Cancer CRCdb

TF information

TF name:	TFAP2A
TF family:	AP-2
Ensembl gene ID:	ENSG00000137203
Ensembl protein ID:	ENSP00000419961, ENSP00000368928, ENSP00000418541, ENSP00000316516, ENSP00000417735, ENSP00000417495, ENSP00000368933, ENSP00000419696
Entrez gene ID:	7020

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of TFAP2A in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_02_006	Other	Cervical	cervical-cancer_parental	0.5
Sample_02_007	Other	Cervical	cervical-cancer_vector	0.45033112582781
Sample_02_021	Cell line	Colon	V429	0.88008071490343
Sample_02_029	Cell line	Colorectal	LS174T	0.33333333333333
Sample_02_069	Cell line	Brain	SF268	0.16030534351145
Sample_02_079	Cell line	Mammary Gland	T-47D_1	1
Sample_02_080	Cell line	Lung	Calu-3	0.31818181818182
Sample_02_095	Cell line	Mammary Gland	MDA-MB-468	0.45719844357977
Sample_02_096	Cell line	Mammary Gland	ZR-75-1_1	1
Sample_02_114	Cell line	Mammary Gland	CAL51	0.92964824120603
Sample_02_115	Cell line	Mammary Gland	MCF-7	0.6
Sample_02_166	Cell line	Mammary Gland	HCC1954_Parental	0.6
Sample_02_179	Cell line	Urinary bladder	T24	0.94252873563218
Sample_02_180	Cell line	Human melanoma	CJM	0.625
Sample_02_182	Cell line	Human melanoma	LOX-IMVI	0.30747126436782
Sample_02_184	Cell line	Skin	SKMEL30	0.20578778135048
Sample_02_196	Cell line	Stomach	NCC59	0.35714285714286
Sample_02_219	Cell line	Mammary Gland	MDA-MB-231	1
Sample_02_228	Cell line	Oesophagus	KYSE510	0.8685927306617
Sample_02_258	Other	Lung	NCI-H1299_EGFP-NEO_reporter_cells_DMSO	0.055555555555556
Sample_02_358	Cell line	Colon	LS180	0.82030015797788
Sample_02_359	Cell line	Colon	Colo741	0.48795180722892
Sample_02_394	Cell line	Mammary Gland	T-47D_2	1
Sample_02_395	Cell line	Mammary Gland	BT-549	0.68559440559441
Sample_02_403	Cell line	Mammary Gland	T-47D_untreat	1
Sample_02_404	Cell line	Mammary Gland	ZR-75-1_2	0.56115107913669

TFAP2A distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name
Sample_02_006	Cervical	Other	cervical-cancer_parental
Sample_02_007	Cervical	Other	cervical-cancer_vector
Sample_02_021	Colon	Cell line	V429
Sample_02_029	Colorectal	Cell line	LS174T
Sample_02_079	Mammary Gland	Cell line	T-47D_1
Sample_02_096	Mammary Gland	Cell line	ZR-75-1_1
Sample_02_114	Mammary Gland	Cell line	CAL51
Sample_02_166	Mammary Gland	Cell line	HCC1954_Parental
Sample_02_179	Urinary bladder	Cell line	T24
Sample_02_219	Mammary Gland	Cell line	MDA-MB-231
Sample_02_228	Oesophagus	Cell line	KYSE510
Sample_02_358	Colon	Cell line	LS180
Sample_02_359	Colon	Cell line	Colo741
Sample_02_394	Mammary Gland	Cell line	T-47D_2
Sample_02_395	Mammary Gland	Cell line	BT-549
Sample_02_403	Mammary Gland	Cell line	T-47D_untreat
Sample_02_404	Mammary Gland	Cell line	ZR-75-1_2

