TF information
| TF name: | HES1 |
| TF family: | bHLH |
| Ensembl gene ID: | ENSG00000114315 |
| Ensembl protein ID: | ENSP00000232424 |
| Entrez gene ID: | 3280 |
| Database name | Link | Database name | Link |
| NCBI Gene: |  |
Genecards: |  |
| Uniprot: |  |
Wikipedia: |  |
| Cosmic 3D: |  |
Geneontology: |  |
| CCLE: |  |
Frequency of HES1 in all biosamples
| Sample ID | Biosample type | Tissue type | Biosample name | TF Frequency |
|---|---|---|---|---|
| Sample_01_001 | Cell line | Prostate | 22Rv1 | 0.24697336561743 |
| Sample_01_022 | Cell line | Prostate | C4-2B | 0.28571428571429 |
| Sample_01_046 | Cell line | Mammary Gland | MCF-7 | 0.8 |
| Sample_01_059 | Cell line | Lung | PC-9 | 0.4 |
| Sample_02_007 | Other | Cervical | cervical-cancer_vector | 0.059602649006623 |
| Sample_02_021 | Cell line | Colon | V429 | 0.32257134620928 |
| Sample_02_079 | Cell line | Mammary Gland | T-47D_1 | 1 |
| Sample_02_080 | Cell line | Lung | Calu-3 | 0.22727272727273 |
| Sample_02_095 | Cell line | Mammary Gland | MDA-MB-468 | 0.38832684824903 |
| Sample_02_096 | Cell line | Mammary Gland | ZR-75-1_1 | 0.96739130434783 |
| Sample_02_116 | Cell line | Mammary Gland | MDA-MB-231_untreat | 0.16666666666667 |
| Sample_02_164 | Cell line | Lung | H2087_Parental | 0.21666666666667 |
| Sample_02_166 | Cell line | Mammary Gland | HCC1954_Parental | 0.504 |
| Sample_02_168 | Cell line | Prostate | LNCaP | 0.19011406844106 |
| Sample_02_184 | Cell line | Skin | SKMEL30 | 0.18971061093248 |
| Sample_02_187 | Cell line | Stomach | KATOIII | 0.33333333333333 |
| Sample_02_191 | Cell line | Stomach | SNU719 | 0.35714285714286 |
| Sample_02_192 | Cell line | Stomach | MKN45 | 0.5 |
| Sample_02_196 | Cell line | Stomach | NCC59 | 0.14285714285714 |
| Sample_02_199 | Cell line | Stomach | KATO3 | 0.33333333333333 |
| Sample_02_203 | Cell line | Stomach | YCC21 | 0.33333333333333 |
| Sample_02_204 | Cell line | Stomach | IM95 | 0.27272727272727 |
| Sample_02_205 | Tissue | Stomach | Gastric_Primary_Sample_T | 0.13333333333333 |
| Sample_02_208 | Cell line | Stomach | YCC3 | 0.75 |
| Sample_02_220 | Cell line | Brain | BE2C_1 | 0.16666666666667 |
| Sample_02_227 | Cell line | Oesophagus | TE7 | 0.2 |
| Sample_02_228 | Cell line | Oesophagus | KYSE510 | 0.06430568499534 |
| Sample_02_236 | Cell line | Colon | V206 | 0.18840579710145 |
| Sample_02_237 | Cell line | Colon | V389 | 0.22278667402908 |
| Sample_02_241 | Cell line | Colon | V456 | 0.2686230248307 |
| Sample_02_242 | Cell line | Colon | V481 | 0.18989937832468 |
| Sample_02_258 | Other | Lung | NCI-H1299_EGFP-NEO_reporter_cells_DMSO | 0.15555555555556 |
