Cancer CRCdb

TF information

TF name:	SMAD3
TF family:	MH1
Ensembl gene ID:	ENSG00000166949
Ensembl protein ID:	ENSP00000332973, ENSP00000453082, ENSP00000401133, ENSP00000455095, ENSP00000437757, ENSP00000453684, ENSP00000458060
Entrez gene ID:	4088

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of SMAD3 in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_01_001	Cell line	Prostate	22Rv1	0.077481840193705
Sample_01_046	Cell line	Mammary Gland	MCF-7	0.4
Sample_02_007	Other	Cervical	cervical-cancer_vector	0.18211920529801
Sample_02_021	Cell line	Colon	V429	0.48255981550879
Sample_02_069	Cell line	Brain	SF268	0.70229007633588
Sample_02_080	Cell line	Lung	Calu-3	1
Sample_02_114	Cell line	Mammary Gland	CAL51	0.99497487437186
Sample_02_116	Cell line	Mammary Gland	MDA-MB-231_untreat	0.83333333333333
Sample_02_164	Cell line	Lung	H2087_Parental	0.98333333333333
Sample_02_166	Cell line	Mammary Gland	HCC1954_Parental	1
Sample_02_180	Cell line	Human melanoma	CJM	0.703125
Sample_02_181	Cell line	Human melanoma	COLO679	1
Sample_02_182	Cell line	Human melanoma	LOX-IMVI	0.69252873563218
Sample_02_183	Cell line	Skin	SKMEL2	0.8974358974359
Sample_02_184	Cell line	Skin	SKMEL30	0.43729903536977
Sample_02_188	Cell line	Stomach	MKN1	1
Sample_02_196	Cell line	Stomach	NCC59	0.28571428571429
Sample_02_197	Cell line	Stomach	SNU1750	0.44444444444444
Sample_02_205	Tissue	Stomach	Gastric_Primary_Sample_T	0.62222222222222
Sample_02_219	Cell line	Mammary Gland	MDA-MB-231	0.76470588235294
Sample_02_227	Cell line	Oesophagus	TE7	1
Sample_02_228	Cell line	Oesophagus	KYSE510	1
Sample_02_241	Cell line	Colon	V456	0.48532731376975
Sample_02_258	Other	Lung	NCI-H1299_EGFP-NEO_reporter_cells_DMSO	0.82666666666667
Sample_02_267	Cell line	Kidney	786-O	1
Sample_02_268	Cell line	Kidney	A-498	0.81816503599778
Sample_02_280	Cell line	Mammary Gland	SUM159_DMSO_24h	0.96666666666667
Sample_02_285	Cell line	Liver	HuH7_untreat	0.94425087108014
Sample_02_310	Cell line	Neuroblastoma	SJNB8	0.41480996068152
Sample_02_311	Cell line	Neuroblastoma	SK-N-AS	0.45454545454545
Sample_02_316	Cell line	Neuroblastoma	CHP212	0.46153846153846
Sample_02_317	Cell line	Neuroblastoma	GICAN	0.47297297297297
Sample_02_322	Cell line	Colon	Caco-2	0.63257065948856
Sample_02_354	Cell line	Colon	Colo205	0.80930930930931
Sample_02_356	Cell line	Colon	Sw480	0.61290322580645
Sample_02_359	Cell line	Colon	Colo741	0.83734939759036
Sample_02_361	Cell line	Colon	HT29_DMSO	1
Sample_02_395	Cell line	Mammary Gland	BT-549	1
Sample_02_406	Cell line	Mammary Gland	ZR-75-30_parental	0.94202898550725
Sample_02_424	Cell line	Colon	SW620	0.81159420289855
Sample_02_430	Cell line	Kidney	12364284	1

