1. TF detail

TF information

TF name: JUNB
TF family: TF_bZIP
Ensembl gene ID: ENSG00000171223
Ensembl protein ID: ENSP00000303315
Entrez gene ID: 3726
Database name Link Database name Link
NCBI Gene: Genecards:
Uniprot: Wikipedia:
Cosmic 3D: Geneontology:
CCLE:
Frequency of JUNB in all biosamples
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Sample ID Biosample type Tissue type Biosample name TF Frequency
Sample_01_022Cell lineProstateC4-2B0.28571428571429
Sample_01_046Cell lineMammary GlandMCF-70.5
Sample_02_021Cell lineColonV4290.37763044104929
Sample_02_078Primary cellNeuroblastomalow-MYCN-Neuroblastoma-patient-cells0.375
Sample_02_080Cell lineLungCalu-30.36363636363636
Sample_02_095Cell lineMammary GlandMDA-MB-4680.55330739299611
Sample_02_096Cell lineMammary GlandZR-75-1_10.48913043478261
Sample_02_115Cell lineMammary GlandMCF-71
Sample_02_116Cell lineMammary GlandMDA-MB-231_untreat0.33333333333333
Sample_02_161Cell lineBrainU871
Sample_02_164Cell lineLungH2087_Parental0.65
Sample_02_166Cell lineMammary GlandHCC1954_Parental0.424
Sample_02_168Cell lineProstateLNCaP0.23954372623574
Sample_02_180Cell lineHuman melanomaCJM0.4765625
Sample_02_181Cell lineHuman melanomaCOLO6790.20426666666667
Sample_02_182Cell lineHuman melanomaLOX-IMVI0.50574712643678
Sample_02_183Cell lineSkinSKMEL20.46153846153846
Sample_02_184Cell lineSkinSKMEL300.14790996784566
Sample_02_188Cell lineStomachMKN10.5
Sample_02_192Cell lineStomachMKN450.5
Sample_02_195Cell lineStomachOCUM11
Sample_02_200Cell lineStomachRERF-GC-1B1
Sample_02_204Cell lineStomachIM950.54545454545455
Sample_02_205TissueStomachGastric_Primary_Sample_T0.62962962962963
Sample_02_219Cell lineMammary GlandMDA-MB-2310.55882352941176
Sample_02_220Cell lineBrainBE2C_10.57692307692308
Sample_02_227Cell lineOesophagusTE70.84
Sample_02_228Cell lineOesophagusKYSE5100.40074557315937
Sample_02_236Cell lineColonV2060.18633540372671
Sample_02_237Cell lineColonV3890.22841892140622
Sample_02_241Cell lineColonV4560.22234762979684
Sample_02_242Cell lineColonV4810.288790617189
Sample_02_254Cell lineNeuroblastomaIMR5-750.41176470588235
Sample_02_258OtherLungNCI-H1299_EGFP-NEO_reporter_cells_DMSO0.16666666666667
Sample_02_268Cell lineKidneyA-4980.62248477016799
Sample_02_280Cell lineMammary GlandSUM159_DMSO_24h0.825
Sample_02_296Cell lineNeuroblastomaCLB-BER-Lud0.52257077276205
Sample_02_298Cell lineNeuroblastomaCLB-GA0.58904109589041
Sample_02_299Cell lineNeuroblastomaCLB-MA0.23501199040767
Sample_02_300Cell lineNeuroblastomaCLB-PE0.71794871794872
Sample_02_304Cell lineNeuroblastomaN2060.23097826086957
Sample_02_307Cell lineNeuroblastomaSJNB120.43661971830986
Sample_02_308Cell lineNeuroblastomaSJNB10.46875
Sample_02_309Cell lineNeuroblastomaSJNB60.23696682464455
Sample_02_310Cell lineNeuroblastomaSJNB80.34338138925295
