TF information
| TF name: | RARG |
| TF family: | THR-like |
| Ensembl gene ID: | ENSG00000172819 |
| Ensembl protein ID: | ENSP00000343698, ENSP00000388510, ENSP00000444335, ENSP00000377947 |
| Entrez gene ID: | 5916 |
| Database name | Link | Database name | Link |
| NCBI Gene: |  |
Genecards: |  |
| Uniprot: |  |
Wikipedia: |  |
| Cosmic 3D: |  |
Geneontology: |  |
| CCLE: |  |
Frequency of RARG in all biosamples
| Sample ID | Biosample type | Tissue type | Biosample name | TF Frequency |
|---|---|---|---|---|
| Sample_02_096 | Cell line | Mammary Gland | ZR-75-1_1 | 1 |
| Sample_02_115 | Cell line | Mammary Gland | MCF-7 | 0.2 |
| Sample_02_180 | Cell line | Human melanoma | CJM | 0.703125 |
| Sample_02_181 | Cell line | Human melanoma | COLO679 | 0.4384 |
| Sample_02_182 | Cell line | Human melanoma | LOX-IMVI | 0.29597701149425 |
| Sample_02_197 | Cell line | Stomach | SNU1750 | 0.44444444444444 |
| Sample_02_228 | Cell line | Oesophagus | KYSE510 | 0.15657036346692 |
| Sample_02_258 | Other | Lung | NCI-H1299_EGFP-NEO_reporter_cells_DMSO | 0.048888888888889 |
| Sample_02_304 | Cell line | Neuroblastoma | N206 | 0.13586956521739 |
| Sample_02_359 | Cell line | Colon | Colo741 | 0.15361445783133 |
| Sample_02_361 | Cell line | Colon | HT29_DMSO | 0.26902654867257 |
| Sample_02_403 | Cell line | Mammary Gland | T-47D_untreat | 0.15909090909091 |
RARG distribution in samples’ most representative CRC
| Sample ID | Tissue type | Biosample type | Biosample name |
|---|---|---|---|
| Sample_02_096 | Mammary Gland | Cell line | ZR-75-1_1 |
| Sample_02_180 | Human melanoma | Cell line | CJM |
| Sample_02_197 | Stomach | Cell line | SNU1750 |
| Sample_02_359 | Colon | Cell line | Colo741 |
RARG distribution in all CRCs
Genomic distribution of SEs associated with RARG
Genomic distribution of SEs associated with TF
Figure legend:
Genomic distribution of SEs associated with TF: It can roughly understand the genomic regions of SEs associated with TF, and help to carry out the next analysis, such as knocking down the experiment.
What is important information?
The yellow box can be thought of as the common genomic regions that regulates the SEs associated with TF. For example, if a knockdown experiment is performed on this region, then theoretically, the expression of the TF will be greatly reduced.
| Database name | Link |
|---|---|
| Cosmic: |  |
| Cosmic cell lines: |  |
| Depmap: |  |
TCGA somatic mutations and clinical variants of RARG
| rsID | Chr | Start | Stop | Ref | Alt | Gene_region | Gene_symble | Effect | TCGA_Occurrence |
|---|---|---|---|---|---|---|---|---|---|
| rs143739684 | chr12 | 53606944 | 53606944 | G | A | exonic | RARG | nonsynonymous | UCS|1|57|0.01754 |
| - | chr12 | 53621199 | 53621199 | G | A | exonic | RARG | nonsynonymous | SKCM|1|368|0.00272 |
| - | chr12 | 53607384 | 53607384 | C | A | exonic | RARG | nonsynonymous | HNSC|1|512|0.00195 |
| rs761508890 | chr12 | 53609131 | 53609131 | G | A | exonic | RARG | nonsynonymous | HNSC|1|512|0.00195 |
| - | chr12 | 53607425 | 53607425 | C | T | exonic | RARG | synonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr12 | 53607456 | 53607456 | G | - | exonic | RARG | frameshift | COAD|2|367|0.00545,COADREAD|2|489|0.00409 |
