Cancer CRCdb

TF information

TF name:	MNT
TF family:	bHLH
Ensembl gene ID:	ENSG00000070444
Ensembl protein ID:	ENSP00000174618
Entrez gene ID:	4335

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of MNT in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_01_022	Cell line	Prostate	C4-2B	0.11904761904762
Sample_01_046	Cell line	Mammary Gland	MCF-7	0.2
Sample_01_059	Cell line	Lung	PC-9	0.066666666666667
Sample_02_007	Other	Cervical	cervical-cancer_vector	0.029801324503311
Sample_02_021	Cell line	Colon	V429	0.11991928509657
Sample_02_096	Cell line	Mammary Gland	ZR-75-1_1	0.097826086956522
Sample_02_164	Cell line	Lung	H2087_Parental	0.1
Sample_02_168	Cell line	Prostate	LNCaP	0.064638783269962
Sample_02_182	Cell line	Human melanoma	LOX-IMVI	0.014367816091954
Sample_02_184	Cell line	Skin	SKMEL30	0.035369774919614
Sample_02_187	Cell line	Stomach	KATOIII	0.33333333333333
Sample_02_191	Cell line	Stomach	SNU719	0.21428571428571
Sample_02_192	Cell line	Stomach	MKN45	0.33333333333333
Sample_02_204	Cell line	Stomach	IM95	0.090909090909091
Sample_02_205	Tissue	Stomach	Gastric_Primary_Sample_T	0.11851851851852
Sample_02_208	Cell line	Stomach	YCC3	0.125
Sample_02_219	Cell line	Mammary Gland	MDA-MB-231	0.07843137254902
Sample_02_227	Cell line	Oesophagus	TE7	0.04
Sample_02_228	Cell line	Oesophagus	KYSE510	0.025163094128611
Sample_02_236	Cell line	Colon	V206	0.024844720496894
Sample_02_237	Cell line	Colon	V389	0.020099392600773
Sample_02_241	Cell line	Colon	V456	0.11060948081264
Sample_02_242	Cell line	Colon	V481	0.083701852207909
Sample_02_254	Cell line	Neuroblastoma	IMR5-75	0.23529411764706
Sample_02_258	Other	Lung	NCI-H1299_EGFP-NEO_reporter_cells_DMSO	0.015555555555556
Sample_02_268	Cell line	Kidney	A-498	0.047627838286875
Sample_02_280	Cell line	Mammary Gland	SUM159_DMSO_24h	0.033333333333333
Sample_02_298	Cell line	Neuroblastoma	CLB-GA	0.068493150684932
Sample_02_304	Cell line	Neuroblastoma	N206	0.06929347826087
Sample_02_313	Cell line	Neuroblastoma	SK-N-DZ	0.069498069498069
Sample_02_316	Cell line	Neuroblastoma	CHP212	0.13736263736264
Sample_02_317	Cell line	Neuroblastoma	GICAN	0.054054054054054
Sample_02_319	Cell line	Neuroblastoma	NB-EBc1	0.063583815028902
Sample_02_354	Cell line	Colon	Colo205	0.07957957957958
Sample_02_355	Cell line	Colon	HCT15	0.16071428571429
Sample_02_356	Cell line	Colon	Sw480	0.18709677419355
Sample_02_358	Cell line	Colon	LS180	0.031595576619273
Sample_02_359	Cell line	Colon	Colo741	0.015060240963855
Sample_02_395	Cell line	Mammary Gland	BT-549	0.051748251748252
Sample_02_406	Cell line	Mammary Gland	ZR-75-30_parental	0.08695652173913
Sample_02_413	Tissue	Brain	GBM_2493	0.098901098901099
Sample_02_430	Cell line	Kidney	12364284	0.17857142857143

MNT distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name
Sample_02_241	Colon	Cell line	V456
Sample_02_356	Colon	Cell line	Sw480

