Cancer CRCdb

TF information

TF name:	SP3
TF family:	zf-C2H2
Ensembl gene ID:	ENSG00000172845
Ensembl protein ID:	ENSP00000492253, ENSP00000406140, ENSP00000413665, ENSP00000310301
Entrez gene ID:	6670

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of SP3 in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_01_068	Cell line	Prostate: derived from metastatic site: vertebral metastasis	VCaP	0.35616438356164
Sample_02_166	Cell line	Mammary Gland	HCC1954_Parental	0.256
Sample_02_168	Cell line	Prostate	LNCaP	0.083650190114068
Sample_02_228	Cell line	Oesophagus	KYSE510	0.56943150046598
Sample_02_236	Cell line	Colon	V206	0.14285714285714
Sample_02_237	Cell line	Colon	V389	0.055733480581631
Sample_02_241	Cell line	Colon	V456	0.038374717832957
Sample_02_268	Cell line	Kidney	A-498	0.7625992246631
Sample_02_285	Cell line	Liver	HuH7_untreat	0.052264808362369
Sample_02_322	Cell line	Colon	Caco-2	0.29475100942127
Sample_02_358	Cell line	Colon	LS180	0.034755134281201
Sample_02_359	Cell line	Colon	Colo741	0.1144578313253
Sample_02_404	Cell line	Mammary Gland	ZR-75-1_2	0.43165467625899
Sample_02_413	Tissue	Brain	GBM_2493	0.06043956043956
Sample_02_430	Cell line	Kidney	12364284	0.125

SP3 distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name
Sample_02_228	Oesophagus	Cell line	KYSE510
Sample_02_268	Kidney	Cell line	A-498