SMAD3 distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name
Sample_02_021	Colon	Cell line	V429
Sample_02_069	Brain	Cell line	SF268
Sample_02_080	Lung	Cell line	Calu-3
Sample_02_116	Mammary Gland	Cell line	MDA-MB-231_untreat
Sample_02_164	Lung	Cell line	H2087_Parental
Sample_02_166	Mammary Gland	Cell line	HCC1954_Parental
Sample_02_180	Human melanoma	Cell line	CJM
Sample_02_181	Human melanoma	Cell line	COLO679
Sample_02_182	Human melanoma	Cell line	LOX-IMVI
Sample_02_183	Skin	Cell line	SKMEL2
Sample_02_188	Stomach	Cell line	MKN1
Sample_02_197	Stomach	Cell line	SNU1750
Sample_02_205	Stomach	Tissue	Gastric_Primary_Sample_T
Sample_02_219	Mammary Gland	Cell line	MDA-MB-231
Sample_02_227	Oesophagus	Cell line	TE7
Sample_02_228	Oesophagus	Cell line	KYSE510
Sample_02_258	Lung	Other	NCI-H1299_EGFP-NEO_reporter_cells_DMSO
Sample_02_267	Kidney	Cell line	786-O
Sample_02_268	Kidney	Cell line	A-498
Sample_02_280	Mammary Gland	Cell line	SUM159_DMSO_24h
Sample_02_285	Liver	Cell line	HuH7_untreat
Sample_02_310	Neuroblastoma	Cell line	SJNB8
Sample_02_316	Neuroblastoma	Cell line	CHP212
Sample_02_322	Colon	Cell line	Caco-2
Sample_02_354	Colon	Cell line	Colo205
Sample_02_359	Colon	Cell line	Colo741
Sample_02_361	Colon	Cell line	HT29_DMSO
Sample_02_395	Mammary Gland	Cell line	BT-549
Sample_02_406	Mammary Gland	Cell line	ZR-75-30_parental
Sample_02_424	Colon	Cell line	SW620
Sample_02_430	Kidney	Cell line	12364284