| - | chr12 | 53605571 | 53605571 | G | C | exonic | RARG | nonsynonymous | LIHC|1|373|0.00268 |
| - | chr12 | 53608274 | 53608274 | G | A | exonic | RARG | stopgain | BLCA|1|396|0.00253 |
| - | chr12 | 53607845 | 53607845 | G | C | exonic | RARG | nonsynonymous | BLCA|1|396|0.00253 |
| - | chr12 | 53605639 | 53605639 | T | C | exonic | RARG | nonsynonymous | CESC|1|194|0.00515 |
| - | chr12 | 53608320 | 53608320 | - | A | exonic | RARG | frameshift | BLCA|1|396|0.00253 |
| - | chr12 | 53621202 | 53621202 | C | A | exonic | RARG | nonsynonymous | HNSC|1|512|0.00195 |
| - | chr12 | 53607463 | 53607463 | A | G | exonic | RARG | nonsynonymous | BLCA|1|396|0.00253 |
| - | chr12 | 53608313 | 53608313 | G | A | exonic | RARG | stopgain | CESC|1|194|0.00515 |
| - | chr12 | 53607927 | 53607927 | C | T | exonic | RARG | synonymous | UCEC|1|248|0.00403 |
| - | chr12 | 53606961 | 53606961 | C | T | exonic | RARG | nonsynonymous | LUSC|1|178|0.00562 |
| - | chr12 | 53609485 | 53609485 | C | T | exonic | RARG | nonsynonymous | UCEC|1|248|0.00403 |
| - | chr12 | 53609510 | 53609510 | G | A | exonic | RARG | nonsynonymous | LUAD|1|543|0.00184 |
| - | chr12 | 53609159 | 53609159 | G | T | exonic | RARG | nonsynonymous | TGCT|1|155|0.00645 |
| rs758257136 | chr12 | 53608349 | 53608349 | C | T | exonic | RARG | nonsynonymous | BLCA|1|396|0.00253 |
| rs766890278 | chr12 | 53605501 | 53605501 | G | A | exonic | RARG | nonsynonymous | SKCM|1|368|0.00272 |
| - | chr12 | 53609502 | 53609502 | G | C | exonic | RARG | stopgain | BRCA|2|982|0.00204 |
| - | chr12 | 53609161 | 53609161 | T | C | exonic | RARG | nonsynonymous | LIHC|1|373|0.00268 |
| - | chr12 | 53605536 | 53605536 | C | T | exonic | RARG | nonsynonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr12 | 53608001 | 53608001 | G | T | exonic | RARG | nonsynonymous | THYM|1|123|0.00813 |
| - | chr12 | 53607867 | 53607867 | G | A | exonic | RARG | synonymous | BLCA|1|396|0.00253,PAAD|1|185|0.00541 |
| - | chr12 | 53607847 | 53607847 | A | G | exonic | RARG | nonsynonymous | KIPAN|1|799|0.00125,KIRP|1|282|0.00355 |
| - | chr12 | 53607282 | 53607282 | C | T | exonic | RARG | nonsynonymous | BLCA|1|396|0.00253 |
| - | chr12 | 53621310 | 53621310 | C | T | exonic | RARG | nonsynonymous | OV|1|469|0.00213 |
| - | chr12 | 53621285 | 53621285 | C | - | exonic | RARG | frameshift | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr12 | 53609209 | 53609209 | G | A | exonic | RARG | nonsynonymous | HNSC|1|512|0.00195,UCEC|1|248|0.00403 |
| rs756249363 | chr12 | 53621300 | 53621300 | C | T | exonic | RARG | synonymous | SKCM|1|368|0.00272 |
| rs770432568 | chr12 | 53609098 | 53609098 | C | T | exonic | RARG | nonsynonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204,UCEC|1|248|0.00403 |
| - | chr12 | 53608014 | 53608014 | G | A | exonic | RARG | synonymous | SKCM|1|368|0.00272 |
| rs749068937 | chr12 | 53621311 | 53621311 | G | A | exonic | RARG | stopgain | COAD|2|367|0.00545,COADREAD|2|489|0.00409 |
| - | chr12 | 53621231 | 53621231 | G | A | exonic | RARG | synonymous | BLCA|1|396|0.00253,STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr12 | 53607872 | 53607872 | G | C | exonic | RARG | nonsynonymous | CESC|1|194|0.00515 |
