZBTB7A | nonsynonymous | HNSC|1|512|0.00195 |
| - | chr19 | 4054047 | 4054047 | C | T | exonic | ZBTB7A | nonsynonymous | HNSC|1|512|0.00195 |
| - | chr19 | 4048233 | 4048233 | C | A | exonic | ZBTB7A | nonsynonymous | KIPAN|1|799|0.00125,KIRC|1|451|0.00222 |
| rs557211563 | chr19 | 4047884 | 4047884 | C | T | exonic | ZBTB7A | nonsynonymous | UCEC|1|248|0.00403 |
| - | chr19 | 4054897 | 4054897 | G | A | exonic | ZBTB7A | nonsynonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| rs753160204 | chr19 | 4054814 | 4054814 | G | A | exonic | ZBTB7A | synonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr19 | 4054266 | 4054266 | T | A | exonic | ZBTB7A | nonsynonymous | HNSC|1|512|0.00195 |
| - | chr19 | 4054026 | 4054026 | C | T | exonic | ZBTB7A | nonsynonymous | GBMLGG|1|820|0.00122,LGG|1|530|0.00189 |
| - | chr19 | 4054160 | 4054160 | G | T | exonic | ZBTB7A | nonsynonymous | HNSC|1|512|0.00195 |
| - | chr19 | 4054014 | 4054014 | C | A | exonic | ZBTB7A | nonsynonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr19 | 4054023 | 4054023 | G | T | exonic | ZBTB7A | nonsynonymous | LUSC|1|178|0.00562 |
| - | chr19 | 4054676 | 4054676 | C | T | exonic | ZBTB7A | stopgain | COADREAD|1|489|0.00204,READ|1|122|0.00820 |
| - | chr19 | 4054349 | 4054349 | C | A | exonic | ZBTB7A | synonymous | CESC|1|194|0.00515 |
| - | chr19 | 4054879 | 4054879 | C | T | exonic | ZBTB7A | nonsynonymous | UCS|1|57|0.01754 |
| - | chr19 | 4048050 | 4048050 | G | A | exonic | ZBTB7A | synonymous | BLCA|1|396|0.00253 |
| rs770385730 | chr19 | 4055177 | 4055177 | G | A | exonic | ZBTB7A | synonymous | LUAD|1|543|0.00184 |
| - | chr19 | 4048152 | 4048152 | G | A | exonic | ZBTB7A | synonymous | BLCA|1|396|0.00253 |
| - | chr19 | 4054681 | 4054681 | G | A | exonic | ZBTB7A | nonsynonymous | SKCM|1|368|0.00272 |
| - | chr19 | 4048140 | 4048140 | G | C | exonic | ZBTB7A | nonsynonymous | PAAD|1|185|0.00541 |
| - | chr19 | 4054957 | 4054957 | C | T | exonic | ZBTB7A | nonsynonymous | BLCA|1|396|0.00253 |
| rs757689355 | chr19 | 4048173 | 4048173 | G | A | exonic | ZBTB7A | synonymous | PRAD|1|499|0.00200 |
| - | chr19 | 4048115 | 4048115 | G | A | exonic | ZBTB7A | nonsynonymous | SARC|1|247|0.00405 |
| - | chr19 | 4047779 | 4047779 | C | T | exonic | ZBTB7A | nonsynonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr19 | 4055177 | 4055177 | G | T | exonic | ZBTB7A | nonsynonymous | TGCT|1|155|0.00645 |
| - | chr19 | 4048040 | 4048040 | C | T | exonic | ZBTB7A | nonsynonymous | ESCA|1|185|0.00541 |
| - | chr19 | 4054661 | 4054661 | C | T | exonic | ZBTB7A | synonymous | ESCA|1|185|0.00541 |
| - | chr19 | 4054919 | 4054919 | C | T | exonic | ZBTB7A | synonymous | TGCT|1|155|0.00645 |
| TF_name | Disease_name | Disease_class | Disease_semantic_type | TF_disease_source |
|---|---|---|---|---|
| ZBTB7A | Glioblastoma | C04 | Neoplastic Process | CTD_human |
| ZBTB7A | Leukemia, Myelocytic, Acute | C04 | Neoplastic Process | CTD_human |
| ZBTB7A | Acute Myeloid Leukemia, M1 | C04 | Neoplastic Process | CTD_human |
| ZBTB7A | Prostatic Neoplasms | C04;C12 | Neoplastic Process | CTD_human |
| ZBTB7A | Giant Cell Glioblastoma | C04 | Neoplastic Process | CTD_human |
| ZBTB7A | Malignant neoplasm of prostate | C04;C12 | Neoplastic Process | CTD_human |
| ZBTB7A | Glioblastoma Multiforme | C04 | Neoplastic Process | CTD_human |
| ZBTB7A | Acute Myeloid Leukemia (AML-M2) | C04 | Neoplastic Process | CTD_human |
| pathway_ID | pathway_name | pathway_source | gene_number | edge_number |
|---|
| GO_term_name | GO_term_type | TF_name |
|---|---|---|
| GO_REGULATION_OF_OSTEOCLAST_DIFFERENTIATION | BP | ZBTB7A |
| GO_REGULATION_OF_LEUKOCYTE_DIFFERENTIATION | BP | ZBTB7A |
| GO_REGULATION_OF_MYELOID_CELL_DIFFERENTIATION | BP | ZBTB7A |
| GO_REGULATION_OF_HEMOPOIESIS | BP | ZBTB7A |
| GO_TRANSCRIPTION_FACTOR_ACTIVITY_RNA_POLYMERASE_II_CORE_PROMOTER_PROXIMAL_REGION_SEQUENCE_SPECIFIC_BINDING | MF | ZBTB7A |
| GO_HISTONE_ACETYLTRANSFERASE_BINDING | MF | ZBTB7A |
| GO_CORE_PROMOTER_PROXIMAL_REGION_DNA_BINDING | MF | ZBTB7A |