Cancer CRCdb

TF information

TF name:	NR3C1
TF family:	ESR-like
Ensembl gene ID:	ENSG00000113580
Ensembl protein ID:	ENSP00000427672, ENSP00000343205, ENSP00000405282, ENSP00000422518, ENSP00000231509, ENSP00000377977, ENSP00000387672, ENSP00000377979
Entrez gene ID:	2908

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of NR3C1 in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_02_164	Cell line	Lung	H2087_Parental	0.2
Sample_02_219	Cell line	Mammary Gland	MDA-MB-231	0.34313725490196
Sample_02_228	Cell line	Oesophagus	KYSE510	0.24137931034483
Sample_02_268	Cell line	Kidney	A-498	0.47498615469817
Sample_02_280	Cell line	Mammary Gland	SUM159_DMSO_24h	0.15
Sample_02_395	Cell line	Mammary Gland	BT-549	0.12027972027972
Sample_02_430	Cell line	Kidney	12364284	0.71428571428571

NR3C1 distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name
Sample_02_268	Kidney	Cell line	A-498
Sample_02_430	Kidney	Cell line	12364284

NR3C1 distribution in all CRCs

Genomic distribution of SEs associated with NR3C1

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Mutation of NR3C1

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of NR3C1

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr5	142658945	142658945	G	T	exonic	NR3C1	nonsynonymous	UCEC\|1\|248\|0.00403
rs750532455	chr5	142780298	142780298	C	A	exonic	NR3C1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr5	142779740	142779740	T	G	exonic	NR3C1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr5	142779852	142779852	T	A	exonic	NR3C1	nonsynonymous	LUAD\|1\|543\|0.00184
rs764178904	chr5	142780067	142780067	G	A	exonic	NR3C1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr5	142779539	142779539	G	A	exonic	NR3C1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr5	142661457	142661457	C	T	exonic	NR3C1	synonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr5	142675052	142675052	T	-	exonic	NR3C1	stopgain	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr5	142661564	142661564	C	T	exonic	NR3C1	nonsynonymous	KICH\|1\|66\|0.01515,KIPAN\|1\|799\|0.00125
-	chr5	142658957	142658957	G	-	exonic	NR3C1	frameshift	PRAD\|1\|499\|0.00200
-	chr5	142780154	142780154	A	C	exonic	NR3C1	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr5	142780030	142780030	G	A	exonic	NR3C1	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs750359967	chr5	142779374	142779374	T	C	exonic	NR3C1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr5	142780168	142780178	GGACAGATCTG	-	exonic	NR3C1	frameshift	HNSC\|1\|512\|0.00195
rs775051931	chr5	142662181	142662181	G	A	exonic	NR3C1	synonymous	ACC\|1\|90\|0.01111
-	chr5	142680245	142680245	T	A	exonic	NR3C1	stopgain	LIHC\|1\|373\|0.00268
-	chr5	142779831	142779831	C	G	exonic	NR3C1	nonsynonymous	CESC\|1\|194\|0.00515
rs867004642	chr5	142779665	142779665	G	A	exonic	NR3C1	nonsynonymous	SKCM\|2\|368\|0.00543
-	chr5	142779662	142779662	A	G	exonic	NR3C1	nonsynonymous	KICH\|1\|66\|0.01515,KIPAN\|1\|799\|0.00125
-	chr5	142779923	142779923	G	C	exonic	NR3C1	nonsynonymous	CESC\|1\|194\|0.00515
-	chr5	142693707	142693707	G	T	exonic	NR3C1	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr5	142780379	142780379	G	T	exonic	NR3C1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs745857266	chr5	142779275	142779275	G	A	exonic	NR3C1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr5	142780248	142780248	G	C	exonic	NR3C1	nonsynonymous	CESC\|1\|194\|0.00515
-	chr5	142780089	142780089	G	A	exonic	NR3C1	stopgain	UCEC\|1\|248\|0.00403
-	chr5	142779763	142779763	T	C	exonic	NR3C1	synonymous	UCEC\|1\|248\|0.00403
-	chr5	142780125	142780125	C	-	exonic	NR3C1	frameshift	SKCM\|1\|368\|0.00272