SMAD3 distribution in all CRCs

Genomic distribution of SEs associated with SMAD3

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Mutation of SMAD3

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of SMAD3

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr15	67358570	67358570	G	T	exonic	SMAD3	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr15	67477081	67477081	C	G	exonic	SMAD3	synonymous	BLCA\|1\|396\|0.00253
-	chr15	67459118	67459118	G	T	exonic	SMAD3	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|2\|489\|0.00409,READ\|1\|122\|0.00820
-	chr15	67477178	67477178	G	T	exonic	SMAD3	nonsynonymous	PRAD\|1\|499\|0.00200
rs387906850	chr15	67473779	67473779	C	T	exonic	SMAD3	nonsynonymous	ESCA\|1\|185\|0.00541
rs794727798	chr15	67473722	67473722	C	T	exonic	SMAD3	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253,UCEC\|1\|248\|0.00403
-	chr15	67473630	67473630	A	G	exonic	SMAD3	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr15	67482870	67482870	C	A	exonic	SMAD3	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr15	67358513	67358513	C	T	exonic	SMAD3	synonymous	LUSC\|1\|178\|0.00562
-	chr15	67473711	67473711	C	A	exonic	SMAD3	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr15	67473662	67473662	T	G	exonic	SMAD3	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr15	67457298	67457298	T	C	exonic	SMAD3	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr15	67473668	67473668	G	T	exonic	SMAD3	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr15	67482832	67482832	C	T	exonic	SMAD3	synonymous	SKCM\|1\|368\|0.00272
-	chr15	67482810	67482810	A	T	exonic	SMAD3	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr15	67479786	67479786	C	A	exonic	SMAD3	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr15	67462911	67462911	G	A	exonic	SMAD3	synonymous	UCEC\|1\|248\|0.00403
-	chr15	67358682	67358682	T	A	exonic	SMAD3	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr15	67473647	67473647	C	T	exonic	SMAD3	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr15	67482846	67482846	C	T	exonic	SMAD3	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr15	67430400	67430400	C	T	exonic	SMAD3	synonymous	UCEC\|1\|248\|0.00403
rs863223740	chr15	67473723	67473723	G	A	exonic	SMAD3	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,LUAD\|1\|543\|0.00184
-	chr15	67477190	67477190	A	G	exonic	SMAD3	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr15	67473578	67473578	G	A	splicing	SMAD3	splicing	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr15	67457307	67457307	G	A	exonic	SMAD3	stopgain	CESC\|1\|194\|0.00515
rs863223765	chr15	67457304	67457304	G	A	exonic	SMAD3	nonsynonymous	BRCA\|1\|982\|0.00102
rs760286714	chr15	67457389	67457389	C	T	exonic	SMAD3	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr15	67457388	67457388	G	T	exonic	SMAD3	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr15	67473637	67473637	G	A	exonic	SMAD3	synonymous	LUAD\|1\|543\|0.00184
-	chr15	67457639	67457639	-	C	exonic	SMAD3	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr15	67477167	67477167	G	A	exonic	SMAD3	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr15	67358664	67358664	C	T	exonic	SMAD3	stopgain	KICH\|1\|66\|0.01515,KIPAN\|1\|799\|0.00125
-	chr15	67358639	67358639	C	T	exonic	SMAD3	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs868489900	chr15	67457245	67457245	C	T	exonic	SMAD3	synonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
rs779602560	chr15	67479838	67479838	C	T	exonic	SMAD3	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr15	67358517	67358517	C	T	exonic	SMAD3	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr15	67477111	67477111	G	-	exonic	SMAD3	frameshift	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr15	67477076	67477076	C	T	exonic	SMAD3	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr15	67473681	67473681	C	T	exonic	SMAD3	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr15	67473668	67473668	G	A	exonic	SMAD3	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr15	67482873	67482873	A	T	exonic	SMAD3	stoploss	PAAD\|1\|185\|0.00541
-	chr15	67457257	67457257	G	T	exonic	SMAD3	synonymous	LUAD\|1\|543\|0.00184
