TF information
| TF name: | NFE2L2 |
| TF family: | TF_bZIP |
| Ensembl gene ID: | ENSG00000116044 |
| Ensembl protein ID: | ENSP00000380252, ENSP00000411575, ENSP00000467401, ENSP00000380253, ENSP00000391590 |
| Entrez gene ID: | 4780 |
| Database name | Link | Database name | Link |
| NCBI Gene: |  |
Genecards: |  |
| Uniprot: |  |
Wikipedia: |  |
| Cosmic 3D: |  |
Geneontology: |  |
| CCLE: |  |
Frequency of NFE2L2 in all biosamples
| Sample ID | Biosample type | Tissue type | Biosample name | TF Frequency |
|---|---|---|---|---|
| Sample_01_059 | Cell line | Lung | PC-9 | 0.86666666666667 |
| Sample_02_021 | Cell line | Colon | V429 | 0.65897953300663 |
| Sample_02_114 | Cell line | Mammary Gland | CAL51 | 0.56281407035176 |
| Sample_02_164 | Cell line | Lung | H2087_Parental | 0.13333333333333 |
| Sample_02_179 | Cell line | Urinary bladder | T24 | 0.47126436781609 |
| Sample_02_196 | Cell line | Stomach | NCC59 | 0.14285714285714 |
| Sample_02_205 | Tissue | Stomach | Gastric_Primary_Sample_T | 0.31111111111111 |
| Sample_02_228 | Cell line | Oesophagus | KYSE510 | 0.58713886300093 |
| Sample_02_236 | Cell line | Colon | V206 | 0.80952380952381 |
| Sample_02_237 | Cell line | Colon | V389 | 0.48625069022639 |
| Sample_02_242 | Cell line | Colon | V481 | 0.52499519323207 |
| Sample_02_258 | Other | Lung | NCI-H1299_EGFP-NEO_reporter_cells_DMSO | 0.20666666666667 |
| Sample_02_268 | Cell line | Kidney | A-498 | 0.58574856931881 |
| Sample_02_280 | Cell line | Mammary Gland | SUM159_DMSO_24h | 0.4 |
| Sample_02_285 | Cell line | Liver | HuH7_untreat | 0.087108013937282 |
| Sample_02_299 | Cell line | Neuroblastoma | CLB-MA | 0.033573141486811 |
| Sample_02_310 | Cell line | Neuroblastoma | SJNB8 | 0.14023591087811 |
| Sample_02_313 | Cell line | Neuroblastoma | SK-N-DZ | 0.1003861003861 |
| Sample_02_322 | Cell line | Colon | Caco-2 | 0.080753701211306 |
| Sample_02_354 | Cell line | Colon | Colo205 | 0.37087087087087 |
| Sample_02_358 | Cell line | Colon | LS180 | 0.0260663507109 |
| Sample_02_359 | Cell line | Colon | Colo741 | 0.081325301204819 |
| Sample_02_430 | Cell line | Kidney | 12364284 | 0.25 |
NFE2L2 distribution in samples’ most representative CRC
| Sample ID | Tissue type | Biosample type | Biosample name |
|---|---|---|---|
| Sample_01_059 | Lung | Cell line | PC-9 |
| Sample_02_021 | Colon | Cell line | V429 |
| Sample_02_179 | Urinary bladder | Cell line | T24 |
| Sample_02_228 | Oesophagus | Cell line | KYSE510 |
| Sample_02_236 | Colon | Cell line | V206 |
| Sample_02_237 | Colon | Cell line | V389 |
| Sample_02_268 | Kidney | Cell line | A-498 |
NFE2L2 distribution in all CRCs
Genomic distribution of SEs associated with NFE2L2
Genomic distribution of SEs associated with TF
Figure legend:
Genomic distribution of SEs associated with TF: It can roughly understand the genomic regions of SEs associated with TF, and help to carry out the next analysis, such as knocking down the experiment.
What is important information?
The yellow box can be thought of as the common genomic regions that regulates the SEs associated with TF. For example, if a knockdown experiment is performed on this region, then theoretically, the expression of the TF will be greatly reduced.