TFAP2A distribution in all CRCs

Genomic distribution of SEs associated with TFAP2A

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Mutation of TFAP2A

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of TFAP2A

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr6	10398662	10398662	C	G	exonic	TFAP2A	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr6	10402728	10402728	C	A	exonic	TFAP2A	stopgain	ESCA\|1\|185\|0.00541
-	chr6	10410495	10410495	G	A	exonic	TFAP2A	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	10398754	10398754	C	T	exonic	TFAP2A	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr6	10404875	10404875	G	T	exonic	TFAP2A	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr6	10402804	10402804	T	-	exonic	TFAP2A	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs1803117	chr6	10400743	10400743	G	A	exonic	TFAP2A	synonymous	HNSC\|1\|512\|0.00195
-	chr6	10404773	10404773	G	C	exonic	TFAP2A	synonymous	BLCA\|1\|396\|0.00253
-	chr6	10404880	10404880	C	T	exonic	TFAP2A	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr6	10398904	10398904	G	C	exonic	TFAP2A	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr6	10398686	10398686	G	T	exonic	TFAP2A	synonymous	SKCM\|1\|368\|0.00272
-	chr6	10404901	10404901	C	T	exonic	TFAP2A	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr6	10398887	10398887	C	T	exonic	TFAP2A	synonymous	LUAD\|4\|543\|0.00737
rs756122879	chr6	10400781	10400781	C	T	exonic	TFAP2A	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr6	10410368	10410368	C	T	exonic	TFAP2A	synonymous	BRCA\|1\|982\|0.00102
-	chr6	10400725	10400725	A	T	exonic	TFAP2A	nonsynonymous	SARC\|1\|247\|0.00405
-	chr6	10398847	10398847	G	C	exonic	TFAP2A	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr6	10410284	10410284	C	G	exonic	TFAP2A	synonymous	LUAD\|1\|543\|0.00184
-	chr6	10410439	10410439	G	A	exonic	TFAP2A	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr6	10402728	10402728	C	G	exonic	TFAP2A	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr6	10398657	10398657	C	T	exonic	TFAP2A	nonsynonymous	BRCA\|1\|982\|0.00102,HNSC\|1\|512\|0.00195
-	chr6	10398872	10398872	G	A	exonic	TFAP2A	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	10410388	10410388	C	T	exonic	TFAP2A	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr6	10404842	10404842	G	T	exonic	TFAP2A	synonymous	LUAD\|1\|543\|0.00184
-	chr6	10400775	10400775	C	T	exonic	TFAP2A	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,UCEC\|2\|248\|0.00806
rs151344526	chr6	10404781	10404781	C	T	exonic	TFAP2A	nonsynonymous	CESC\|1\|194\|0.00515,HNSC\|1\|512\|0.00195
-	chr6	10410153	10410153	T	C	exonic	TFAP2A	nonsynonymous	KICH\|1\|66\|0.01515,KIPAN\|1\|799\|0.00125
-	chr6	10410138	10410138	A	G	exonic	TFAP2A	nonsynonymous	BRCA\|2\|982\|0.00204
-	chr6	10410399	10410399	G	A	exonic	TFAP2A	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr6	10404933	10404933	G	A	exonic	TFAP2A	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr6	10410393	10410393	G	A	exonic	TFAP2A	nonsynonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
rs575186761	chr6	10400727	10400727	C	T	exonic	TFAP2A	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr6	10415182	10415182	C	A	exonic	TFAP2A	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr6	10398786	10398786	G	A	exonic	TFAP2A	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr6	10410440	10410440	G	A	exonic	TFAP2A	synonymous	SKCM\|1\|368\|0.00272
-	chr6	10419699	10419699	C	A	UTR5	TFAP2A	unknown	PAAD\|1\|185\|0.00541
-	chr6	10402829	10402829	T	-	exonic	TFAP2A	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	10398921	10398921	A	C	exonic	TFAP2A	nonsynonymous	BRCA\|1\|982\|0.00102
rs779173083	chr6	10410446	10410446	T	G	exonic	TFAP2A	synonymous	LUAD\|1\|543\|0.00184
-	chr6	10402739	10402739	G	T	exonic	TFAP2A	nonsynonymous	TGCT\|1\|155\|0.00645
-	chr6	10400783	10400783	C	A	exonic	TFAP2A	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr6	10400738	10400738	C	G	exonic	TFAP2A	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr6	10398750	10398750	G	T	exonic	TFAP2A	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr6	10410338	10410338	C	T	exonic	TFAP2A	synonymous	BLCA\|1\|396\|0.00253
