Cancer CRCdb

TF information

TF name:	PBX1
TF family:	Homeobox
Ensembl gene ID:	ENSG00000185630
Ensembl protein ID:	ENSP00000453188, ENSP00000439943, ENSP00000405890, ENSP00000485692, ENSP00000483563, ENSP00000356872, ENSP00000452727
Entrez gene ID:	5087

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of PBX1 in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_01_001	Cell line	Prostate	22Rv1	0.4818401937046
Sample_01_059	Cell line	Lung	PC-9	0.13333333333333
Sample_02_007	Other	Cervical	cervical-cancer_vector	0.21854304635762
Sample_02_079	Cell line	Mammary Gland	T-47D_1	0.77777777777778
Sample_02_095	Cell line	Mammary Gland	MDA-MB-468	0.4284046692607
Sample_02_096	Cell line	Mammary Gland	ZR-75-1_1	0.5
Sample_02_200	Cell line	Stomach	RERF-GC-1B	1
Sample_02_228	Cell line	Oesophagus	KYSE510	0.45107176141659
Sample_02_268	Cell line	Kidney	A-498	0.33597932434927
Sample_02_310	Cell line	Neuroblastoma	SJNB8	0.35517693315858
Sample_02_311	Cell line	Neuroblastoma	SK-N-AS	0.77922077922078
Sample_02_319	Cell line	Neuroblastoma	NB-EBc1	0.53179190751445
Sample_02_322	Cell line	Colon	Caco-2	0.28398384925976
Sample_02_394	Cell line	Mammary Gland	T-47D_2	0.69230769230769
Sample_02_403	Cell line	Mammary Gland	T-47D_untreat	0.67045454545455
Sample_02_404	Cell line	Mammary Gland	ZR-75-1_2	0.43884892086331

PBX1 distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name
Sample_01_001	Prostate	Cell line	22Rv1
Sample_02_079	Mammary Gland	Cell line	T-47D_1
Sample_02_096	Mammary Gland	Cell line	ZR-75-1_1
Sample_02_200	Stomach	Cell line	RERF-GC-1B
Sample_02_228	Oesophagus	Cell line	KYSE510
Sample_02_310	Neuroblastoma	Cell line	SJNB8
Sample_02_311	Neuroblastoma	Cell line	SK-N-AS
Sample_02_319	Neuroblastoma	Cell line	NB-EBc1
Sample_02_394	Mammary Gland	Cell line	T-47D_2
Sample_02_403	Mammary Gland	Cell line	T-47D_untreat
Sample_02_404	Mammary Gland	Cell line	ZR-75-1_2