| Sample_02_268 | Cell line | Kidney | A-498 | 0.061657744138822 |
| Sample_02_280 | Cell line | Mammary Gland | SUM159_DMSO_24h | 0.125 |
| Sample_02_285 | Cell line | Liver | HuH7_untreat | 0.16724738675958 |
| Sample_02_304 | Cell line | Neuroblastoma | N206 | 0.11005434782609 |
| Sample_02_319 | Cell line | Neuroblastoma | NB-EBc1 | 0.12138728323699 |
| Sample_02_322 | Cell line | Colon | Caco-2 | 0.31224764468371 |
| Sample_02_338 | Cell line | Neuroblastoma | BE2 | 0.14705882352941 |
| Sample_02_354 | Cell line | Colon | Colo205 | 0.15315315315315 |
| Sample_02_356 | Cell line | Colon | Sw480 | 0.16129032258065 |
| Sample_02_358 | Cell line | Colon | LS180 | 0.23143759873618 |
| Sample_02_361 | Cell line | Colon | HT29_DMSO | 0.29734513274336 |
| Sample_02_394 | Cell line | Mammary Gland | T-47D_2 | 0.26923076923077 |
| Sample_02_395 | Cell line | Mammary Gland | BT-549 | 0.15272727272727 |
| Sample_02_403 | Cell line | Mammary Gland | T-47D_untreat | 0.80681818181818 |
| Sample_02_404 | Cell line | Mammary Gland | ZR-75-1_2 | 0.76978417266187 |
| Sample_02_424 | Cell line | Colon | SW620 | 0.21739130434783 |
| Sample_02_430 | Cell line | Kidney | 12364284 | 0.28571428571429 |
HES1 distribution in samples’ most representative CRC
| Sample ID | Tissue type | Biosample type | Biosample name |
|---|---|---|---|
| Sample_01_046 | Mammary Gland | Cell line | MCF-7 |
| Sample_02_021 | Colon | Cell line | V429 |
| Sample_02_079 | Mammary Gland | Cell line | T-47D_1 |
| Sample_02_095 | Mammary Gland | Cell line | MDA-MB-468 |
| Sample_02_096 | Mammary Gland | Cell line | ZR-75-1_1 |
| Sample_02_191 | Stomach | Cell line | SNU719 |
| Sample_02_192 | Stomach | Cell line | MKN45 |
| Sample_02_208 | Stomach | Cell line | YCC3 |
| Sample_02_358 | Colon | Cell line | LS180 |
| Sample_02_361 | Colon | Cell line | HT29_DMSO |
| Sample_02_403 | Mammary Gland | Cell line | T-47D_untreat |
| Sample_02_404 | Mammary Gland | Cell line | ZR-75-1_2 |
HES1 distribution in all CRCs
Genomic distribution of SEs associated with HES1
Genomic distribution of SEs associated with TF
Figure legend:
Genomic distribution of SEs associated with TF: It can roughly understand the genomic regions of SEs associated with TF, and help to carry out the next analysis, such as knocking down the experiment.
What is important information?
The yellow box can be thought of as the common genomic regions that regulates the SEs associated with TF. For example, if a knockdown experiment is performed on this region, then theoretically, the expression of the TF will be greatly reduced.