| Database name | Link |
|---|---|
| Cosmic: |  |
| Cosmic cell lines: |  |
| Depmap: |  |
TCGA somatic mutations and clinical variants of NFE2L2
| rsID | Chr | Start | Stop | Ref | Alt | Gene_region | Gene_symble | Effect | TCGA_Occurrence |
|---|---|---|---|---|---|---|---|---|---|
| - | chr2 | 178095718 | 178095718 | T | G | exonic | NFE2L2 | nonsynonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr2 | 178098800 | 178098800 | T | C | exonic | NFE2L2 | nonsynonymous | ESCA|1|185|0.00541,KIPAN|1|799|0.00125,KIRP|1|282|0.00355,LIHC|1|373|0.00268 |
| - | chr2 | 178098956 | 178098956 | A | G | exonic | NFE2L2 | nonsynonymous | HNSC|1|512|0.00195 |
| - | chr2 | 178098968 | 178098968 | T | A | exonic | NFE2L2 | nonsynonymous | LUSC|1|178|0.00562 |
| rs765842312 | chr2 | 178095685 | 178095685 | C | A | exonic | NFE2L2 | nonsynonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr2 | 178096193 | 178096193 | C | G | exonic | NFE2L2 | nonsynonymous | CESC|1|194|0.00515 |
| rs770882525 | chr2 | 178096533 | 178096533 | C | G | exonic | NFE2L2 | nonsynonymous | CESC|1|194|0.00515 |
| - | chr2 | 178096314 | 178096314 | G | C | exonic | NFE2L2 | nonsynonymous | KIPAN|1|799|0.00125,KIRP|1|282|0.00355 |
| rs763240080 | chr2 | 178095644 | 178095644 | C | T | exonic | NFE2L2 | nonsynonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr2 | 178098809 | 178098809 | T | A | exonic | NFE2L2 | nonsynonymous | LUAD|1|543|0.00184 |
| rs747179142 | chr2 | 178096298 | 178096298 | C | T | exonic | NFE2L2 | nonsynonymous | SKCM|1|368|0.00272 |
| - | chr2 | 178096096 | 178096096 | C | A | exonic | NFE2L2 | nonsynonymous | LUAD|1|543|0.00184 |
| - | chr2 | 178095793 | 178095793 | T | A | exonic | NFE2L2 | nonsynonymous | LUAD|1|543|0.00184 |
| rs775813661 | chr2 | 178098832 | 178098832 | G | A | exonic | NFE2L2 | synonymous | COADREAD|1|489|0.00204,READ|1|122|0.00820 |
| - | chr2 | 178095854 | 178095854 | C | T | exonic | NFE2L2 | nonsynonymous | ESCA|1|185|0.00541 |
| - | chr2 | 178095961 | 178095961 | T | C | exonic | NFE2L2 | nonsynonymous | HNSC|1|512|0.00195 |
| - | chr2 | 178098928 | 178098928 | G | T | exonic | NFE2L2 | nonsynonymous | ESCA|1|185|0.00541 |
| - | chr2 | 178098944 | 178098944 | - | T | exonic | NFE2L2 | frameshift | ESCA|1|185|0.00541 |
| - | chr2 | 178098957 | 178098957 | G | A | exonic | NFE2L2 | nonsynonymous | ESCA|1|185|0.00541,HNSC|1|512|0.00195,LUSC|2|178|0.01124 |
| - | chr2 | 178095623 | 178095623 | C | T | exonic | NFE2L2 | nonsynonymous | HNSC|1|512|0.00195 |
| - | chr2 | 178098944 | 178098944 | C | G | exonic | NFE2L2 | nonsynonymous | BLCA|2|396|0.00505,HNSC|1|512|0.00195,LUSC|1|178|0.00562 |
| - | chr2 | 178129282 | 178129282 | G | T | exonic | NFE2L2 | nonsynonymous | TGCT|1|155|0.00645 |
| - | chr2 | 178098946 | 178098956 | ACTTACTCCAA | - | exonic | NFE2L2 | frameshift | BLCA|1|396|0.00253 |
| - | chr2 | 178098909 | 178098909 | A | G | exonic | NFE2L2 | nonsynonymous | ESCA|1|185|0.00541 |
| - | chr2 | 178097307 | 178097307 | G | T | exonic | NFE2L2 | nonsynonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr2 | 178098956 | 178098956 | A | C | exonic | NFE2L2 | nonsynonymous | KIPAN|1|799|0.00125,KIRP|1|282|0.00355 |
| - | chr2 | 178095734 | 178095734 | T | G | exonic | NFE2L2 | nonsynonymous | BLCA|1|396|0.00253 |
| - | chr2 | 178098808 | 178098808 | C | A | exonic | NFE2L2 | nonsynonymous | CESC|1|194|0.00515 |
| - | chr2 | 178095822 | 178095822 | C | T | exonic | NFE2L2 | synonymous | SKCM|1|368|0.00272 |
| - | chr2 | 178098804 | 178098804 | C | G | exonic | NFE2L2 | nonsynonymous | LIHC|1|373|0.00268 |