PBX1 distribution in all CRCs

Genomic distribution of SEs associated with PBX1

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Mutation of PBX1

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of PBX1

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr1	164768969	164768969	C	T	exonic	PBX1	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr1	164815824	164815824	A	G	exonic	PBX1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr1	164761814	164761814	G	A	exonic	PBX1	nonsynonymous	BLCA\|1\|396\|0.00253
rs868781414	chr1	164790786	164790786	C	T	exonic	PBX1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr1	164761762	164761762	A	G	exonic	PBX1	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr1	164761831	164761831	G	A	exonic	PBX1	synonymous	SKCM\|1\|368\|0.00272
-	chr1	164789392	164789392	G	A	exonic	PBX1	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr1	164781364	164781364	G	A	exonic	PBX1	synonymous	PAAD\|1\|185\|0.00541
-	chr1	164790803	164790803	G	A	exonic	PBX1	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr1	164789339	164789339	C	G	exonic	PBX1	nonsynonymous	LUAD\|1\|543\|0.00184
rs769833066	chr1	164768965	164768965	G	T	exonic	PBX1	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr1	164529123	164529123	C	A	exonic	PBX1	nonsynonymous	ESCA\|1\|185\|0.00541
rs146653553	chr1	164790855	164790855	G	A	exonic	PBX1	nonsynonymous	SKCM\|1\|368\|0.00272
rs771675680	chr1	164769020	164769020	C	T	exonic	PBX1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr1	164781252	164781252	G	A	exonic	PBX1	nonsynonymous	SKCM\|2\|368\|0.00543
-	chr1	164768945	164768945	G	A	exonic	PBX1	nonsynonymous	LIHC\|1\|373\|0.00268,UCEC\|1\|248\|0.00403
-	chr1	164761751	164761751	C	T	exonic	PBX1	stopgain	SKCM\|2\|368\|0.00543
-	chr1	164789369	164789369	T	G	exonic	PBX1	nonsynonymous	LUAD\|2\|543\|0.00368
-	chr1	164781365	164781365	C	G	exonic	PBX1	nonsynonymous	SKCM\|1\|368\|0.00272
rs768635810	chr1	164761842	164761842	C	T	exonic	PBX1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr1	164789349	164789349	G	T	exonic	PBX1	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr1	164761860	164761860	C	T	exonic	PBX1	nonsynonymous	PRAD\|1\|499\|0.00200
-	chr1	164761843	164761850	GGCGGCAG	-	exonic	PBX1	frameshift	LUSC\|1\|178\|0.00562
-	chr1	164781342	164781342	C	A	exonic	PBX1	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr1	164761730	164761730	G	C	splicing	PBX1	splicing	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr1	164789393	164789393	C	T	exonic	PBX1	nonsynonymous	UCEC\|2\|248\|0.00806
-	chr1	164532502	164532502	G	A	exonic	PBX1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr1	164781319	164781319	-	TATA	exonic	PBX1	frameshift	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr1	164529145	164529145	G	T	exonic	PBX1	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr1	164532540	164532540	A	-	exonic	PBX1	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr1	164761854	164761854	C	T	exonic	PBX1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr1	164789324	164789324	T	G	exonic	PBX1	nonsynonymous	PRAD\|1\|499\|0.00200
-	chr1	164761949	164761949	C	T	exonic	PBX1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr1	164769086	164769086	G	A	exonic	PBX1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr1	164815847	164815847	T	-	exonic	PBX1	frameshift	TGCT\|1\|155\|0.00645
-	chr1	164789372	164789372	A	G	exonic	PBX1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr1	164789402	164789402	G	A	exonic	PBX1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr1	164776782	164776782	G	T	exonic	PBX1	synonymous	SKCM\|1\|368\|0.00272
-	chr1	164769111	164769111	G	A	exonic	PBX1	nonsynonymous	SKCM\|2\|368\|0.00543
-	chr1	164769035	164769035	A	C	exonic	PBX1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr1	164776830	164776830	T	-	exonic	PBX1	frameshift	HNSC\|1\|512\|0.00195
-	chr1	164790850	164790850	C	T	exonic	PBX1	nonsynonymous	UCEC\|1\|248\|0.00403
rs765425125	chr1	164789358	164789358	C	T	exonic	PBX1	synonymous	PAAD\|1\|185\|0.00541
rs200580172	chr1	164761813	164761813	C	T	exonic	PBX1	synonymous	PRAD\|1\|499\|0.00200
-	chr1	164789377	164789377	G	A	exonic	PBX1	nonsynonymous	SKCM\|2\|368\|0.00543
-	chr1	164769081	164769081	C	T	exonic	PBX1	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr1	164532483	164532483	C	A	exonic	PBX1	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr1	164761954	164761954	G	C	exonic	PBX1	synonymous	LUSC\|1\|178\|0.00562
-	chr1	164761875	164761875	G	T	exonic	PBX1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr1	164761955	164761955	G	T	exonic	PBX1	stopgain	UCEC\|1\|248\|0.00403