MNT distribution in all CRCs

Genomic distribution of SEs associated with MNT

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Mutation of MNT

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of MNT

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr17	2290288	2290288	C	A	exonic	MNT	synonymous	ESCA\|1\|185\|0.00541
-	chr17	2298352	2298352	A	G	exonic	MNT	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr17	2303970	2303970	G	A	exonic	MNT	synonymous	UCS\|1\|57\|0.01754
rs769146103	chr17	2290636	2290636	A	C	exonic	MNT	synonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr17	2291286	2291286	T	C	exonic	MNT	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs199848480	chr17	2298633	2298633	T	G	exonic	MNT	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr17	2290553	2290553	C	T	exonic	MNT	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr17	2290863	2290863	G	A	exonic	MNT	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr17	2298257	2298257	G	-	exonic	MNT	frameshift	COAD\|2\|367\|0.00545,COADREAD\|2\|489\|0.00409
-	chr17	2290583	2290583	G	A	exonic	MNT	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr17	2291304	2291304	C	G	exonic	MNT	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr17	2291156	2291156	G	T	exonic	MNT	nonsynonymous	TGCT\|1\|155\|0.00645
-	chr17	2298206	2298206	C	A	exonic	MNT	stopgain	UCEC\|1\|248\|0.00403
-	chr17	2290427	2290427	G	A	exonic	MNT	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr17	2298309	2298309	C	T	exonic	MNT	synonymous	UCEC\|1\|248\|0.00403
-	chr17	2298723	2298723	C	A	exonic	MNT	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr17	2290266	2290266	G	A	exonic	MNT	stopgain	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr17	2290738	2290739	CT	-	exonic	MNT	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	2298243	2298243	T	G	exonic	MNT	synonymous	HNSC\|1\|512\|0.00195
rs372877661	chr17	2298369	2298369	C	T	exonic	MNT	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr17	2290445	2290445	T	C	exonic	MNT	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs368726975	chr17	2290369	2290369	C	T	exonic	MNT	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs750625027	chr17	2290383	2290383	C	T	exonic	MNT	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr17	2290939	2290939	A	G	exonic	MNT	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr17	2298236	2298236	G	T	exonic	MNT	nonsynonymous	CESC\|1\|194\|0.00515
-	chr17	2290573	2290573	G	A	exonic	MNT	synonymous	UCEC\|1\|248\|0.00403
rs753145734	chr17	2290510	2290510	C	T	exonic	MNT	synonymous	UCEC\|1\|248\|0.00403
-	chr17	2297369	2297369	T	G	exonic	MNT	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs751790336	chr17	2290499	2290499	G	A	exonic	MNT	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	2297373	2297373	A	G	exonic	MNT	synonymous	LUAD\|1\|543\|0.00184
-	chr17	2290424	2290424	T	C	exonic	MNT	nonsynonymous	KICH\|1\|66\|0.01515,KIPAN\|1\|799\|0.00125
-	chr17	2290220	2290220	G	-	exonic	MNT	frameshift	BLCA\|1\|396\|0.00253
rs747816884	chr17	2298498	2298498	G	A	exonic	MNT	synonymous	TGCT\|1\|155\|0.00645
-	chr17	2298252	2298252	C	A	exonic	MNT	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs769757715	chr17	2290542	2290542	C	T	exonic	MNT	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr17	2298503	2298503	A	G	exonic	MNT	synonymous	PRAD\|1\|499\|0.00200
-	chr17	2298341	2298341	C	A	exonic	MNT	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr17	2298167	2298167	-	C	splicing	MNT	unknown	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr17	2298449	2298449	C	T	exonic	MNT	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr17	2290484	2290484	G	T	exonic	MNT	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr17	2298250	2298250	G	A	exonic	MNT	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	2298413	2298413	G	-	exonic	MNT	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	2290453	2290453	G	C	exonic	MNT	synonymous	HNSC\|2\|512\|0.00391
-	chr17	2290577	2290577	T	C	exonic	MNT	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	2291254	2291254	G	C	exonic	MNT	synonymous	CESC\|1\|194\|0.00515
-	chr17	2290772	2290772	A	G	exonic	MNT	nonsynonymous	SKCM\|1\|368\|0.00272
rs377109755	chr17	2298447	2298447	G	A	exonic	MNT	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs768727951	chr17	2298237	2298237	C	T	exonic	MNT	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	2290370	2290370	G	T	exonic	MNT	stopgain	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr17	2290344	2290344	C	A	exonic	MNT	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr17	2288155	2288155	C	T	UTR3	MNT	unknown	ESCA\|1\|185\|0.00541
-	chr17	2290637	2290637	C	-	exonic	MNT	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr17	2297393	2297393	C	-	exonic	MNT	frameshift	BRCA\|1\|982\|0.00102
rs138518103	chr17	2298631	2298631	G	A	exonic	MNT	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr17	2290511	2290511	G	A	exonic	MNT	nonsynonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr17	2290273	2290273	C	A	exonic	MNT	synonymous	CESC\|1\|194\|0.00515
rs563339380	chr17	2290871	2290871	C	T	exonic	MNT	nonsynonymous	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr17	2290884	2290884	T	C	exonic	MNT	nonsynonymous	LIHC\|1\|373\|0.00268

Disease information of MNT

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
MNT	Cleft Palate	C05;C07;C16	Congenital Abnormality	CTD_human
MNT	Miller Dieker syndrome	C10;C16	Disease or Syndrome	CTD_human
MNT	Craniofacial Abnormalities	C05;C16	Congenital Abnormality	CTD_human
MNT	Classical Lissencephaly	C10;C16	Disease or Syndrome	CTD_human
MNT	Cleft palate, isolated	C05;C07;C16	Congenital Abnormality	CTD_human
MNT	X-Linked Lissencephaly	C10;C16	Disease or Syndrome	CTD_human
MNT	Subcortical Band Heterotopia	C10;C16	Disease or Syndrome	CTD_human
MNT	Classical Lissencephalies and Subcortical Band Heterotopias	C10;C16	Disease or Syndrome	CTD_human

Pathway associated with MNT

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number

Go term information of MNT

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GO_term_name	GO_term_type	TF_name
GO_CELL_AGING	BP	MNT
GO_CHROMATIN_BINDING	MF	MNT

Survival analysis of MNT

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of MNT

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)