Cancer CRCdb

TF information

TF name:	EHF
TF family:	ETS
Ensembl gene ID:	ENSG00000135373
Ensembl protein ID:	ENSP00000433508, ENSP00000435837, ENSP00000435835, ENSP00000399733, ENSP00000257831
Entrez gene ID:	26298

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of EHF in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_01_001	Cell line	Prostate	22Rv1	0.9225181598063
Sample_01_059	Cell line	Lung	PC-9	0.46666666666667
Sample_01_068	Cell line	Prostate: derived from metastatic site: vertebral metastasis	VCaP	0.65753424657534
Sample_02_021	Cell line	Colon	V429	0.8535601037763
Sample_02_029	Cell line	Colorectal	LS174T	0.66666666666667
Sample_02_079	Cell line	Mammary Gland	T-47D_1	1
Sample_02_080	Cell line	Lung	Calu-3	0.45454545454545
Sample_02_095	Cell line	Mammary Gland	MDA-MB-468	1
Sample_02_096	Cell line	Mammary Gland	ZR-75-1_1	0.90217391304348
Sample_02_116	Cell line	Mammary Gland	MDA-MB-231_untreat	0.66666666666667
Sample_02_166	Cell line	Mammary Gland	HCC1954_Parental	0.74
Sample_02_168	Cell line	Prostate	LNCaP	1
Sample_02_180	Cell line	Human melanoma	CJM	0.140625
Sample_02_181	Cell line	Human melanoma	COLO679	0.17866666666667
Sample_02_196	Cell line	Stomach	NCC59	0.71428571428571
Sample_02_199	Cell line	Stomach	KATO3	1
Sample_02_203	Cell line	Stomach	YCC21	1
Sample_02_204	Cell line	Stomach	IM95	0.77272727272727
Sample_02_205	Tissue	Stomach	Gastric_Primary_Sample_T	0.73333333333333
Sample_02_208	Cell line	Stomach	YCC3	0.875
Sample_02_219	Cell line	Mammary Gland	MDA-MB-231	0.7156862745098
Sample_02_228	Cell line	Oesophagus	KYSE510	0.6076421248835
Sample_02_236	Cell line	Colon	V206	0.68530020703934
Sample_02_237	Cell line	Colon	V389	0.99992637585128
Sample_02_241	Cell line	Colon	V456	0.7313769751693
Sample_02_242	Cell line	Colon	V481	1
Sample_02_354	Cell line	Colon	Colo205	1
Sample_02_358	Cell line	Colon	LS180	0.96563981042654
Sample_02_361	Cell line	Colon	HT29_DMSO	1
Sample_02_394	Cell line	Mammary Gland	T-47D_2	1
Sample_02_403	Cell line	Mammary Gland	T-47D_untreat	1
Sample_02_404	Cell line	Mammary Gland	ZR-75-1_2	0.5863309352518
Sample_02_424	Cell line	Colon	SW620	1

EHF distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name
Sample_01_001	Prostate	Cell line	22Rv1
Sample_01_059	Lung	Cell line	PC-9
Sample_01_068	Prostate: derived from metastatic site: vertebral metastasis	Cell line	VCaP
Sample_02_021	Colon	Cell line	V429
Sample_02_029	Colorectal	Cell line	LS174T
Sample_02_079	Mammary Gland	Cell line	T-47D_1
Sample_02_080	Lung	Cell line	Calu-3
Sample_02_095	Mammary Gland	Cell line	MDA-MB-468
Sample_02_096	Mammary Gland	Cell line	ZR-75-1_1
Sample_02_116	Mammary Gland	Cell line	MDA-MB-231_untreat
Sample_02_166	Mammary Gland	Cell line	HCC1954_Parental
Sample_02_168	Prostate	Cell line	LNCaP
Sample_02_196	Stomach	Cell line	NCC59
Sample_02_199	Stomach	Cell line	KATO3
Sample_02_203	Stomach	Cell line	YCC21
Sample_02_204	Stomach	Cell line	IM95
Sample_02_205	Stomach	Tissue	Gastric_Primary_Sample_T
Sample_02_208	Stomach	Cell line	YCC3
Sample_02_219	Mammary Gland	Cell line	MDA-MB-231
Sample_02_228	Oesophagus	Cell line	KYSE510
Sample_02_236	Colon	Cell line	V206
Sample_02_237	Colon	Cell line	V389
Sample_02_241	Colon	Cell line	V456
Sample_02_242	Colon	Cell line	V481
Sample_02_354	Colon	Cell line	Colo205
Sample_02_358	Colon	Cell line	LS180
Sample_02_361	Colon	Cell line	HT29_DMSO
Sample_02_394	Mammary Gland	Cell line	T-47D_2
Sample_02_403	Mammary Gland	Cell line	T-47D_untreat
Sample_02_404	Mammary Gland	Cell line	ZR-75-1_2
Sample_02_424	Colon	Cell line	SW620