-	chr15	67473643	67473643	C	G	exonic	SMAD3	nonsynonymous	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr15	67479829	67479829	G	C	exonic	SMAD3	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr15	67479715	67479715	A	C	exonic	SMAD3	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr15	67482849	67482849	G	T	exonic	SMAD3	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr15	67473777	67473777	C	G	exonic	SMAD3	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr15	67473751	67473751	C	G	exonic	SMAD3	synonymous	BLCA\|1\|396\|0.00253
-	chr15	67457287	67457287	C	A	exonic	SMAD3	synonymous	LUSC\|1\|178\|0.00562
rs762012589	chr15	67482855	67482855	G	A	exonic	SMAD3	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,HNSC\|1\|512\|0.00195
-	chr15	67477141	67477141	G	A	exonic	SMAD3	synonymous	UCEC\|1\|248\|0.00403
-	chr15	67457371	67457371	G	A	exonic	SMAD3	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr15	67477081	67477081	C	T	exonic	SMAD3	synonymous	BLCA\|2\|396\|0.00505
-	chr15	67482863	67482863	A	C	exonic	SMAD3	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr15	67473685	67473685	G	A	exonic	SMAD3	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr15	67479784	67479784	A	G	exonic	SMAD3	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr15	67477152	67477152	G	A	exonic	SMAD3	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr15	67479782	67479782	C	T	exonic	SMAD3	synonymous	BLCA\|1\|396\|0.00253
-	chr15	67457330	67457330	G	A	exonic	SMAD3	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr15	67457410	67457410	G	C	exonic	SMAD3	nonsynonymous	CESC\|1\|194\|0.00515
-	chr15	67477184	67477184	G	A	exonic	SMAD3	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr15	67457635	67457635	G	A	exonic	SMAD3	nonsynonymous	BLCA\|1\|396\|0.00253,COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr15	67473606	67473606	C	T	exonic	SMAD3	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr15	67477138	67477138	C	G	exonic	SMAD3	synonymous	HNSC\|1\|512\|0.00195
rs576157357	chr15	67430385	67430385	G	A	exonic	SMAD3	synonymous	UCEC\|1\|248\|0.00403
-	chr15	67473595	67473595	C	G	exonic	SMAD3	synonymous	SKCM\|1\|368\|0.00272
-	chr15	67479750	67479750	G	T	exonic	SMAD3	nonsynonymous	ESCA\|1\|185\|0.00541
rs751780616	chr15	67479737	67479737	C	T	exonic	SMAD3	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr15	67473727	67473727	C	T	exonic	SMAD3	synonymous	BLCA\|1\|396\|0.00253
-	chr15	67473711	67473711	C	T	exonic	SMAD3	nonsynonymous	SARC\|1\|247\|0.00405
-	chr15	67477105	67477105	C	A	exonic	SMAD3	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr15	67482777	67482777	G	T	exonic	SMAD3	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr15	67473741	67473741	-	G	exonic	SMAD3	frameshift	BRCA\|1\|982\|0.00102
-	chr15	67482843	67482843	C	T	exonic	SMAD3	nonsynonymous	ESCA\|1\|185\|0.00541,HNSC\|1\|512\|0.00195
-	chr15	67479716	67479716	G	C	exonic	SMAD3	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr15	67482773	67482773	C	A	exonic	SMAD3	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr15	67457672	67457672	C	T	exonic	SMAD3	nonsynonymous	SKCM\|1\|368\|0.00272
rs758823376	chr15	67457265	67457265	G	A	exonic	SMAD3	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs773543026	chr15	67473650	67473650	G	A	exonic	SMAD3	nonsynonymous	BLCA\|1\|396\|0.00253
rs758586312	chr15	67477161	67477161	G	A	exonic	SMAD3	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr15	67479753	67479753	C	T	exonic	SMAD3	stopgain	SKCM\|1\|368\|0.00272
rs387906854	chr15	67457361	67457361	C	T	exonic	SMAD3	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr15	67459160	67459160	T	C	exonic	SMAD3	synonymous	HNSC\|1\|512\|0.00195
-	chr15	67482771	67482771	C	-	exonic	SMAD3	frameshift	LIHC\|1\|373\|0.00268
-	chr15	67358560	67358560	A	G	exonic	SMAD3	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr15	67479712	67479712	T	C	exonic	SMAD3	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr15	67482774	67482774	C	T	exonic	SMAD3	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820,SKCM\|1\|368\|0.00272
-	chr15	67358559	67358559	C	T	exonic	SMAD3	stopgain	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr15	67473677	67473677	C	T	exonic	SMAD3	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr15	67482849	67482849	G	A	exonic	SMAD3	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253

