TF information

TF name: MYB
TF family: MYB
Ensembl gene ID: ENSG00000118513
Ensembl protein ID: ENSP00000432948, ENSP00000432877, ENSP00000434723, ENSP00000434816, ENSP00000326328, ENSP00000435578, ENSP00000437264, ENSP00000410825, ENSP00000434420, ENSP00000433844, ENSP00000477898, ENSP00000435293, ENSP00000434795, ENSP00000434639, ENSP00000356788, ENSP00000390460
Entrez gene ID: 4602
Database name Link Database name Link
NCBI Gene: Genecards:
Uniprot: Wikipedia:
Cosmic 3D: Geneontology:
CCLE:

Frequency of MYB in all biosamples
Sample ID Biosample type Tissue type Biosample name TF Frequency
Sample_02_191Cell lineStomachSNU7190.28571428571429
Sample_02_236Cell lineColonV2060.34989648033126
Sample_02_237Cell lineColonV3890.55299098104178
Sample_02_241Cell lineColonV4560.62641083521445
Sample_02_242Cell lineColonV4810.31522784079985
Sample_02_354Cell lineColonColo2050.92042042042042
Sample_02_361Cell lineColonHT29_DMSO0.47256637168142
Sample_02_424Cell lineColonSW6200.78260869565217

MYB distribution in samples’ most representative CRC
Sample ID Tissue type Biosample type Biosample name
Sample_02_237ColonCell lineV389
Sample_02_354ColonCell lineColo205
Sample_02_424ColonCell lineSW620

MYB distribution in all CRCs
Biosample type
Biosample name
Sample ID

Genomic distribution of SEs associated with MYB
Download

Mutation of MYB
Database name Link
gnomAD: gnomAD
ExAC: ExAC
ICGC:
Database name Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of MYB