| Database name | Link |
|---|---|
| Cosmic: |  |
| Cosmic cell lines: |  |
| Depmap: |  |
TCGA somatic mutations and clinical variants of HES1
| rsID | Chr | Start | Stop | Ref | Alt | Gene_region | Gene_symble | Effect | TCGA_Occurrence |
|---|---|---|---|---|---|---|---|---|---|
| - | chr3 | 193854767 | 193854767 | G | A | exonic | HES1 | synonymous | UCEC|1|248|0.00403 |
| - | chr3 | 193854477 | 193854478 | GA | - | exonic | HES1 | frameshift | BLCA|1|396|0.00253 |
| - | chr3 | 193855479 | 193855479 | G | A | exonic | HES1 | synonymous | HNSC|1|512|0.00195 |
| - | chr3 | 193855974 | 193855974 | C | G | exonic | HES1 | nonsynonymous | THYM|1|123|0.00813 |
| - | chr3 | 193854479 | 193854479 | T | - | exonic | HES1 | frameshift | LIHC|1|373|0.00268 |
| - | chr3 | 193855938 | 193855938 | C | T | exonic | HES1 | synonymous | UCEC|1|248|0.00403 |
| - | chr3 | 193854818 | 193854818 | G | A | exonic | HES1 | synonymous | LIHC|1|373|0.00268,OV|1|469|0.00213 |
| - | chr3 | 193855656 | 193855656 | G | A | exonic | HES1 | synonymous | PAAD|1|185|0.00541 |
| - | chr3 | 193854483 | 193854483 | G | A | exonic | HES1 | synonymous | UCEC|1|248|0.00403 |
| - | chr3 | 193855629 | 193855629 | C | T | exonic | HES1 | synonymous | BLCA|1|396|0.00253,SKCM|1|368|0.00272 |
| - | chr3 | 193854425 | 193854425 | A | T | exonic | HES1 | nonsynonymous | LIHC|1|373|0.00268 |
| - | chr3 | 193854273 | 193854273 | G | A | exonic | HES1 | nonsynonymous | CESC|1|194|0.00515 |
| - | chr3 | 193854477 | 193854477 | G | A | exonic | HES1 | synonymous | BLCA|1|396|0.00253 |
| - | chr3 | 193855740 | 193855740 | C | T | exonic | HES1 | synonymous | CESC|1|194|0.00515 |
| - | chr3 | 193854469 | 193854469 | A | - | exonic | HES1 | frameshift | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr3 | 193854190 | 193854190 | G | C | exonic | HES1 | nonsynonymous | BLCA|1|396|0.00253 |
| rs375649870 | chr3 | 193855682 | 193855682 | C | T | exonic | HES1 | nonsynonymous | BLCA|1|396|0.00253 |
| - | chr3 | 193855810 | 193855810 | G | A | exonic | HES1 | nonsynonymous | BLCA|1|396|0.00253 |
| - | chr3 | 193854451 | 193854451 | G | A | exonic | HES1 | nonsynonymous | BLCA|1|396|0.00253 |
| - | chr3 | 193854434 | 193854434 | G | A | exonic | HES1 | nonsynonymous | BLCA|1|396|0.00253,BRCA|1|982|0.00102 |
| rs770004050 | chr3 | 193855643 | 193855643 | A | C | exonic | HES1 | nonsynonymous | GBM|1|290|0.00345,GBMLGG|1|820|0.00122 |
| - | chr3 | 193854764 | 193854764 | C | T | exonic | HES1 | synonymous | ESCA|1|185|0.00541 |
| - | chr3 | 193854182 | 193854182 | A | C | exonic | HES1 | nonsynonymous | UCEC|1|248|0.00403 |
