Cancer CRCdb

TF information

TF name:	ZBTB7B
TF family:	ZBTB
Ensembl gene ID:	ENSG00000160685
Ensembl protein ID:	ENSP00000438647, ENSP00000438647, ENSP00000357411, ENSP00000357411, ENSP00000406286, ENSP00000406286, ENSP00000292176
Entrez gene ID:	51043

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of ZBTB7B in all biosamples

Download

Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_01_001	Cell line	Prostate	22Rv1	0.30266343825666
Sample_01_022	Cell line	Prostate	C4-2B	0.52380952380952
Sample_01_068	Cell line	Prostate: derived from metastatic site: vertebral metastasis	VCaP	0.10958904109589
Sample_02_007	Other	Cervical	cervical-cancer_vector	0.17549668874172
Sample_02_029	Cell line	Colorectal	LS174T	0.66666666666667
Sample_02_078	Primary cell	Neuroblastoma	low-MYCN-Neuroblastoma-patient-cells	0.375
Sample_02_079	Cell line	Mammary Gland	T-47D_1	0.44444444444444
Sample_02_095	Cell line	Mammary Gland	MDA-MB-468	0.76926070038911
Sample_02_096	Cell line	Mammary Gland	ZR-75-1_1	0.96739130434783
Sample_02_164	Cell line	Lung	H2087_Parental	0.5
Sample_02_166	Cell line	Mammary Gland	HCC1954_Parental	0.192
Sample_02_168	Cell line	Prostate	LNCaP	0.19771863117871
Sample_02_179	Cell line	Urinary bladder	T24	0.13793103448276
Sample_02_220	Cell line	Brain	BE2C_1	0.41025641025641
Sample_02_227	Cell line	Oesophagus	TE7	0.6
Sample_02_228	Cell line	Oesophagus	KYSE510	0.60391425908667
Sample_02_237	Cell line	Colon	V389	0.14371433830296
Sample_02_250	Tissue	Brain	tumormodel3691	0.3125
Sample_02_254	Cell line	Neuroblastoma	IMR5-75	0.17647058823529
Sample_02_258	Other	Lung	NCI-H1299_EGFP-NEO_reporter_cells_DMSO	0.25111111111111
Sample_02_280	Cell line	Mammary Gland	SUM159_DMSO_24h	0.475
Sample_02_285	Cell line	Liver	HuH7_untreat	0.26480836236934
Sample_02_296	Cell line	Neuroblastoma	CLB-BER-Lud	0.094873756694721
Sample_02_299	Cell line	Neuroblastoma	CLB-MA	0.13908872901679
Sample_02_300	Cell line	Neuroblastoma	CLB-PE	0.23076923076923
Sample_02_304	Cell line	Neuroblastoma	N206	0.11277173913043
Sample_02_307	Cell line	Neuroblastoma	SJNB12	0.32394366197183
Sample_02_308	Cell line	Neuroblastoma	SJNB1	0.328125
Sample_02_310	Cell line	Neuroblastoma	SJNB8	0.13630406290957
Sample_02_313	Cell line	Neuroblastoma	SK-N-DZ	0.25096525096525
Sample_02_316	Cell line	Neuroblastoma	CHP212	0.14835164835165
Sample_02_319	Cell line	Neuroblastoma	NB-EBc1	0.16184971098266
Sample_02_322	Cell line	Colon	Caco-2	0.4764468371467
Sample_02_323	Cell line	Colon	RKO	0.4
Sample_02_338	Cell line	Neuroblastoma	BE2	0.41176470588235
Sample_02_354	Cell line	Colon	Colo205	0.42042042042042
Sample_02_355	Cell line	Colon	HCT15	0.45833333333333
Sample_02_358	Cell line	Colon	LS180	0.18641390205371
Sample_02_359	Cell line	Colon	Colo741	0.23192771084337
Sample_02_361	Cell line	Colon	HT29_DMSO	0.21238938053097
Sample_02_394	Cell line	Mammary Gland	T-47D_2	0.42307692307692
Sample_02_395	Cell line	Mammary Gland	BT-549	0.25762237762238
Sample_02_403	Cell line	Mammary Gland	T-47D_untreat	0.35227272727273
Sample_02_404	Cell line	Mammary Gland	ZR-75-1_2	0.76978417266187
Sample_02_406	Cell line	Mammary Gland	ZR-75-30_parental	0.30434782608696
Sample_02_413	Tissue	Brain	GBM_2493	0.2967032967033

