TF information
| TF name: | TP73 |
| TF family: | P53 |
| Ensembl gene ID: | ENSG00000078900 |
| Ensembl protein ID: | ENSP00000367537, ENSP00000367534, ENSP00000340740, ENSP00000367529, ENSP00000474322, ENSP00000367539, ENSP00000367545, ENSP00000346423, ENSP00000474626, ENSP00000350366, ENSP00000475143 |
| Entrez gene ID: | 7161 |
| Database name | Link | Database name | Link |
| NCBI Gene: |  |
Genecards: |  |
| Uniprot: |  |
Wikipedia: |  |
| Cosmic 3D: |  |
Geneontology: |  |
| CCLE: |  |
Frequency of TP73 in all biosamples
| Sample ID | Biosample type | Tissue type | Biosample name | TF Frequency |
|---|---|---|---|---|
| Sample_02_228 | Cell line | Oesophagus | KYSE510 | 0.13886300093197 |
TP73 distribution in samples’ most representative CRC
| Sample ID | Tissue type | Biosample type | Biosample name |
|---|
TP73 distribution in all CRCs
Genomic distribution of SEs associated with TP73
Genomic distribution of SEs associated with TF
Figure legend:
Genomic distribution of SEs associated with TF: It can roughly understand the genomic regions of SEs associated with TF, and help to carry out the next analysis, such as knocking down the experiment.
What is important information?
The yellow box can be thought of as the common genomic regions that regulates the SEs associated with TF. For example, if a knockdown experiment is performed on this region, then theoretically, the expression of the TF will be greatly reduced.
| Database name | Link |
|---|---|
| Cosmic: |  |
| Cosmic cell lines: |  |
| Depmap: |  |
TCGA somatic mutations and clinical variants of TP73
| rsID | Chr | Start | Stop | Ref | Alt | Gene_region | Gene_symble | Effect | TCGA_Occurrence |
|---|---|---|---|---|---|---|---|---|---|
| - | chr1 | 3624130 | 3624130 | G | A | exonic | TP73 | synonymous | BLCA|1|396|0.00253 |
| - | chr1 | 3647493 | 3647493 | C | G | exonic | TP73 | nonsynonymous | SKCM|1|368|0.00272 |
| - | chr1 | 3638591 | 3638591 | C | T | exonic | TP73 | nonsynonymous | UCEC|1|248|0.00403 |
| - | chr1 | 3598993 | 3598993 | C | T | exonic | TP73 | synonymous | CESC|1|194|0.00515 |
| - | chr1 | 3639990 | 3639990 | T | A | exonic | TP73 | nonsynonymous | SKCM|1|368|0.00272 |
| rs530648280 | chr1 | 3649416 | 3649416 | C | T | exonic | TP73 | nonsynonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204,LUAD|4|543|0.00737 |
| - | chr1 | 3649564 | 3649564 | A | G | exonic | TP73 | nonsynonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr1 | 3599704 | 3599704 | T | C | exonic | TP73 | nonsynonymous | KIPAN|1|799|0.00125,KIRC|1|451|0.00222 |
| - | chr1 | 3638726 | 3638726 | G | A | exonic | TP73 | nonsynonymous | CESC|1|194|0.00515 |
| - | chr1 | 3649571 | 3649571 | C | T | exonic | TP73 | synonymous | CESC|1|194|0.00515 |
| - | chr1 | 3624237 | 3624237 | C | T | exonic | TP73 | nonsynonymous | BRCA|1|982|0.00102 |
| - | chr1 | 3639996 | 3639996 | G | C | exonic | TP73 | nonsynonymous | ESCA|1|185|0.00541 |
| - | chr1 | 3624323 | 3624323 | C | T | exonic | TP73 | stopgain | KIPAN|1|799|0.00125,KIRC|1|451|0.00222 |
| - | chr1 | 3639930 | 3639930 | C | T | exonic | TP73 | nonsynonymous | ACC|1|90|0.01111 |
| - | chr1 | 3646622 | 3646622 | G | T | exonic | TP73 | nonsynonymous | LUAD|1|543|0.00184 |
| - | chr1 | 3638614 | 3638614 | C | T | exonic | TP73 | synonymous | CESC|1|194|0.00515 |