| - | chr12 | 53607344 | 53607344 | G | A | exonic | RARG | synonymous | BLCA|2|396|0.00505 |
| rs769476878 | chr12 | 53609518 | 53609518 | G | A | exonic | RARG | nonsynonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr12 | 53609519 | 53609519 | G | C | exonic | RARG | nonsynonymous | LUAD|1|543|0.00184 |
| - | chr12 | 53607314 | 53607314 | T | A | exonic | RARG | synonymous | CHOL|1|35|0.02857 |
| - | chr12 | 53607418 | 53607418 | G | A | exonic | RARG | synonymous | SKCM|1|368|0.00272 |
| - | chr12 | 53621178 | 53621178 | T | A | exonic | RARG | nonsynonymous | LUAD|1|543|0.00184 |
| - | chr12 | 53607931 | 53607931 | A | G | exonic | RARG | nonsynonymous | BLCA|1|396|0.00253 |
| - | chr12 | 53607337 | 53607337 | G | C | exonic | RARG | nonsynonymous | BLCA|1|396|0.00253 |
| - | chr12 | 53607911 | 53607911 | G | A | exonic | RARG | nonsynonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr12 | 53608327 | 53608338 | TAGCTGTCAGGT | - | exonic | RARG | nonframeshift | HNSC|1|512|0.00195 |
| - | chr12 | 53621180 | 53621180 | G | C | exonic | RARG | synonymous | KIPAN|1|799|0.00125,KIRC|1|451|0.00222 |
| - | chr12 | 53607427 | 53607427 | C | T | exonic | RARG | nonsynonymous | PAAD|1|185|0.00541 |
| - | chr12 | 53609077 | 53609077 | C | T | exonic | RARG | nonsynonymous | UCEC|1|248|0.00403 |
| - | chr12 | 53621207 | 53621207 | C | G | exonic | RARG | nonsynonymous | HNSC|1|512|0.00195 |
| - | chr12 | 53607867 | 53607867 | G | C | exonic | RARG | synonymous | BLCA|1|396|0.00253 |
| - | chr12 | 53608385 | 53608385 | G | A | exonic | RARG | stopgain | UCEC|1|248|0.00403 |
| rs556025298 | chr12 | 53621213 | 53621213 | G | A | exonic | RARG | synonymous | ESCA|1|185|0.00541 |
| rs775669227 | chr12 | 53609099 | 53609099 | G | A | exonic | RARG | synonymous | BLCA|1|396|0.00253 |
| - | chr12 | 53606933 | 53606933 | G | T | exonic | RARG | nonsynonymous | ESCA|1|185|0.00541 |
| - | chr12 | 53605612 | 53605612 | G | C | exonic | RARG | nonsynonymous | HNSC|1|512|0.00195 |
| - | chr12 | 53605514 | 53605514 | G | C | exonic | RARG | nonsynonymous | BLCA|2|396|0.00505 |
| - | chr12 | 53609155 | 53609155 | T | C | exonic | RARG | nonsynonymous | HNSC|1|512|0.00195 |
| - | chr12 | 53609533 | 53609533 | G | A | exonic | RARG | nonsynonymous | HNSC|1|512|0.00195 |
| - | chr12 | 53607319 | 53607319 | C | T | exonic | RARG | nonsynonymous | BLCA|2|396|0.00505 |
| - | chr12 | 53621266 | 53621266 | C | A | exonic | RARG | nonsynonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr12 | 53605598 | 53605598 | A | G | exonic | RARG | synonymous | BLCA|1|396|0.00253 |
| - | chr12 | 53608346 | 53608346 | C | T | exonic | RARG | nonsynonymous | BLCA|1|396|0.00253 |
| rs755978003 | chr12 | 53609167 | 53609167 | C | T | exonic | RARG | nonsynonymous | PCPG|1|184|0.00543 |
| - | chr12 | 53607028 | 53607028 | C | T | splicing | RARG | splicing | BLCA|1|396|0.00253 |
| - | chr12 | 53609147 | 53609147 | G | A | exonic | RARG | synonymous | GBMLGG|1|820|0.00122,LGG|1|530|0.00189 |
| - | chr12 | 53608330 | 53608330 | C | T | exonic | RARG | nonsynonymous | PRAD|1|499|0.00200 |
| - | chr12 | 53607440 | 53607440 | C | G | exonic | RARG | nonsynonymous | BLCA|1|396|0.00253 |
| - | chr12 | 53607995 | 53607995 | G | A | exonic | RARG | stopgain | PAAD|1|185|0.00541 |