Disease information of SMAD3

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
SMAD3	Aneurysm, Dissecting	C14	Disease or Syndrome	CTD_human
SMAD3	Aortic Aneurysm	C14	Disease or Syndrome	CTD_human
SMAD3	Arthrogryposis	C05;C16	Disease or Syndrome	GENOMICS_ENGLAND
SMAD3	Cerebrovascular Disorders	C10;C14	Disease or Syndrome	GENOMICS_ENGLAND
SMAD3	Cocaine Abuse	C25;F03	Mental or Behavioral Dysfunction	CTD_human
SMAD3	Crohn Disease	C06	Disease or Syndrome	CTD_human
SMAD3	Ehlers-Danlos Syndrome	C14;C15;C16;C17	Disease or Syndrome	GENOMICS_ENGLAND
SMAD3	Fibroid Tumor	C04	Neoplastic Process	CTD_human
SMAD3	Liver Cirrhosis	C06	Disease or Syndrome	CTD_human
SMAD3	Liver Cirrhosis, Alcoholic	C06;C25	Disease or Syndrome	CTD_human
SMAD3	Marfan Syndrome	C05;C14;C16;C17	Disease or Syndrome	CLINGEN
SMAD3	Degenerative polyarthritis	C05	Disease or Syndrome	CTD_human
SMAD3	Uterine Fibroids	C04	Neoplastic Process	CTD_human
SMAD3	Uterine Neoplasms	C04;C13	Neoplastic Process	CTD_human
SMAD3	Osteoarthrosis Deformans	C05	Disease or Syndrome	CTD_human
SMAD3	Juvenile-Onset Still Disease	C05;C17;C20	Disease or Syndrome	CTD_human
SMAD3	Uterine Cancer	C04;C13	Neoplastic Process	CTD_human
SMAD3	Crohn's disease of large bowel	C06	Disease or Syndrome	CTD_human
SMAD3	Aortic Aneurysm, Thoracic	C14	Disease or Syndrome	GENOMICS_ENGLAND
SMAD3	Cocaine-Related Disorders	C25;F03	Mental or Behavioral Dysfunction	CTD_human
SMAD3	Fibrosis, Liver	C06	Disease or Syndrome	CTD_human
SMAD3	Crohn's disease of the ileum	C06	Disease or Syndrome	CTD_human
SMAD3	Dissection of aorta	C14	Pathologic Function	CTD_human
SMAD3	Congenital aneurysm of ascending aorta	C14	Congenital Abnormality	GENOMICS_ENGLAND
SMAD3	Craniofacial Abnormalities	C05;C16	Congenital Abnormality	CTD_human
SMAD3	Cocaine Dependence	C25;F03	Mental or Behavioral Dysfunction	CTD_human
SMAD3	Ventricular Remodeling	C23	Organ or Tissue Function	CTD_human
SMAD3	Left Ventricle Remodeling	C23	Organ or Tissue Function	CTD_human
SMAD3	Regional enteritis	C06	Disease or Syndrome	CTD_human
SMAD3	IIeocolitis	C06	Disease or Syndrome	CTD_human
SMAD3	Colorectal Cancer	C04;C06	Neoplastic Process	UNIPROT
SMAD3	Loeys-Dietz Aortic Aneurysm Syndrome	C05;C14;C16	Disease or Syndrome	CTD_human
SMAD3	Loeys-Dietz Syndrome	C05;C14;C16	Disease or Syndrome	CTD_human
SMAD3	LOEYS-DIETZ SYNDROME 3		Disease or Syndrome	CLINGEN;ORPHANET;UNIPROT
SMAD3	Juvenile arthritis	C05;C17;C20	Disease or Syndrome	CTD_human
SMAD3	Intellectual Disability	C10;C23;F01;F03	Mental or Behavioral Dysfunction	GENOMICS_ENGLAND
SMAD3	Juvenile psoriatic arthritis	C05;C17;C20	Disease or Syndrome	CTD_human
SMAD3	Dissection, Blood Vessel	C14	Pathologic Function	CTD_human

Pathway associated with SMAD3

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number
pathway0000321	BMP signaling pathway ( TGF-beta_BMP Diagram(MolecularVariation) )	inoh	34	385
pathway0000631	Downregulation of SMAD2/3:SMAD4 transcriptional activity	reactome	23	145
pathway0000632	Downregulation of TGF-beta receptor signaling	reactome	26	168
pathway0000897	Gene expression of smad6/7 by R-smad:smad4 ( TGF-beta_super_family_signaling_pathway(canonical) )	inoh	8	27
pathway0000898	Gene expression of smad7 by R-smad:smad4 ( TGF-beta_super_family_signaling_pathway(canonical) )	inoh	7	20
pathway0001078	ID	netpath	38	213
pathway0001455	Negative regulation of (transcription by R-smad:smad4) in TGF beta super family signaling pathway ( TGF-beta_super_family_signaling_pathway(canonical) )	inoh	21	184
pathway0001830	Regulation of cytoplasmic and nuclear SMAD2/3 signaling	pid	20	69
pathway0002008	Signaling by Activin	reactome	11	38
pathway0002024	Signaling by NODAL	reactome	19	89
pathway0002067	SMAD2/3 MH2 Domain Mutants in Cancer	reactome	7	20
pathway0002068	SMAD2/3 Phosphorylation Motif Mutants in Cancer	reactome	6	15
pathway0002069	SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	reactome	32	197
pathway0002214	TGF-beta receptor signaling activates SMADs	reactome	12	33
pathway0002215	TGF-beta receptor signaling	pid	53	411
pathway0002218	TGF-beta_super_family_signaling_pathway(canonical) ( TGF-beta_BMP Diagram(MolecularVariation) )	inoh	51	970
pathway0002223	TGFBR1 KD Mutants in Cancer	reactome	7	21
pathway0002657	Colorectal cancer	kegg	63	642
pathway0002680	Hs_Cell_Cycle_WP179_89516	wikipathways	33	97
pathway0002740	Hs_Endoderm_Differentiation_WP2853_88152	wikipathways	62	260
pathway0002751	Hs_Integrated_Cancer_Pathway_WP1971_82939	wikipathways	33	206
pathway0002826	Hs_Mesodermal_Commitment_Pathway_WP2857_87780	wikipathways	47	175
pathway0002853	Hs_TGF-beta_Signaling_Pathway_WP366_90028	wikipathways	67	576
pathway0002863	Hs_Androgen_receptor_signaling_pathway_WP138_79958	wikipathways	27	107