-	chr1	164769116	164769116	C	T	exonic	PBX1	synonymous	SKCM\|1\|368\|0.00272
-	chr1	164776878	164776878	G	T	exonic	PBX1	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr1	164789390	164789390	G	T	exonic	PBX1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr1	164776849	164776849	A	T	exonic	PBX1	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr1	164769105	164769105	G	A	exonic	PBX1	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr1	164776859	164776859	C	T	exonic	PBX1	nonsynonymous	KIPAN\|2\|799\|0.00250,KIRC\|2\|451\|0.00443
-	chr1	164789207	164789207	G	-	intronic	PBX1	unknown	BRCA\|1\|982\|0.00102
-	chr1	164761883	164761883	G	T	exonic	PBX1	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr1	164769010	164769010	G	A	exonic	PBX1	synonymous	SKCM\|1\|368\|0.00272
-	chr1	164781388	164781388	T	C	splicing	PBX1	splicing	SKCM\|1\|368\|0.00272
-	chr1	164532548	164532548	G	T	exonic	PBX1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr1	164761864	164761864	G	A	exonic	PBX1	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr1	164769004	164769004	C	T	exonic	PBX1	synonymous	SKCM\|1\|368\|0.00272
rs147201088	chr1	164761828	164761828	G	A	exonic	PBX1	synonymous	SKCM\|1\|368\|0.00272
-	chr1	164761826	164761826	G	C	exonic	PBX1	nonsynonymous	CESC\|1\|194\|0.00515
-	chr1	164769122	164769122	G	T	exonic	PBX1	nonsynonymous	LUAD\|1\|543\|0.00184
rs541105414	chr1	164790828	164790828	G	A	exonic	PBX1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr1	164790779	164790779	T	C	exonic	PBX1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr1	164790798	164790798	A	G	exonic	PBX1	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr1	164769120	164769120	A	T	exonic	PBX1	nonsynonymous	LUAD\|1\|543\|0.00184
rs747269460	chr1	164789420	164789420	A	T	exonic	PBX1	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr1	164532529	164532529	T	C	exonic	PBX1	synonymous	UCEC\|1\|248\|0.00403
-	chr1	164736176	164736176	-	GCTGGTCTCGAACTCCCGACCTC	intronic	PBX1	unknown	-
-	chr1	164815893	164815893	C	A	exonic	PBX1	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr1	164769123	164769123	C	T	exonic	PBX1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs554904027	chr1	164816108	164816108	T	-	UTR3	PBX1	unknown	BRCA\|1\|982\|0.00102,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr1	164815989	164815989	C	T	UTR3	PBX1	unknown	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr1	164789376	164789376	G	A	exonic	PBX1	synonymous	SKCM\|1\|368\|0.00272
-	chr1	164761924	164761924	A	C	exonic	PBX1	nonsynonymous	DLBC\|1\|48\|0.02083
-	chr1	164769100	164769100	C	T	exonic	PBX1	synonymous	SKCM\|1\|368\|0.00272
-	chr1	164768975	164768975	C	T	exonic	PBX1	stopgain	UCEC\|1\|248\|0.00403
-	chr1	164761879	164761879	G	A	exonic	PBX1	synonymous	SKCM\|1\|368\|0.00272
-	chr1	164761953	164761953	C	T	exonic	PBX1	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr1	164769117	164769117	T	A	exonic	PBX1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr1	164776856	164776856	A	G	exonic	PBX1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr1	164761873	164761873	T	C	exonic	PBX1	synonymous	LUAD\|2\|543\|0.00368
-	chr1	164815832	164815832	T	G	exonic	PBX1	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs2275558	chr1	164529120	164529120	G	A	exonic	PBX1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr1	164761970	164761970	G	T	exonic	PBX1	stopgain	LUAD\|1\|543\|0.00184
-	chr1	164768972	164768972	C	A	exonic	PBX1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr1	164789343	164789343	A	T	exonic	PBX1	synonymous	ESCA\|1\|185\|0.00541
rs201029742	chr1	164790823	164790823	G	T	exonic	PBX1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr1	164776788	164776788	A	G	exonic	PBX1	synonymous	LIHC\|1\|373\|0.00268
-	chr1	164768988	164768988	G	T	exonic	PBX1	nonsynonymous	ESCA\|1\|185\|0.00541,LUAD\|1\|543\|0.00184
-	chr1	164610617	164610617	A	G	intronic	PBX1	unknown	BRCA\|1\|982\|0.00102
-	chr1	164789352	164789352	C	T	exonic	PBX1	synonymous	SKCM\|1\|368\|0.00272
-	chr1	164761784	164761784	C	T	exonic	PBX1	nonsynonymous	UCS\|1\|57\|0.01754
-	chr1	164610544	164610544	C	T	intronic	PBX1	unknown	CESC\|1\|194\|0.00515
rs370789005	chr1	164815933	164815933	C	T	UTR3	PBX1	unknown	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr1	164776781	164776781	G	A	exonic	PBX1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr1	164761910	164761910	G	A	exonic	PBX1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr1	164781371	164781371	A	G	exonic	PBX1	nonsynonymous	LUSC\|1\|178\|0.00562