| - | chr2 | 178095480 | 178095480 | A | T | UTR3 | NFE2L2 | unknown | KIPAN|1|799|0.00125,KIRC|1|451|0.00222 |
| - | chr2 | 178098801 | 178098801 | C | G | exonic | NFE2L2 | nonsynonymous | LUAD|1|543|0.00184 |
| - | chr2 | 178095546 | 178095546 | G | A | exonic | NFE2L2 | synonymous | HNSC|1|512|0.00195 |
| - | chr2 | 178098936 | 178098936 | - | TACTTCTCGACT | exonic | NFE2L2 | nonframeshift | - |
| - | chr2 | 178098799 | 178098799 | T | A | exonic | NFE2L2 | nonsynonymous | BLCA|1|396|0.00253,CESC|1|194|0.00515,CHOL|1|35|0.02857,UCEC|2|248|0.00806 |
| - | chr2 | 178098009 | 178098009 | G | C | exonic | NFE2L2 | nonsynonymous | BRCA|1|982|0.00102 |
| - | chr2 | 178095761 | 178095761 | C | G | exonic | NFE2L2 | nonsynonymous | BLCA|1|396|0.00253 |
| - | chr2 | 178098966 | 178098966 | C | A | exonic | NFE2L2 | nonsynonymous | LIHC|1|373|0.00268 |
| - | chr2 | 178098807 | 178098807 | T | G | exonic | NFE2L2 | nonsynonymous | UCEC|2|248|0.00806 |
| - | chr2 | 178098751 | 178098751 | T | G | exonic | NFE2L2 | synonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr2 | 178098968 | 178098968 | T | G | exonic | NFE2L2 | nonsynonymous | LIHC|1|373|0.00268,LUSC|1|178|0.00562 |
| - | chr2 | 178095964 | 178095964 | C | G | exonic | NFE2L2 | nonsynonymous | HNSC|1|512|0.00195 |
| - | chr2 | 178096229 | 178096229 | C | G | exonic | NFE2L2 | nonsynonymous | CESC|1|194|0.00515 |
| rs749353894 | chr2 | 178098009 | 178098009 | G | A | exonic | NFE2L2 | nonsynonymous | COADREAD|1|489|0.00204,READ|1|122|0.00820 |
| - | chr2 | 178098975 | 178098975 | A | T | exonic | NFE2L2 | nonsynonymous | ESCA|1|185|0.00541 |
| - | chr2 | 178095660 | 178095660 | G | C | exonic | NFE2L2 | synonymous | UCS|1|57|0.01754 |
| - | chr2 | 178098959 | 178098959 | T | C | exonic | NFE2L2 | nonsynonymous | LUAD|1|543|0.00184,LUSC|1|178|0.00562 |
| - | chr2 | 178098900 | 178098900 | C | - | exonic | NFE2L2 | frameshift | CESC|1|194|0.00515 |
| - | chr2 | 178096691 | 178096691 | G | T | exonic | NFE2L2 | nonsynonymous | TGCT|1|155|0.00645 |
| - | chr2 | 178095532 | 178095532 | G | C | exonic | NFE2L2 | nonsynonymous | BLCA|1|396|0.00253 |
| - | chr2 | 178098973 | 178098973 | C | G | exonic | NFE2L2 | nonsynonymous | HNSC|2|512|0.00391,LUSC|1|178|0.00562 |
| - | chr2 | 178095888 | 178095888 | G | A | exonic | NFE2L2 | synonymous | CESC|1|194|0.00515 |
| - | chr2 | 178095531 | 178095531 | T | C | exonic | NFE2L2 | synonymous | BRCA|1|982|0.00102 |
| - | chr2 | 178098972 | 178098972 | T | A | exonic | NFE2L2 | nonsynonymous | LIHC|1|373|0.00268 |
| - | chr2 | 178096690 | 178096690 | G | T | exonic | NFE2L2 | nonsynonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| rs768430025 | chr2 | 178096180 | 178096180 | G | A | exonic | NFE2L2 | nonsynonymous | LUAD|1|543|0.00184 |
| - | chr2 | 178098803 | 178098803 | C | G | exonic | NFE2L2 | nonsynonymous | BLCA|1|396|0.00253,LIHC|1|373|0.00268 |
| - | chr2 | 178098816 | 178098816 | C | G | exonic | NFE2L2 | nonsynonymous | CESC|1|194|0.00515 |
| - | chr2 | 178096372 | 178096372 | G | C | exonic | NFE2L2 | nonsynonymous | BRCA|1|982|0.00102 |
| - | chr2 | 178098862 | 178098862 | T | G | exonic | NFE2L2 | nonsynonymous | LIHC|1|373|0.00268 |
| - | chr2 | 178096090 | 178096090 | C | T | exonic | NFE2L2 | nonsynonymous | LUAD|1|543|0.00184 |
| - | chr2 | 178098807 | 178098807 | T | C | exonic | NFE2L2 | nonsynonymous | HNSC|1|512|0.00195 |
| - | chr2 | 178095799 | 178095799 | G | A | exonic | NFE2L2 | nonsynonymous | COADREAD|1|489|0.00204,READ|1|122|0.00820 |
| - | chr2 | 178097253 | 178097269 | GGGCTCTCGATGTGACC | - | exonic | NFE2L2 | frameshift | - |