| - | chr1 | 3638759 | 3638759 | G | A | exonic | TP73 | nonsynonymous | SKCM|1|368|0.00272 |
| - | chr1 | 3639953 | 3639953 | G | A | exonic | TP73 | nonsynonymous | SKCM|1|368|0.00272 |
| - | chr1 | 3624233 | 3624233 | A | G | exonic | TP73 | nonsynonymous | SKCM|1|368|0.00272 |
| - | chr1 | 3599737 | 3599737 | C | G | exonic | TP73 | nonsynonymous | LUAD|1|543|0.00184 |
| - | chr1 | 3639972 | 3639972 | - | TAT | exonic | TP73 | nonframeshift | CESC|1|194|0.00515 |
| - | chr1 | 3599745 | 3599745 | G | A | splicing | TP73 | splicing | LIHC|1|373|0.00268,LUAD|1|543|0.00184 |
| rs374066676 | chr1 | 3644768 | 3644768 | C | T | exonic | TP73 | nonsynonymous | SKCM|1|368|0.00272 |
| rs771419405 | chr1 | 3640009 | 3640009 | C | T | exonic | TP73 | synonymous | SKCM|1|368|0.00272 |
| - | chr1 | 3624317 | 3624317 | T | G | exonic | TP73 | nonsynonymous | UCS|1|57|0.01754 |
| - | chr1 | 3624302 | 3624302 | C | T | exonic | TP73 | nonsynonymous | BLCA|1|396|0.00253 |
| - | chr1 | 3624325 | 3624325 | G | T | exonic | TP73 | nonsynonymous | OV|1|469|0.00213 |
| rs764078571 | chr1 | 3598953 | 3598953 | C | T | exonic | TP73 | synonymous | SARC|1|247|0.00405 |
| rs746207826 | chr1 | 3624162 | 3624162 | C | T | exonic | TP73 | nonsynonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| rs776097108 | chr1 | 3645962 | 3645962 | G | A | exonic | TP73 | synonymous | BLCA|1|396|0.00253,COAD|1|367|0.00272,COADREAD|1|489|0.00204,PAAD|2|185|0.01081 |
| - | chr1 | 3624244 | 3624244 | C | T | exonic | TP73 | synonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr1 | 3649318 | 3649318 | G | C | exonic | TP73 | nonsynonymous | BLCA|1|396|0.00253 |
| - | chr1 | 3644235 | 3644235 | G | A | exonic | TP73 | nonsynonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| rs774822513 | chr1 | 3638720 | 3638720 | G | A | exonic | TP73 | nonsynonymous | CESC|1|194|0.00515,PAAD|1|185|0.00541 |
| rs146218192 | chr1 | 3599709 | 3599709 | G | A | exonic | TP73 | nonsynonymous | KICH|1|66|0.01515,KIPAN|1|799|0.00125 |
| - | chr1 | 3644231 | 3644231 | C | T | exonic | TP73 | synonymous | BLCA|1|396|0.00253 |
| - | chr1 | 3638708 | 3638708 | G | C | exonic | TP73 | nonsynonymous | BLCA|1|396|0.00253 |
| - | chr1 | 3640003 | 3640003 | G | A | exonic | TP73 | synonymous | BLCA|1|396|0.00253 |
| - | chr1 | 3644215 | 3644215 | C | T | exonic | TP73 | nonsynonymous | SKCM|1|368|0.00272 |
| - | chr1 | 3624240 | 3624240 | C | T | exonic | TP73 | nonsynonymous | THCA|1|504|0.00198 |
| rs752617133 | chr1 | 3644760 | 3644760 | C | T | exonic | TP73 | synonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| rs747896985 | chr1 | 3649497 | 3649497 | C | T | exonic | TP73 | nonsynonymous | BLCA|1|396|0.00253 |
| rs771056792 | chr1 | 3638592 | 3638592 | C | T | exonic | TP73 | nonsynonymous | THYM|1|123|0.00813 |
| - | chr1 | 3647612 | 3647612 | C | T | exonic | TP73 | stopgain | UCEC|1|248|0.00403 |
| rs369898417 | chr1 | 3648065 | 3648065 | A | G | exonic | TP73 | nonsynonymous | PRAD|1|499|0.00200 |
| - | chr1 | 3647598 | 3647598 | C | - | exonic | TP73 | frameshift | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr1 | 3638739 | 3638739 | C | T | exonic | TP73 | nonsynonymous | LAML|1|197|0.00508 |
| - | chr1 | 3599647 | 3599647 | A | C | exonic | TP73 | nonsynonymous | LUAD|2|543|0.00368 |
| - | chr1 | 3638723 | 3638723 | G | T | exonic | TP73 | nonsynonymous | LUAD|1|543|0.00184 |
