Cancer CRCdb

TF information

TF name:	IRF6
TF family:	IRF
Ensembl gene ID:	ENSG00000117595
Ensembl protein ID:	ENSP00000355988, ENSP00000496669, ENSP00000403855
Entrez gene ID:	3664

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of IRF6 in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_02_228	Cell line	Oesophagus	KYSE510	0.30848089468779
Sample_02_307	Cell line	Neuroblastoma	SJNB12	0.26760563380282

IRF6 distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name

IRF6 distribution in all CRCs

Genomic distribution of SEs associated with IRF6

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Mutation of IRF6

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of IRF6

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr1	209969826	209969826	C	G	exonic	IRF6	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr1	209968740	209968740	C	T	exonic	IRF6	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr1	209963951	209963951	A	G	exonic	IRF6	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr1	209964014	209964014	C	T	exonic	IRF6	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr1	209964020	209964020	G	A	exonic	IRF6	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr1	209974644	209974644	G	A	exonic	IRF6	nonsynonymous	SKCM\|1\|368\|0.00272
rs121434228	chr1	209963054	209963054	C	T	exonic	IRF6	stopgain	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr1	209961990	209961990	C	A	splicing	IRF6	splicing	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs121434227	chr1	209969821	209969821	C	T	exonic	IRF6	nonsynonymous	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr1	209963041	209963041	G	A	exonic	IRF6	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr1	209963024	209963024	G	C	exonic	IRF6	synonymous	CESC\|1\|194\|0.00515
-	chr1	209964001	209964001	C	G	exonic	IRF6	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr1	209961934	209961934	C	T	exonic	IRF6	nonsynonymous	SKCM\|1\|368\|0.00272,UCEC\|1\|248\|0.00403
-	chr1	209963949	209963949	G	A	exonic	IRF6	synonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr1	209968692	209968692	C	T	exonic	IRF6	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr1	209969776	209969776	C	A	exonic	IRF6	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr1	209968732	209968732	C	T	exonic	IRF6	synonymous	SKCM\|1\|368\|0.00272
-	chr1	209969729	209969729	C	A	exonic	IRF6	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr1	209974602	209974602	C	T	exonic	IRF6	nonsynonymous	SKCM\|2\|368\|0.00543
-	chr1	209968651	209968651	G	A	exonic	IRF6	synonymous	SKCM\|1\|368\|0.00272
-	chr1	209964021	209964021	C	A	exonic	IRF6	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr1	209964183	209964183	C	G	exonic	IRF6	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr1	209968639	209968639	G	A	exonic	IRF6	synonymous	BLCA\|1\|396\|0.00253
-	chr1	209974655	209974655	C	T	exonic	IRF6	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr1	209974733	209974733	C	T	exonic	IRF6	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr1	209961912	209961912	G	A	exonic	IRF6	synonymous	BLCA\|1\|396\|0.00253
rs2013162	chr1	209968684	209968684	C	T	exonic	IRF6	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr1	209969813	209969813	G	A	exonic	IRF6	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr1	209964161	209964161	G	A	exonic	IRF6	stopgain	HNSC\|1\|512\|0.00195
-	chr1	209969722	209969722	G	A	exonic	IRF6	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr1	209969771	209969771	T	C	exonic	IRF6	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr1	209974759	209974759	G	C	UTR5	IRF6	unknown	BLCA\|1\|396\|0.00253
-	chr1	209974721	209974721	C	G	exonic	IRF6	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr1	209964227	209964227	C	A	exonic	IRF6	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr1	209974658	209974658	T	G	exonic	IRF6	nonsynonymous	CHOL\|1\|35\|0.02857
-	chr1	209969723	209969723	G	A	exonic	IRF6	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr1	209974688	209974688	G	A	exonic	IRF6	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr1	209969762	209969762	G	A	exonic	IRF6	nonsynonymous	OV\|1\|469\|0.00213
-	chr1	209974723	209974723	G	A	exonic	IRF6	synonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr1	209965672	209965672	G	A	exonic	IRF6	synonymous	HNSC\|1\|512\|0.00195
-	chr1	209961969	209961969	C	A	exonic	IRF6	synonymous	LUAD\|1\|543\|0.00184
rs121434224	chr1	209969798	209969798	C	A	exonic	IRF6	stopgain	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr1	209969711	209969711	C	A	exonic	IRF6	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr1	209968742	209968742	C	T	exonic	IRF6	stopgain	TGCT\|1\|155\|0.00645
-	chr1	209963984	209963984	C	T	exonic	IRF6	nonsynonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr1	209961801	209961801	G	-	exonic	IRF6	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr1	209969876	209969876	T	A	exonic	IRF6	stopgain	SARC\|1\|247\|0.00405
-	chr1	209961772	209961772	G	A	exonic	IRF6	nonsynonymous	SKCM\|2\|368\|0.00543
-	chr1	209961787	209961787	G	A	exonic	IRF6	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr1	209963869	209963869	T	G	exonic	IRF6	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr1	209969704	209969704	A	C	exonic	IRF6	nonsynonymous	CHOL\|1\|35\|0.02857
-	chr1	209969828	209969828	G	C	exonic	IRF6	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr1	209969798	209969798	C	G	exonic	IRF6	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr1	209961987	209961987	G	A	exonic	IRF6	synonymous	SKCM\|1\|368\|0.00272
-	chr1	209974619	209974619	C	T	exonic	IRF6	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr1	209968703	209968703	T	C	exonic	IRF6	nonsynonymous	OV\|1\|469\|0.00213