| rs746016111 | chr2 | 178096082 | 178096082 | C | T | exonic | NFE2L2 | nonsynonymous | BLCA|1|396|0.00253 |
| rs181294188 | chr2 | 178095985 | 178095985 | C | T | exonic | NFE2L2 | nonsynonymous | UCEC|1|248|0.00403 |
| rs372010034 | chr2 | 178095651 | 178095651 | T | C | exonic | NFE2L2 | synonymous | PCPG|1|184|0.00543 |
| - | chr2 | 178098803 | 178098803 | C | T | exonic | NFE2L2 | nonsynonymous | BRCA|3|982|0.00305,KIPAN|1|799|0.00125,KIRC|1|451|0.00222 |
| - | chr2 | 178098968 | 178098968 | T | C | exonic | NFE2L2 | nonsynonymous | LIHC|1|373|0.00268,LUAD|1|543|0.00184 |
| - | chr2 | 178098961 | 178098974 | TATATCTTGCCTCC | - | exonic | NFE2L2 | frameshift | LIHC|1|373|0.00268 |
| - | chr2 | 178098950 | 178098950 | A | C | exonic | NFE2L2 | nonsynonymous | HNSC|1|512|0.00195 |
| - | chr2 | 178096727 | 178096727 | - | A | exonic | NFE2L2 | frameshift | HNSC|1|512|0.00195 |
| - | chr2 | 178098912 | 178098912 | C | T | exonic | NFE2L2 | nonsynonymous | ESCA|1|185|0.00541 |
| - | chr2 | 178098806 | 178098806 | G | T | exonic | NFE2L2 | nonsynonymous | KIPAN|1|799|0.00125,KIRP|1|282|0.00355,LUSC|1|178|0.00562 |
| - | chr2 | 178097233 | 178097233 | G | C | exonic | NFE2L2 | nonsynonymous | BLCA|1|396|0.00253 |
| - | chr2 | 178098803 | 178098803 | C | A | exonic | NFE2L2 | nonsynonymous | KIPAN|1|799|0.00125,KIRP|1|282|0.00355,LUSC|1|178|0.00562,UCEC|1|248|0.00403 |
| - | chr2 | 178098806 | 178098806 | G | A | exonic | NFE2L2 | nonsynonymous | BLCA|1|396|0.00253,LIHC|1|373|0.00268 |
| - | chr2 | 178095836 | 178095836 | G | A | exonic | NFE2L2 | nonsynonymous | UCEC|1|248|0.00403 |
| - | chr2 | 178098815 | 178098815 | T | C | exonic | NFE2L2 | nonsynonymous | LUSC|1|178|0.00562 |
| - | chr2 | 178095740 | 178095740 | G | A | exonic | NFE2L2 | nonsynonymous | UCS|1|57|0.01754 |
| - | chr2 | 178098966 | 178098966 | C | G | exonic | NFE2L2 | nonsynonymous | LUAD|1|543|0.00184,LUSC|1|178|0.00562 |
| - | chr2 | 178098806 | 178098806 | G | C | exonic | NFE2L2 | nonsynonymous | UCEC|1|248|0.00403 |
| - | chr2 | 178098800 | 178098800 | T | G | exonic | NFE2L2 | nonsynonymous | ESCA|1|185|0.00541 |
| - | chr2 | 178098969 | 178098969 | G | T | exonic | NFE2L2 | nonsynonymous | UCEC|1|248|0.00403 |
| - | chr2 | 178098936 | 178098937 | AT | - | exonic | NFE2L2 | frameshift | LUSC|1|178|0.00562 |
| - | chr2 | 178096052 | 178096052 | C | A | exonic | NFE2L2 | stopgain | KIPAN|1|799|0.00125,KIRC|1|451|0.00222 |
| - | chr2 | 178096252 | 178096252 | G | T | exonic | NFE2L2 | stopgain | UVM|1|80|0.01250 |
| - | chr2 | 178096114 | 178096114 | G | A | exonic | NFE2L2 | nonsynonymous | SKCM|1|368|0.00272 |
| - | chr2 | 178096545 | 178096545 | G | C | exonic | NFE2L2 | nonsynonymous | HNSC|1|512|0.00195 |
| - | chr2 | 178095969 | 178095969 | G | A | exonic | NFE2L2 | synonymous | HNSC|1|512|0.00195 |
| - | chr2 | 178096592 | 178096592 | G | A | exonic | NFE2L2 | nonsynonymous | KIPAN|2|799|0.00250,KIRC|2|451|0.00443 |
| - | chr2 | 178098944 | 178098944 | C | T | exonic | NFE2L2 | nonsynonymous | CESC|1|194|0.00515,LUSC|3|178|0.01685 |
| - | chr2 | 178095920 | 178095920 | C | G | exonic | NFE2L2 | nonsynonymous | CESC|1|194|0.00515 |
| - | chr2 | 178097218 | 178097218 | C | A | exonic | NFE2L2 | stopgain | CESC|1|194|0.00515 |
| - | chr2 | 178096113 | 178096113 | G | A | exonic | NFE2L2 | synonymous | SKCM|1|368|0.00272 |
| - | chr2 | 178098962 | 178098962 | A | G | exonic | NFE2L2 | nonsynonymous | HNSC|2|512|0.00391,PAAD|1|185|0.00541 |
| - | chr2 | 178098961 | 178098961 | T | C | exonic | NFE2L2 | nonsynonymous | LIHC|1|373|0.00268 |
