Cancer CRCdb

TF information

TF name:	RUNX1
TF family:	Runt
Ensembl gene ID:	ENSG00000159216
Ensembl protein ID:	ENSP00000388189, ENSP00000382184, ENSP00000409227, ENSP00000351123, ENSP00000382182, ENSP00000300305, ENSP00000340690
Entrez gene ID:	100506403

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of RUNX1 in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_01_046	Cell line	Mammary Gland	MCF-7	0.15
Sample_01_059	Cell line	Lung	PC-9	0.066666666666667
Sample_02_021	Cell line	Colon	V429	0.76909772268665
Sample_02_095	Cell line	Mammary Gland	MDA-MB-468	0.95992217898833
Sample_02_116	Cell line	Mammary Gland	MDA-MB-231_untreat	0.66666666666667
Sample_02_164	Cell line	Lung	H2087_Parental	0.56666666666667
Sample_02_166	Cell line	Mammary Gland	HCC1954_Parental	1
Sample_02_182	Cell line	Human melanoma	LOX-IMVI	0.42241379310345
Sample_02_196	Cell line	Stomach	NCC59	0.21428571428571
Sample_02_219	Cell line	Mammary Gland	MDA-MB-231	1
Sample_02_227	Cell line	Oesophagus	TE7	0.56
Sample_02_228	Cell line	Oesophagus	KYSE510	0.97483690587139
Sample_02_237	Cell line	Colon	V389	0.71610528253267
Sample_02_258	Other	Lung	NCI-H1299_EGFP-NEO_reporter_cells_DMSO	0.36444444444444
Sample_02_268	Cell line	Kidney	A-498	0.65183681004246
Sample_02_280	Cell line	Mammary Gland	SUM159_DMSO_24h	0.61666666666667
Sample_02_317	Cell line	Neuroblastoma	GICAN	0.10810810810811
Sample_02_323	Cell line	Colon	RKO	0.5
Sample_02_354	Cell line	Colon	Colo205	0.73123123123123
Sample_02_355	Cell line	Colon	HCT15	0.67261904761905
Sample_02_356	Cell line	Colon	Sw480	0.49032258064516
Sample_02_358	Cell line	Colon	LS180	0.53751974723539
Sample_02_359	Cell line	Colon	Colo741	0.5421686746988
Sample_02_395	Cell line	Mammary Gland	BT-549	0.51244755244755
Sample_02_404	Cell line	Mammary Gland	ZR-75-1_2	0.59712230215827
Sample_02_406	Cell line	Mammary Gland	ZR-75-30_parental	0.27536231884058
Sample_02_424	Cell line	Colon	SW620	1
Sample_02_430	Cell line	Kidney	12364284	0.26785714285714

RUNX1 distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name
Sample_02_021	Colon	Cell line	V429
Sample_02_095	Mammary Gland	Cell line	MDA-MB-468
Sample_02_116	Mammary Gland	Cell line	MDA-MB-231_untreat
Sample_02_166	Mammary Gland	Cell line	HCC1954_Parental
Sample_02_182	Human melanoma	Cell line	LOX-IMVI
Sample_02_219	Mammary Gland	Cell line	MDA-MB-231
Sample_02_227	Oesophagus	Cell line	TE7
Sample_02_228	Oesophagus	Cell line	KYSE510
Sample_02_237	Colon	Cell line	V389
Sample_02_268	Kidney	Cell line	A-498
Sample_02_280	Mammary Gland	Cell line	SUM159_DMSO_24h
Sample_02_354	Colon	Cell line	Colo205
Sample_02_355	Colon	Cell line	HCT15
Sample_02_358	Colon	Cell line	LS180
Sample_02_359	Colon	Cell line	Colo741
Sample_02_395	Mammary Gland	Cell line	BT-549
Sample_02_404	Mammary Gland	Cell line	ZR-75-1_2
Sample_02_424	Colon	Cell line	SW620