SP3 distribution in all CRCs

Genomic distribution of SEs associated with SP3

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Mutation of SP3

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of SP3

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr2	174820400	174820400	C	A	exonic	SP3	synonymous	LUAD\|1\|543\|0.00184
-	chr2	174777836	174777836	C	T	exonic	SP3	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr2	174783494	174783494	T	A	exonic	SP3	nonsynonymous	LUAD\|1\|543\|0.00184
rs777854788	chr2	174774779	174774779	A	G	exonic	SP3	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr2	174820498	174820498	C	A	exonic	SP3	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr2	174820423	174820423	C	T	exonic	SP3	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820,UCEC\|1\|248\|0.00403
-	chr2	174783487	174783487	C	T	exonic	SP3	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr2	174820594	174820594	C	T	exonic	SP3	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr2	174820592	174820592	G	T	exonic	SP3	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr2	174777852	174777852	C	A	exonic	SP3	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr2	174820187	174820187	T	G	exonic	SP3	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr2	174777881	174777881	C	T	exonic	SP3	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr2	174828613	174828613	T	G	splicing	SP3	splicing	LUAD\|1\|543\|0.00184
-	chr2	174777830	174777830	T	C	exonic	SP3	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr2	174819714	174819714	-	T	exonic	SP3	frameshift	SARC\|1\|247\|0.00405
-	chr2	174777845	174777845	C	A	exonic	SP3	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr2	174777831	174777831	C	A	exonic	SP3	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr2	174777861	174777861	T	C	exonic	SP3	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr2	174820364	174820364	G	T	exonic	SP3	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs61748248	chr2	174774847	174774847	C	T	exonic	SP3	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr2	174774973	174774973	A	C	exonic	SP3	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr2	174777882	174777882	G	A	exonic	SP3	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
rs761430393	chr2	174774850	174774850	G	A	exonic	SP3	nonsynonymous	CESC\|1\|194\|0.00515
-	chr2	174820648	174820648	T	G	exonic	SP3	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr2	174774748	174774748	G	C	exonic	SP3	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr2	174820667	174820667	A	G	exonic	SP3	synonymous	SKCM\|1\|368\|0.00272
-	chr2	174820642	174820642	C	A	exonic	SP3	stopgain	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253,UCEC\|1\|248\|0.00403
-	chr2	174820133	174820133	C	T	exonic	SP3	synonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr2	174774706	174774706	T	C	exonic	SP3	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|2\|489\|0.00409,READ\|1\|122\|0.00820
-	chr2	174828561	174828561	T	C	exonic	SP3	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr2	174774887	174774887	G	A	exonic	SP3	nonsynonymous	BRCA\|2\|982\|0.00204
-	chr2	174820238	174820238	G	A	exonic	SP3	synonymous	UCEC\|1\|248\|0.00403
-	chr2	174820362	174820362	T	A	exonic	SP3	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr2	174819870	174819870	G	T	exonic	SP3	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr2	174774691	174774691	G	A	exonic	SP3	nonsynonymous	CESC\|1\|194\|0.00515
-	chr2	174774931	174774931	T	C	exonic	SP3	nonsynonymous	SARC\|1\|247\|0.00405
rs758298021	chr2	174774752	174774752	C	T	exonic	SP3	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr2	174783399	174783399	C	T	exonic	SP3	nonsynonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr2	174777809	174777809	C	G	exonic	SP3	nonsynonymous	PRAD\|1\|499\|0.00200
-	chr2	174783444	174783444	G	A	exonic	SP3	nonsynonymous	SKCM\|2\|368\|0.00543