rs763734598	chr5	142779718	142779718	C	T	exonic	NR3C1	synonymous	SKCM\|1\|368\|0.00272
-	chr5	142662288	142662288	G	A	exonic	NR3C1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr5	142680131	142680131	T	A	exonic	NR3C1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr5	142779885	142779885	T	G	exonic	NR3C1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs370839677	chr5	142779330	142779330	C	T	exonic	NR3C1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr5	142680274	142680274	G	C	exonic	NR3C1	stopgain	LUAD\|1\|543\|0.00184
-	chr5	142779500	142779500	C	A	exonic	NR3C1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr5	142661474	142661474	G	T	exonic	NR3C1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr5	142779583	142779583	G	A	exonic	NR3C1	synonymous	SKCM\|1\|368\|0.00272
-	chr5	142662143	142662143	G	C	exonic	NR3C1	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr5	142779998	142779998	G	A	exonic	NR3C1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr5	142678313	142678313	C	G	exonic	NR3C1	nonsynonymous	OV\|1\|469\|0.00213
-	chr5	142661537	142661537	C	T	exonic	NR3C1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr5	142780282	142780282	A	C	exonic	NR3C1	synonymous	UCEC\|1\|248\|0.00403
-	chr5	142675083	142675083	C	A	exonic	NR3C1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr5	142779683	142779683	G	A	exonic	NR3C1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr5	142779904	142779904	C	T	exonic	NR3C1	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr5	142675154	142675154	G	A	exonic	NR3C1	stopgain	UCEC\|1\|248\|0.00403
-	chr5	142689724	142689724	C	T	exonic	NR3C1	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr5	142779799	142779799	C	T	exonic	NR3C1	synonymous	LUAD\|1\|543\|0.00184
-	chr5	142779446	142779446	G	T	exonic	NR3C1	nonsynonymous	UCEC\|2\|248\|0.00806
-	chr5	142779482	142779482	C	G	exonic	NR3C1	nonsynonymous	HNSC\|1\|512\|0.00195
rs376527205	chr5	142780187	142780187	G	A	exonic	NR3C1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr5	142779613	142779613	A	C	exonic	NR3C1	synonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr5	142680269	142680269	C	A	exonic	NR3C1	stopgain	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr5	142661488	142661488	C	G	exonic	NR3C1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr5	142661596	142661596	T	G	exonic	NR3C1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr5	142780104	142780104	C	G	exonic	NR3C1	nonsynonymous	BLCA\|1\|396\|0.00253
rs761295829	chr5	142680112	142680112	G	A	exonic	NR3C1	nonsynonymous	BRCA\|1\|982\|0.00102
rs750705576	chr5	142779844	142779844	G	T	exonic	NR3C1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr5	142680325	142680325	C	T	exonic	NR3C1	nonsynonymous	BLCA\|2\|396\|0.00505
-	chr5	142680092	142680092	G	A	exonic	NR3C1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr5	142680226	142680226	G	A	exonic	NR3C1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr5	142680225	142680225	C	A	exonic	NR3C1	synonymous	LUSC\|1\|178\|0.00562
-	chr5	142780157	142780157	G	A	exonic	NR3C1	nonsynonymous	CESC\|1\|194\|0.00515
rs766706619	chr5	142779948	142779948	C	T	exonic	NR3C1	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr5	142675046	142675046	T	G	exonic	NR3C1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr5	142780229	142780229	C	T	exonic	NR3C1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr5	142693630	142693630	C	A	exonic	NR3C1	stopgain	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr5	142779245	142779258	GTTCGACCAGGGAA	-	exonic	NR3C1	frameshift	-