| - | chr2 | 178095817 | 178095817 | C | T | exonic | NFE2L2 | nonsynonymous | SKCM|1|368|0.00272 |
| - | chr2 | 178097223 | 178097223 | G | C | exonic | NFE2L2 | stopgain | GBMLGG|1|820|0.00122,LGG|1|530|0.00189 |
| - | chr2 | 178095787 | 178095787 | C | G | exonic | NFE2L2 | nonsynonymous | CESC|1|194|0.00515 |
| - | chr2 | 178098953 | 178098953 | C | G | exonic | NFE2L2 | nonsynonymous | BLCA|1|396|0.00253,ESCA|1|185|0.00541,LUSC|2|178|0.01124 |
| - | chr2 | 178098945 | 178098945 | G | C | exonic | NFE2L2 | nonsynonymous | BLCA|5|396|0.01263,ESCA|1|185|0.00541,HNSC|1|512|0.00195,KIPAN|1|799|0.00125,KIRC|1|451|0.00222,LUSC|1|178|0.00562,UCEC|2|248|0.00806 |
| - | chr2 | 178098975 | 178098975 | A | G | exonic | NFE2L2 | nonsynonymous | BLCA|1|396|0.00253,HNSC|1|512|0.00195,LUAD|1|543|0.00184 |
| - | chr2 | 178096428 | 178096428 | T | G | exonic | NFE2L2 | synonymous | BRCA|1|982|0.00102 |
| - | chr2 | 178096193 | 178096193 | C | A | exonic | NFE2L2 | stopgain | COADREAD|1|489|0.00204,READ|1|122|0.00820 |
| - | chr2 | 178097980 | 178097980 | C | G | exonic | NFE2L2 | nonsynonymous | CESC|1|194|0.00515 |
| - | chr2 | 178098960 | 178098960 | C | A | exonic | NFE2L2 | nonsynonymous | BLCA|1|396|0.00253,CESC|1|194|0.00515,HNSC|1|512|0.00195,LUSC|1|178|0.00562 |
| - | chr2 | 178095665 | 178095665 | - | T | exonic | NFE2L2 | frameshift | SKCM|1|368|0.00272 |
| - | chr2 | 178098809 | 178098809 | T | C | exonic | NFE2L2 | nonsynonymous | ESCA|1|185|0.00541 |
| - | chr2 | 178098960 | 178098960 | C | T | exonic | NFE2L2 | nonsynonymous | LUSC|1|178|0.00562 |
| - | chr2 | 178098810 | 178098810 | C | T | exonic | NFE2L2 | nonsynonymous | BLCA|2|396|0.00505,CESC|1|194|0.00515,ESCA|1|185|0.00541,HNSC|4|512|0.00781 |
| - | chr2 | 178098954 | 178098954 | C | T | exonic | NFE2L2 | nonsynonymous | BLCA|1|396|0.00253,LUAD|1|543|0.00184 |
| - | chr2 | 178098960 | 178098960 | - | AT | exonic | NFE2L2 | frameshift | ESCA|1|185|0.00541 |
| - | chr2 | 178098888 | 178098888 | T | G | exonic | NFE2L2 | nonsynonymous | BLCA|1|396|0.00253 |
| - | chr2 | 178098920 | 178098942 | CGCTGACTGAAGTCAAATACTTC | - | exonic | NFE2L2 | frameshift | LUAD|1|543|0.00184 |
| - | chr2 | 178098804 | 178098804 | C | A | exonic | NFE2L2 | nonsynonymous | HNSC|1|512|0.00195,LIHC|1|373|0.00268 |
| - | chr2 | 178098810 | 178098810 | C | G | exonic | NFE2L2 | nonsynonymous | BLCA|1|396|0.00253,ESCA|2|185|0.01081,HNSC|4|512|0.00781,LUSC|4|178|0.02247 |
| - | chr2 | 178098960 | 178098960 | C | G | exonic | NFE2L2 | nonsynonymous | BLCA|2|396|0.00505,CESC|2|194|0.01031,ESCA|1|185|0.00541,HNSC|5|512|0.00977,KIPAN|1|799|0.00125,KIRC|1|451|0.00222,LUAD|1|543|0.00184,LUSC|2|178|0.01124,UCEC|1|248|0.00403 |
| - | chr2 | 178097915 | 178097915 | A | C | intronic | NFE2L2 | unknown | UCEC|1|248|0.00403 |
| - | chr2 | 178096565 | 178096565 | T | C | exonic | NFE2L2 | nonsynonymous | PRAD|1|499|0.00200 |
| - | chr2 | 178098962 | 178098963 | AT | - | exonic | NFE2L2 | frameshift | LIHC|1|373|0.00268 |
| - | chr2 | 178097235 | 178097235 | T | C | exonic | NFE2L2 | nonsynonymous | UCEC|1|248|0.00403 |
| - | chr2 | 178098804 | 178098804 | C | T | exonic | NFE2L2 | nonsynonymous | ESCA|1|185|0.00541,LUSC|2|178|0.01124 |
| - | chr2 | 178095977 | 178095977 | C | T | exonic | NFE2L2 | nonsynonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr2 | 178098810 | 178098810 | C | A | exonic | NFE2L2 | stopgain | LUAD|1|543|0.00184 |
| - | chr2 | 178129392 | 178129399 | GCGGCGGC | - | UTR5 | NFE2L2 | unknown | SARC|1|247|0.00405 |