-	chr2	174820756	174820756	T	C	exonic	SP3	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr2	174820676	174820676	G	A	exonic	SP3	synonymous	BLCA\|1\|396\|0.00253
-	chr2	174820671	174820671	C	T	exonic	SP3	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr2	174820616	174820616	A	G	exonic	SP3	synonymous	COAD\|3\|367\|0.00817,COADREAD\|3\|489\|0.00613
-	chr2	174820742	174820742	G	A	exonic	SP3	synonymous	LUSC\|1\|178\|0.00562
-	chr2	174820856	174820856	C	G	exonic	SP3	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr2	174783515	174783515	T	A	splicing	SP3	splicing	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr2	174820216	174820216	-	A	exonic	SP3	frameshift	BRCA\|1\|982\|0.00102
-	chr2	174777920	174777920	G	C	exonic	SP3	stopgain	BRCA\|1\|982\|0.00102
-	chr2	174820366	174820366	C	T	exonic	SP3	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr2	174829203	174829204	CC	-	exonic	SP3	frameshift	PAAD\|1\|185\|0.00541
rs774329460	chr2	174820297	174820297	G	A	exonic	SP3	nonsynonymous	THYM\|1\|123\|0.00813
-	chr2	174820115	174820115	C	T	exonic	SP3	synonymous	BLCA\|1\|396\|0.00253,COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr2	174820696	174820696	G	C	exonic	SP3	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr2	174783366	174783366	C	T	exonic	SP3	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs759683077	chr2	174820570	174820570	T	C	exonic	SP3	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr2	174774917	174774917	T	-	exonic	SP3	frameshift	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr2	174819619	174819619	T	C	exonic	SP3	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr2	174820724	174820724	C	T	exonic	SP3	synonymous	HNSC\|1\|512\|0.00195
rs769641050	chr2	174820712	174820712	G	A	exonic	SP3	synonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr2	174819881	174819881	C	A	exonic	SP3	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr2	174777934	174777934	G	C	exonic	SP3	synonymous	BLCA\|1\|396\|0.00253
-	chr2	174774866	174774866	C	T	exonic	SP3	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr2	174774770	174774770	C	A	exonic	SP3	stopgain	UCEC\|1\|248\|0.00403
-	chr2	174819648	174819648	G	A	exonic	SP3	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr2	174820592	174820592	G	A	exonic	SP3	synonymous	OV\|1\|469\|0.00213
-	chr2	174819867	174819867	G	A	exonic	SP3	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr2	174829164	174829164	T	C	exonic	SP3	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr2	174820558	174820558	T	-	exonic	SP3	frameshift	LIHC\|1\|373\|0.00268
rs753208366	chr2	174783367	174783367	G	A	exonic	SP3	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,UCEC\|2\|248\|0.00806
-	chr2	174777796	174777796	A	G	splicing	SP3	splicing	PRAD\|1\|499\|0.00200
-	chr2	174820457	174820457	T	C	exonic	SP3	synonymous	LIHC\|1\|373\|0.00268
-	chr2	174819672	174819674	GTT	-	exonic	SP3	nonframeshift	BRCA\|2\|982\|0.00204
-	chr2	174820238	174820238	G	C	exonic	SP3	synonymous	LUAD\|1\|543\|0.00184
-	chr2	174820544	174820547	ACCA	-	exonic	SP3	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr2	174820352	174820352	C	T	exonic	SP3	synonymous	HNSC\|1\|512\|0.00195
-	chr2	174820722	174820722	A	C	exonic	SP3	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr2	174819640	174819640	T	C	exonic	SP3	nonsynonymous	HNSC\|2\|512\|0.00391
-	chr2	174774894	174774894	T	-	exonic	SP3	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr2	174820868	174820868	A	G	exonic	SP3	synonymous	UCEC\|1\|248\|0.00403
-	chr2	174820690	174820690	C	A	exonic	SP3	nonsynonymous	PRAD\|1\|499\|0.00200
-	chr2	174820452	174820452	T	G	exonic	SP3	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr2	174820235	174820235	A	G	exonic	SP3	synonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr2	174777899	174777899	C	T	exonic	SP3	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr2	174777827	174777827	T	C	exonic	SP3	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr2	174820388	174820388	C	T	exonic	SP3	synonymous	SKCM\|1\|368\|0.00272