-	chr5	142779486	142779486	G	C	exonic	NR3C1	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr5	142779719	142779719	G	A	exonic	NR3C1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr5	142689710	142689710	G	A	exonic	NR3C1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr5	142661473	142661473	A	G	exonic	NR3C1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|3\|489\|0.00613,OV\|1\|469\|0.00213,READ\|2\|122\|0.01639
-	chr5	142675037	142675037	G	T	exonic	NR3C1	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr5	142680152	142680152	C	T	exonic	NR3C1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr5	142678313	142678313	C	T	exonic	NR3C1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr5	142779770	142779770	G	T	exonic	NR3C1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr5	142779434	142779434	A	T	exonic	NR3C1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr5	142680214	142680214	A	C	exonic	NR3C1	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr5	142689668	142689668	G	A	exonic	NR3C1	synonymous	SKCM\|1\|368\|0.00272
-	chr5	142689733	142689733	T	G	exonic	NR3C1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr5	142779750	142779750	T	G	exonic	NR3C1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr5	142779960	142779960	C	T	exonic	NR3C1	nonsynonymous	TGCT\|1\|155\|0.00645
-	chr5	142662264	142662264	C	A	exonic	NR3C1	stopgain	UCEC\|1\|248\|0.00403
-	chr5	142662237	142662237	A	C	exonic	NR3C1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr5	142780341	142780341	C	A	exonic	NR3C1	stopgain	LUAD\|1\|543\|0.00184
-	chr5	142780104	142780104	C	T	exonic	NR3C1	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr5	142661520	142661520	G	T	exonic	NR3C1	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr5	142779717	142779717	C	T	exonic	NR3C1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr5	142680139	142680139	G	A	exonic	NR3C1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr5	142780378	142780378	A	G	exonic	NR3C1	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr5	142780280	142780280	G	T	exonic	NR3C1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr5	142780147	142780147	C	G	exonic	NR3C1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr5	142662143	142662143	G	T	exonic	NR3C1	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189,UCEC\|1\|248\|0.00403
-	chr5	142693601	142693601	T	C	exonic	NR3C1	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr5	142680255	142680255	A	G	exonic	NR3C1	synonymous	BLCA\|1\|396\|0.00253
rs138266608	chr5	142680225	142680225	C	T	exonic	NR3C1	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr5	142689712	142689712	C	A	exonic	NR3C1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs756187323	chr5	142779985	142779985	C	A	exonic	NR3C1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr5	142780045	142780045	C	T	exonic	NR3C1	synonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr5	142779335	142779335	A	G	exonic	NR3C1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr5	142689725	142689725	G	A	exonic	NR3C1	stopgain	BRCA\|1\|982\|0.00102
-	chr5	142675062	142675062	C	A	exonic	NR3C1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr5	142780402	142780402	C	A	exonic	NR3C1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr5	142779650	142779650	T	C	exonic	NR3C1	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr5	142658932	142658932	G	A	exonic	NR3C1	synonymous	CESC\|1\|194\|0.00515
-	chr5	142780179	142780179	G	A	exonic	NR3C1	nonsynonymous	UVM\|1\|80\|0.01250
-	chr5	142779553	142779553	G	A	exonic	NR3C1	synonymous	COAD\|1\|367\|0.00272,COADREAD\|2\|489\|0.00409,READ\|1\|122\|0.00820
rs72542740	chr5	142780110	142780110	C	T	exonic	NR3C1	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189