Go term information of SMAD3

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GO_term_name	GO_term_type	TF_name
GO_SMAD_PROTEIN_SIGNAL_TRANSDUCTION	BP	SMAD3
GO_LEUKOCYTE_ACTIVATION	BP	SMAD3
GO_LENS_FIBER_CELL_DIFFERENTIATION	BP	SMAD3
GO_REGULATION_OF_WOUND_HEALING	BP	SMAD3
GO_REGULATION_OF_PHOSPHATASE_ACTIVITY	BP	SMAD3
GO_POSITIVE_REGULATION_OF_EPITHELIAL_TO_MESENCHYMAL_TRANSITION	BP	SMAD3
GO_POSITIVE_REGULATION_OF_INTERLEUKIN_1_BETA_PRODUCTION	BP	SMAD3
GO_FORMATION_OF_PRIMARY_GERM_LAYER	BP	SMAD3
GO_NEGATIVE_REGULATION_OF_FAT_CELL_DIFFERENTIATION	BP	SMAD3
GO_CELLULAR_RESPONSE_TO_ORGANIC_CYCLIC_COMPOUND	BP	SMAD3
GO_EMBRYONIC_SKELETAL_SYSTEM_MORPHOGENESIS	BP	SMAD3
GO_OSTEOBLAST_DIFFERENTIATION	BP	SMAD3
GO_MODIFICATION_OF_MORPHOLOGY_OR_PHYSIOLOGY_OF_OTHER_ORGANISM	BP	SMAD3
GO_NEGATIVE_REGULATION_OF_NITROGEN_COMPOUND_METABOLIC_PROCESS	BP	SMAD3
GO_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS	BP	SMAD3
GO_REGULATION_OF_POSITIVE_CHEMOTAXIS	BP	SMAD3
GO_REGULATION_OF_MUSCLE_TISSUE_DEVELOPMENT	BP	SMAD3
GO_REGULATION_OF_EXTRACELLULAR_MATRIX_ORGANIZATION	BP	SMAD3
GO_ACTIVATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY	BP	SMAD3
GO_REGULATION_OF_EXTRACELLULAR_MATRIX_ASSEMBLY	BP	SMAD3
GO_SPECIFICATION_OF_SYMMETRY	BP	SMAD3
GO_POSITIVE_REGULATION_OF_CELL_MATRIX_ADHESION	BP	SMAD3
GO_NEGATIVE_REGULATION_OF_WOUND_HEALING	BP	SMAD3
GO_REGULATION_OF_BIOMINERAL_TISSUE_DEVELOPMENT	BP	SMAD3
GO_EMBRYONIC_HEART_TUBE_DEVELOPMENT	BP	SMAD3
GO_LYMPHOCYTE_ACTIVATION	BP	SMAD3
GO_REGULATION_OF_TRANSCRIPTION_FACTOR_IMPORT_INTO_NUCLEUS	BP	SMAD3
GO_REGULATION_OF_ADHERENS_JUNCTION_ORGANIZATION	BP	SMAD3
GO_REGULATION_OF_NUCLEOCYTOPLASMIC_TRANSPORT	BP	SMAD3
GO_REGULATION_OF_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_SIGNALING_PATHWAY	BP	SMAD3
GO_RESPONSE_TO_OXYGEN_LEVELS	BP	SMAD3
GO_POSITIVE_REGULATION_OF_BIOMINERAL_TISSUE_DEVELOPMENT	BP	SMAD3
GO_REGULATION_OF_TRANSFORMING_GROWTH_FACTOR_BETA_PRODUCTION	BP	SMAD3