-	chr1	209961957	209961957	C	T	exonic	IRF6	synonymous	SKCM\|1\|368\|0.00272
-	chr1	209963984	209963984	C	A	exonic	IRF6	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr1	209974642	209974642	G	A	exonic	IRF6	synonymous	LIHC\|1\|373\|0.00268
-	chr1	209964001	209964001	C	T	exonic	IRF6	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr1	209968635	209968635	C	G	exonic	IRF6	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr1	209974728	209974728	T	A	exonic	IRF6	stopgain	LUAD\|1\|543\|0.00184
-	chr1	209964128	209964128	G	A	exonic	IRF6	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr1	209964105	209964105	G	T	exonic	IRF6	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr1	209968671	209968671	G	A	exonic	IRF6	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr1	209969815	209969815	G	A	exonic	IRF6	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr1	209961966	209961966	C	T	exonic	IRF6	nonsynonymous	SKCM\|2\|368\|0.00543
-	chr1	209963962	209963962	G	A	exonic	IRF6	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr1	209964204	209964204	G	A	exonic	IRF6	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr1	209974608	209974608	C	T	exonic	IRF6	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr1	209965758	209965758	G	C	exonic	IRF6	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr1	209969798	209969798	C	T	exonic	IRF6	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr1	209965712	209965712	G	T	exonic	IRF6	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr1	209963884	209963884	C	T	exonic	IRF6	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr1	209961873	209961873	G	C	exonic	IRF6	nonsynonymous	CESC\|1\|194\|0.00515
rs41303263	chr1	209964141	209964141	A	G	exonic	IRF6	synonymous	BLCA\|1\|396\|0.00253
-	chr1	209968732	209968732	C	A	exonic	IRF6	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr1	209965706	209965706	C	T	exonic	IRF6	stopgain	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr1	209968716	209968716	C	T	exonic	IRF6	nonsynonymous	SKCM\|1\|368\|0.00272
rs121434229	chr1	209974625	209974625	C	T	exonic	IRF6	nonsynonymous	PRAD\|1\|499\|0.00200
-	chr1	209968702	209968702	T	C	exonic	IRF6	synonymous	COAD\|2\|367\|0.00545,COADREAD\|2\|489\|0.00409
-	chr1	209964078	209964078	G	A	exonic	IRF6	synonymous	BLCA\|1\|396\|0.00253
-	chr1	209969868	209969868	C	A	exonic	IRF6	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr1	209963071	209963071	A	C	exonic	IRF6	nonsynonymous	PRAD\|1\|499\|0.00200
-	chr1	209969892	209969892	C	T	exonic	IRF6	stopgain	UCEC\|1\|248\|0.00403
-	chr1	209965773	209965773	C	T	splicing	IRF6	splicing	PAAD\|1\|185\|0.00541
-	chr1	209974625	209974625	C	G	exonic	IRF6	nonsynonymous	OV\|1\|469\|0.00213
-	chr1	209974736	209974736	A	T	exonic	IRF6	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr1	209964185	209964185	G	A	exonic	IRF6	stopgain	LUSC\|1\|178\|0.00562
-	chr1	209969822	209969822	G	T	exonic	IRF6	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr1	209969858	209969858	C	T	exonic	IRF6	nonsynonymous	CESC\|1\|194\|0.00515
-	chr1	209974599	209974599	T	G	exonic	IRF6	nonsynonymous	UCS\|1\|57\|0.01754
-	chr1	209965773	209965773	C	A	splicing	IRF6	splicing	LUAD\|1\|543\|0.00184,LUSC\|1\|178\|0.00562
-	chr1	209964145	209964145	A	G	exonic	IRF6	nonsynonymous	ACC\|1\|90\|0.01111
-	chr1	209964089	209964089	G	C	exonic	IRF6	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
rs774866638	chr1	209961960	209961960	G	A	exonic	IRF6	synonymous	LUAD\|1\|543\|0.00184
-	chr1	209964227	209964227	C	G	exonic	IRF6	nonsynonymous	OV\|1\|469\|0.00213
-	chr1	209964079	209964079	A	T	exonic	IRF6	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr1	209963884	209963890	CTCTCAA	-	exonic	IRF6	frameshift	PRAD\|1\|499\|0.00200
-	chr1	209969745	209969745	C	A	exonic	IRF6	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr1	209961786	209961786	G	A	exonic	IRF6	synonymous	SARC\|1\|247\|0.00405
-	chr1	209961817	209961817	G	A	exonic	IRF6	nonsynonymous	SKCM\|1\|368\|0.00272
rs778870225	chr1	209961873	209961873	G	A	exonic	IRF6	synonymous	SARC\|1\|247\|0.00405,SKCM\|2\|368\|0.00543
-	chr1	209969757	209969757	C	A	exonic	IRF6	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr1	209963069	209963069	G	T	exonic	IRF6	stopgain	ESCA\|1\|185\|0.00541
rs200808685	chr1	209963840	209963840	C	T	exonic	IRF6	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr1	209964129	209964129	A	C	exonic	IRF6	synonymous	SKCM\|1\|368\|0.00272
rs750021967	chr1	209961847	209961847	C	T	exonic	IRF6	nonsynonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
rs748882482	chr1	209964012	209964012	G	A	exonic	IRF6	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr1	209974644	209974644	G	C	exonic	IRF6	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr1	209969692	209969692	C	G	splicing	IRF6	splicing	HNSC\|2\|512\|0.00391
-	chr1	209964110	209964110	C	T	exonic	IRF6	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr1	209968664	209968664	T	C	exonic	IRF6	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr1	209968741	209968741	C	A	exonic	IRF6	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr1	209964072	209964072	G	A	exonic	IRF6	synonymous	SKCM\|1\|368\|0.00272
-	chr1	209961959	209961959	C	T	exonic	IRF6	nonsynonymous	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr1	209969720	209969720	G	A	exonic	IRF6	stopgain	LUSC\|1\|178\|0.00562
rs28942093	chr1	209974754	209974754	G	A	exonic	IRF6	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr1	209964097	209964097	G	A	exonic	IRF6	nonsynonymous	UCEC\|1\|248\|0.00403
rs778608344	chr1	209974763	209974763	-	G	splicing	IRF6	unknown	KIPAN\|5\|799\|0.00626,KIRC\|5\|451\|0.01109,PAAD\|1\|185\|0.00541

