TF information
| TF name: | CEBPA |
| TF family: | TF_bZIP |
| Ensembl gene ID: | ENSG00000245848 |
| Ensembl protein ID: | ENSP00000427514 |
| Entrez gene ID: | 1050 |
| Database name | Link | Database name | Link |
| NCBI Gene: |  |
Genecards: |  |
| Uniprot: |  |
Wikipedia: |  |
| Cosmic 3D: |  |
Geneontology: |  |
| CCLE: |  |
Frequency of CEBPA in all biosamples
| Sample ID | Biosample type | Tissue type | Biosample name | TF Frequency |
|---|---|---|---|---|
| Sample_01_022 | Cell line | Prostate | C4-2B | 0.19047619047619 |
| Sample_02_007 | Other | Cervical | cervical-cancer_vector | 0.15894039735099 |
| Sample_02_204 | Cell line | Stomach | IM95 | 0.22727272727273 |
| Sample_02_208 | Cell line | Stomach | YCC3 | 0.375 |
| Sample_02_228 | Cell line | Oesophagus | KYSE510 | 0.24790307548928 |
| Sample_02_236 | Cell line | Colon | V206 | 0.17805383022774 |
| Sample_02_237 | Cell line | Colon | V389 | 0.21137493097736 |
| Sample_02_241 | Cell line | Colon | V456 | 0.2020316027088 |
| Sample_02_242 | Cell line | Colon | V481 | 0.11151701595847 |
| Sample_02_285 | Cell line | Liver | HuH7_untreat | 0.26829268292683 |
| Sample_02_322 | Cell line | Colon | Caco-2 | 0.055181695827725 |
| Sample_02_358 | Cell line | Colon | LS180 | 0.11137440758294 |
| Sample_02_361 | Cell line | Colon | HT29_DMSO | 0.12389380530973 |
| Sample_02_404 | Cell line | Mammary Gland | ZR-75-1_2 | 0.24460431654676 |
CEBPA distribution in samples’ most representative CRC
| Sample ID | Tissue type | Biosample type | Biosample name |
|---|
CEBPA distribution in all CRCs
Genomic distribution of SEs associated with CEBPA
Genomic distribution of SEs associated with TF
Figure legend:
Genomic distribution of SEs associated with TF: It can roughly understand the genomic regions of SEs associated with TF, and help to carry out the next analysis, such as knocking down the experiment.
What is important information?
The yellow box can be thought of as the common genomic regions that regulates the SEs associated with TF. For example, if a knockdown experiment is performed on this region, then theoretically, the expression of the TF will be greatly reduced.
| Database name | Link |
|---|---|
| Cosmic: |  |
| Cosmic cell lines: |  |
| Depmap: |  |
TCGA somatic mutations and clinical variants of CEBPA
| rsID | Chr | Start | Stop | Ref | Alt | Gene_region | Gene_symble | Effect | TCGA_Occurrence |
|---|---|---|---|---|---|---|---|---|---|
| - | chr19 | 33792412 | 33792412 | G | T | exonic | CEBPA | synonymous | KIPAN|1|799|0.00125,KIRC|1|451|0.00222 |
| - | chr19 | 33792407 | 33792407 | T | C | exonic | CEBPA | nonsynonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr19 | 33793131 | 33793140 | TGTCGATGGA | - | exonic | CEBPA | frameshift | - |
| - | chr19 | 33792294 | 33792294 | G | - | exonic | CEBPA | frameshift | LAML|1|197|0.00508 |
| - | chr19 | 33792374 | 33792374 | T | G | exonic | CEBPA | nonsynonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr19 | 33792896 | 33792896 | C | - | exonic | CEBPA | frameshift | LAML|1|197|0.00508 |