GO_MODIFICATION_BY_SYMBIONT_OF_HOST_MORPHOLOGY_OR_PHYSIOLOGY	BP	SMAD3
GO_POSITIVE_REGULATION_OF_CELL_JUNCTION_ASSEMBLY	BP	SMAD3
GO_HEART_MORPHOGENESIS	BP	SMAD3
GO_EMBRYONIC_PATTERN_SPECIFICATION	BP	SMAD3
GO_POSITIVE_REGULATION_OF_EXTRACELLULAR_MATRIX_ORGANIZATION	BP	SMAD3
GO_SOMITOGENESIS	BP	SMAD3
GO_POSITIVE_REGULATION_OF_STEM_CELL_DIFFERENTIATION	BP	SMAD3
GO_DIGESTIVE_TRACT_MORPHOGENESIS	BP	SMAD3
GO_REGULATION_OF_INTERLEUKIN_1_PRODUCTION	BP	SMAD3
GO_POSITIVE_REGULATION_OF_INTERLEUKIN_1_PRODUCTION	BP	SMAD3
GO_REGULATION_OF_OSTEOBLAST_PROLIFERATION	BP	SMAD3
GO_SEGMENTATION	BP	SMAD3
GO_POSITIVE_REGULATION_OF_PEPTIDASE_ACTIVITY	BP	SMAD3
GO_CRANIAL_SKELETAL_SYSTEM_DEVELOPMENT	BP	SMAD3
GO_POSITIVE_REGULATION_OF_NUCLEOCYTOPLASMIC_TRANSPORT	BP	SMAD3
GO_POSITIVE_REGULATION_OF_CARTILAGE_DEVELOPMENT	BP	SMAD3
GO_REGULATION_OF_CELLULAR_RESPONSE_TO_TRANSFORMING_GROWTH_FACTOR_BETA_STIMULUS	BP	SMAD3
GO_REGULATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY	BP	SMAD3
GO_MODULATION_BY_VIRUS_OF_HOST_MORPHOLOGY_OR_PHYSIOLOGY	BP	SMAD3
GO_POSITIVE_REGULATION_OF_TRANSFORMING_GROWTH_FACTOR_BETA_PRODUCTION	BP	SMAD3
GO_REGULATION_OF_ACTIN_FILAMENT_BUNDLE_ASSEMBLY	BP	SMAD3
GO_POSITIVE_REGULATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY	BP	SMAD3
GO_POSTTRANSCRIPTIONAL_GENE_SILENCING	BP	SMAD3
GO_CELLULAR_RESPONSE_TO_DSRNA	BP	SMAD3
GO_DSRNA_FRAGMENTATION	BP	SMAD3
GO_REGULATION_OF_CATENIN_IMPORT_INTO_NUCLEUS	BP	SMAD3
GO_PERICARDIUM_DEVELOPMENT	BP	SMAD3
GO_POSITIVE_REGULATION_OF_ADHERENS_JUNCTION_ORGANIZATION	BP	SMAD3
GO_ACTIVIN_RECEPTOR_SIGNALING_PATHWAY	BP	SMAD3
GO_UROGENITAL_SYSTEM_DEVELOPMENT	BP	SMAD3
GO_POSITIVE_REGULATION_OF_PROTEIN_IMPORT	BP	SMAD3
GO_PARAXIAL_MESODERM_DEVELOPMENT	BP	SMAD3
GO_NEGATIVE_REGULATION_OF_TRANSFORMING_GROWTH_FACTOR_BETA_RECEPTOR_SIGNALING_PATHWAY	BP	SMAD3
GO_OSTEOBLAST_DEVELOPMENT	BP	SMAD3
GO_REGULATION_OF_CELL_MATRIX_ADHESION	BP	SMAD3
GO_ENDOCRINE_SYSTEM_DEVELOPMENT	BP	SMAD3