| - | chr2 | 178098956 | 178098956 | A | T | exonic | NFE2L2 | nonsynonymous | HNSC|1|512|0.00195,KIPAN|1|799|0.00125,KIRC|1|451|0.00222 |
| - | chr2 | 178098800 | 178098800 | T | A | exonic | NFE2L2 | nonsynonymous | HNSC|1|512|0.00195 |
| - | chr2 | 178098918 | 178098918 | G | C | exonic | NFE2L2 | nonsynonymous | UCEC|1|248|0.00403 |
| - | chr2 | 178095647 | 178095647 | G | A | exonic | NFE2L2 | nonsynonymous | HNSC|1|512|0.00195,PCPG|1|184|0.00543 |
| - | chr2 | 178098937 | 178098944 | TACTTCTC | - | exonic | NFE2L2 | frameshift | LUAD|1|543|0.00184 |
| - | chr2 | 178098799 | 178098799 | T | G | exonic | NFE2L2 | nonsynonymous | KIPAN|2|799|0.00250,KIRC|1|451|0.00222,KIRP|1|282|0.00355,LIHC|1|373|0.00268,LUAD|1|543|0.00184 |
| TF_name | Disease_name | Disease_class | Disease_semantic_type | TF_disease_source |
|---|---|---|---|---|
| NFE2L2 | Malignant neoplasm of skin | C04;C17 | Neoplastic Process | CTD_human |
| NFE2L2 | Non-Small Cell Lung Carcinoma | C04;C08 | Neoplastic Process | CGI;CTD_human |
| NFE2L2 | Squamous cell carcinoma | C04 | Neoplastic Process | CTD_human |
| NFE2L2 | Cholestasis | C06 | Disease or Syndrome | CTD_human |
| NFE2L2 | Diabetic Nephropathy | C12;C13;C19 | Disease or Syndrome | CTD_human |
| NFE2L2 | Drug toxicity | C25 | Injury or Poisoning | CTD_human |
| NFE2L2 | Pathological accumulation of air in tissues | C23 | Pathologic Function | CTD_human |
| NFE2L2 | Experimental Autoimmune Encephalomyelitis | C10;C20 | Experimental Model of Disease | CTD_human |
| NFE2L2 | Endometrial Neoplasms | C04;C13 | Neoplastic Process | CTD_human |
| NFE2L2 | Fatty Liver | C06 | Disease or Syndrome | CTD_human |
| NFE2L2 | Gastrointestinal Diseases | C06 | Disease or Syndrome | CTD_human |
| NFE2L2 | Nodular glomerulosclerosis | C12;C13;C19 | Disease or Syndrome | CTD_human |
| NFE2L2 | Heart failure | C14 | Disease or Syndrome | CTD_human |
| NFE2L2 | Congestive heart failure | C14 | Disease or Syndrome | CTD_human |
| NFE2L2 | Hepatitis, Toxic | C06;C25 | Injury or Poisoning | CTD_human |
| NFE2L2 | Hyperglycemia | C18 | Disease or Syndrome | CTD_human |
| NFE2L2 | Hyperplasia | C23 | Pathologic Function | CTD_human |
| NFE2L2 | Keratosis | C17 | Disease or Syndrome | CTD_human |
| NFE2L2 | Keratosis Blennorrhagica | C17 | Disease or Syndrome | CTD_human |
| NFE2L2 | Kidney Diseases | C12;C13 | Disease or Syndrome | CTD_human |
| NFE2L2 | Kidney Failure, Acute | C12;C13 | Disease or Syndrome | CTD_human |
| NFE2L2 | Left-Sided Heart Failure | C14 | Disease or Syndrome | CTD_human |
| NFE2L2 | Liver Cirrhosis | C06 | Disease or Syndrome | CTD_human |
| NFE2L2 | Liver Cirrhosis, Experimental | C06 | Experimental Model of Disease | CTD_human |
| NFE2L2 | Liver neoplasms | C04;C06 | Neoplastic Process | CTD_human |
| NFE2L2 | Necrosis | C23 | Organ or Tissue Function | CTD_human |
| NFE2L2 | Prostatic Neoplasms | C04;C12 | Neoplastic Process | CTD_human |
| NFE2L2 | Pulmonary Fibrosis | C08 | Disease or Syndrome | CTD_human |
| NFE2L2 | Skin Neoplasms | C04;C17 | Neoplastic Process | CTD_human |
| NFE2L2 | Adverse reaction to drug | C25 | Pathologic Function | CTD_human |
| NFE2L2 | Ovarian Failure, Premature | C13;C19 | Disease or Syndrome | CTD_human |
| NFE2L2 | Hamman-Rich syndrome | C08 | Disease or Syndrome | CTD_human |
| NFE2L2 | Gonadotropin-Resistant Ovary Syndrome | C13;C19 | Disease or Syndrome | CTD_human |
| NFE2L2 | Keratoma | C17 | Acquired Abnormality | CTD_human |
| NFE2L2 | Encephalopathy, Toxic | C10;C25 | Injury or Poisoning | CTD_human |
| NFE2L2 | Adenocarcinoma of lung (disorder) | C04;C08 | Neoplastic Process | CTD_human |