ZBTB7B distribution in samples’ most representative CRC

Download

Sample ID	Tissue type	Biosample type	Biosample name
Sample_01_022	Prostate	Cell line	C4-2B
Sample_02_029	Colorectal	Cell line	LS174T
Sample_02_095	Mammary Gland	Cell line	MDA-MB-468
Sample_02_096	Mammary Gland	Cell line	ZR-75-1_1
Sample_02_220	Brain	Cell line	BE2C_1
Sample_02_227	Oesophagus	Cell line	TE7
Sample_02_228	Oesophagus	Cell line	KYSE510
Sample_02_280	Mammary Gland	Cell line	SUM159_DMSO_24h
Sample_02_322	Colon	Cell line	Caco-2
Sample_02_338	Neuroblastoma	Cell line	BE2
Sample_02_355	Colon	Cell line	HCT15
Sample_02_404	Mammary Gland	Cell line	ZR-75-1_2

ZBTB7B distribution in all CRCs

Genomic distribution of SEs associated with ZBTB7B

Download

Mutation of ZBTB7B

Download

Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of ZBTB7B

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr1	154987313	154987313	C	T	exonic	ZBTB7B	synonymous	SKCM\|2\|368\|0.00543
-	chr1	154988249	154988249	G	C	exonic	ZBTB7B	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr1	154988032	154988032	C	T	exonic	ZBTB7B	nonsynonymous	SKCM\|1\|368\|0.00272
rs140676784	chr1	154987273	154987273	G	A	exonic	ZBTB7B	nonsynonymous	PRAD\|1\|499\|0.00200
rs767033789	chr1	154988066	154988066	C	T	exonic	ZBTB7B	synonymous	UCEC\|1\|248\|0.00403
-	chr1	154987938	154987938	C	T	exonic	ZBTB7B	stopgain	SKCM\|1\|368\|0.00272
-	chr1	154988869	154988869	A	G	exonic	ZBTB7B	nonsynonymous	PRAD\|1\|499\|0.00200
-	chr1	154987882	154987882	G	A	exonic	ZBTB7B	nonsynonymous	LUAD\|2\|543\|0.00368
rs769906210	chr1	154988027	154988027	G	A	exonic	ZBTB7B	synonymous	UCEC\|1\|248\|0.00403
-	chr1	154987926	154987926	C	T	exonic	ZBTB7B	nonsynonymous	LUAD\|1\|543\|0.00184
rs746882430	chr1	154987340	154987340	C	T	exonic	ZBTB7B	synonymous	UCEC\|1\|248\|0.00403
-	chr1	154988210	154988235	AGGCAAACTGCCTCGCCACATGAGGA	-	exonic	ZBTB7B	frameshift	UCEC\|1\|248\|0.00403
-	chr1	154988148	154988148	C	T	exonic	ZBTB7B	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr1	154987461	154987461	G	A	exonic	ZBTB7B	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr1	154988705	154988705	G	T	exonic	ZBTB7B	nonsynonymous	BLCA\|2\|396\|0.00505,UCEC\|1\|248\|0.00403
-	chr1	154988033	154988033	C	T	exonic	ZBTB7B	synonymous	SKCM\|1\|368\|0.00272
-	chr1	154987431	154987431	C	A	exonic	ZBTB7B	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr1	154988787	154988787	G	C	exonic	ZBTB7B	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr1	154987872	154987872	G	-	exonic	ZBTB7B	frameshift	COAD\|2\|367\|0.00545,COADREAD\|2\|489\|0.00409
-	chr1	154988215	154988215	A	G	exonic	ZBTB7B	nonsynonymous	UCS\|1\|57\|0.01754
-	chr1	154988736	154988736	G	C	exonic	ZBTB7B	nonsynonymous	UCS\|1\|57\|0.01754
rs753915738	chr1	154988787	154988787	G	A	exonic	ZBTB7B	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr1	154987266	154987266	G	C	exonic	ZBTB7B	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr1	154988224	154988224	G	A	exonic	ZBTB7B	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr1	154987252	154987252	G	A	exonic	ZBTB7B	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr1	154987149	154987149	G	A	exonic	ZBTB7B	nonsynonymous	ESCA\|2\|185\|0.01081
-	chr1	154987232	154987232	C	G	exonic	ZBTB7B	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
rs745329823	chr1	154987592	154987592	C	T	exonic	ZBTB7B	synonymous	UCEC\|1\|248\|0.00403
rs753140920	chr1	154987481	154987481	C	T	exonic	ZBTB7B	synonymous	UCEC\|1\|248\|0.00403
-	chr1	154987953	154987953	T	A	exonic	ZBTB7B	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr1	154987431	154987431	C	T	exonic	ZBTB7B	synonymous	UCEC\|1\|248\|0.00403