Disease information of NR3C1

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
NR3C1	Alcoholic Intoxication	C25;F03	Mental or Behavioral Dysfunction	PSYGENET
NR3C1	Bipolar Disorder	F03	Mental or Behavioral Dysfunction	CTD_human;PSYGENET
NR3C1	Depression, Bipolar	F03	Mental or Behavioral Dysfunction	CTD_human
NR3C1	Cocaine Abuse	C25;F03	Mental or Behavioral Dysfunction	CTD_human
NR3C1	Mental Depression	F01	Mental or Behavioral Dysfunction	PSYGENET
NR3C1	Endogenous depression	F03	Mental or Behavioral Dysfunction	CTD_human
NR3C1	Depressive disorder	F03	Mental or Behavioral Dysfunction	CTD_human;PSYGENET
NR3C1	Endometriosis	C13	Disease or Syndrome	CTD_human
NR3C1	Hypertensive disease	C14	Disease or Syndrome	CTD_human
NR3C1	Hypokalemia	C18	Finding	CTD_human
NR3C1	Manic Disorder	F03	Mental or Behavioral Dysfunction	CTD_human
NR3C1	Melancholia	F03	Mental or Behavioral Dysfunction	CTD_human
NR3C1	Ocular Hypertension	C11	Disease or Syndrome	CTD_human
NR3C1	Prostatic Neoplasms	C04;C12	Neoplastic Process	CTD_human
NR3C1	Psychosis, Brief Reactive	F03	Mental or Behavioral Dysfunction	CTD_human
NR3C1	Psychotic Disorders	F03	Mental or Behavioral Dysfunction	CTD_human
NR3C1	Schizoaffective Disorder	F03	Mental or Behavioral Dysfunction	CTD_human
NR3C1	Schizophrenia	F03	Mental or Behavioral Dysfunction	CTD_human
NR3C1	Schizophreniform Disorders	F03	Mental or Behavioral Dysfunction	CTD_human
NR3C1	Unipolar Depression	F03	Mental or Behavioral Dysfunction	CTD_human;PSYGENET
NR3C1	Depressive Syndrome	F03	Mental or Behavioral Dysfunction	CTD_human
NR3C1	Cocaine-Related Disorders	C25;F03	Mental or Behavioral Dysfunction	CTD_human
NR3C1	Female Pseudohermaphroditism	C12;C13;C16;C19	Congenital Abnormality	CTD_human
NR3C1	Endometrioma	C13	Neoplastic Process	CTD_human
NR3C1	Depression, Neurotic	F03	Mental or Behavioral Dysfunction	CTD_human
NR3C1	Manic	F03	Mental or Behavioral Dysfunction	CTD_human
NR3C1	Malignant neoplasm of prostate	C04;C12	Neoplastic Process	CTD_human
NR3C1	Mood Disorders	F03	Mental or Behavioral Dysfunction	PSYGENET
NR3C1	Lung Diseases, Obstructive	C08	Disease or Syndrome	CTD_human
NR3C1	Cocaine Dependence	C25;F03	Mental or Behavioral Dysfunction	CTD_human
NR3C1	Major Depressive Disorder	F03	Mental or Behavioral Dysfunction	PSYGENET
NR3C1	Glucocorticoid Receptor Deficiency	C16;C18	Disease or Syndrome	CTD_human;ORPHANET;UNIPROT
NR3C1	Pseudohermaphroditism, Female, With Hypokalemia, Due To Glucocorticoid Resistance	C16;C18	Disease or Syndrome	CTD_human
NR3C1	BODY COMPOSITION, BENEFICIAL	C16;C18	Finding	CTD_human
NR3C1	46, XX Disorders of Sex Development	C12;C13;C16;C19	Congenital Abnormality	CTD_human

Pathway associated with NR3C1

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number
pathway0000316	BMAL1:CLOCK,NPAS2 activates circadian gene expression	reactome	42	282
pathway0000401	Cellular roles of Anthrax toxin	pid	25	73
pathway0000825	FOXA2 and FOXA3 transcription factor networks	pid	45	202
pathway0001120	IL2	netpath	81	1364
pathway0001534	Nuclear Receptor transcription pathway	reactome	51	284
pathway0001744	PTK6 Expression	reactome	5	9
pathway0001825	Regulation of Androgen receptor activity	pid	54	338
pathway0002750	Hs_Serotonin_Receptor_4-6-7_and_NR3C_Signaling_WP734_74438	wikipathways	15	37
pathway0002755	Hs_White_fat_cell_differentiation_WP3946_90940	wikipathways	30	59
pathway0002808	Hs_Transcription_factor_regulation_in_adipogenesis_WP3599_88581	wikipathways	9	16
pathway0002812	Hs_Sudden_Infant_Death_Syndrome_(SIDS)_Susceptibility_Pathways_WP706_86078	wikipathways	33	60

Go term information of NR3C1

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GO_term_name	GO_term_type	TF_name
GO_INTRACELLULAR_STEROID_HORMONE_RECEPTOR_SIGNALING_PATHWAY	BP	NR3C1
GO_HORMONE_MEDIATED_SIGNALING_PATHWAY	BP	NR3C1
GO_CELLULAR_RESPONSE_TO_HORMONE_STIMULUS	BP	NR3C1
GO_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_ACTIVITY_SEQUENCE_SPECIFIC_DNA_BINDING	MF	NR3C1
GO_TRANSCRIPTIONAL_ACTIVATOR_ACTIVITY_RNA_POLYMERASE_II_CORE_PROMOTER_PROXIMAL_REGION_SEQUENCE_SPECIFIC_BINDING	MF	NR3C1
GO_ZINC_ION_BINDING	MF	NR3C1

Survival analysis of NR3C1

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of NR3C1

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)