| - | chr12 | 53609489 | 53609489 | C | T | exonic | RARG | nonsynonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr12 | 53607910 | 53607910 | G | A | exonic | RARG | nonsynonymous | SKCM|2|368|0.00543 |
| - | chr12 | 53607396 | 53607396 | T | C | exonic | RARG | nonsynonymous | HNSC|1|512|0.00195 |
| - | chr12 | 53613943 | 53613943 | C | T | exonic | RARG | nonsynonymous | ESCA|1|185|0.00541 |
| - | chr12 | 53607432 | 53607432 | G | A | exonic | RARG | nonsynonymous | BLCA|2|396|0.00505 |
| - | chr12 | 53608237 | 53608237 | T | C | exonic | RARG | nonsynonymous | HNSC|1|512|0.00195 |
| rs764641682 | chr12 | 53613976 | 53613976 | - | G | exonic | RARG | frameshift | ESCA|1|185|0.00541 |
| - | chr12 | 53607361 | 53607361 | C | G | exonic | RARG | nonsynonymous | OV|1|469|0.00213 |
| - | chr12 | 53621287 | 53621287 | C | A | exonic | RARG | nonsynonymous | HNSC|1|512|0.00195 |
| rs754842832 | chr12 | 53607025 | 53607025 | G | A | exonic | RARG | nonsynonymous | BRCA|1|982|0.00102,LIHC|1|373|0.00268 |
| - | chr12 | 53609563 | 53609563 | C | T | exonic | RARG | nonsynonymous | TGCT|1|155|0.00645 |
| rs747235920 | chr12 | 53607386 | 53607386 | G | A | exonic | RARG | synonymous | BLCA|1|396|0.00253 |
| - | chr12 | 53608001 | 53608001 | G | A | exonic | RARG | nonsynonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204,LIHC|1|373|0.00268 |
| - | chr12 | 53607445 | 53607445 | T | C | exonic | RARG | nonsynonymous | BLCA|1|396|0.00253 |
| - | chr12 | 53607956 | 53607956 | C | G | exonic | RARG | nonsynonymous | BLCA|1|396|0.00253 |
| - | chr12 | 53607014 | 53607014 | C | T | exonic | RARG | synonymous | LUAD|1|543|0.00184 |
| - | chr12 | 53607444 | 53607444 | G | A | exonic | RARG | nonsynonymous | HNSC|1|512|0.00195 |
| - | chr12 | 53608246 | 53608246 | A | G | exonic | RARG | nonsynonymous | UCEC|1|248|0.00403 |
| rs141058411 | chr12 | 53609169 | 53609169 | C | T | exonic | RARG | nonsynonymous | COAD|2|367|0.00545,COADREAD|2|489|0.00409 |
| - | chr12 | 53609125 | 53609125 | G | A | exonic | RARG | stopgain | BLCA|1|396|0.00253 |
| rs201815743 | chr12 | 53607428 | 53607428 | G | A | exonic | RARG | synonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr12 | 53607325 | 53607325 | C | T | exonic | RARG | nonsynonymous | BLCA|1|396|0.00253 |
| - | chr12 | 53607434 | 53607434 | G | C | exonic | RARG | nonsynonymous | CESC|1|194|0.00515 |
| - | chr12 | 53608258 | 53608258 | G | A | exonic | RARG | nonsynonymous | CESC|1|194|0.00515 |
| - | chr12 | 53608271 | 53608271 | C | T | exonic | RARG | nonsynonymous | BLCA|1|396|0.00253 |
| rs765464326 | chr12 | 53621185 | 53621185 | G | A | exonic | RARG | synonymous | SKCM|1|368|0.00272 |
| - | chr12 | 53606945 | 53606945 | G | C | exonic | RARG | synonymous | UVM|1|80|0.01250 |
| - | chr12 | 53607384 | 53607384 | C | T | exonic | RARG | nonsynonymous | BRCA|1|982|0.00102 |
| TF_name | Disease_name | Disease_class | Disease_semantic_type | TF_disease_source |
|---|---|---|---|---|
| RARG | Malignant neoplasm of breast | C04;C17 | Neoplastic Process | UNIPROT |
| RARG | Cleft Palate | C05;C07;C16 | Congenital Abnormality | CTD_human |
| RARG | Heart Diseases | C14 | Disease or Syndrome | CTD_human |