RUNX1 distribution in all CRCs

Genomic distribution of SEs associated with RUNX1

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Mutation of RUNX1

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of RUNX1

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr21	36171607	36171607	G	T	exonic	RUNX1	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr21	36231833	36231833	G	T	exonic	RUNX1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr21	36164864	36164864	G	A	exonic	RUNX1	synonymous	BRCA\|1\|982\|0.00102
-	chr21	36231829	36231829	T	C	exonic	RUNX1	synonymous	COAD\|3\|367\|0.00817,COADREAD\|3\|489\|0.00613
-	chr21	36252892	36252892	C	G	exonic	RUNX1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr21	36421175	36421175	C	G	exonic	RUNX1	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr21	36206708	36206708	C	T	exonic	RUNX1	synonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr21	36231785	36231785	G	T	exonic	RUNX1	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr21	36231789	36231789	C	T	exonic	RUNX1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|2\|489\|0.00409,READ\|1\|122\|0.00820
-	chr21	36252995	36252995	C	-	exonic	RUNX1	frameshift	BRCA\|1\|982\|0.00102
-	chr21	36259154	36259154	G	A	exonic	RUNX1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr21	36252917	36252917	C	G	exonic	RUNX1	nonsynonymous	LAML\|1\|197\|0.00508
-	chr21	36164595	36164595	C	T	exonic	RUNX1	nonsynonymous	CESC\|1\|194\|0.00515
-	chr21	36252869	36252869	C	A	exonic	RUNX1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs780816315	chr21	36259264	36259264	C	T	exonic	RUNX1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr21	36421187	36421187	C	G	exonic	RUNX1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr21	36164851	36164851	-	G	exonic	RUNX1	frameshift	BRCA\|1\|982\|0.00102
-	chr21	36206865	36206865	G	T	exonic	RUNX1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr21	36231792	36231792	C	T	exonic	RUNX1	nonsynonymous	LAML\|1\|197\|0.00508,LUAD\|4\|543\|0.00737
-	chr21	36421171	36421171	G	T	exonic	RUNX1	stopgain	UCEC\|1\|248\|0.00403
-	chr21	36252856	36252856	-	T	exonic	RUNX1	frameshift	BRCA\|3\|982\|0.00305
-	chr21	36252867	36252867	A	G	exonic	RUNX1	synonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr21	36421162	36421162	G	A	exonic	RUNX1	nonsynonymous	SKCM\|1\|368\|0.00272,UCEC\|1\|248\|0.00403
-	chr21	36231864	36231864	T	A	exonic	RUNX1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr21	36171607	36171607	G	A	exonic	RUNX1	stopgain	LAML\|1\|197\|0.00508
-	chr21	36231862	36231862	A	G	exonic	RUNX1	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr21	36228598	36228598	C	G	intronic	RUNX1	unknown	CESC\|1\|194\|0.00515
-	chr21	36171641	36171641	G	A	exonic	RUNX1	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr21	36252994	36252994	-	C	exonic	RUNX1	frameshift	BRCA\|6\|982\|0.00611
-	chr21	36231773	36231773	C	A	exonic	RUNX1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr21	36206799	36206799	A	G	exonic	RUNX1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr21	36171616	36171616	G	A	exonic	RUNX1	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr21	36252883	36252883	T	C	exonic	RUNX1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr21	36259150	36259150	A	G	exonic	RUNX1	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr21	36259214	36259214	C	T	exonic	RUNX1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr21	36259153	36259153	G	A	exonic	RUNX1	nonsynonymous	LAML\|1\|197\|0.00508
-	chr21	36252869	36252869	-	GCTA	exonic	RUNX1	stopgain	LAML\|1\|197\|0.00508
-	chr21	36252880	36252880	-	G	exonic	RUNX1	frameshift	BRCA\|1\|982\|0.00102
-	chr21	36252876	36252876	C	A	exonic	RUNX1	nonsynonymous	LAML\|1\|197\|0.00508
-	chr21	36231773	36231773	C	T	exonic	RUNX1	nonsynonymous	UCEC\|2\|248\|0.00806
rs761688033	chr21	36171606	36171606	C	T	exonic	RUNX1	nonsynonymous	COAD\|3\|367\|0.00817,COADREAD\|4\|489\|0.00818,READ\|1\|122\|0.00820
rs555366994	chr21	36206775	36206775	G	A	exonic	RUNX1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr21	36206716	36206716	G	A	exonic	RUNX1	stopgain	BRCA\|1\|982\|0.00102
rs749004431	chr21	36206863	36206863	C	T	exonic	RUNX1	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr21	36259279	36259279	A	-	exonic	RUNX1	frameshift	HNSC\|1\|512\|0.00195
-	chr21	36206764	36206764	G	A	exonic	RUNX1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr21	36252921	36252921	A	T	exonic	RUNX1	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs752616540	chr21	36164782	36164782	C	T	exonic	RUNX1	nonsynonymous	TGCT\|1\|155\|0.00645