| - | chr3 | 193855884 | 193855884 | - | G | exonic | HES1 | frameshift | BLCA|1|396|0.00253 |
| - | chr3 | 193855591 | 193855591 | C | G | exonic | HES1 | nonsynonymous | CESC|1|194|0.00515 |
| rs761011090 | chr3 | 193855991 | 193855991 | C | T | exonic | HES1 | nonsynonymous | OV|1|469|0.00213 |
| - | chr3 | 193854779 | 193854779 | - | AC | exonic | HES1 | frameshift | LUAD|1|543|0.00184 |
| - | chr3 | 193854187 | 193854187 | G | C | exonic | HES1 | nonsynonymous | BLCA|1|396|0.00253 |
| - | chr3 | 193855508 | 193855508 | A | G | exonic | HES1 | nonsynonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr3 | 193855609 | 193855609 | - | C | exonic | HES1 | frameshift | BLCA|1|396|0.00253 |
| - | chr3 | 193854814 | 193854814 | A | G | exonic | HES1 | nonsynonymous | SKCM|1|368|0.00272 |
| - | chr3 | 193854208 | 193854208 | G | A | exonic | HES1 | synonymous | TGCT|1|155|0.00645 |
| - | chr3 | 193855564 | 193855564 | G | C | exonic | HES1 | nonsynonymous | BLCA|1|396|0.00253 |
| - | chr3 | 193854457 | 193854457 | C | - | exonic | HES1 | stopgain | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr3 | 193854434 | 193854434 | G | T | exonic | HES1 | nonsynonymous | BLCA|1|396|0.00253 |
| - | chr3 | 193855908 | 193855908 | T | - | exonic | HES1 | frameshift | LUAD|1|543|0.00184 |
| - | chr3 | 193855956 | 193855956 | C | A | exonic | HES1 | nonsynonymous | BLCA|1|396|0.00253 |
| - | chr3 | 193854799 | 193854799 | T | C | exonic | HES1 | nonsynonymous | ESCA|1|185|0.00541 |
| - | chr3 | 193854430 | 193854430 | A | T | exonic | HES1 | stopgain | SKCM|1|368|0.00272 |
| TF_name | Disease_name | Disease_class | Disease_semantic_type | TF_disease_source |
|---|---|---|---|---|
| HES1 | Malignant neoplasm of breast | C04;C17 | Neoplastic Process | CTD_human |
| HES1 | Malignant tumor of colon | C04;C06 | Neoplastic Process | CTD_human |
| HES1 | Non-Small Cell Lung Carcinoma | C04;C08 | Neoplastic Process | CTD_human |
| HES1 | Uterine Cervical Neoplasm | C04;C13 | Neoplastic Process | CTD_human |
| HES1 | Colonic Neoplasms | C04;C06 | Neoplastic Process | CTD_human |
| HES1 | Glioblastoma | C04 | Neoplastic Process | CTD_human |
| HES1 | Lung Neoplasms | C04;C08 | Neoplastic Process | CTD_human |
| HES1 | Meningioma | C04;C10 | Neoplastic Process | CTD_human |
| HES1 | oligodendroglioma | C04 | Neoplastic Process | CTD_human |
| HES1 | Meningiomas, Multiple | C04;C10 | Neoplastic Process | CTD_human |
| HES1 | Neuroectodermal Tumor, Primitive | C04 | Neoplastic Process | CTD_human |
| HES1 | Malignant neoplasm of lung | C04;C08 | Neoplastic Process | CTD_human |
| HES1 | Malignant Meningioma | C04;C10 | Neoplastic Process | CTD_human |