| - | chr1 | 3644260 | 3644260 | C | T | exonic | TP73 | nonsynonymous | TGCT|1|155|0.00645 |
| - | chr1 | 3624293 | 3624293 | G | T | exonic | TP73 | stopgain | CESC|1|194|0.00515 |
| rs375226336 | chr1 | 3643784 | 3643784 | C | T | exonic | TP73 | nonsynonymous | PRAD|1|499|0.00200 |
| rs201857112 | chr1 | 3646582 | 3646582 | G | A | exonic | TP73 | synonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204,UCEC|1|248|0.00403 |
| - | chr1 | 3638723 | 3638724 | GT | - | exonic | TP73 | frameshift | CESC|1|194|0.00515 |
| rs771075520 | chr1 | 3647495 | 3647495 | C | T | exonic | TP73 | nonsynonymous | SKCM|1|368|0.00272 |
| - | chr1 | 3638768 | 3638768 | G | T | exonic | TP73 | stopgain | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr1 | 3638758 | 3638758 | G | A | exonic | TP73 | synonymous | SKCM|3|368|0.00815 |
| rs781452147 | chr1 | 3624161 | 3624161 | G | A | exonic | TP73 | nonsynonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr1 | 3649534 | 3649534 | G | T | exonic | TP73 | nonsynonymous | TGCT|1|155|0.00645 |
| rs751836786 | chr1 | 3599693 | 3599693 | G | A | exonic | TP73 | synonymous | SKCM|1|368|0.00272 |
| - | chr1 | 3644716 | 3644716 | G | T | exonic | TP73 | nonsynonymous | ESCA|1|185|0.00541 |
| - | chr1 | 3645929 | 3645929 | G | T | exonic | TP73 | synonymous | CESC|1|194|0.00515 |
| - | chr1 | 3599659 | 3599659 | C | T | exonic | TP73 | nonsynonymous | BRCA|1|982|0.00102 |
| - | chr1 | 3624158 | 3624177 | CGCGCGGCCTCGGCCAGCCC | - | exonic | TP73 | frameshift | LUAD|1|543|0.00184 |
| - | chr1 | 3646622 | 3646622 | G | - | exonic | TP73 | frameshift | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| rs775511685 | chr1 | 3638707 | 3638707 | G | A | exonic | TP73 | synonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr1 | 3638670 | 3638670 | G | T | exonic | TP73 | nonsynonymous | UCEC|1|248|0.00403 |
| - | chr1 | 3599744 | 3599744 | G | - | exonic | TP73 | frameshift | LIHC|1|373|0.00268 |
| - | chr1 | 3624151 | 3624151 | G | A | exonic | TP73 | nonsynonymous | THCA|1|504|0.00198 |
| rs574845163 | chr1 | 3647593 | 3647593 | C | T | exonic | TP73 | nonsynonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr1 | 3638665 | 3638665 | C | T | exonic | TP73 | synonymous | SKCM|2|368|0.00543 |
| rs755616910 | chr1 | 3599708 | 3599708 | C | T | exonic | TP73 | synonymous | HNSC|1|512|0.00195 |
| rs749787981 | chr1 | 3624168 | 3624168 | C | T | exonic | TP73 | nonsynonymous | BLCA|2|396|0.00505 |
| rs868380825 | chr1 | 3598964 | 3598964 | G | A | exonic | TP73 | nonsynonymous | UCEC|1|248|0.00403 |
| rs139554277 | chr1 | 3646621 | 3646621 | C | T | exonic | TP73 | synonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| rs202137544 | chr1 | 3644716 | 3644716 | G | A | exonic | TP73 | nonsynonymous | UCEC|1|248|0.00403 |
| rs755077036 | chr1 | 3607508 | 3607508 | G | T | exonic | TP73 | synonymous | TGCT|1|155|0.00645 |
| - | chr1 | 3644706 | 3644706 | C | - | exonic | TP73 | frameshift | COAD|1|367|0.00272,COADREAD|1|489|0.00204,STAD|1|395|0.00253,STES|1|395|0.00253 |
| rs753917723 | chr1 | 3639969 | 3639969 | C | T | exonic | TP73 | nonsynonymous | CESC|1|194|0.00515 |
| - | chr1 | 3645988 | 3645988 | - | G | exonic | TP73 | frameshift | KIPAN|1|799|0.00125,KIRC|1|451|0.00222 |