-	chr1	154987854	154987854	G	T	exonic	ZBTB7B	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr1	154987219	154987219	G	A	exonic	ZBTB7B	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr1	154987270	154987270	A	G	exonic	ZBTB7B	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr1	154987962	154987962	G	C	exonic	ZBTB7B	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr1	154988052	154988052	G	C	exonic	ZBTB7B	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr1	154987144	154987144	G	A	exonic	ZBTB7B	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr1	154988201	154988201	C	-	exonic	ZBTB7B	frameshift	BLCA\|1\|396\|0.00253
-	chr1	154987802	154987802	G	T	exonic	ZBTB7B	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr1	154988999	154988999	C	T	exonic	ZBTB7B	synonymous	BLCA\|1\|396\|0.00253
-	chr1	154987921	154987921	C	T	exonic	ZBTB7B	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr1	154988894	154988894	C	A	exonic	ZBTB7B	synonymous	BRCA\|1\|982\|0.00102
-	chr1	154988852	154988852	G	A	exonic	ZBTB7B	synonymous	SKCM\|1\|368\|0.00272
-	chr1	154988280	154988280	C	T	exonic	ZBTB7B	stopgain	UCEC\|1\|248\|0.00403
-	chr1	154988753	154988753	C	T	exonic	ZBTB7B	synonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
rs750849996	chr1	154988264	154988264	C	T	exonic	ZBTB7B	synonymous	PRAD\|1\|499\|0.00200,UCEC\|1\|248\|0.00403
-	chr1	154987342	154987342	G	A	exonic	ZBTB7B	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr1	154975263	154975263	G	A	UTR5	ZBTB7B	unknown	CESC\|1\|194\|0.00515
-	chr1	154988725	154988725	A	G	exonic	ZBTB7B	nonsynonymous	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr1	154987421	154987421	G	A	exonic	ZBTB7B	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr1	154988740	154988740	G	T	exonic	ZBTB7B	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr1	154988082	154988082	G	T	exonic	ZBTB7B	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr1	154987765	154987765	A	-	exonic	ZBTB7B	frameshift	UCS\|1\|57\|0.01754
-	chr1	154987403	154987403	T	A	exonic	ZBTB7B	stopgain	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr1	154987619	154987619	G	C	exonic	ZBTB7B	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr1	154987160	154987160	G	C	exonic	ZBTB7B	synonymous	BRCA\|1\|982\|0.00102
-	chr1	154988095	154988095	C	A	exonic	ZBTB7B	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr1	154988223	154988223	C	T	exonic	ZBTB7B	nonsynonymous	UCS\|1\|57\|0.01754
-	chr1	154987308	154987308	T	C	exonic	ZBTB7B	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr1	154988714	154988714	C	-	exonic	ZBTB7B	frameshift	ESCA\|1\|185\|0.00541
-	chr1	154987608	154987608	C	T	exonic	ZBTB7B	stopgain	UCS\|1\|57\|0.01754
-	chr1	154988699	154988700	CG	-	exonic	ZBTB7B	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr1	154988817	154988817	G	C	exonic	ZBTB7B	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr1	154987239	154987239	G	A	exonic	ZBTB7B	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr1	154987218	154987218	C	T	exonic	ZBTB7B	nonsynonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr1	154987712	154987712	G	T	exonic	ZBTB7B	synonymous	ESCA\|1\|185\|0.00541,LUAD\|1\|543\|0.00184
-	chr1	154988172	154988172	C	T	exonic	ZBTB7B	stopgain	BLCA\|1\|396\|0.00253
rs368877809	chr1	154988273	154988273	C	T	exonic	ZBTB7B	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr1	154987311	154987312	TT	-	exonic	ZBTB7B	frameshift	UCS\|1\|57\|0.01754
rs146374595	chr1	154988870	154988870	C	T	exonic	ZBTB7B	synonymous	LUAD\|1\|543\|0.00184
-	chr1	154988918	154988918	C	T	exonic	ZBTB7B	synonymous	LUSC\|1\|178\|0.00562
-	chr1	154988052	154988052	G	A	exonic	ZBTB7B	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr1	154987865	154987865	C	T	exonic	ZBTB7B	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr1	154987446	154987446	G	C	exonic	ZBTB7B	nonsynonymous	BLCA\|1\|396\|0.00253
rs746864508	chr1	154988858	154988858	C	T	exonic	ZBTB7B	synonymous	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr1	154987929	154987929	G	A	exonic	ZBTB7B	nonsynonymous	CESC\|1\|194\|0.00515