rs201591227	chr6	10398708	10398708	T	G	exonic	TFAP2A	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr6	10404834	10404834	G	T	exonic	TFAP2A	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr6	10415202	10415202	G	A	exonic	TFAP2A	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr6	10398689	10398689	G	C	exonic	TFAP2A	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr6	10400698	10400698	-	T	exonic	TFAP2A	frameshift	SKCM\|1\|368\|0.00272
-	chr6	10410431	10410431	G	A	exonic	TFAP2A	synonymous	SKCM\|2\|368\|0.00543
-	chr6	10404933	10404933	G	C	exonic	TFAP2A	nonsynonymous	HNSC\|1\|512\|0.00195,LUAD\|1\|543\|0.00184
-	chr6	10398931	10398931	A	G	exonic	TFAP2A	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr6	10419659	10419659	C	A	exonic	TFAP2A	nonsynonymous	LUAD\|1\|543\|0.00184,SKCM\|1\|368\|0.00272
rs754476051	chr6	10410434	10410434	T	G	exonic	TFAP2A	synonymous	PAAD\|1\|185\|0.00541
-	chr6	10407038	10407038	C	-	exonic	TFAP2A	stopgain	ESCA\|1\|185\|0.00541
-	chr6	10398935	10398935	C	G	exonic	TFAP2A	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr6	10407063	10407063	C	G	exonic	TFAP2A	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr6	10404765	10404765	G	A	exonic	TFAP2A	nonsynonymous	CESC\|1\|194\|0.00515
rs779059756	chr6	10398806	10398806	G	A	exonic	TFAP2A	synonymous	LUAD\|1\|543\|0.00184
-	chr6	10410329	10410329	G	C	exonic	TFAP2A	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs745981703	chr6	10398701	10398701	G	A	exonic	TFAP2A	synonymous	HNSC\|1\|512\|0.00195
-	chr6	10410525	10410525	-	G	exonic	TFAP2A	frameshift	HNSC\|1\|512\|0.00195
rs377114324	chr6	10400787	10400787	C	T	exonic	TFAP2A	nonsynonymous	UCEC\|1\|248\|0.00403
rs766641930	chr6	10410257	10410257	C	T	exonic	TFAP2A	synonymous	UCEC\|1\|248\|0.00403
-	chr6	10404842	10404842	G	A	exonic	TFAP2A	synonymous	BLCA\|1\|396\|0.00253
rs200131527	chr6	10410363	10410363	G	A	exonic	TFAP2A	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr6	10415192	10415192	G	A	exonic	TFAP2A	synonymous	BRCA\|1\|982\|0.00102
-	chr6	10398771	10398771	A	G	exonic	TFAP2A	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	10402840	10402840	C	T	exonic	TFAP2A	synonymous	UCEC\|1\|248\|0.00403
-	chr6	10415208	10415208	T	G	exonic	TFAP2A	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr6	10410427	10410427	G	A	exonic	TFAP2A	stopgain	BLCA\|2\|396\|0.00505
-	chr6	10415184	10415184	T	G	exonic	TFAP2A	nonsynonymous	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr6	10419705	10419705	A	G	UTR5	TFAP2A	unknown	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	10398805	10398805	C	T	exonic	TFAP2A	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr6	10410201	10410201	T	C	exonic	TFAP2A	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr6	10404789	10404789	G	A	exonic	TFAP2A	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr6	10419816	10419816	G	A	upstream	TFAP2A	unknown	BRCA\|1\|982\|0.00102
-	chr6	10410466	10410466	-	G	exonic	TFAP2A	frameshift	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr6	10402725	10402725	C	A	exonic	TFAP2A	stopgain	LUAD\|1\|543\|0.00184
-	chr6	10398916	10398916	C	A	exonic	TFAP2A	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr6	10402730	10402730	A	C	exonic	TFAP2A	nonsynonymous	CESC\|1\|194\|0.00515
-	chr6	10411817	10411817	T	A	exonic	TFAP2A	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr6	10410384	10410384	T	C	exonic	TFAP2A	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr6	10415218	10415218	T	G	exonic	TFAP2A	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr6	10410244	10410244	G	A	exonic	TFAP2A	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr6	10400740	10400740	G	A	exonic	TFAP2A	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr6	10415183	10415183	C	G	exonic	TFAP2A	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr6	10419655	10419655	C	A	exonic	TFAP2A	nonsynonymous	UCEC\|1\|248\|0.00403