GO_POSITIVE_REGULATION_OF_CATENIN_IMPORT_INTO_NUCLEUS	BP	SMAD3
GO_NEGATIVE_REGULATION_OF_OSSIFICATION	BP	SMAD3
GO_REGULATION_OF_CELLULAR_COMPONENT_MOVEMENT	BP	SMAD3
GO_ACTIVATION_OF_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY_INVOLVED_IN_APOPTOTIC_SIGNALING_PATHWAY	BP	SMAD3
GO_NEGATIVE_REGULATION_OF_OSTEOBLAST_DIFFERENTIATION	BP	SMAD3
GO_POSITIVE_REGULATION_OF_ACTIN_FILAMENT_BUNDLE_ASSEMBLY	BP	SMAD3
GO_MESODERM_DEVELOPMENT	BP	SMAD3
GO_CELL_DEVELOPMENT	BP	SMAD3
GO_MESENCHYME_MORPHOGENESIS	BP	SMAD3
GO_POSITIVE_REGULATION_OF_CHEMOTAXIS	BP	SMAD3
GO_REGULATION_OF_INTRACELLULAR_TRANSPORT	BP	SMAD3
GO_POSITIVE_REGULATION_OF_DEPHOSPHORYLATION	BP	SMAD3
GO_EMBRYONIC_ORGAN_DEVELOPMENT	BP	SMAD3
GO_POSITIVE_REGULATION_OF_CHONDROCYTE_DIFFERENTIATION	BP	SMAD3
GO_THYROID_GLAND_DEVELOPMENT	BP	SMAD3
GO_POSITIVE_REGULATION_OF_PHOSPHATASE_ACTIVITY	BP	SMAD3
GO_LENS_DEVELOPMENT_IN_CAMERA_TYPE_EYE	BP	SMAD3
GO_REGULATION_OF_EPITHELIAL_TO_MESENCHYMAL_TRANSITION	BP	SMAD3
GO_EMBRYONIC_CRANIAL_SKELETON_MORPHOGENESIS	BP	SMAD3
GO_SIGNAL_TRANSDUCTION_INVOLVED_IN_REGULATION_OF_GENE_EXPRESSION	BP	SMAD3
GO_POSITIVE_REGULATION_OF_OSSIFICATION	BP	SMAD3
GO_BETA_CATENIN_BINDING	MF	SMAD3
GO_UBIQUITIN_LIKE_PROTEIN_BINDING	MF	SMAD3
GO_BHLH_TRANSCRIPTION_FACTOR_BINDING	MF	SMAD3
GO_PROTEIN_HETERODIMERIZATION_ACTIVITY	MF	SMAD3
GO_ENHANCER_BINDING	MF	SMAD3
GO_COLLAGEN_BINDING	MF	SMAD3
GO_R_SMAD_BINDING	MF	SMAD3
GO_CO_SMAD_BINDING	MF	SMAD3
GO_TRANSFORMING_GROWTH_FACTOR_BETA_RECEPTOR_BINDING	MF	SMAD3
GO_ACTIVATING_TRANSCRIPTION_FACTOR_BINDING	MF	SMAD3
GO_RNA_POLYMERASE_II_ACTIVATING_TRANSCRIPTION_FACTOR_BINDING	MF	SMAD3
GO_TRANSCRIPTION_FACTOR_ACTIVITY_RNA_POLYMERASE_II_CORE_PROMOTER_SEQUENCE_SPECIFIC	MF	SMAD3
GO_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_BINDING	MF	SMAD3

Survival analysis of SMAD3

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of SMAD3

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)