| HES1 | Adult Oligodendroglioma | C04 | Neoplastic Process | CTD_human |
| HES1 | Childhood Oligodendroglioma | C04 | Neoplastic Process | CTD_human |
| HES1 | Mixed Oligodendroglioma-Astrocytoma | C04 | Neoplastic Process | CTD_human |
| HES1 | Benign Meningioma | C04;C10 | Neoplastic Process | CTD_human |
| HES1 | Spongioblastoma | C04 | Neoplastic Process | CTD_human |
| HES1 | Giant Cell Glioblastoma | C04 | Neoplastic Process | CTD_human |
| HES1 | Anaplastic Oligodendroglioma | C04 | Neoplastic Process | CTD_human |
| HES1 | Medulloepithelioma | C04 | Neoplastic Process | CTD_human |
| HES1 | Meningothelial meningioma | C04;C10 | Neoplastic Process | CTD_human |
| HES1 | Fibrous Meningioma | C04;C10 | Neoplastic Process | CTD_human |
| HES1 | Psammomatous Meningioma | C04;C10 | Neoplastic Process | CTD_human |
| HES1 | Angiomatous Meningioma | C04;C10 | Neoplastic Process | CTD_human |
| HES1 | Hemangioblastic Meningioma | C04;C10 | Neoplastic Process | CTD_human |
| HES1 | Hemangiopericytic Meningioma | C04;C10 | Neoplastic Process | CTD_human |
| HES1 | Transitional Meningioma | C04;C10 | Neoplastic Process | CTD_human |
| HES1 | Oligodendroblastoma | C04 | Neoplastic Process | CTD_human |
| HES1 | Spinal Meningioma | C04;C10 | Neoplastic Process | CTD_human |
| HES1 | Intracranial Meningioma | C04;C10 | Neoplastic Process | CTD_human |
| HES1 | Clear Cell Meningioma | C04;C10 | Neoplastic Process | CTD_human |
| HES1 | Xanthomatous Meningioma | C04;C10 | Neoplastic Process | CTD_human |
| HES1 | Breast Carcinoma | C04;C17 | Neoplastic Process | CTD_human |
| HES1 | Ependymoblastoma | C04 | Neoplastic Process | CTD_human |
| HES1 | Cerebral Convexity Meningioma | C04;C10 | Neoplastic Process | CTD_human |
| HES1 | Parasagittal Meningioma | C04;C10 | Neoplastic Process | CTD_human |
| HES1 | Mixed Oligodendroglioma-Ependymoma | C04 | Neoplastic Process | CTD_human |
| HES1 | Well Differentiated Oligodendroglioma | C04 | Neoplastic Process | CTD_human |
| HES1 | Lymphangioleiomyomatosis | C04;C15;C20 | Neoplastic Process | CTD_human |
| HES1 | Cerebral Primitive Neuroectodermal Tumor | C04 | Neoplastic Process | CTD_human |
| HES1 | Carcinoma, Pancreatic Ductal | C04;C06;C19 | Neoplastic Process | CTD_human |
| HES1 | Mammary Neoplasms, Human | C04;C17 | Neoplastic Process | CTD_human |
| HES1 | Intraorbital Meningioma | C04;C10 | Neoplastic Process | CTD_human |
| HES1 | Intraventricular Meningioma | C04;C10 | Neoplastic Process | CTD_human |
| HES1 | Olfactory Groove Meningioma | C04;C10 | Neoplastic Process | CTD_human |
| HES1 | Secretory meningioma | C04;C10 | Neoplastic Process | CTD_human |