| rs142165895 | chr1 | 3638722 | 3638722 | C | T | exonic | TP73 | synonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr1 | 3599677 | 3599677 | A | G | exonic | TP73 | nonsynonymous | THCA|1|504|0.00198 |
| rs761898929 | chr1 | 3624256 | 3624256 | G | A | exonic | TP73 | synonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| rs148777835 | chr1 | 3599692 | 3599692 | C | T | exonic | TP73 | nonsynonymous | ESCA|1|185|0.00541 |
| - | chr1 | 3646013 | 3646013 | G | - | splicing | TP73 | unknown | UCEC|1|248|0.00403 |
| - | chr1 | 3647494 | 3647494 | C | G | exonic | TP73 | nonsynonymous | SKCM|1|368|0.00272 |
| TF_name | Disease_name | Disease_class | Disease_semantic_type | TF_disease_source |
|---|---|---|---|---|
| TP73 | Malignant neoplasm of breast | C04;C17 | Neoplastic Process | CTD_human |
| TP73 | Inflammation | C23 | Pathologic Function | CTD_human |
| TP73 | Adult T-Cell Lymphoma/Leukemia | C04;C15;C20 | Neoplastic Process | CTD_human |
| TP73 | Lung Neoplasms | C04;C08 | Neoplastic Process | CTD_human |
| TP73 | Small cell carcinoma of lung | C04;C08 | Neoplastic Process | ORPHANET |
| TP73 | Alveolar rhabdomyosarcoma | C04 | Neoplastic Process | CTD_human |
| TP73 | Malignant neoplasm of lung | C04;C08 | Neoplastic Process | CTD_human |
| TP73 | Breast Carcinoma | C04;C17 | Neoplastic Process | CTD_human |
| TP73 | Mammary Neoplasms, Human | C04;C17 | Neoplastic Process | CTD_human |
| TP73 | Mammary Neoplasms | C04;C17 | Neoplastic Process | CTD_human |
| pathway_ID | pathway_name | pathway_source | gene_number | edge_number |
|---|---|---|---|---|
| pathway0000075 | Activation of PUMA and translocation to mitochondria | reactome | 8 | 24 |
| pathway0001577 | p53 pathway by glucose deprivation | panther | 21 | 124 |
| pathway0001578 | p53 pathway | panther | 39 | 274 |
| pathway0001580 | P53 pathway feedback loops 1 | panther | 6 | 16 |
| pathway0001581 | p53 pathway feedback loops 2 | panther | 42 | 372 |
| pathway0001864 | Regulation of TP53 Activity through Association with Co-factors | reactome | 14 | 26 |
| pathway0002271 | TP53 Regulates Transcription of Caspase Activators and Caspases | reactome | 12 | 33 |
| pathway0002272 | TP53 Regulates Transcription of Death Receptors and Ligands | reactome | 12 | 29 |
| pathway0002274 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release | reactome | 19 | 53 |
| pathway0002277 | TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain | reactome | 14 | 26 |
| pathway0002575 | p53 signaling pathway | kegg | 66 | 297 |
| pathway0002617 | Neurotrophin signaling pathway | kegg | 126 | 2153 |
| pathway0002691 | Hs_DNA_Damage_Response_(only_ATM_dependent)_WP710_79974 | wikipathways | 36 | 219 |
| pathway0002692 | Hs_TP53_Network_WP1742_71700 | wikipathways | 10 | 32 |
| pathway0002737 | Hs_Regulation_of_Actin_Cytoskeleton_WP51_79977 | wikipathways | 36 | 58 |
| pathway0002752 | Hs_ATM_Signaling_Pathway_WP2516_90247 | wikipathways | 32 | 187 |
| pathway0002753 | Hs_DNA_IR-Double_Strand_Breaks_(DSBs)_and_cellular_response_via_ATM_WP3959_91367 | wikipathways | 50 | 393 |
| GO_term_name | GO_term_type | TF_name |
|---|---|---|
| GO_NEGATIVE_REGULATION_OF_NEURON_APOPTOTIC_PROCESS | BP | TP73 |
| GO_RESPONSE_TO_IONIZING_RADIATION | BP | TP73 |
| GO_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE_BY_P53_CLASS_MEDIATOR | BP | TP73 |