| - | chr19 | 33792385 | 33792385 | C | T | exonic | CEBPA | synonymous | HNSC|1|512|0.00195 |
| - | chr19 | 33793120 | 33793120 | G | - | exonic | CEBPA | stopgain | LAML|1|197|0.00508 |
| - | chr19 | 33792456 | 33792456 | G | A | exonic | CEBPA | nonsynonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204,ESCA|1|185|0.00541 |
| - | chr19 | 33793132 | 33793141 | GTCGATGGAC | - | exonic | CEBPA | frameshift | - |
| - | chr19 | 33792381 | 33792381 | C | T | exonic | CEBPA | nonsynonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr19 | 33792390 | 33792390 | G | A | exonic | CEBPA | stopgain | COAD|1|367|0.00272,COADREAD|2|489|0.00409,READ|1|122|0.00820 |
| - | chr19 | 33792420 | 33792420 | C | T | exonic | CEBPA | nonsynonymous | SKCM|1|368|0.00272 |
| - | chr19 | 33792389 | 33792389 | T | C | exonic | CEBPA | nonsynonymous | COAD|2|367|0.00545,COADREAD|2|489|0.00409 |
| - | chr19 | 33792404 | 33792404 | - | CT | exonic | CEBPA | frameshift | LAML|1|197|0.00508 |
| - | chr19 | 33793191 | 33793191 | C | G | exonic | CEBPA | nonsynonymous | LAML|1|197|0.00508 |
| - | chr19 | 33792481 | 33792481 | C | G | exonic | CEBPA | nonsynonymous | CESC|1|194|0.00515 |
| - | chr19 | 33792453 | 33792453 | C | T | exonic | CEBPA | nonsynonymous | BLCA|1|396|0.00253,COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr19 | 33793146 | 33793146 | C | A | exonic | CEBPA | stopgain | LAML|1|197|0.00508 |
| - | chr19 | 33793107 | 33793140 | CGGCCGGGTCGATGTAGGCGCTGATGTCGATGGA | - | exonic | CEBPA | frameshift | - |
| - | chr19 | 33792759 | 33792759 | G | A | exonic | CEBPA | nonsynonymous | LIHC|1|373|0.00268 |
| - | chr19 | 33792387 | 33792387 | G | A | exonic | CEBPA | stopgain | KIPAN|1|799|0.00125,KIRC|1|451|0.00222 |
| - | chr19 | 33792337 | 33792337 | C | T | exonic | CEBPA | synonymous | BLCA|1|396|0.00253 |
| - | chr19 | 33792350 | 33792350 | A | G | exonic | CEBPA | nonsynonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr19 | 33793145 | 33793145 | T | C | exonic | CEBPA | nonsynonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr19 | 33792408 | 33792408 | - | AA | exonic | CEBPA | frameshift | LAML|1|197|0.00508 |
| - | chr19 | 33792390 | 33792390 | - | CA | exonic | CEBPA | frameshift | LAML|1|197|0.00508 |
| - | chr19 | 33792440 | 33792440 | A | T | exonic | CEBPA | nonsynonymous | BLCA|1|396|0.00253 |
| rs752254340 | chr19 | 33792919 | 33792919 | C | T | exonic | CEBPA | synonymous | LIHC|1|373|0.00268 |
| - | chr19 | 33792302 | 33792302 | C | T | exonic | CEBPA | nonsynonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr19 | 33793120 | 33793120 | G | T | exonic | CEBPA | stopgain | KIPAN|1|799|0.00125,KIRP|1|282|0.00355 |
| - | chr19 | 33793073 | 33793073 | T | C | exonic | CEBPA | nonsynonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr19 | 33792245 | 33792245 | C | G | exonic | CEBPA | stoploss | LUSC|1|178|0.00562 |
| - | chr19 | 33792369 | 33792370 | TC | - | exonic | CEBPA | frameshift | LAML|1|197|0.00508 |
| - | chr19 | 33793112 | 33793122 | GGGTCGATGTA | - | exonic | CEBPA | frameshift | - |