| HES1 | Microcystic meningioma | C04;C10 | Neoplastic Process | CTD_human |
| HES1 | Mammary Neoplasms | C04;C17 | Neoplastic Process | CTD_human |
| HES1 | Angioblastic Meningioma | C04;C10 | Neoplastic Process | CTD_human |
| HES1 | Posterior Fossa Meningioma | C04;C10 | Neoplastic Process | CTD_human |
| HES1 | Sphenoid Wing Meningioma | C04;C10 | Neoplastic Process | CTD_human |
| HES1 | Glioblastoma Multiforme | C04 | Neoplastic Process | CTD_human |
| HES1 | Papillary Meningioma | C04;C10 | Neoplastic Process | CTD_human |
| HES1 | cervical cancer | C04;C13 | Neoplastic Process | CTD_human |
| pathway_ID | pathway_name | pathway_source | gene_number | edge_number |
|---|---|---|---|---|
| pathway0000229 | ATF-2 transcription factor network | pid | 59 | 451 |
| pathway0000335 | C-MYB transcription factor network | pid | 87 | 525 |
| pathway0000483 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | reactome | 57 | 500 |
| pathway0000484 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | reactome | 57 | 500 |
| pathway0000752 | Fanconi anemia pathway | pid | 48 | 794 |
| pathway0001078 | ID | netpath | 38 | 213 |
| pathway0001516 | Notch-mediated HES/HEY network | pid | 48 | 337 |
| pathway0001517 | Notch | netpath | 76 | 661 |
| pathway0001524 | NOTCH1 Intracellular Domain Regulates Transcription | reactome | 47 | 463 |
| pathway0001526 | NOTCH2 intracellular domain regulates transcription | reactome | 12 | 53 |
| pathway0001837 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells | reactome | 7 | 9 |
| pathway0002393 | Validated transcriptional targets of deltaNp63 isoforms | pid | 47 | 101 |
| pathway0002589 | Notch signaling pathway | kegg | 44 | 313 |
| pathway0002631 | Maturity onset diabetes of the young | kegg | 25 | 76 |
| pathway0002825 | Hs_Gene_regulatory_network_modelling_somitogenesis_WP2854_87527 | wikipathways | 12 | 26 |
| GO_term_name | GO_term_type | TF_name |
|---|---|---|
| GO_METANEPHRIC_NEPHRON_MORPHOGENESIS | BP | HES1 |
| GO_LABYRINTHINE_LAYER_DEVELOPMENT | BP | HES1 |
| GO_SOMATIC_STEM_CELL_POPULATION_MAINTENANCE | BP | HES1 |
| GO_VENTRICULAR_SEPTUM_MORPHOGENESIS | BP | HES1 |
| GO_NEGATIVE_REGULATION_OF_OLIGODENDROCYTE_DIFFERENTIATION | BP | HES1 |
| GO_POSITIVE_REGULATION_OF_RESPONSE_TO_STIMULUS | BP | HES1 |
| GO_ESTABLISHMENT_OF_EPITHELIAL_CELL_POLARITY | BP | HES1 |
| GO_NEGATIVE_REGULATION_OF_GLIOGENESIS | BP | HES1 |
| GO_METANEPHRIC_EPITHELIUM_DEVELOPMENT | BP | HES1 |
| GO_SMOOTH_MUSCLE_CELL_DIFFERENTIATION | BP | HES1 |
| GO_NEGATIVE_REGULATION_OF_STEM_CELL_DIFFERENTIATION | BP | HES1 |
| GO_NEGATIVE_REGULATION_OF_GLIAL_CELL_DIFFERENTIATION | BP | HES1 |