Sample_02_311Cell lineNeuroblastomaSK-N-AS0.68831168831169
Sample_02_313Cell lineNeuroblastomaSK-N-DZ0.26254826254826
Sample_02_314Cell lineNeuroblastomaSK-N-FI0.45061728395062
Sample_02_316Cell lineNeuroblastomaCHP2120.5
Sample_02_318Cell lineNeuroblastomaNB690.3203125
Sample_02_319Cell lineNeuroblastomaNB-EBc10.32369942196532
Sample_02_322Cell lineColonCaco-20.41722745625841
Sample_02_338Cell lineNeuroblastomaBE20.57352941176471
Sample_02_354Cell lineColonColo2050.5
Sample_02_358Cell lineColonLS1800.10466034755134
Sample_02_359Cell lineColonColo7410.16867469879518
Sample_02_361Cell lineColonHT29_DMSO0.43362831858407
Sample_02_395Cell lineMammary GlandBT-5490.39832167832168
Sample_02_403Cell lineMammary GlandT-47D_untreat0.32954545454545
Sample_02_404Cell lineMammary GlandZR-75-1_20.33812949640288
Sample_02_406Cell lineMammary GlandZR-75-30_parental0.3768115942029
Sample_02_413TissueBrainGBM_24930.43956043956044
Sample_02_424Cell lineColonSW6200.2463768115942
Sample_02_430Cell lineKidney123642840.26785714285714
JUNB distribution in samples’ most representative CRC
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Sample ID Tissue type Biosample type Biosample name
Sample_01_022ProstateCell lineC4-2B
Sample_02_078NeuroblastomaPrimary celllow-MYCN-Neuroblastoma-patient-cells
Sample_02_080LungCell lineCalu-3
Sample_02_095Mammary GlandCell lineMDA-MB-468
Sample_02_115Mammary GlandCell lineMCF-7
Sample_02_161BrainCell lineU87
Sample_02_168ProstateCell lineLNCaP
Sample_02_182Human melanomaCell lineLOX-IMVI
Sample_02_183SkinCell lineSKMEL2
Sample_02_195StomachCell lineOCUM1
Sample_02_200StomachCell lineRERF-GC-1B
Sample_02_204StomachCell lineIM95
Sample_02_205StomachTissueGastric_Primary_Sample_T
Sample_02_220BrainCell lineBE2C_1
Sample_02_227OesophagusCell lineTE7
Sample_02_254NeuroblastomaCell lineIMR5-75
Sample_02_268KidneyCell lineA-498
Sample_02_280Mammary GlandCell lineSUM159_DMSO_24h
Sample_02_296NeuroblastomaCell lineCLB-BER-Lud
Sample_02_300NeuroblastomaCell lineCLB-PE
Sample_02_308NeuroblastomaCell lineSJNB1
Sample_02_311NeuroblastomaCell lineSK-N-AS
Sample_02_314NeuroblastomaCell lineSK-N-FI
Sample_02_316NeuroblastomaCell lineCHP212
Sample_02_319NeuroblastomaCell lineNB-EBc1
Sample_02_322ColonCell lineCaco-2
Sample_02_338NeuroblastomaCell lineBE2
Sample_02_361ColonCell lineHT29_DMSO
Sample_02_395Mammary GlandCell lineBT-549
Sample_02_406Mammary GlandCell lineZR-75-30_parental
Sample_02_413BrainTissueGBM_2493
Sample_02_424ColonCell lineSW620
JUNB distribution in all CRCs
Biosample type
Biosample name
Sample ID
Genomic distribution of SEs associated with JUNB
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Mutation of JUNB
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Database name Link
gnomAD: gnomAD
ExAC: ExAC
ICGC:
Database name Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of JUNB