| RARG | Congenital musculoskeletal anomalies | C05;C16 | Congenital Abnormality | CTD_human |
| RARG | Cardiotoxicity | C23;C25;C26 | Injury or Poisoning | CTD_human |
| RARG | Cleft palate, isolated | C05;C07;C16 | Congenital Abnormality | CTD_human |
| pathway_ID | pathway_name | pathway_source | gene_number | edge_number |
|---|---|---|---|---|
| pathway0001534 | Nuclear Receptor transcription pathway | reactome | 51 | 284 |
| pathway0001883 | Retinoic acid receptors-mediated signaling | pid | 30 | 235 |
| pathway0001947 | RXR and RAR heterodimerization with other nuclear receptor | pid | 26 | 164 |
| pathway0002028 | Signaling by Retinoic Acid | reactome | 20 | 78 |
| GO_term_name | GO_term_type | TF_name |
|---|---|---|
| GO_GLAND_MORPHOGENESIS | BP | RARG |
| GO_PROSTATE_GLAND_MORPHOGENESIS | BP | RARG |
| GO_REGULATION_OF_CARTILAGE_DEVELOPMENT | BP | RARG |
| GO_HINDLIMB_MORPHOGENESIS | BP | RARG |
| GO_REGULATION_OF_MYELINATION | BP | RARG |
| GO_REGULATION_OF_NERVOUS_SYSTEM_DEVELOPMENT | BP | RARG |
| GO_CHONDROCYTE_DEVELOPMENT | BP | RARG |
| GO_MORPHOGENESIS_OF_EMBRYONIC_EPITHELIUM | BP | RARG |
| GO_BONE_GROWTH | BP | RARG |
| GO_WNT_SIGNALING_PATHWAY | BP | RARG |
| GO_GLANDULAR_EPITHELIAL_CELL_DEVELOPMENT | BP | RARG |
| GO_ANTERIOR_POSTERIOR_PATTERN_SPECIFICATION | BP | RARG |
| GO_CHONDROCYTE_DIFFERENTIATION | BP | RARG |
| GO_REGULATION_OF_CHONDROCYTE_DIFFERENTIATION | BP | RARG |
| GO_MULTICELLULAR_ORGANISM_GROWTH | BP | RARG |
| GO_EXOCRINE_SYSTEM_DEVELOPMENT | BP | RARG |
| GO_REGULATION_OF_CELL_DIFFERENTIATION | BP | RARG |
| GO_EMBRYONIC_HINDLIMB_MORPHOGENESIS | BP | RARG |
| GO_FACE_DEVELOPMENT | BP | RARG |
| GO_NEGATIVE_REGULATION_OF_CARTILAGE_DEVELOPMENT | BP | RARG |
| GO_ORGAN_GROWTH | BP | RARG |
| GO_DNA_TEMPLATED_TRANSCRIPTION_INITIATION | BP | RARG |
| GO_TRACHEA_DEVELOPMENT | BP | RARG |
| GO_CELLULAR_RESPONSE_TO_STEROID_HORMONE_STIMULUS | BP | RARG |
| GO_CARTILAGE_DEVELOPMENT_INVOLVED_IN_ENDOCHONDRAL_BONE_MORPHOGENESIS | BP | RARG |
| GO_STEROID_HORMONE_MEDIATED_SIGNALING_PATHWAY | BP | RARG |
| GO_CONNECTIVE_TISSUE_DEVELOPMENT | BP | RARG |
| GO_EMBRYONIC_EYE_MORPHOGENESIS | BP | RARG |
| GO_SENSORY_ORGAN_DEVELOPMENT | BP | RARG |
| GO_BONE_MORPHOGENESIS | BP | RARG |
| GO_SENSORY_ORGAN_MORPHOGENESIS | BP | RARG |
| GO_ENDOCHONDRAL_BONE_MORPHOGENESIS | BP | RARG |
| GO_DEVELOPMENTAL_GROWTH_INVOLVED_IN_MORPHOGENESIS | BP | RARG |
| GO_PROSTATE_GLAND_DEVELOPMENT | BP | RARG |
| GO_GROWTH_PLATE_CARTILAGE_DEVELOPMENT | BP | RARG |
| GO_RETINOIC_ACID_RECEPTOR_SIGNALING_PATHWAY | BP | RARG |
| GO_SKELETAL_SYSTEM_MORPHOGENESIS | BP | RARG |
| GO_EMBRYONIC_CAMERA_TYPE_EYE_DEVELOPMENT | BP | RARG |
| GO_NEGATIVE_REGULATION_OF_CHONDROCYTE_DIFFERENTIATION | BP | RARG |
| GO_GLANDULAR_EPITHELIAL_CELL_DIFFERENTIATION | BP | RARG |
| GO_EYE_MORPHOGENESIS | BP | RARG |
| GO_CHROMOSOME | CC | RARG |
| GO_TRANSCRIPTION_FACTOR_COMPLEX | CC | RARG |
| GO_TRANSCRIPTION_FACTOR_ACTIVITY_DIRECT_LIGAND_REGULATED_SEQUENCE_SPECIFIC_DNA_BINDING | MF | RARG |
| GO_STEROID_HORMONE_RECEPTOR_ACTIVITY | MF | RARG |
| GO_NUCLEIC_ACID_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY | MF | RARG |
| GO_RETINOIC_ACID_RECEPTOR_BINDING | MF | RARG |
| GO_RETINOID_X_RECEPTOR_BINDING | MF | RARG |