-	chr1	154988705	154988705	G	C	exonic	ZBTB7B	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr1	154987446	154987446	G	A	exonic	ZBTB7B	nonsynonymous	LAML\|1\|197\|0.00508
-	chr1	154987672	154987672	A	G	exonic	ZBTB7B	nonsynonymous	OV\|1\|469\|0.00213
-	chr1	154987966	154987967	AA	-	exonic	ZBTB7B	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr1	154988888	154988888	C	G	exonic	ZBTB7B	synonymous	LUAD\|1\|543\|0.00184
-	chr1	154988695	154988695	G	T	splicing	ZBTB7B	splicing	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr1	154987528	154987528	C	T	exonic	ZBTB7B	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr1	154987500	154987500	C	T	exonic	ZBTB7B	nonsynonymous	BLCA\|2\|396\|0.00505
-	chr1	154988247	154988247	G	A	exonic	ZBTB7B	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr1	154988092	154988092	G	A	exonic	ZBTB7B	nonsynonymous	LIHC\|2\|373\|0.00536
-	chr1	154988235	154988235	A	G	exonic	ZBTB7B	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr1	154988154	154988154	C	T	exonic	ZBTB7B	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs775270351	chr1	154987334	154987334	C	T	exonic	ZBTB7B	synonymous	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
rs750458229	chr1	154989004	154989004	A	G	exonic	ZBTB7B	nonsynonymous	LUAD\|1\|543\|0.00184
rs372544089	chr1	154987852	154987852	C	T	exonic	ZBTB7B	nonsynonymous	ESCA\|1\|185\|0.00541
rs753049116	chr1	154987372	154987372	C	T	exonic	ZBTB7B	nonsynonymous	ESCA\|2\|185\|0.01081
-	chr1	154987923	154987923	C	T	exonic	ZBTB7B	nonsynonymous	SKCM\|1\|368\|0.00272
rs150590726	chr1	154987740	154987740	C	T	exonic	ZBTB7B	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr1	154987838	154987838	G	T	exonic	ZBTB7B	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr1	154988976	154988976	G	A	exonic	ZBTB7B	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr1	154987574	154987574	A	C	exonic	ZBTB7B	synonymous	HNSC\|1\|512\|0.00195
-	chr1	154987844	154987844	G	T	exonic	ZBTB7B	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs367725892	chr1	154987719	154987719	C	T	exonic	ZBTB7B	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr1	154987922	154987922	C	T	exonic	ZBTB7B	synonymous	SKCM\|1\|368\|0.00272
-	chr1	154975307	154975307	C	T	UTR5	ZBTB7B	unknown	ESCA\|1\|185\|0.00541
-	chr1	154987459	154987459	C	A	exonic	ZBTB7B	nonsynonymous	UCS\|1\|57\|0.01754
rs766949384	chr1	154988739	154988739	C	T	exonic	ZBTB7B	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr1	154988846	154988846	C	T	exonic	ZBTB7B	synonymous	SKCM\|1\|368\|0.00272
-	chr1	154987493	154987493	A	G	exonic	ZBTB7B	synonymous	LIHC\|1\|373\|0.00268
-	chr1	154988244	154988244	G	C	exonic	ZBTB7B	nonsynonymous	LUAD\|1\|543\|0.00184
rs199978828	chr1	154987749	154987749	C	T	exonic	ZBTB7B	nonsynonymous	UVM\|1\|80\|0.01250
-	chr1	154988002	154988002	G	T	exonic	ZBTB7B	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr1	154989067	154989067	G	T	exonic	ZBTB7B	nonsynonymous	LUAD\|1\|543\|0.00184
rs145349387	chr1	154987363	154987363	G	T	exonic	ZBTB7B	nonsynonymous	DLBC\|1\|48\|0.02083
-	chr1	154987971	154987971	G	A	exonic	ZBTB7B	nonsynonymous	HNSC\|1\|512\|0.00195
rs775109575	chr1	154988174	154988174	G	A	exonic	ZBTB7B	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr1	154987748	154987748	C	T	exonic	ZBTB7B	synonymous	SKCM\|1\|368\|0.00272

Disease information of ZBTB7B

Download

TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
ZBTB7B	Obesity	C18;C23	Disease or Syndrome	CTD_human

Pathway associated with ZBTB7B

Download

pathway_ID	pathway_name	pathway_source	gene_number	edge_number

Go term information of ZBTB7B

Download

GO_term_name	GO_term_type	TF_name
GO_ECTODERM_DEVELOPMENT	BP	ZBTB7B

Survival analysis of ZBTB7B

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of ZBTB7B

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)