Disease information of SP3

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
SP3	Psychotic Disorders	F03	Mental or Behavioral Dysfunction	PSYGENET
SP3	Nonorganic psychosis		Mental or Behavioral Dysfunction	PSYGENET

Pathway associated with SP3

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number
pathway0000044	a6b1 and a6b4 Integrin signaling	pid	46	383
pathway0000066	Activation of caspases through apoptosome-mediated cleavage	reactome	5	11
pathway0000067	Activation of DNA fragmentation factor	reactome	13	34
pathway0000147	Alpha6Beta4Integrin	netpath	74	899
pathway0000176	AndrogenReceptor	netpath	167	2267
pathway0000196	Apoptosis signaling pathway	panther	104	1308
pathway0000197	Apoptotic cleavage of cell adhesion proteins	reactome	11	15
pathway0000198	Apoptotic cleavage of cellular proteins	reactome	18	40
pathway0000270	BCR	netpath	161	2850
pathway0000343	Calcineurin-regulated NFAT-dependent transcription in lymphocytes	pid	50	304
pathway0000376	Caspase-mediated cleavage of cytoskeletal proteins	reactome	12	27
pathway0000377	Caspase Cascade in Apoptosis	pid	57	396
pathway0000581	Degradation of the extracellular matrix	reactome	72	250
pathway0000639	Drosophila Toll-like receptor signaling ( Drosophila Toll-like receptor signaling )	inoh	236	3833
pathway0000716	ERKs are inactivated	reactome	12	41
pathway0000754	FAS (CD95) signaling pathway	pid	36	259
pathway0000756	FAS signaling pathway	panther	37	148
pathway0001033	HIV-1 Nef: Negative effector of Fas and TNF-alpha	pid	33	281
pathway0001046	Huntington disease	panther	113	1222
pathway0001282	Ligand-independent caspase activation via DCC	reactome	10	15
pathway0001295	LPA receptor mediated events	pid	65	700
pathway0001430	NADE modulates death signalling	reactome	6	14
pathway0001583	p75(NTR)-mediated signaling	pid	74	564
pathway0001700	Posttranslational regulation of adherens junction stability and dissassembly	pid	50	343
pathway0001935	Role of Calcineurin-dependent NFAT signaling in lymphocytes	pid	54	450
pathway0002020	Signaling by Hippo	reactome	20	82
pathway0002021	Signaling by Interleukins	reactome	47	197
pathway0002065	SMAC-mediated dissociation of IAP:caspase complexes	reactome	5	10
pathway0002066	SMAC binds to IAPs	reactome	5	10
pathway0002127	SUMOylation of transcription factors	reactome	14	57
pathway0002144	Syndecan-2-mediated signaling events	pid	38	177
pathway0002198	TCF dependent signaling in response to WNT	reactome	31	189
pathway0002249	TNFalpha	netpath	274	5236
pathway0002575	p53 signaling pathway	kegg	66	297
pathway0002584	Apoptosis	kegg	88	932
pathway0002607	Natural killer cell mediated cytotoxicity	kegg	125	1438
pathway0002641	Amyotrophic lateral sclerosis (ALS)	kegg	53	237
pathway0002646	Epithelial cell signaling in Helicobacter pylori infection	kegg	67	524
pathway0002652	Toxoplasmosis	kegg	131	1443
pathway0002653	Amoebiasis	kegg	103	942
pathway0002657	Colorectal cancer	kegg	63	642
pathway0002679	Viral myocarditis	kegg	66	239
pathway0002694	Hs_DNA_Damage_Response_WP707_82937	wikipathways	28	166
pathway0002695	Hs_miRNA_Regulation_of_DNA_Damage_Response_WP1530_84694	wikipathways	28	154
pathway0002699	Hs_Corticotropin-releasing_hormone_signaling_pathway_WP2355_90017	wikipathways	41	162
pathway0002719	Hs_Apoptosis_WP254_88977	wikipathways	31	127
pathway0002731	Hs_Integrated_Breast_Cancer_Pathway_WP1984_82941	wikipathways	122	1333
pathway0002734	Hs_Apoptosis_Modulation_and_Signaling_WP1772_91293	wikipathways	71	522
pathway0002738	Hs_Alzheimers_Disease_WP2059_87372	wikipathways	24	65
pathway0002739	Hs_Copper_homeostasis_WP3286_89205	wikipathways	15	38
pathway0002749	Hs_Amyotrophic_lateral_sclerosis_(ALS)_WP2447_85186	wikipathways	16	40
pathway0002751	Hs_Integrated_Cancer_Pathway_WP1971_82939	wikipathways	33	206
pathway0002760	Hs_Oncostatin_M_Signaling_Pathway_WP2374_73668	wikipathways	44	408
pathway0002762	Hs_TNF_related_weak_inducer_of_apoptosis_(TWEAK)_Signaling_Pathway_WP2036_89910	wikipathways	27	164
pathway0002789	Hs_Complement_and_Coagulation_Cascades_WP558_90196	wikipathways	21	30
pathway0002791	Hs_Spinal_Cord_Injury_WP2431_87678	wikipathways	21	31
pathway0002792	Hs_G13_Signaling_Pathway_WP524_72112	wikipathways	18	18
pathway0002812	Hs_Sudden_Infant_Death_Syndrome_(SIDS)_Susceptibility_Pathways_WP706_86078	wikipathways	33	60
pathway0002860	Hs_Prolactin_Signaling_Pathway_WP2037_90015	wikipathways	52	570