Disease information of TFAP2A

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
TFAP2A	Malignant neoplasm of breast	C04;C17	Neoplastic Process	CTD_human
TFAP2A	Congenital ocular coloboma (disorder)	C11;C16	Congenital Abnormality	GENOMICS_ENGLAND
TFAP2A	Eye Abnormalities	C11;C16	Congenital Abnormality	CTD_human
TFAP2A	Kidney Diseases	C12;C13	Disease or Syndrome	CTD_human
TFAP2A	Schizophrenia	F03	Mental or Behavioral Dysfunction	PSYGENET
TFAP2A	Cataract	C11	Acquired Abnormality	GENOMICS_ENGLAND
TFAP2A	Polydactyly	C05;C16	Congenital Abnormality	GENOMICS_ENGLAND
TFAP2A	Branchio-Oto-Renal Syndrome	C16	Disease or Syndrome	CTD_human
TFAP2A	Branchio-Oculo-Facial Syndrome	C16	Disease or Syndrome	CTD_human;ORPHANET;UNIPROT
TFAP2A	Craniofacial Abnormalities	C05;C16	Congenital Abnormality	CTD_human
TFAP2A	Breast Carcinoma	C04;C17	Neoplastic Process	CTD_human
TFAP2A	Mammary Neoplasms, Human	C04;C17	Neoplastic Process	CTD_human
TFAP2A	Mammary Neoplasms	C04;C17	Neoplastic Process	CTD_human
TFAP2A	Branchiootorenal Syndrome 2	C16	Disease or Syndrome	CTD_human
TFAP2A	Intellectual Disability	C10;C23;F01;F03	Mental or Behavioral Dysfunction	GENOMICS_ENGLAND

Pathway associated with TFAP2A

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number
pathway0002699	Hs_Corticotropin-releasing_hormone_signaling_pathway_WP2355_90017	wikipathways	41	162
pathway0002747	Hs_Neural_Crest_Differentiation_WP2064_79263	wikipathways	40	129
pathway0002841	Hs_Ectoderm_Differentiation_WP2858_89329	wikipathways	56	137
pathway0002849	Hs_Hypothetical_Craniofacial_Development_Pathway_WP3655_88473	wikipathways	5	6