-	chr21	36252876	36252876	C	T	exonic	RUNX1	synonymous	COAD\|2\|367\|0.00545,COADREAD\|2\|489\|0.00409
-	chr21	36252865	36252865	C	G	exonic	RUNX1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr21	36171737	36171737	G	C	exonic	RUNX1	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr21	36231877	36231877	T	G	splicing	RUNX1	splicing	LAML\|1\|197\|0.00508
-	chr21	36231855	36231855	T	C	exonic	RUNX1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs754168875	chr21	36259204	36259204	T	C	exonic	RUNX1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr21	36252878	36252878	T	C	exonic	RUNX1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,LAML\|2\|197\|0.01015
-	chr21	36259149	36259149	G	A	exonic	RUNX1	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr21	36171704	36171704	-	A	exonic	RUNX1	frameshift	BRCA\|2\|982\|0.00204
rs533383085	chr21	36171665	36171665	C	T	exonic	RUNX1	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr21	36164874	36164874	C	T	exonic	RUNX1	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr21	36231857	36231857	-	CA	exonic	RUNX1	frameshift	BLCA\|1\|396\|0.00253
-	chr21	36171672	36171672	G	-	exonic	RUNX1	frameshift	BLCA\|1\|396\|0.00253
-	chr21	36252902	36252902	G	A	exonic	RUNX1	stopgain	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs751954304	chr21	36252901	36252901	T	C	exonic	RUNX1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs758682659	chr21	36171666	36171666	G	A	exonic	RUNX1	nonsynonymous	UVM\|1\|80\|0.01250
-	chr21	36252865	36252865	C	A	exonic	RUNX1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr21	36252931	36252931	A	G	exonic	RUNX1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr21	36206781	36206781	G	A	exonic	RUNX1	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr21	36206874	36206874	T	-	exonic	RUNX1	frameshift	BRCA\|1\|982\|0.00102
-	chr21	36231833	36231833	G	A	exonic	RUNX1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,UCEC\|1\|248\|0.00403
-	chr21	36252877	36252877	C	T	exonic	RUNX1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,LAML\|1\|197\|0.00508
-	chr21	36231830	36231830	T	C	exonic	RUNX1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr21	36206753	36206753	C	T	exonic	RUNX1	synonymous	BRCA\|1\|982\|0.00102
-	chr21	36252852	36252852	-	CCTCTTCCACTTCGAC	splicing	RUNX1	unknown	-
rs752926959	chr21	36252917	36252917	C	T	exonic	RUNX1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs773689002	chr21	36252918	36252918	G	A	exonic	RUNX1	synonymous	LUSC\|1\|178\|0.00562,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr21	36231781	36231781	T	C	exonic	RUNX1	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr21	36193995	36193995	T	A	splicing	RUNX1	splicing	LIHC\|1\|373\|0.00268
-	chr21	36171600	36171600	-	A	exonic	RUNX1	frameshift	HNSC\|1\|512\|0.00195
-	chr21	36228737	36228737	C	T	intronic	RUNX1	unknown	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr21	36164596	36164617	GCGGCGGCGAGCGCTCGCCGCC	-	exonic	RUNX1	frameshift	LAML\|1\|197\|0.00508
-	chr21	36252858	36252858	-	CCACTTCGA	exonic	RUNX1	nonframeshift	-
rs747906151	chr21	36206846	36206846	G	A	exonic	RUNX1	synonymous	HNSC\|1\|512\|0.00195
-	chr21	36231783	36231783	G	A	exonic	RUNX1	stopgain	LAML\|4\|197\|0.02030
-	chr21	36253009	36253009	A	G	exonic	RUNX1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr21	36259155	36259155	C	T	exonic	RUNX1	synonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr21	36259226	36259226	G	A	exonic	RUNX1	synonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr21	36206818	36206818	G	A	exonic	RUNX1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr21	36171619	36171619	C	T	exonic	RUNX1	nonsynonymous	BRCA\|1\|982\|0.00102
rs74315450	chr21	36231782	36231782	C	T	exonic	RUNX1	nonsynonymous	LAML\|1\|197\|0.00508,LUAD\|1\|543\|0.00184
-	chr21	36171624	36171624	G	A	exonic	RUNX1	nonsynonymous	HNSC\|2\|512\|0.00391
rs74315451	chr21	36252962	36252962	C	G	exonic	RUNX1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr21	36265261	36265261	C	T	splicing	RUNX1	splicing	LUAD\|1\|543\|0.00184
-	chr21	36252958	36252958	C	T	exonic	RUNX1	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr21	36252940	36252940	G	A	exonic	RUNX1	nonsynonymous	LAML\|1\|197\|0.00508
-	chr21	36164573	36164573	G	A	exonic	RUNX1	synonymous	OV\|1\|469\|0.00213