Disease information of PBX1

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
PBX1	Burkitt Lymphoma	C02;C04;C15;C20	Neoplastic Process	CTD_human;ORPHANET
PBX1	Drug abuse	C25;F03	Mental or Behavioral Dysfunction	CTD_human
PBX1	Drug habituation	C25;F03	Mental or Behavioral Dysfunction	CTD_human
PBX1	Drug Use Disorders	C25;F03	Mental or Behavioral Dysfunction	CTD_human
PBX1	Organic Mental Disorders, Substance-Induced	C25;F03	Mental or Behavioral Dysfunction	CTD_human
PBX1	Substance Dependence	C25;F03	Mental or Behavioral Dysfunction	CTD_human
PBX1	Substance Use Disorders	C25;F03	Mental or Behavioral Dysfunction	CTD_human
PBX1	Substance-Related Disorders	C25;F03	Mental or Behavioral Dysfunction	CTD_human
PBX1	African Burkitt's lymphoma	C02;C04;C15;C20	Neoplastic Process	CTD_human
PBX1	Bilateral renal hypoplasia		Congenital Abnormality	ORPHANET
PBX1	Substance abuse problem	C25;F03	Mental or Behavioral Dysfunction	CTD_human
PBX1	Precursor B-cell lymphoblastic leukemia		Neoplastic Process	ORPHANET
PBX1	Drug Dependence	C25;F03	Mental or Behavioral Dysfunction	CTD_human
PBX1	Cakut	C12;C13;C16	Disease or Syndrome	GENOMICS_ENGLAND
PBX1	Intellectual Disability	C10;C23;F01;F03	Mental or Behavioral Dysfunction	GENOMICS_ENGLAND
PBX1	Prescription Drug Abuse	C25;F03	Finding	CTD_human

Pathway associated with PBX1

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number
pathway0002301	Transcriptional regulation of pluripotent stem cells	reactome	28	184

Go term information of PBX1

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GO_term_name	GO_term_type	TF_name
GO_EMBRYONIC_HEMOPOIESIS	BP	PBX1
GO_SOMATIC_STEM_CELL_POPULATION_MAINTENANCE	BP	PBX1
GO_POSITIVE_REGULATION_OF_MITOTIC_CELL_CYCLE	BP	PBX1
GO_POSITIVE_REGULATION_OF_CELL_CYCLE_G2_M_PHASE_TRANSITION	BP	PBX1
GO_PROXIMAL_DISTAL_PATTERN_FORMATION	BP	PBX1
GO_NEPHRON_EPITHELIUM_DEVELOPMENT	BP	PBX1
GO_RENAL_TUBULE_DEVELOPMENT	BP	PBX1
GO_BRANCHING_INVOLVED_IN_URETERIC_BUD_MORPHOGENESIS	BP	PBX1
GO_POSITIVE_REGULATION_OF_CELL_CYCLE_PROCESS	BP	PBX1
GO_ADRENAL_GLAND_DEVELOPMENT	BP	PBX1
GO_MAINTENANCE_OF_CELL_NUMBER	BP	PBX1
GO_MORPHOGENESIS_OF_A_BRANCHING_STRUCTURE	BP	PBX1
GO_NEGATIVE_REGULATION_OF_DEVELOPMENTAL_PROCESS	BP	PBX1
GO_REGULATION_OF_CELL_CYCLE_PHASE_TRANSITION	BP	PBX1
GO_KIDNEY_MORPHOGENESIS	BP	PBX1
GO_NEPHRON_DEVELOPMENT	BP	PBX1
GO_POSITIVE_REGULATION_OF_CELL_CYCLE	BP	PBX1
GO_MESONEPHROS_DEVELOPMENT	BP	PBX1
GO_SPLEEN_DEVELOPMENT	BP	PBX1
GO_REGULATION_OF_OSSIFICATION	BP	PBX1
GO_TRANSCRIPTION_FACTOR_BINDING	MF	PBX1

Survival analysis of PBX1

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of PBX1

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)