Go term information of TFAP2A

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GO_term_name	GO_term_type	TF_name
GO_NEGATIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS	BP	TFAP2A
GO_MORPHOGENESIS_OF_AN_EPITHELIUM	BP	TFAP2A
GO_CRANIAL_NERVE_MORPHOGENESIS	BP	TFAP2A
GO_NEURAL_RETINA_DEVELOPMENT	BP	TFAP2A
GO_FORELIMB_MORPHOGENESIS	BP	TFAP2A
GO_CRANIAL_NERVE_DEVELOPMENT	BP	TFAP2A
GO_ANATOMICAL_STRUCTURE_ARRANGEMENT	BP	TFAP2A
GO_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER	BP	TFAP2A
GO_PALATE_DEVELOPMENT	BP	TFAP2A
GO_REGULATION_OF_BIOMINERAL_TISSUE_DEVELOPMENT	BP	TFAP2A
GO_EMBRYONIC_FORELIMB_MORPHOGENESIS	BP	TFAP2A
GO_EMBRYONIC_CAMERA_TYPE_EYE_MORPHOGENESIS	BP	TFAP2A
GO_EYELID_DEVELOPMENT_IN_CAMERA_TYPE_EYE	BP	TFAP2A
GO_POSITIVE_REGULATION_OF_BIOMINERAL_TISSUE_DEVELOPMENT	BP	TFAP2A
GO_APPENDAGE_DEVELOPMENT	BP	TFAP2A
GO_NERVE_DEVELOPMENT	BP	TFAP2A
GO_REGULATION_OF_ODONTOGENESIS	BP	TFAP2A
GO_CRANIAL_SKELETAL_SYSTEM_DEVELOPMENT	BP	TFAP2A
GO_RETINA_LAYER_FORMATION	BP	TFAP2A
GO_CELLULAR_RESPONSE_TO_INORGANIC_SUBSTANCE	BP	TFAP2A
GO_UROGENITAL_SYSTEM_DEVELOPMENT	BP	TFAP2A
GO_SCHWANN_CELL_DEVELOPMENT	BP	TFAP2A
GO_AUTONOMIC_NERVOUS_SYSTEM_DEVELOPMENT	BP	TFAP2A
GO_EMBRYONIC_EYE_MORPHOGENESIS	BP	TFAP2A
GO_BONE_MORPHOGENESIS	BP	TFAP2A
GO_SCHWANN_CELL_DIFFERENTIATION	BP	TFAP2A
GO_RESPONSE_TO_BIOTIC_STIMULUS	BP	TFAP2A
GO_RESPONSE_TO_TRANSITION_METAL_NANOPARTICLE	BP	TFAP2A
GO_PARASYMPATHETIC_NERVOUS_SYSTEM_DEVELOPMENT	BP	TFAP2A
GO_NEGATIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER	BP	TFAP2A
GO_RESPONSE_TO_WATER	BP	TFAP2A
GO_POSITIVE_REGULATION_OF_NEURON_APOPTOTIC_PROCESS	BP	TFAP2A
GO_EMBRYONIC_CAMERA_TYPE_EYE_FORMATION	BP	TFAP2A
GO_EMBRYONIC_CAMERA_TYPE_EYE_DEVELOPMENT	BP	TFAP2A
GO_RESPONSE_TO_IRON_ION	BP	TFAP2A
GO_RETINA_MORPHOGENESIS_IN_CAMERA_TYPE_EYE	BP	TFAP2A
GO_RESPONSE_TO_WATER_DEPRIVATION	BP	TFAP2A
GO_EMBRYONIC_CRANIAL_SKELETON_MORPHOGENESIS	BP	TFAP2A
GO_INNER_EAR_MORPHOGENESIS	BP	TFAP2A
GO_REGULATION_OF_OSSIFICATION	BP	TFAP2A
GO_GOLGI_APPARATUS	CC	TFAP2A
GO_TRANSCRIPTIONAL_REPRESSOR_ACTIVITY_RNA_POLYMERASE_II_TRANSCRIPTION_REGULATORY_REGION_SEQUENCE_SPECIFIC_BINDING	MF	TFAP2A
GO_RNA_POLYMERASE_II_CORE_PROMOTER_SEQUENCE_SPECIFIC_DNA_BINDING	MF	TFAP2A
GO_TRANSCRIPTIONAL_REPRESSOR_ACTIVITY_RNA_POLYMERASE_II_CORE_PROMOTER_PROXIMAL_REGION_SEQUENCE_SPECIFIC_BINDING	MF	TFAP2A

Survival analysis of TFAP2A

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of TFAP2A

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)