| GO_POSITIVE_REGULATION_OF_GLIAL_CELL_DIFFERENTIATION | BP | HES1 |
| GO_POSITIVE_REGULATION_OF_NOTCH_SIGNALING_PATHWAY | BP | HES1 |
| GO_THYMUS_DEVELOPMENT | BP | HES1 |
| GO_PITUITARY_GLAND_DEVELOPMENT | BP | HES1 |
| GO_ARTERY_DEVELOPMENT | BP | HES1 |
| GO_POSITIVE_REGULATION_OF_T_CELL_PROLIFERATION | BP | HES1 |
| GO_VASCULAR_SMOOTH_MUSCLE_CELL_DIFFERENTIATION | BP | HES1 |
| GO_POSITIVE_REGULATION_OF_STAT_CASCADE | BP | HES1 |
| GO_POSITIVE_REGULATION_OF_ORGANELLE_ORGANIZATION | BP | HES1 |
| GO_CRANIAL_NERVE_DEVELOPMENT | BP | HES1 |
| GO_INNER_EAR_RECEPTOR_STEREOCILIUM_ORGANIZATION | BP | HES1 |
| GO_POSITIVE_REGULATION_OF_DNA_BINDING | BP | HES1 |
| GO_REGULATION_OF_ORGAN_FORMATION | BP | HES1 |
| GO_REGULATION_OF_ASTROCYTE_DIFFERENTIATION | BP | HES1 |
| GO_FOREBRAIN_GENERATION_OF_NEURONS | BP | HES1 |
| GO_PANCREAS_DEVELOPMENT | BP | HES1 |
| GO_POSITIVE_REGULATION_OF_LEUKOCYTE_PROLIFERATION | BP | HES1 |
| GO_CELL_MOTILITY | BP | HES1 |
| GO_AORTA_DEVELOPMENT | BP | HES1 |
| GO_REGULATION_OF_EPITHELIAL_CELL_DIFFERENTIATION | BP | HES1 |
| GO_PLACENTA_BLOOD_VESSEL_DEVELOPMENT | BP | HES1 |
| GO_EMBRYO_DEVELOPMENT | BP | HES1 |
| GO_ESTABLISHMENT_OF_CELL_POLARITY | BP | HES1 |
| GO_EPIDERMAL_CELL_DIFFERENTIATION | BP | HES1 |
| GO_EMBRYONIC_PLACENTA_DEVELOPMENT | BP | HES1 |
| GO_POSITIVE_REGULATION_OF_BMP_SIGNALING_PATHWAY | BP | HES1 |
| GO_NEGATIVE_REGULATION_OF_HEMATOPOIETIC_PROGENITOR_CELL_DIFFERENTIATION | BP | HES1 |
| GO_EMBRYONIC_HEART_TUBE_DEVELOPMENT | BP | HES1 |
| GO_ARTERY_MORPHOGENESIS | BP | HES1 |
| GO_REGULATION_OF_GLIAL_CELL_PROLIFERATION | BP | HES1 |
| GO_CELL_DIFFERENTIATION_INVOLVED_IN_KIDNEY_DEVELOPMENT | BP | HES1 |
| GO_CELL_MATURATION | BP | HES1 |
| GO_REGULATION_OF_HEART_MORPHOGENESIS | BP | HES1 |
| GO_REGULATION_OF_PEPTIDYL_TYROSINE_PHOSPHORYLATION | BP | HES1 |
| GO_ROSTROCAUDAL_NEURAL_TUBE_PATTERNING | BP | HES1 |
| GO_NEGATIVE_REGULATION_OF_GLIAL_CELL_PROLIFERATION | BP | HES1 |
| GO_LABYRINTHINE_LAYER_BLOOD_VESSEL_DEVELOPMENT | BP | HES1 |
| GO_RENAL_TUBULE_DEVELOPMENT | BP | HES1 |
| GO_MIDBRAIN_DEVELOPMENT | BP | HES1 |
| GO_GLOMERULUS_DEVELOPMENT | BP | HES1 |
| GO_MESONEPHRIC_TUBULE_MORPHOGENESIS | BP | HES1 |
| GO_STAT_CASCADE | BP | HES1 |
| GO_REGULATION_OF_OLIGODENDROCYTE_DIFFERENTIATION | BP | HES1 |
| GO_REGULATION_OF_INTRACELLULAR_PROTEIN_TRANSPORT | BP | HES1 |
| GO_CARDIAC_VENTRICLE_DEVELOPMENT | BP | HES1 |
| GO_AUDITORY_RECEPTOR_CELL_DIFFERENTIATION | BP | HES1 |
| GO_CELL_MORPHOGENESIS_INVOLVED_IN_DIFFERENTIATION | BP | HES1 |
| GO_METANEPHRIC_NEPHRON_DEVELOPMENT | BP | HES1 |
| GO_EMBRYONIC_MORPHOGENESIS | BP | HES1 |