rs868726626	chr21	36231861	36231861	G	A	exonic	RUNX1	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr21	36171749	36171749	C	T	exonic	RUNX1	synonymous	SKCM\|1\|368\|0.00272
-	chr21	36171709	36171709	-	T	exonic	RUNX1	frameshift	PAAD\|1\|185\|0.00541
rs763823959	chr21	36228727	36228727	G	A	intronic	RUNX1	unknown	BLCA\|1\|396\|0.00253,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr21	36252860	36252860	C	G	exonic	RUNX1	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr21	36259161	36259161	C	G	exonic	RUNX1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr21	36164827	36164827	G	A	exonic	RUNX1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr21	36252978	36252978	A	G	exonic	RUNX1	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr21	36231791	36231791	T	C	exonic	RUNX1	nonsynonymous	BRCA\|1\|982\|0.00102,COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr21	36252998	36252998	C	G	exonic	RUNX1	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr21	36231807	36231807	T	C	exonic	RUNX1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr21	36252857	36252861	TTCCA	-	exonic	RUNX1	frameshift	LAML\|1\|197\|0.00508
-	chr21	36259170	36259170	G	T	exonic	RUNX1	synonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr21	36252939	36252939	-	G	exonic	RUNX1	frameshift	LAML\|1\|197\|0.00508
-	chr21	36206830	36206830	G	A	exonic	RUNX1	synonymous	SKCM\|1\|368\|0.00272
-	chr21	36171624	36171624	G	-	exonic	RUNX1	frameshift	BRCA\|1\|982\|0.00102
-	chr21	36171723	36171723	T	A	exonic	RUNX1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr21	36206776	36206776	-	G	exonic	RUNX1	frameshift	BRCA\|1\|982\|0.00102
-	chr21	36259263	36259263	G	A	exonic	RUNX1	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr21	36171743	36171755	TTGGATCTGCCTT	-	exonic	RUNX1	frameshift	BLCA\|1\|396\|0.00253
-	chr21	36252892	36252892	C	A	exonic	RUNX1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr21	36252869	36252869	C	T	exonic	RUNX1	nonsynonymous	COAD\|3\|367\|0.00817,COADREAD\|3\|489\|0.00613
-	chr21	36252853	36252853	C	G	splicing	RUNX1	splicing	BRCA\|1\|982\|0.00102
-	chr21	36421143	36421143	C	G	exonic	RUNX1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr21	36231854	36231854	A	G	exonic	RUNX1	nonsynonymous	COAD\|4\|367\|0.01090,COADREAD\|4\|489\|0.00818
-	chr21	36231860	36231860	A	G	exonic	RUNX1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr21	36259341	36259341	G	C	exonic	RUNX1	synonymous	UCS\|1\|57\|0.01754
-	chr21	36259202	36259202	A	G	exonic	RUNX1	nonsynonymous	ACC\|1\|90\|0.01111
-	chr21	36252900	36252900	C	T	exonic	RUNX1	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr21	36259146	36259146	A	C	exonic	RUNX1	synonymous	UCEC\|1\|248\|0.00403
-	chr21	36231870	36231870	T	-	exonic	RUNX1	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr21	36164838	36164838	C	T	exonic	RUNX1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr21	36206728	36206728	G	C	exonic	RUNX1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr21	36252902	36252902	G	T	exonic	RUNX1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr21	36231783	36231783	G	C	exonic	RUNX1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr21	36171724	36171724	A	G	exonic	RUNX1	nonsynonymous	COAD\|2\|367\|0.00545,COADREAD\|2\|489\|0.00409
-	chr21	36259142	36259142	T	A	exonic	RUNX1	stopgain	BRCA\|1\|982\|0.00102
-	chr21	36421376	36421376	A	C	intronic	RUNX1	unknown	UCEC\|1\|248\|0.00403
-	chr21	36231819	36231819	A	G	exonic	RUNX1	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr21	36206728	36206728	G	A	exonic	RUNX1	stopgain	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr21	36206817	36206817	C	A	exonic	RUNX1	nonsynonymous	BLCA\|1\|396\|0.00253,UCEC\|1\|248\|0.00403
-	chr21	36171681	36171681	G	A	exonic	RUNX1	nonsynonymous	HNSC\|2\|512\|0.00391
-	chr21	36252880	36252880	A	G	exonic	RUNX1	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr21	36252925	36252925	T	C	exonic	RUNX1	nonsynonymous	COAD\|2\|367\|0.00545,COADREAD\|2\|489\|0.00409
-	chr21	36252915	36252915	T	C	exonic	RUNX1	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr21	36259190	36259190	C	T	exonic	RUNX1	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr21	36259157	36259157	G	-	exonic	RUNX1	frameshift	BRCA\|1\|982\|0.00102
-	chr21	36171685	36171685	G	A	exonic	RUNX1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr21	36252858	36252858	-	CCACTTCGAGGAAAG	exonic	RUNX1	nonframeshift	-
-	chr21	36252946	36252946	T	C	exonic	RUNX1	nonsynonymous	BRCA\|1\|982\|0.00102