| - | chr19 | 33792349 | 33792349 | C | T | exonic | CEBPA | synonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr19 | 33792390 | 33792390 | - | GGGTTCTGCTT | exonic | CEBPA | frameshift | LAML|1|197|0.00508 |
| - | chr19 | 33793191 | 33793191 | C | - | exonic | CEBPA | frameshift | LAML|1|197|0.00508 |
| - | chr19 | 33793104 | 33793129 | AGGCGGCCGGGTCGATGTAGGCGCTG | - | exonic | CEBPA | frameshift | - |
| - | chr19 | 33792544 | 33792544 | C | A | exonic | CEBPA | synonymous | TGCT|1|155|0.00645 |
| rs867463920 | chr19 | 33792753 | 33792753 | A | G | exonic | CEBPA | nonsynonymous | LIHC|1|373|0.00268 |
| - | chr19 | 33792575 | 33792575 | G | - | exonic | CEBPA | frameshift | THYM|1|123|0.00813 |
| - | chr19 | 33792395 | 33792395 | - | CA | exonic | CEBPA | frameshift | LAML|1|197|0.00508 |
| - | chr19 | 33793130 | 33793136 | ATGTCGA | - | exonic | CEBPA | frameshift | - |
| - | chr19 | 33792423 | 33792423 | G | A | exonic | CEBPA | nonsynonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204,LAML|1|197|0.00508 |
| - | chr19 | 33792464 | 33792464 | - | G | exonic | CEBPA | frameshift | LAML|1|197|0.00508 |
| - | chr19 | 33792396 | 33792400 | CCACG | - | exonic | CEBPA | frameshift | LAML|1|197|0.00508 |
| - | chr19 | 33792306 | 33792306 | G | A | exonic | CEBPA | nonsynonymous | CESC|1|194|0.00515 |
| - | chr19 | 33792755 | 33792755 | G | T | exonic | CEBPA | nonsynonymous | LIHC|1|373|0.00268 |
| - | chr19 | 33792731 | 33792731 | G | T | exonic | CEBPA | nonsynonymous | LIHC|2|373|0.00536 |
| - | chr19 | 33792390 | 33792390 | G | T | exonic | CEBPA | nonsynonymous | COADREAD|1|489|0.00204,READ|1|122|0.00820 |
| - | chr19 | 33793127 | 33793140 | CTGATGTCGATGGA | - | exonic | CEBPA | frameshift | - |
| rs369632687 | chr19 | 33792321 | 33792321 | C | T | exonic | CEBPA | nonsynonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr19 | 33793069 | 33793069 | G | A | exonic | CEBPA | synonymous | LIHC|1|373|0.00268 |
| - | chr19 | 33792304 | 33792304 | C | T | exonic | CEBPA | synonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr19 | 33792439 | 33792439 | G | T | exonic | CEBPA | synonymous | BLCA|1|396|0.00253 |
| - | chr19 | 33792317 | 33792317 | A | C | exonic | CEBPA | nonsynonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr19 | 33792932 | 33793303 | CCGGGCGGGGGCCCGTGCGCTCCCCCGGGCATGACGGCGCCGCCGGGGCCCGCGGGCGCGCCCGGGTAGTCAAAGTCGCCGCCGCCGCCGCCGCCCGTGGGGCCCACGGCCGCCTTGGCCTTCTCCTGCTGCCGGCTGTGCTGGAACAGGTCGGCCAGGAACTCGTCGTTGAAGGCGGCCGGGTCGATGTAGGCGCTGATGTCGATGGACGTCTCGTGCTCGCAGATGCCGCCCAGCGGCTCCGGGGCGGCAGGT | - | exonic | CEBPA | frameshift | - |
| - | chr19 | 33793108 | 33793108 | G | T | exonic | CEBPA | synonymous | KIPAN|1|799|0.00125,KIRP|1|282|0.00355 |
| - | chr19 | 33792316 | 33792316 | C | T | exonic | CEBPA | synonymous | COAD|2|367|0.00545,COADREAD|2|489|0.00409 |
| - | chr19 | 33793280 | 33793280 | G | T | exonic | CEBPA | nonsynonymous | ESCA|1|185|0.00541 |
| rs137852728 | chr19 | 33793253 | 33793253 | G | - | exonic | CEBPA | frameshift | LAML|1|197|0.00508 |
| - | chr19 | 33793009 | 33793010 | GC | - | exonic | CEBPA | frameshift | THYM|1|123|0.00813 |