| GO_NEGATIVE_REGULATION_OF_EPIDERMIS_DEVELOPMENT | BP | HES1 |
| GO_REGULATION_OF_NOTCH_SIGNALING_PATHWAY | BP | HES1 |
| GO_VENTRICULAR_SEPTUM_DEVELOPMENT | BP | HES1 |
| GO_POSITIVE_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT3_PROTEIN | BP | HES1 |
| GO_REGULATION_OF_EPIDERMAL_CELL_DIFFERENTIATION | BP | HES1 |
| GO_REGULATION_OF_HEMATOPOIETIC_PROGENITOR_CELL_DIFFERENTIATION | BP | HES1 |
| GO_NEURONAL_STEM_CELL_POPULATION_MAINTENANCE | BP | HES1 |
| GO_MECHANORECEPTOR_DIFFERENTIATION | BP | HES1 |
| GO_CELL_FATE_DETERMINATION | BP | HES1 |
| GO_NEGATIVE_REGULATION_OF_EPIDERMAL_CELL_DIFFERENTIATION | BP | HES1 |
| GO_HAIR_CELL_DIFFERENTIATION | BP | HES1 |
| GO_POSITIVE_REGULATION_OF_PEPTIDYL_TYROSINE_PHOSPHORYLATION | BP | HES1 |
| GO_RENAL_SYSTEM_VASCULATURE_DEVELOPMENT | BP | HES1 |
| GO_COCHLEA_DEVELOPMENT | BP | HES1 |
| GO_REGULATION_OF_CELL_PROLIFERATION_INVOLVED_IN_HEART_MORPHOGENESIS | BP | HES1 |
| GO_HINDBRAIN_MORPHOGENESIS | BP | HES1 |
| GO_PHARYNGEAL_SYSTEM_DEVELOPMENT | BP | HES1 |
| GO_NEGATIVE_REGULATION_OF_EPITHELIAL_CELL_DIFFERENTIATION | BP | HES1 |
| GO_SMOOTHENED_SIGNALING_PATHWAY | BP | HES1 |
| GO_REGULATION_OF_DEVELOPMENT_HETEROCHRONIC | BP | HES1 |
| GO_REGULATION_OF_GLIAL_CELL_DIFFERENTIATION | BP | HES1 |
| GO_AUTONOMIC_NERVOUS_SYSTEM_DEVELOPMENT | BP | HES1 |
| GO_NEUROEPITHELIAL_CELL_DIFFERENTIATION | BP | HES1 |
| GO_ENDOCRINE_SYSTEM_DEVELOPMENT | BP | HES1 |
| GO_REGULATION_OF_EMBRYONIC_DEVELOPMENT | BP | HES1 |
| GO_CELL_PROJECTION_ORGANIZATION | BP | HES1 |
| GO_STEM_CELL_DIFFERENTIATION | BP | HES1 |
| GO_NEURON_FATE_COMMITMENT | BP | HES1 |
| GO_REGULATION_OF_TYROSINE_PHOSPHORYLATION_OF_STAT3_PROTEIN | BP | HES1 |
| GO_PLACENTA_DEVELOPMENT | BP | HES1 |
| GO_CARDIAC_SEPTUM_MORPHOGENESIS | BP | HES1 |
| GO_ADENOHYPOPHYSIS_DEVELOPMENT | BP | HES1 |
| GO_POSITIVE_REGULATION_OF_EMBRYONIC_DEVELOPMENT | BP | HES1 |
| GO_POSITIVE_REGULATION_OF_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_SIGNALING_PATHWAY | BP | HES1 |
| GO_REGULATION_OF_CELLULAR_PROTEIN_LOCALIZATION | BP | HES1 |
| GO_PARASYMPATHETIC_NERVOUS_SYSTEM_DEVELOPMENT | BP | HES1 |
| GO_AORTA_MORPHOGENESIS | BP | HES1 |
| GO_EPITHELIAL_CELL_FATE_COMMITMENT | BP | HES1 |
| GO_POSITIVE_REGULATION_OF_ASTROCYTE_DIFFERENTIATION | BP | HES1 |
| GO_NEURAL_TUBE_PATTERNING | BP | HES1 |
| GO_INNER_EAR_RECEPTOR_CELL_DEVELOPMENT | BP | HES1 |
| GO_METANEPHROS_MORPHOGENESIS | BP | HES1 |
| GO_POSITIVE_REGULATION_OF_GLIOGENESIS | BP | HES1 |
| GO_HISTONE_DEACETYLASE_BINDING | MF | HES1 |
| GO_REGULATORY_REGION_NUCLEIC_ACID_BINDING | MF | HES1 |
| GO_CHAPERONE_BINDING | MF | HES1 |