EHF distribution in all CRCs

Genomic distribution of SEs associated with EHF

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Mutation of EHF

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of EHF

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr11	34668007	34668007	G	A	exonic	EHF	nonsynonymous	SKCM\|2\|368\|0.00543
-	chr11	34664191	34664191	G	C	exonic	EHF	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr11	34680445	34680445	G	C	exonic	EHF	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr11	34668200	34668200	C	G	exonic	EHF	synonymous	HNSC\|1\|512\|0.00195
-	chr11	34680176	34680176	G	A	exonic	EHF	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr11	34664228	34664228	C	T	exonic	EHF	synonymous	SKCM\|1\|368\|0.00272
-	chr11	34673089	34673089	A	T	exonic	EHF	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr11	34668056	34668056	G	A	exonic	EHF	stopgain	UCEC\|1\|248\|0.00403
-	chr11	34670626	34670626	-	G	exonic	EHF	frameshift	LUAD\|1\|543\|0.00184
-	chr11	34664214	34664214	C	G	exonic	EHF	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr11	34670588	34670588	C	-	exonic	EHF	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr11	34668171	34668171	-	G	exonic	EHF	frameshift	PAAD\|1\|185\|0.00541
-	chr11	34680429	34680429	T	C	exonic	EHF	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr11	34673125	34673125	A	G	exonic	EHF	nonsynonymous	PCPG\|1\|184\|0.00543
-	chr11	34668169	34668169	C	-	exonic	EHF	frameshift	SKCM\|1\|368\|0.00272
-	chr11	34680084	34680084	G	A	exonic	EHF	synonymous	BLCA\|1\|396\|0.00253
-	chr11	34680231	34680231	G	C	exonic	EHF	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr11	34667996	34667996	-	T	exonic	EHF	frameshift	LUAD\|1\|543\|0.00184
rs775169543	chr11	34680408	34680408	G	A	exonic	EHF	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs757126229	chr11	34680266	34680266	G	A	exonic	EHF	nonsynonymous	ESCA\|1\|185\|0.00541
rs763605744	chr11	34680082	34680082	C	T	exonic	EHF	nonsynonymous	SKCM\|2\|368\|0.00543
-	chr11	34673102	34673102	G	A	exonic	EHF	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr11	34668230	34668230	C	T	exonic	EHF	synonymous	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr11	34680227	34680228	AG	-	exonic	EHF	frameshift	UCEC\|1\|248\|0.00403
-	chr11	34673334	34673334	A	G	exonic	EHF	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr11	34680110	34680110	T	A	exonic	EHF	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr11	34673324	34673324	C	T	exonic	EHF	synonymous	BLCA\|1\|396\|0.00253
-	chr11	34667997	34667997	T	-	exonic	EHF	frameshift	PAAD\|1\|185\|0.00541
rs760166294	chr11	34668216	34668216	C	T	exonic	EHF	nonsynonymous	UCS\|1\|57\|0.01754
-	chr11	34680413	34680413	G	T	exonic	EHF	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr11	34680084	34680084	G	C	exonic	EHF	synonymous	BLCA\|1\|396\|0.00253,LUSC\|1\|178\|0.00562
-	chr11	34673286	34673286	T	C	exonic	EHF	synonymous	UCEC\|1\|248\|0.00403
-	chr11	34680419	34680419	C	G	exonic	EHF	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr11	34668230	34668230	C	G	exonic	EHF	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr11	34680205	34680205	G	T	exonic	EHF	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr11	34678466	34678466	G	C	exonic	EHF	nonsynonymous	HNSC\|1\|512\|0.00195
rs747033466	chr11	34680177	34680177	C	T	exonic	EHF	synonymous	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr11	34668187	34668187	C	T	exonic	EHF	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr11	34680103	34680103	G	A	exonic	EHF	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr11	34680239	34680239	G	T	exonic	EHF	nonsynonymous	PRAD\|1\|499\|0.00200
rs775856876	chr11	34670585	34670585	G	C	exonic	EHF	synonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr11	34678508	34678508	A	-	exonic	EHF	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr11	34670605	34670605	T	C	exonic	EHF	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr11	34668238	34668238	C	T	intronic	EHF	unknown	CESC\|1\|194\|0.00515
-	chr11	34680224	34680224	A	G	exonic	EHF	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr11	34668094	34668094	A	T	exonic	EHF	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr11	34680476	34680476	T	C	exonic	EHF	stoploss	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr11	34668215	34668222	GCATCTGA	-	exonic	EHF	frameshift	OV\|1\|469\|0.00213
-	chr11	34673338	34673338	G	A	exonic	EHF	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr11	34668117	34668117	G	C	exonic	EHF	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr11	34668199	34668199	T	C	exonic	EHF	nonsynonymous	LUAD\|1\|543\|0.00184
rs752457173	chr11	34680128	34680128	A	G	exonic	EHF	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr11	34680094	34680094	C	T	exonic	EHF	nonsynonymous	BLCA\|1\|396\|0.00253
rs199838917	chr11	34680178	34680178	G	A	exonic	EHF	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189

Disease information of EHF

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
EHF	Prostatic Neoplasms	C04;C12	Neoplastic Process	CTD_human
EHF	Malignant neoplasm of prostate	C04;C12	Neoplastic Process	CTD_human

Pathway associated with EHF

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number
pathway0001604	PDGF signaling pathway	panther	113	1684

Go term information of EHF

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GO_term_name	GO_term_type	TF_name
GO_TRANSCRIPTIONAL_ACTIVATOR_ACTIVITY_RNA_POLYMERASE_II_TRANSCRIPTION_REGULATORY_REGION_SEQUENCE_SPECIFIC_BINDING	MF	EHF
GO_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_ACTIVITY_SEQUENCE_SPECIFIC_DNA_BINDING	MF	EHF
GO_TRANSCRIPTIONAL_ACTIVATOR_ACTIVITY_RNA_POLYMERASE_II_CORE_PROMOTER_PROXIMAL_REGION_SEQUENCE_SPECIFIC_BINDING	MF	EHF

Survival analysis of EHF

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of EHF

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)