| - | chr19 | 33792991 | 33792991 | - | C | exonic | CEBPA | frameshift | LAML|1|197|0.00508 |
| - | chr19 | 33792368 | 33792368 | - | CA | exonic | CEBPA | frameshift | LAML|1|197|0.00508 |
| - | chr19 | 33792421 | 33792421 | G | A | exonic | CEBPA | synonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr19 | 33793184 | 33793184 | G | - | exonic | CEBPA | frameshift | LAML|1|197|0.00508 |
| TF_name | Disease_name | Disease_class | Disease_semantic_type | TF_disease_source |
|---|---|---|---|---|
| CEBPA | Malignant neoplasm of skin | C04;C17 | Neoplastic Process | CTD_human |
| CEBPA | Squamous cell carcinoma | C04 | Neoplastic Process | CTD_human |
| CEBPA | Cytopenia | Pathologic Function | GENOMICS_ENGLAND | |
| CEBPA | Pathological accumulation of air in tissues | C23 | Pathologic Function | CTD_human |
| CEBPA | Head and Neck Neoplasms | C04 | Neoplastic Process | CTD_human |
| CEBPA | Head Neoplasms | C04 | Neoplastic Process | CTD_human |
| CEBPA | Female infertility | C13 | Pathologic Function | CTD_human |
| CEBPA | Leukemia, Myelocytic, Acute | C04 | Neoplastic Process | CGI;CTD_human;UNIPROT |
| CEBPA | Acute Promyelocytic Leukemia | C04 | Neoplastic Process | CTD_human |
| CEBPA | Acute Myeloid Leukemia, M1 | C04 | Neoplastic Process | CTD_human |
| CEBPA | Neck Neoplasms | C04 | Neoplastic Process | CTD_human |
| CEBPA | Neoplasms, Radiation-Induced | C04;C26 | Neoplastic Process | CTD_human |
| CEBPA | Obesity | C18;C23 | Disease or Syndrome | CTD_human |
| CEBPA | Precancerous Conditions | C04 | Neoplastic Process | CTD_human |
| CEBPA | Pulmonary Fibrosis | C08 | Disease or Syndrome | CTD_human |
| CEBPA | Skin Neoplasms | C04;C17 | Neoplastic Process | CTD_human |
| CEBPA | Sterility, Postpartum | C13 | Pathologic Function | CTD_human |
| CEBPA | Hamman-Rich syndrome | C08 | Disease or Syndrome | CTD_human |
| CEBPA | Congenital anemia | Disease or Syndrome | GENOMICS_ENGLAND | |
| CEBPA | Malignant Head and Neck Neoplasm | C04 | Neoplastic Process | CTD_human |
| CEBPA | Condition, Preneoplastic | C04 | Neoplastic Process | CTD_human |
| CEBPA | Subfertility, Female | C13 | Disease or Syndrome | CTD_human |
| CEBPA | Hematologic Neoplasms | C04;C15 | Neoplastic Process | GENOMICS_ENGLAND |
| CEBPA | Cancer of Neck | C04 | Neoplastic Process | CTD_human |
| CEBPA | Cancer of Head | C04 | Neoplastic Process | CTD_human |
| CEBPA | Radiation-Induced Cancer | C04;C26 | Neoplastic Process | CTD_human |
| CEBPA | Upper Aerodigestive Tract Neoplasms | C04 | Neoplastic Process | CTD_human |
| CEBPA | Female sterility | C13 | Finding | CTD_human |
| CEBPA | Acute Myeloid Leukemia (AML-M2) | C04 | Neoplastic Process | CTD_human |
| CEBPA | Liver carcinoma | C04;C06 | Neoplastic Process | CTD_human |
| CEBPA | LEUKEMIA, ACUTE MYELOID, SUSCEPTIBILITY TO | Finding | UNIPROT | |
| CEBPA | MYELODYSPLASTIC SYNDROME | C15 | Neoplastic Process | CGI |
| pathway_ID | pathway_name | pathway_source | gene_number | edge_number |
|---|---|---|---|---|
| pathway0000176 | AndrogenReceptor | netpath | 167 | 2267 |
| pathway0000335 | C-MYB transcription factor network | pid | 87 | 525 |