Go term information of SP3

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GO_term_name	GO_term_type	TF_name
GO_REGULATION_OF_T_CELL_RECEPTOR_SIGNALING_PATHWAY	BP	SP3
GO_REGULATION_OF_G_PROTEIN_COUPLED_RECEPTOR_PROTEIN_SIGNALING_PATHWAY	BP	SP3
GO_ANATOMICAL_STRUCTURE_FORMATION_INVOLVED_IN_MORPHOGENESIS	BP	SP3
GO_REGULATION_OF_ANTIGEN_RECEPTOR_MEDIATED_SIGNALING_PATHWAY	BP	SP3
GO_NEGATIVE_REGULATION_OF_CYCLIN_DEPENDENT_PROTEIN_KINASE_ACTIVITY	BP	SP3
GO_NEGATIVE_REGULATION_OF_ERK1_AND_ERK2_CASCADE	BP	SP3
GO_REGULATION_OF_AUTOPHAGY	BP	SP3
GO_NATURAL_KILLER_CELL_DIFFERENTIATION	BP	SP3
GO_REGULATION_OF_PROTEIN_BINDING	BP	SP3
GO_SINGLE_ORGANISM_MEMBRANE_FUSION	BP	SP3
GO_B_CELL_HOMEOSTASIS	BP	SP3
GO_SINGLE_ORGANISM_BEHAVIOR	BP	SP3
GO_MYELOID_CELL_HOMEOSTASIS	BP	SP3
GO_POSITIVE_REGULATION_OF_NEURON_DEATH	BP	SP3
GO_IMMUNE_SYSTEM_PROCESS	BP	SP3
GO_NEGATIVE_REGULATION_OF_KINASE_ACTIVITY	BP	SP3
GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_PROLIFERATION	BP	SP3
GO_POSITIVE_REGULATION_OF_BINDING	BP	SP3
GO_EMBRYONIC_SKELETAL_SYSTEM_DEVELOPMENT	BP	SP3
GO_RESPONSE_TO_WOUNDING	BP	SP3
GO_T_CELL_HOMEOSTASIS	BP	SP3
GO_CELLULAR_RESPONSE_TO_EXTRACELLULAR_STIMULUS	BP	SP3
GO_ERYTHROCYTE_HOMEOSTASIS	BP	SP3
GO_REGULATION_OF_KINASE_ACTIVITY	BP	SP3
GO_MYELOID_LEUKOCYTE_DIFFERENTIATION	BP	SP3
GO_LYMPHOCYTE_HOMEOSTASIS	BP	SP3
GO_POSITIVE_REGULATION_OF_MITOTIC_CELL_CYCLE	BP	SP3
GO_NEGATIVE_REGULATION_OF_B_CELL_ACTIVATION	BP	SP3
GO_POSITIVE_REGULATION_OF_CYTOPLASMIC_TRANSPORT	BP	SP3
GO_NEGATIVE_REGULATION_OF_CELL_CELL_ADHESION	BP	SP3
GO_SKELETAL_SYSTEM_DEVELOPMENT	BP	SP3
GO_HIPPO_SIGNALING	BP	SP3
GO_BLASTOCYST_FORMATION	BP	SP3
GO_REGULATION_OF_ACTIVATED_T_CELL_PROLIFERATION	BP	SP3
GO_PROTEIN_MODIFICATION_BY_SMALL_PROTEIN_REMOVAL	BP	SP3
GO_NEGATIVE_REGULATION_OF_MAPK_CASCADE	BP	SP3
GO_ACTIVATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY	BP	SP3
GO_HISTONE_DEUBIQUITINATION	BP	SP3
GO_WOUND_HEALING	BP	SP3
GO_B_CELL_DIFFERENTIATION	BP	SP3
GO_NEGATIVE_REGULATION_OF_T_CELL_RECEPTOR_SIGNALING_PATHWAY	BP	SP3
GO_RESPONSE_TO_ALKALOID	BP	SP3
GO_IN_UTERO_EMBRYONIC_DEVELOPMENT	BP	SP3
GO_DNA_CATABOLIC_PROCESS	BP	SP3
GO_HIPPOCAMPUS_DEVELOPMENT	BP	SP3
GO_EMBRYONIC_CAMERA_TYPE_EYE_MORPHOGENESIS	BP	SP3
GO_KERATINOCYTE_DIFFERENTIATION	BP	SP3
GO_APOPTOTIC_NUCLEAR_CHANGES	BP	SP3
GO_PLATELET_MORPHOGENESIS	BP	SP3
GO_CENTROSOME_CYCLE	BP	SP3
GO_PROTEIN_STABILIZATION	BP	SP3
GO_NEGATIVE_REGULATION_OF_PHOSPHORUS_METABOLIC_PROCESS	BP	SP3