| NFE2L2 | Toxic Encephalitis | C10;C25 | Injury or Poisoning | CTD_human |
| NFE2L2 | Dermatitis, Allergic Contact | C17;C20 | Disease or Syndrome | CTD_human |
| NFE2L2 | Vascular System Injuries | C14;C26 | Injury or Poisoning | CTD_human |
| NFE2L2 | Neurotoxicity Syndromes | C10;C25 | Injury or Poisoning | CTD_human |
| NFE2L2 | Heart Failure, Right-Sided | C14 | Disease or Syndrome | CTD_human |
| NFE2L2 | Fibrosis, Liver | C06 | Disease or Syndrome | CTD_human |
| NFE2L2 | Acute Lung Injury | C08 | Injury or Poisoning | CTD_human |
| NFE2L2 | Squamous cell carcinoma of esophagus | C04;C06 | Neoplastic Process | CTD_human |
| NFE2L2 | Chromosome Breaks | C23 | Cell or Molecular Dysfunction | CTD_human |
| NFE2L2 | Malignant neoplasm of liver | C04;C06 | Neoplastic Process | CTD_human |
| NFE2L2 | Malignant neoplasm of prostate | C04;C12 | Neoplastic Process | CTD_human |
| NFE2L2 | Chromosome Breakage | C23 | Cell or Molecular Dysfunction | CTD_human |
| NFE2L2 | Non-alcoholic Fatty Liver Disease | C06 | Disease or Syndrome | CTD_human |
| NFE2L2 | Endometrial Carcinoma | C04;C13 | Neoplastic Process | CTD_human |
| NFE2L2 | Functional Gastrointestinal Disorders | C06 | Disease or Syndrome | CTD_human |
| NFE2L2 | Carcinogenesis | C04;C23 | Neoplastic Process | CTD_human |
| NFE2L2 | Drug-Induced Liver Disease | C06;C25 | Disease or Syndrome | CTD_human |
| NFE2L2 | Carcinoma, Pancreatic Ductal | C04;C06;C19 | Neoplastic Process | CTD_human |
| NFE2L2 | Squamous cell carcinoma of the head and neck | C04 | Neoplastic Process | CGI |
| NFE2L2 | Hepatitis, Drug-Induced | C06;C25 | Disease or Syndrome | CTD_human |
| NFE2L2 | Cholera Infantum | C06 | Disease or Syndrome | CTD_human |
| NFE2L2 | Acute Kidney Insufficiency | C12;C13 | Disease or Syndrome | CTD_human |
| NFE2L2 | Hyperglycemia, Postprandial | C18 | Finding | CTD_human |
| NFE2L2 | Myocardial Failure | C14 | Disease or Syndrome | CTD_human |
| NFE2L2 | Heart Decompensation | C14 | Pathologic Function | CTD_human |
| NFE2L2 | Liver carcinoma | C04;C06 | Neoplastic Process | CTD_human |
| NFE2L2 | Acute kidney injury | C12;C13 | Injury or Poisoning | CTD_human |
| NFE2L2 | Steatohepatitis | C06 | Disease or Syndrome | CTD_human |
| NFE2L2 | Nonalcoholic Steatohepatitis | C06 | Disease or Syndrome | CTD_human |
| NFE2L2 | Hypergonadotropic Ovarian Failure, X-Linked | C10;C13;C16;C19 | Disease or Syndrome | CTD_human |
| NFE2L2 | Drug-Induced Acute Liver Injury | C06;C25 | Disease or Syndrome | CTD_human |
| NFE2L2 | Chemical and Drug Induced Liver Injury | C06;C25 | Disease or Syndrome | CTD_human |
| NFE2L2 | Chemically-Induced Liver Toxicity | C06;C25 | Disease or Syndrome | CTD_human |
| pathway_ID | pathway_name | pathway_source | gene_number | edge_number |
|---|---|---|---|---|
| pathway0002579 | Protein processing in endoplasmic reticulum | kegg | 166 | 1160 |
| pathway0002756 | Hs_Photodynamic_therapy-induced_unfolded_protein_response_WP3613_89330 | wikipathways | 6 | 6 |
| pathway0002777 | Hs_Transcriptional_activation_by_NRF2_WP3_79527 | wikipathways | 6 | 7 |
| GO_term_name | GO_term_type | TF_name |
|---|---|---|
| GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_REACTIVE_OXYGEN_SPECIES | BP | NFE2L2 |
| GO_REGULATION_OF_ENDOTHELIAL_CELL_APOPTOTIC_PROCESS | BP | NFE2L2 |
| GO_REGULATION_OF_COAGULATION | BP | NFE2L2 |
| GO_RESPONSE_TO_FLUID_SHEAR_STRESS | BP | NFE2L2 |
| GO_NEGATIVE_REGULATION_OF_STEM_CELL_DIFFERENTIATION | BP | NFE2L2 |
| GO_CELLULAR_RESPONSE_TO_FLUID_SHEAR_STRESS | BP | NFE2L2 |