Disease information of RUNX1

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
RUNX1	Rheumatoid Arthritis	C05;C17;C20	Disease or Syndrome	CTD_human
RUNX1	Burkitt Lymphoma	C02;C04;C15;C20	Neoplastic Process	ORPHANET
RUNX1	Cytopenia		Pathologic Function	GENOMICS_ENGLAND
RUNX1	Glioblastoma	C04	Neoplastic Process	CTD_human
RUNX1	Childhood Acute Lymphoblastic Leukemia	C04;C15;C20	Neoplastic Process	CTD_human
RUNX1	Leukemia, Lymphocytic, Acute, L2	C04;C15;C20	Neoplastic Process	CTD_human
RUNX1	Leukemia, Myelocytic, Acute	C04	Neoplastic Process	CGI;CTD_human
RUNX1	Myeloid Leukemia, Chronic	C04;C15	Neoplastic Process	ORPHANET
RUNX1	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	C04;C15;C20	Neoplastic Process	CTD_human
RUNX1	Acute Myeloid Leukemia, M1	C04	Neoplastic Process	CTD_human
RUNX1	Platelet Storage Pool Deficiency	C15	Disease or Syndrome	ORPHANET
RUNX1	Prostatic Neoplasms	C04;C12	Neoplastic Process	CTD_human
RUNX1	Congenital anemia		Disease or Syndrome	GENOMICS_ENGLAND
RUNX1	Giant Cell Glioblastoma	C04	Neoplastic Process	CTD_human
RUNX1	Juvenile Myelomonocytic Leukemia	C04;C15	Neoplastic Process	CTD_human
RUNX1	Malignant neoplasm of prostate	C04;C12	Neoplastic Process	CTD_human
RUNX1	Hematologic Neoplasms	C04;C15	Neoplastic Process	GENOMICS_ENGLAND
RUNX1	Precursor B-cell lymphoblastic leukemia		Neoplastic Process	ORPHANET
RUNX1	Glioblastoma Multiforme	C04	Neoplastic Process	CTD_human
RUNX1	Platelet Disorder, Familial, with Associated Myeloid Malignancy	C04;C15;C16	Disease or Syndrome	CLINGEN;CTD_human;ORPHANET;UNIPROT
RUNX1	Acute Myeloid Leukemia (AML-M2)	C04	Neoplastic Process	CTD_human
RUNX1	Precursor Cell Lymphoblastic Leukemia Lymphoma	C04;C15;C20	Neoplastic Process	CTD_human
RUNX1	Hematopoetic Myelodysplasia	C15	Pathologic Function	CTD_human
RUNX1	Albinism with hemorrhagic diathesis and pigmented reticuloendothelial cells	C11;C15;C16;C17;C18	Disease or Syndrome	ORPHANET
RUNX1	MYELODYSPLASTIC SYNDROME	C15	Neoplastic Process	CTD_human