rsID Chr Start Stop Ref Alt Gene_region Gene_symble Effect TCGA_Occurrence
rs751179343chr191290262112902621CTexonicJUNBsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr191290346412903464CTexonicJUNBsynonymous BRCA|1|982|0.00102
-chr191290281912902819GCexonicJUNBsynonymous LUAD|1|543|0.00184
-chr191290346412903464CGexonicJUNBnonsynonymous CESC|1|194|0.00515
-chr191290339212903392CGexonicJUNBnonsynonymous BLCA|1|396|0.00253,HNSC|1|512|0.00195
-chr191290350012903500CTexonicJUNBsynonymous PAAD|1|185|0.00541
-chr191290337412903374G-exonicJUNBframeshift THCA|1|504|0.00198
-chr191290349412903494CTexonicJUNBsynonymous KIPAN|1|799|0.00125,KIRC|1|451|0.00222
-chr191290294912902949G-exonicJUNBframeshift STAD|1|395|0.00253,STES|1|395|0.00253
-chr191290277112902771CTexonicJUNBsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr191290260112902601GTexonicJUNBstopgain PAAD|1|185|0.00541
-chr191290278712902787TCexonicJUNBnonsynonymous KIPAN|1|799|0.00125,KIRP|1|282|0.00355
-chr191290353612903536CTexonicJUNBsynonymous CESC|1|194|0.00515
-chr191290330212903302CTexonicJUNBsynonymous HNSC|1|512|0.00195
-chr191290295812902958G-exonicJUNBframeshift COAD|1|367|0.00272,COADREAD|3|489|0.00613,READ|2|122|0.01639
-chr191290356512903565AGexonicJUNBnonsynonymous BLCA|1|396|0.00253
-chr191290299012902990CTexonicJUNBsynonymous BLCA|1|396|0.00253,CESC|1|194|0.00515
-chr191290278512902785GAexonicJUNBnonsynonymous DLBC|1|48|0.02083
-chr191290297912902979CAexonicJUNBnonsynonymous LIHC|1|373|0.00268
-chr191290351812903518GTexonicJUNBsynonymous ESCA|1|185|0.00541
-chr191290273512902735CTexonicJUNBsynonymous BLCA|1|396|0.00253
-chr191290292512902925G-exonicJUNBframeshift STAD|2|395|0.00506,STES|2|395|0.00506
-chr191290362812903628GCexonicJUNBstoploss CESC|1|194|0.00515
-chr191290358512903585ATexonicJUNBnonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr191290294712902954CAGGGGGC-exonicJUNBframeshift SARC|1|247|0.00405
-chr191290361812903618CGexonicJUNBnonsynonymous KIPAN|1|799|0.00125,KIRC|1|451|0.00222
rs558783117chr191290283112902831CTexonicJUNBsynonymous BRCA|1|982|0.00102
-chr191290336812903368CAexonicJUNBsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr191290353312903533CGexonicJUNBsynonymous LUSC|1|178|0.00562
-chr191290300812903008ACexonicJUNBnonsynonymous BLCA|1|396|0.00253
-chr191290292612902926GAexonicJUNBnonsynonymous HNSC|1|512|0.00195
-chr191290342412903424-GexonicJUNBframeshift PRAD|1|499|0.00200
-chr191290283912902839CTexonicJUNBnonsynonymous BLCA|1|396|0.00253
-chr191290274912902749CAexonicJUNBnonsynonymous LUAD|1|543|0.00184
-chr191290320812903208AGexonicJUNBnonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr191290291712902917A-exonicJUNBframeshift BLCA|1|396|0.00253
Disease information of JUNB
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TF_name Disease_name Disease_class Disease_semantic_type TF_disease_source
JUNB Lung Neoplasms C04;C08 Neoplastic Process CTD_human
JUNB Status Epilepticus C10;C23 Disease or Syndrome CTD_human
JUNB Myocardial Ischemia C14 Disease or Syndrome CTD_human
JUNB Adenocarcinoma of lung (disorder) C04;C08 Neoplastic Process CTD_human
JUNB Middle Cerebral Artery Syndrome C10;C14 Disease or Syndrome CTD_human
JUNB Malignant neoplasm of lung C04;C08 Neoplastic Process CTD_human