GO_MITOTIC_NUCLEAR_DIVISION	BP	SP3
GO_PALLIUM_DEVELOPMENT	BP	SP3
GO_CELL_CYCLE_G1_S_PHASE_TRANSITION	BP	SP3
GO_SIGNAL_TRANSDUCTION_IN_ABSENCE_OF_LIGAND	BP	SP3
GO_BLASTOCYST_DEVELOPMENT	BP	SP3
GO_POSITIVE_REGULATION_OF_PEPTIDASE_ACTIVITY	BP	SP3
GO_RESPONSE_TO_UV	BP	SP3
GO_HOMEOSTASIS_OF_NUMBER_OF_CELLS	BP	SP3
GO_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_MITOCHONDRION	BP	SP3
GO_REGULATION_OF_PROTEIN_STABILITY	BP	SP3
GO_NEGATIVE_REGULATION_OF_T_CELL_PROLIFERATION	BP	SP3
GO_RESPONSE_TO_NICOTINE	BP	SP3
GO_REGULATION_OF_MITOPHAGY	BP	SP3
GO_NATURAL_KILLER_CELL_ACTIVATION	BP	SP3
GO_RESPONSE_TO_AMINO_ACID	BP	SP3
GO_PROTEIN_K48_LINKED_DEUBIQUITINATION	BP	SP3
GO_REGULATION_OF_B_CELL_ACTIVATION	BP	SP3
GO_REGULATION_OF_CELL_CELL_ADHESION	BP	SP3
GO_NEURON_APOPTOTIC_PROCESS	BP	SP3
GO_GRANULOCYTE_DIFFERENTIATION	BP	SP3
GO_NEGATIVE_REGULATION_OF_B_CELL_PROLIFERATION	BP	SP3
GO_MITOCHONDRIAL_FUSION	BP	SP3
GO_CELL_CYCLE	BP	SP3
GO_NEGATIVE_REGULATION_OF_JNK_CASCADE	BP	SP3
GO_CELLULAR_RESPONSE_TO_STARVATION	BP	SP3
GO_MEGAKARYOCYTE_DIFFERENTIATION	BP	SP3
GO_MICROTUBULE_ORGANIZING_CENTER_ORGANIZATION	BP	SP3
GO_RESPONSE_TO_GROWTH_FACTOR	BP	SP3
GO_APOPTOTIC_DNA_FRAGMENTATION	BP	SP3
GO_REGULATION_OF_B_CELL_PROLIFERATION	BP	SP3
GO_DEPHOSPHORYLATION	BP	SP3
GO_REGULATION_OF_HOMOTYPIC_CELL_CELL_ADHESION	BP	SP3
GO_NEGATIVE_REGULATION_OF_STRESS_ACTIVATED_PROTEIN_KINASE_SIGNALING_CASCADE	BP	SP3
GO_NEGATIVE_REGULATION_OF_CELL_ACTIVATION	BP	SP3
GO_REGULATION_OF_CYCLIN_DEPENDENT_PROTEIN_KINASE_ACTIVITY	BP	SP3
GO_NEGATIVE_REGULATION_OF_ANTIGEN_RECEPTOR_MEDIATED_SIGNALING_PATHWAY	BP	SP3
GO_RESPIRATORY_SYSTEM_DEVELOPMENT	BP	SP3
GO_EMBRYONIC_EYE_MORPHOGENESIS	BP	SP3
GO_SENSORY_ORGAN_MORPHOGENESIS	BP	SP3
GO_TROPHECTODERMAL_CELL_DIFFERENTIATION	BP	SP3
GO_RESPONSE_TO_X_RAY	BP	SP3
GO_PROTEIN_K63_LINKED_DEUBIQUITINATION	BP	SP3
GO_PLACENTA_DEVELOPMENT	BP	SP3
GO_SPLICEOSOMAL_COMPLEX_ASSEMBLY	BP	SP3
GO_NEURON_DEATH	BP	SP3
GO_CELLULAR_RESPONSE_TO_STRESS	BP	SP3
GO_RESPONSE_TO_COBALT_ION	BP	SP3
GO_NEUROTROPHIN_TRK_RECEPTOR_SIGNALING_PATHWAY	BP	SP3
GO_CENTROSOME_DUPLICATION	BP	SP3
GO_INACTIVATION_OF_MAPK_ACTIVITY	BP	SP3
GO_CELLULAR_COMPONENT_DISASSEMBLY_INVOLVED_IN_EXECUTION_PHASE_OF_APOPTOSIS	BP	SP3
GO_RNA_SPLICING	BP	SP3
GO_DEFINITIVE_HEMOPOIESIS	BP	SP3
GO_RESPONSE_TO_ALCOHOL	BP	SP3
GO_POSITIVE_REGULATION_OF_NEURON_APOPTOTIC_PROCESS	BP	SP3
GO_EMBRYONIC_CAMERA_TYPE_EYE_DEVELOPMENT	BP	SP3