| GO_POSITIVE_REGULATION_OF_COAGULATION | BP | NFE2L2 |
| GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_OXIDATIVE_STRESS | BP | NFE2L2 |
| GO_CELLULAR_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND | BP | NFE2L2 |
| GO_POSITIVE_REGULATION_OF_PROTEASOMAL_PROTEIN_CATABOLIC_PROCESS | BP | NFE2L2 |
| GO_RESPONSE_TO_INORGANIC_SUBSTANCE | BP | NFE2L2 |
| GO_REGULATION_OF_HYDROGEN_PEROXIDE_INDUCED_CELL_DEATH | BP | NFE2L2 |
| GO_NEGATIVE_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION | BP | NFE2L2 |
| GO_REGULATION_OF_REMOVAL_OF_SUPEROXIDE_RADICALS | BP | NFE2L2 |
| GO_NEGATIVE_REGULATION_OF_HEMATOPOIETIC_PROGENITOR_CELL_DIFFERENTIATION | BP | NFE2L2 |
| GO_NEGATIVE_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY | BP | NFE2L2 |
| GO_NEGATIVE_REGULATION_OF_EPITHELIAL_CELL_APOPTOTIC_PROCESS | BP | NFE2L2 |
| GO_ER_NUCLEUS_SIGNALING_PATHWAY | BP | NFE2L2 |
| GO_REGULATION_OF_CATABOLIC_PROCESS | BP | NFE2L2 |
| GO_CELL_REDOX_HOMEOSTASIS | BP | NFE2L2 |
| GO_CELLULAR_RESPONSE_TO_HYDROGEN_PEROXIDE | BP | NFE2L2 |
| GO_NEGATIVE_REGULATION_OF_HEMOPOIESIS | BP | NFE2L2 |
| GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_IN_RESPONSE_TO_STRESS | BP | NFE2L2 |
| GO_POSITIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS | BP | NFE2L2 |
| GO_RESPONSE_TO_EXTRACELLULAR_STIMULUS | BP | NFE2L2 |
| GO_REGULATION_OF_PROTEIN_CATABOLIC_PROCESS | BP | NFE2L2 |
| GO_POSITIVE_REGULATION_OF_GLUCOSE_TRANSPORT | BP | NFE2L2 |
| GO_POSITIVE_REGULATION_OF_RESPONSE_TO_WOUNDING | BP | NFE2L2 |
| GO_REGULATION_OF_HEMATOPOIETIC_PROGENITOR_CELL_DIFFERENTIATION | BP | NFE2L2 |
| GO_PERK_MEDIATED_UNFOLDED_PROTEIN_RESPONSE | BP | NFE2L2 |
| GO_CELLULAR_RESPONSE_TO_STARVATION | BP | NFE2L2 |
| GO_POSITIVE_REGULATION_OF_WOUND_HEALING | BP | NFE2L2 |
| GO_REGULATION_OF_SUPEROXIDE_METABOLIC_PROCESS | BP | NFE2L2 |
| GO_REGULATION_OF_OXIDATIVE_STRESS_INDUCED_CELL_DEATH | BP | NFE2L2 |
| GO_CELLULAR_RESPONSE_TO_GLUCOSE_STARVATION | BP | NFE2L2 |
| GO_REGULATION_OF_RESPONSE_TO_OXIDATIVE_STRESS | BP | NFE2L2 |
| GO_NEGATIVE_REGULATION_OF_ENDOTHELIAL_CELL_APOPTOTIC_PROCESS | BP | NFE2L2 |
| GO_REGULATION_OF_SULFUR_METABOLIC_PROCESS | BP | NFE2L2 |
| GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_INVOLVED_IN_CELLULAR_RESPONSE_TO_CHEMICAL_STIMULUS | BP | NFE2L2 |
| GO_NEGATIVE_REGULATION_OF_OXIDATIVE_STRESS_INDUCED_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY | BP | NFE2L2 |
| GO_REGULATION_OF_ERAD_PATHWAY | BP | NFE2L2 |
| GO_CELLULAR_RESPONSE_TO_DRUG | BP | NFE2L2 |
| GO_CELLULAR_RESPONSE_TO_OXIDATIVE_STRESS | BP | NFE2L2 |
| GO_RESPONSE_TO_LAMINAR_FLUID_SHEAR_STRESS | BP | NFE2L2 |
| GO_RESPONSE_TO_TOPOLOGICALLY_INCORRECT_PROTEIN | BP | NFE2L2 |
| GO_POSITIVE_REGULATION_OF_ERAD_PATHWAY | BP | NFE2L2 |
| GO_RESPONSE_TO_HYDROGEN_PEROXIDE | BP | NFE2L2 |
| GO_REGULATION_OF_OXIDATIVE_STRESS_INDUCED_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY | BP | NFE2L2 |
| GO_REGULATION_OF_RESPONSE_TO_REACTIVE_OXYGEN_SPECIES | BP | NFE2L2 |
| GO_REGULATION_OF_STEM_CELL_DIFFERENTIATION | BP | NFE2L2 |
| GO_PROTEIN_DNA_COMPLEX | CC | NFE2L2 |
| GO_TRANSCRIPTIONAL_ACTIVATOR_ACTIVITY_RNA_POLYMERASE_II_DISTAL_ENHANCER_SEQUENCE_SPECIFIC_BINDING | MF | NFE2L2 |
| GO_TRANSCRIPTION_FACTOR_ACTIVITY_RNA_POLYMERASE_II_DISTAL_ENHANCER_SEQUENCE_SPECIFIC_BINDING | MF | NFE2L2 |
| GO_TRANSCRIPTION_COFACTOR_BINDING | MF | NFE2L2 |
| GO_ACTIVATING_TRANSCRIPTION_FACTOR_BINDING | MF | NFE2L2 |
| GO_RNA_POLYMERASE_II_ACTIVATING_TRANSCRIPTION_FACTOR_BINDING | MF | NFE2L2 |
| GO_RNA_POLYMERASE_II_DISTAL_ENHANCER_SEQUENCE_SPECIFIC_DNA_BINDING | MF | NFE2L2 |