JUNB Petit mal status C10;C23 Disease or Syndrome CTD_human
JUNB Grand Mal Status Epilepticus C10;C23 Disease or Syndrome CTD_human
JUNB Complex Partial Status Epilepticus C10;C23 Disease or Syndrome CTD_human
JUNB Middle Cerebral Artery Thrombosis C10;C14 Disease or Syndrome CTD_human
JUNB Middle Cerebral Artery Occlusion C10;C14 Acquired Abnormality CTD_human
JUNB Infarction, Middle Cerebral Artery C10;C14 Disease or Syndrome CTD_human
JUNB Status Epilepticus, Subclinical C10;C23 Disease or Syndrome CTD_human
JUNB Non-Convulsive Status Epilepticus C10;C23 Disease or Syndrome CTD_human
JUNB Simple Partial Status Epilepticus C10;C23 Disease or Syndrome CTD_human
JUNB Middle Cerebral Artery Embolus C10;C14 Disease or Syndrome CTD_human
JUNB Left Middle Cerebral Artery Infarction C10;C14 Disease or Syndrome CTD_human
JUNB Embolic Infarction, Middle Cerebral Artery C10;C14 Disease or Syndrome CTD_human
JUNB Thrombotic Infarction, Middle Cerebral Artery C10;C14 Disease or Syndrome CTD_human
JUNB Right Middle Cerebral Artery Infarction C10;C14 Disease or Syndrome CTD_human
Pathway associated with JUNB
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pathway_ID pathway_name pathway_source gene_number edge_number
pathway0000187 AP-1 transcription factor network pid 71 659
pathway0000229 ATF-2 transcription factor network pid 59 451
pathway0000343 Calcineurin-regulated NFAT-dependent transcription in lymphocytes pid 50 304
pathway0000347 Calcium signaling in the CD4+ TCR pathway pid 29 153
pathway0000634 Downstream signaling in nave CD8+ T cells pid 69 708
pathway0001131 IL6-mediated signaling events pid 48 426
pathway0002069 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription reactome 32 197
pathway0002392 Validated transcriptional targets of AP1 family members Fra1 and Fra2 pid 37 165
pathway0002829 Hs_Kit_receptor_signaling_pathway_WP304_78799 wikipathways 46 510
Go term information of JUNB
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GO_term_name GO_term_type TF_name
GO_LABYRINTHINE_LAYER_DEVELOPMENT BP JUNB
GO_RESPONSE_TO_CORTICOSTEROID BP JUNB
GO_MYELOID_LEUKOCYTE_DIFFERENTIATION BP JUNB
GO_BLASTOCYST_FORMATION BP JUNB
GO_DECIDUALIZATION BP JUNB
GO_PLACENTA_BLOOD_VESSEL_DEVELOPMENT BP JUNB
GO_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER BP JUNB
GO_REPRODUCTIVE_SYSTEM_DEVELOPMENT BP JUNB
GO_LABYRINTHINE_LAYER_BLOOD_VESSEL_DEVELOPMENT BP JUNB
GO_RESPONSE_TO_CAMP BP JUNB
GO_RESPONSE_TO_RADIATION BP JUNB
GO_CELLULAR_RESPONSE_TO_INORGANIC_SUBSTANCE BP JUNB
GO_OSSIFICATION BP JUNB
GO_MULTI_MULTICELLULAR_ORGANISM_PROCESS BP JUNB
GO_VASCULOGENESIS BP JUNB
GO_RESPONSE_TO_CORTICOSTERONE BP JUNB
GO_CELLULAR_RESPONSE_TO_CALCIUM_ION BP JUNB
GO_RESPONSE_TO_MINERALOCORTICOID BP JUNB
GO_TROPHECTODERMAL_CELL_DIFFERENTIATION BP JUNB
GO_MYELOID_CELL_DIFFERENTIATION BP JUNB
GO_MATERNAL_PLACENTA_DEVELOPMENT BP JUNB
GO_OSTEOCLAST_DIFFERENTIATION BP JUNB
GO_NEGATIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER BP JUNB
GO_RESPONSE_TO_LIGHT_STIMULUS BP JUNB
GO_NUCLEAR_CHROMOSOME CC JUNB
GO_NUCLEAR_CHROMATIN CC JUNB

Survival analysis of JUNB


Calculate the hazards ratio based on Cox PH Model.
Add the 95% CI as dotted line.

Expression of JUNB

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)