Pathway associated with RUNX1

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number
pathway0001551	Organic cation transport	reactome	9	1
pathway0002393	Validated transcriptional targets of deltaNp63 isoforms	pid	47	101
pathway0002668	Acute myeloid leukemia	kegg	53	562

Go term information of RUNX1

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GO_term_name	GO_term_type	TF_name
GO_POSITIVE_REGULATION_OF_HEMOPOIESIS	BP	RUNX1
GO_NEGATIVE_REGULATION_OF_FAT_CELL_DIFFERENTIATION	BP	RUNX1
GO_POSITIVE_REGULATION_OF_VASCULATURE_DEVELOPMENT	BP	RUNX1
GO_STEM_CELL_PROLIFERATION	BP	RUNX1
GO_POSITIVE_REGULATION_OF_LEUKOCYTE_DIFFERENTIATION	BP	RUNX1
GO_REGULATION_OF_GRANULOCYTE_DIFFERENTIATION	BP	RUNX1
GO_PERIPHERAL_NERVOUS_SYSTEM_NEURON_DIFFERENTIATION	BP	RUNX1
GO_CELL_PROLIFERATION	BP	RUNX1
GO_CHONDROCYTE_DIFFERENTIATION	BP	RUNX1
GO_HEMATOPOIETIC_STEM_CELL_PROLIFERATION	BP	RUNX1
GO_NEGATIVE_REGULATION_OF_MYELOID_LEUKOCYTE_DIFFERENTIATION	BP	RUNX1
GO_REGULATION_OF_IMMUNE_SYSTEM_PROCESS	BP	RUNX1
GO_POSITIVE_REGULATION_OF_MYELOID_CELL_DIFFERENTIATION	BP	RUNX1
GO_CONNECTIVE_TISSUE_DEVELOPMENT	BP	RUNX1
GO_POSITIVE_REGULATION_OF_INTERLEUKIN_2_PRODUCTION	BP	RUNX1
GO_REGULATION_OF_INTERLEUKIN_2_PRODUCTION	BP	RUNX1
GO_NEGATIVE_REGULATION_OF_MYELOID_CELL_DIFFERENTIATION	BP	RUNX1
GO_NEGATIVE_REGULATION_OF_CELL_DIFFERENTIATION	BP	RUNX1
GO_POSITIVE_REGULATION_OF_MYELOID_LEUKOCYTE_DIFFERENTIATION	BP	RUNX1
GO_NUCLEAR_MATRIX	CC	RUNX1
GO_CORE_PROMOTER_BINDING	MF	RUNX1
GO_DOUBLE_STRANDED_DNA_BINDING	MF	RUNX1
GO_TRANSCRIPTION_COREPRESSOR_ACTIVITY	MF	RUNX1

Survival analysis of RUNX1

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of RUNX1

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)