Disease information of IRF6

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
IRF6	Arthrogryposis	C05;C16	Disease or Syndrome	GENOMICS_ENGLAND
IRF6	Cleft upper lip	C07;C16	Congenital Abnormality	CTD_human;ORPHANET
IRF6	Cleft Palate	C05;C07;C16	Congenital Abnormality	CTD_human
IRF6	Hypodontia	C07;C16	Congenital Abnormality	ORPHANET
IRF6	Skin Abnormalities	C16;C17	Congenital Abnormality	CTD_human
IRF6	Cleft palate with cleft lip		Congenital Abnormality	ORPHANET
IRF6	Van der Woude syndrome	C04;C05;C07;C16;C23	Disease or Syndrome	CTD_human;ORPHANET;UNIPROT
IRF6	Limb Deformities, Congenital	C05;C16	Congenital Abnormality	CTD_human
IRF6	Popliteal pterygium syndrome	C05;C07;C11;C12;C13;C16	Disease or Syndrome	CTD_human;ORPHANET;UNIPROT
IRF6	Craniofacial Abnormalities	C05;C16	Congenital Abnormality	CTD_human
IRF6	Cleft lip and alveolus		Congenital Abnormality	ORPHANET
IRF6	OROFACIAL CLEFT 6, SUSCEPTIBILITY TO		Finding	CTD_human;UNIPROT
IRF6	Cleft palate, isolated	C05;C07;C16	Congenital Abnormality	CTD_human
IRF6	Intellectual Disability	C10;C23;F01;F03	Mental or Behavioral Dysfunction	GENOMICS_ENGLAND
IRF6	Oligodontia		Congenital Abnormality	ORPHANET

Pathway associated with IRF6

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number
pathway0002849	Hs_Hypothetical_Craniofacial_Development_Pathway_WP3655_88473	wikipathways	5	6

Go term information of IRF6

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GO_term_name	GO_term_type	TF_name
GO_KERATINOCYTE_PROLIFERATION	BP	IRF6
GO_MAMMARY_GLAND_EPITHELIUM_DEVELOPMENT	BP	IRF6
GO_RESPONSE_TO_TYPE_I_INTERFERON	BP	IRF6
GO_MAMMARY_GLAND_EPITHELIAL_CELL_DIFFERENTIATION	BP	IRF6
GO_KERATINOCYTE_DIFFERENTIATION	BP	IRF6
GO_CELL_PROLIFERATION	BP	IRF6
GO_CELL_CYCLE	BP	IRF6
GO_EPITHELIAL_CELL_PROLIFERATION	BP	IRF6
GO_RESPONSE_TO_CYTOKINE	BP	IRF6

Survival analysis of IRF6

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of IRF6

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)