| pathway0000648 | E2F transcription factor network | pid | 77 | 897 |
| pathway0000825 | FOXA2 and FOXA3 transcription factor networks | pid | 45 | 202 |
| pathway0001128 | IL4 | netpath | 75 | 1239 |
| pathway0001825 | Regulation of Androgen receptor activity | pid | 54 | 338 |
| pathway0001857 | Regulation of retinoblastoma protein | pid | 67 | 718 |
| pathway0002302 | Transcriptional regulation of white adipocyte differentiation | reactome | 79 | 1522 |
| pathway0002391 | Validated targets of C-MYC transcriptional repression | pid | 63 | 385 |
| pathway0002737 | Hs_Regulation_of_Actin_Cytoskeleton_WP51_79977 | wikipathways | 36 | 58 |
| pathway0002757 | Hs_Pathways_Affected_in_Adenoid_Cystic_Carcinoma_WP3651_89271 | wikipathways | 27 | 108 |
| pathway0002788 | Hs_Nucleotide_Metabolism_WP404_68960 | wikipathways | 16 | 29 |
| pathway0002808 | Hs_Transcription_factor_regulation_in_adipogenesis_WP3599_88581 | wikipathways | 9 | 16 |
| GO_term_name | GO_term_type | TF_name |
|---|---|---|
| GO_NEGATIVE_REGULATION_OF_CYCLIN_DEPENDENT_PROTEIN_KINASE_ACTIVITY | BP | CEBPA |
| GO_REGULATION_OF_FAT_CELL_DIFFERENTIATION | BP | CEBPA |
| GO_NEGATIVE_REGULATION_OF_KINASE_ACTIVITY | BP | CEBPA |
| GO_NITROGEN_CYCLE_METABOLIC_PROCESS | BP | CEBPA |
| GO_POSITIVE_REGULATION_OF_FAT_CELL_DIFFERENTIATION | BP | CEBPA |
| GO_CELLULAR_RESPONSE_TO_LITHIUM_ION | BP | CEBPA |
| GO_WHITE_FAT_CELL_DIFFERENTIATION | BP | CEBPA |
| GO_POSITIVE_REGULATION_OF_PROTEASOMAL_PROTEIN_CATABOLIC_PROCESS | BP | CEBPA |
| GO_RESPONSE_TO_METAL_ION | BP | CEBPA |
| GO_LIPID_HOMEOSTASIS | BP | CEBPA |
| GO_IN_UTERO_EMBRYONIC_DEVELOPMENT | BP | CEBPA |
| GO_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_III_PROMOTER | BP | CEBPA |
| GO_CELL_MATURATION | BP | CEBPA |
| GO_POSITIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_PROCESS | BP | CEBPA |
| GO_BROWN_FAT_CELL_DIFFERENTIATION | BP | CEBPA |
| GO_NEGATIVE_REGULATION_OF_MOLECULAR_FUNCTION | BP | CEBPA |
| GO_REGULATION_OF_PROTEASOMAL_PROTEIN_CATABOLIC_PROCESS | BP | CEBPA |
| GO_GRANULOCYTE_DIFFERENTIATION | BP | CEBPA |
| GO_REGULATION_OF_OSTEOBLAST_DIFFERENTIATION | BP | CEBPA |
| GO_MITOCHONDRION_ORGANIZATION | BP | CEBPA |
| GO_TRANSCRIPTION_FROM_RNA_POLYMERASE_I_PROMOTER | BP | CEBPA |
| GO_MACROPHAGE_DIFFERENTIATION | BP | CEBPA |
| GO_POSITIVE_REGULATION_OF_PROTEOLYSIS | BP | CEBPA |
| GO_RESPONSE_TO_LITHIUM_ION | BP | CEBPA |
| GO_NEGATIVE_REGULATION_OF_PHOSPHORYLATION | BP | CEBPA |
| GO_RESPIRATORY_SYSTEM_DEVELOPMENT | BP | CEBPA |
| GO_POSITIVE_REGULATION_OF_OSTEOBLAST_DIFFERENTIATION | BP | CEBPA |
| GO_POSITIVE_REGULATION_OF_DEVELOPMENTAL_PROCESS | BP | CEBPA |
| GO_PLACENTA_DEVELOPMENT | BP | CEBPA |
| GO_STEROL_METABOLIC_PROCESS | BP | CEBPA |
| GO_DEVELOPMENTAL_MATURATION | BP | CEBPA |
| GO_TRANSCRIPTIONAL_ACTIVATOR_ACTIVITY_RNA_POLYMERASE_II_TRANSCRIPTION_REGULATORY_REGION_SEQUENCE_SPECIFIC_BINDING | MF | CEBPA |
| GO_TRANSCRIPTION_FACTOR_ACTIVITY_RNA_POLYMERASE_II_DISTAL_ENHANCER_SEQUENCE_SPECIFIC_BINDING | MF | CEBPA |
| GO_TRANSCRIPTION_FACTOR_ACTIVITY_PROTEIN_BINDING | MF | CEBPA |