| GO_NEGATIVE_REGULATION_OF_CELL_DEVELOPMENT | BP | TP73 |
| GO_REGULATION_OF_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT | BP | TP73 |
| GO_CELLULAR_RESPONSE_TO_UV | BP | TP73 |
| GO_CELLULAR_RESPONSE_TO_LIGHT_STIMULUS | BP | TP73 |
| GO_POSITIVE_REGULATION_OF_GLIAL_CELL_DIFFERENTIATION | BP | TP73 |
| GO_MITOCHONDRIAL_TRANSPORT | BP | TP73 |
| GO_REGULATION_OF_PROTEIN_INSERTION_INTO_MITOCHONDRIAL_MEMBRANE_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY | BP | TP73 |
| GO_NEGATIVE_REGULATION_OF_JUN_KINASE_ACTIVITY | BP | TP73 |
| GO_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE | BP | TP73 |
| GO_REGULATION_OF_CARDIAC_MUSCLE_CELL_PROLIFERATION | BP | TP73 |
| GO_NEGATIVE_REGULATION_OF_MAPK_CASCADE | BP | TP73 |
| GO_NEGATIVE_REGULATION_OF_DEVELOPMENTAL_GROWTH | BP | TP73 |
| GO_NEGATIVE_REGULATION_OF_ORGAN_GROWTH | BP | TP73 |
| GO_REGULATION_OF_MITOCHONDRION_ORGANIZATION | BP | TP73 |
| GO_POSITIVE_REGULATION_OF_MITOCHONDRION_ORGANIZATION | BP | TP73 |
| GO_POSITIVE_REGULATION_OF_OLIGODENDROCYTE_DIFFERENTIATION | BP | TP73 |
| GO_MITOCHONDRIAL_MEMBRANE_ORGANIZATION | BP | TP73 |
| GO_SIGNAL_TRANSDUCTION_IN_RESPONSE_TO_DNA_DAMAGE | BP | TP73 |
| GO_G1_DNA_DAMAGE_CHECKPOINT | BP | TP73 |
| GO_REGULATION_OF_OLIGODENDROCYTE_DIFFERENTIATION | BP | TP73 |
| GO_MITOTIC_DNA_INTEGRITY_CHECKPOINT | BP | TP73 |
| GO_MITOTIC_CELL_CYCLE_CHECKPOINT | BP | TP73 |
| GO_NEGATIVE_REGULATION_OF_JNK_CASCADE | BP | TP73 |
| GO_NEGATIVE_REGULATION_OF_CELL_CYCLE_PHASE_TRANSITION | BP | TP73 |
| GO_NEGATIVE_REGULATION_OF_CELL_CYCLE_G1_S_PHASE_TRANSITION | BP | TP73 |
| GO_REGULATION_OF_MITOCHONDRIAL_OUTER_MEMBRANE_PERMEABILIZATION_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY | BP | TP73 |
| GO_POSITIVE_REGULATION_OF_PROTEIN_MODIFICATION_PROCESS | BP | TP73 |
| GO_NEGATIVE_REGULATION_OF_STRESS_ACTIVATED_PROTEIN_KINASE_SIGNALING_CASCADE | BP | TP73 |
| GO_MISMATCH_REPAIR | BP | TP73 |
| GO_RESPONSE_TO_GAMMA_RADIATION | BP | TP73 |
| GO_REGULATION_OF_CELL_DEATH | BP | TP73 |
| GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_STIMULUS | BP | TP73 |
| GO_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_BY_P53_CLASS_MEDIATOR | BP | TP73 |
| GO_MEMBRANE_ORGANIZATION | BP | TP73 |
| GO_NEGATIVE_REGULATION_OF_MUSCLE_TISSUE_DEVELOPMENT | BP | TP73 |
| GO_REGULATION_OF_HEART_GROWTH | BP | TP73 |
| GO_RESPONSE_TO_X_RAY | BP | TP73 |
| GO_POSITIVE_REGULATION_OF_MITOCHONDRIAL_OUTER_MEMBRANE_PERMEABILIZATION_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY | BP | TP73 |
| GO_CELL_CYCLE_CHECKPOINT | BP | TP73 |
| GO_NEGATIVE_REGULATION_OF_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT | BP | TP73 |
| GO_REGULATION_OF_MEMBRANE_PERMEABILITY | BP | TP73 |
| GO_REGULATION_OF_GLIOGENESIS | BP | TP73 |
| GO_NEGATIVE_REGULATION_OF_NEURON_DEATH | BP | TP73 |
| GO_REGULATION_OF_JUN_KINASE_ACTIVITY | BP | TP73 |
| GO_NEGATIVE_REGULATION_OF_HEART_GROWTH | BP | TP73 |
| GO_CELLULAR_RESPONSE_TO_DNA_DAMAGE_STIMULUS | BP | TP73 |
| GO_POSITIVE_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION | BP | TP73 |
| GO_DNA_DAMAGE_RESPONSE_SIGNAL_TRANSDUCTION_RESULTING_IN_TRANSCRIPTION | BP | TP73 |
| GO_TRANSCRIPTIONAL_ACTIVATOR_ACTIVITY_RNA_POLYMERASE_II_TRANSCRIPTION_REGULATORY_REGION_SEQUENCE_SPECIFIC_BINDING | MF | TP73 |
| GO_DAMAGED_DNA_BINDING | MF | TP73 |
| GO_P53_BINDING | MF | TP73 |