GO_ZYMOGEN_ACTIVATION	BP	SP3
GO_MONOCYTE_DIFFERENTIATION	BP	SP3
GO_PROTEOLYSIS	BP	SP3
GO_ORGANELLE_DISASSEMBLY	BP	SP3
GO_NEUROTROPHIN_SIGNALING_PATHWAY	BP	SP3
GO_NEGATIVE_REGULATION_OF_HOMOTYPIC_CELL_CELL_ADHESION	BP	SP3
GO_LEUKOCYTE_HOMEOSTASIS	BP	SP3
GO_NEGATIVE_REGULATION_OF_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY	BP	SP3
GO_DNA_CATABOLIC_PROCESS_ENDONUCLEOLYTIC	BP	SP3
GO_EYE_MORPHOGENESIS	BP	SP3
GO_IMMUNOLOGICAL_SYNAPSE	CC	SP3
GO_SAGA_COMPLEX	CC	SP3
GO_CYTOPLASMIC_UBIQUITIN_LIGASE_COMPLEX	CC	SP3
GO_SECRETORY_VESICLE	CC	SP3
GO_SPECIFIC_GRANULE	CC	SP3
GO_SAGA_TYPE_COMPLEX	CC	SP3
GO_ACETYLTRANSFERASE_COMPLEX	CC	SP3
GO_PEPTIDASE_REGULATOR_ACTIVITY	MF	SP3
GO_CYSTEINE_TYPE_PEPTIDASE_ACTIVITY	MF	SP3
GO_HISTONE_BINDING	MF	SP3
GO_CORE_PROMOTER_BINDING	MF	SP3
GO_KINASE_BINDING	MF	SP3
GO_CYCLIN_DEPENDENT_PROTEIN_SERINE_THREONINE_KINASE_INHIBITOR_ACTIVITY	MF	SP3
GO_PEPTIDASE_ACTIVATOR_ACTIVITY	MF	SP3
GO_INSULIN_LIKE_GROWTH_FACTOR_BINDING	MF	SP3
GO_PROTEIN_SERINE_THREONINE_KINASE_INHIBITOR_ACTIVITY	MF	SP3
GO_PROTEIN_TYROSINE_SERINE_THREONINE_PHOSPHATASE_ACTIVITY	MF	SP3
GO_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY	MF	SP3
GO_RNA_POLYMERASE_II_CORE_PROMOTER_SEQUENCE_SPECIFIC_DNA_BINDING	MF	SP3
GO_THIOL_DEPENDENT_UBIQUITIN_SPECIFIC_PROTEASE_ACTIVITY	MF	SP3
GO_PEPTIDASE_ACTIVATOR_ACTIVITY_INVOLVED_IN_APOPTOTIC_PROCESS	MF	SP3
GO_DEATH_RECEPTOR_BINDING	MF	SP3
GO_LIPASE_ACTIVATOR_ACTIVITY	MF	SP3
GO_MAP_KINASE_PHOSPHATASE_ACTIVITY	MF	SP3
GO_RAL_GTPASE_BINDING	MF	SP3
GO_CYCLIN_DEPENDENT_PROTEIN_SERINE_THREONINE_KINASE_REGULATOR_ACTIVITY	MF	SP3
GO_TRANSCRIPTIONAL_REPRESSOR_ACTIVITY_RNA_POLYMERASE_II_CORE_PROMOTER_PROXIMAL_REGION_SEQUENCE_SPECIFIC_BINDING	MF	SP3
GO_ZINC_ION_BINDING	MF	SP3
GO_UBIQUITIN_LIKE_PROTEIN_SPECIFIC_PROTEASE_ACTIVITY	MF	SP3
GO_ENDOPEPTIDASE_ACTIVITY	MF	SP3
GO_G_PROTEIN_COUPLED_RECEPTOR_BINDING	MF	SP3
GO_CELL_ADHESION_MOLECULE_BINDING	MF	SP3
GO_ASPARTIC_TYPE_PEPTIDASE_ACTIVITY	MF	SP3
GO_TUMOR_NECROSIS_FACTOR_RECEPTOR_SUPERFAMILY_BINDING	MF	SP3
GO_CORE_PROMOTER_SEQUENCE_SPECIFIC_DNA_BINDING	MF	SP3
GO_GROWTH_FACTOR_BINDING	MF	SP3
GO_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY_INVOLVED_IN_APOPTOTIC_PROCESS	MF	SP3
GO_CYSTEINE_TYPE_ENDOPEPTIDASE_REGULATOR_ACTIVITY_INVOLVED_IN_APOPTOTIC_PROCESS	MF	SP3

Survival analysis of SP3

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of SP3

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)