rsID Chr Start Stop Ref Alt Gene_region Gene_symble Effect TCGA_Occurrence
-chr6135520054135520054CGexonicMYBnonsynonymous BRCA|1|982|0.00102
rs780660118chr6135517065135517065CTexonicMYBsynonymous SKCM|4|368|0.01087
rs778761961chr6135515019135515019TCexonicMYBnonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
rs779757157chr6135521663135521663GAintronicMYBunknown SARC|1|247|0.00405
-chr6135507099135507099GTexonicMYBnonsynonymous ESCA|1|185|0.00541
rs200493203chr6135539381135539381-TUTR3MYBunknown CESC|1|194|0.00515
-chr6135521306135521306AGexonicMYBnonsynonymous COADREAD|1|489|0.00204,READ|1|122|0.00820
rs758156067chr6135516923135516923GAexonicMYBnonsynonymous LIHC|1|373|0.00268
-chr6135521267135521267CGexonicMYBnonsynonymous COADREAD|1|489|0.00204,READ|1|122|0.00820
-chr6135511399135511399GAexonicMYBstopgain BRCA|1|982|0.00102
-chr6135521506135521506GCexonicMYBnonsynonymous OV|1|469|0.00213
-chr6135515530135515530CTexonicMYBstopgain BLCA|1|396|0.00253
-chr6135539063135539063CTexonicMYBnonsynonymous BLCA|1|396|0.00253
-chr6135515566135515566GAexonicMYBnonsynonymous BRCA|1|982|0.00102
-chr6135521455135521455GTexonicMYBnonsynonymous LUSC|1|178|0.00562
-chr6135510996135510996-TexonicMYBframeshift BRCA|1|982|0.00102
-chr6135511006135511007AG-exonicMYBframeshift BRCA|1|982|0.00102
-chr6135509014135509014GAexonicMYBnonsynonymous LUAD|1|543|0.00184
-chr6135514982135514982AGexonicMYBnonsynonymous UCEC|1|248|0.00403
-chr6135511346135511346TCexonicMYBnonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr6135539023135539023CAexonicMYBnonsynonymous LUAD|6|543|0.01105
-chr6135514998135514998CTexonicMYBnonsynonymous GBM|1|290|0.00345,GBMLGG|1|820|0.00122
-chr6135511376135511376-AexonicMYBframeshift BRCA|1|982|0.00102
-chr6135518338135518338A-exonicMYBframeshift COAD|5|367|0.01362,COADREAD|5|489|0.01022,STAD|1|395|0.00253,STES|1|395|0.00253
rs772410551chr6135516946135516946AGexonicMYBnonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr6135507087135507087CTexonicMYBnonsynonymous LUAD|1|543|0.00184
-chr6135521527135521527CTexonicMYBnonsynonymous SKCM|1|368|0.00272
-chr6135511266135511266TCexonicMYBnonsynonymous BRCA|1|982|0.00102
-chr6135507108135507108CTexonicMYBnonsynonymous SKCM|1|368|0.00272
rs757181423chr6135516133135516133CTintronicMYBunknown UCEC|1|248|0.00403
-chr6135540214135540214GAUTR3MYBunknown ESCA|1|185|0.00541
-chr6135509008135509008AGexonicMYBnonsynonymous ESCA|1|185|0.00541
-chr6135520107135520107C-exonicMYBframeshift STAD|1|395|0.00253,STES|1|395|0.00253
-chr6135522782135522782AGexonicMYBsynonymous GBMLGG|1|820|0.00122,LGG|1|530|0.00189
-chr6135517124135517124TCexonicMYBnonsynonymous LIHC|1|373|0.00268
rs570684584chr6135521689135521689CTintronicMYBunknown STAD|1|395|0.00253,STES|1|395|0.00253
-chr6135521253135521253CTexonicMYBsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr6135513631135513631CTexonicMYBnonsynonymous SKCM|1|368|0.00272
-chr6135515025135515025ATexonicMYBnonsynonymous PRAD|1|499|0.00200
rs150884969chr6135518401135518401CTexonicMYBsynonymous COAD|1|367|0.00272,COADREAD|2|489|0.00409,READ|1|122|0.00820
-chr6135511330135511330GTexonicMYBsynonymous LUAD|1|543|0.00184
-chr6135539249135539249GAUTR3MYBunknown ESCA|1|185|0.00541
rs776200677chr6135507123135507123CTexonicMYBnonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr6135518204135518204GCexonicMYBnonsynonymous BLCA|1|396|0.00253
-chr6135518313135518313GTexonicMYBnonsynonymous UCEC|1|248|0.00403
-chr6135518296135518296ATexonicMYBnonsynonymous HNSC|1|512|0.00195
-chr6135522779135522779G-exonicMYBframeshift LUAD|1|543|0.00184
-chr6135522786135522786CTexonicMYBnonsynonymous UCEC|1|248|0.00403
-chr6135521339135521339TCsplicingMYBsplicing ESCA|1|185|0.00541
-chr6135520049135520049TGexonicMYBnonsynonymous BRCA|1|982|0.00102
-chr6135513576135513576CTexonicMYBsynonymous SKCM|1|368|0.00272
rs777839961chr6135516107135516107CTintronicMYBunknown STAD|1|395|0.00253,STES|1|395|0.00253
-chr6135515004135515004CAexonicMYBnonsynonymous SARC|1|247|0.00405
-chr6135516962135516962GAexonicMYBnonsynonymous KIPAN|1|799|0.00125,KIRC|1|451|0.00222
-chr6135513461135513461GTsplicingMYBsplicing ACC|1|90|0.01111
-chr6135518139135518139TGexonicMYBnonsynonymous SKCM|1|368|0.00272
rs770846525chr6135518137135518137CAexonicMYBnonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr6135518299135518299TCexonicMYBsynonymous LIHC|1|373|0.00268
-chr6135522834135522834GAexonicMYBnonsynonymous HNSC|1|512|0.00195
-chr6135517036135517036GTexonicMYBstopgain ACC|1|90|0.01111
rs547508696chr6135518402135518402GAexonicMYBnonsynonymous DLBC|1|48|0.02083
-chr6135539052135539052GCexonicMYBnonsynonymous ESCA|1|185|0.00541
rs749820799chr6135521270135521270GAexonicMYBnonsynonymous SKCM|1|368|0.00272
-chr6135511481135511481GAexonicMYBnonsynonymous LUSC|1|178|0.00562
-chr6135513668135513668CTexonicMYBnonsynonymous SKCM|1|368|0.00272
-chr6135507070135507070ACexonicMYBnonsynonymous SKCM|1|368|0.00272
-chr6135509017135509017TCexonicMYBnonsynonymous UCEC|1|248|0.00403
-chr6135515497135515497CAexonicMYBnonsynonymous LIHC|1|373|0.00268
-chr6135518445135518445CTexonicMYBnonsynonymous SKCM|1|368|0.00272
-chr6135510959135510959TCexonicMYBnonsynonymous LAML|1|197|0.00508
-chr6135518322135518322CAexonicMYBnonsynonymous PAAD|1|185|0.00541
-chr6135521223135521223T-exonicMYBframeshift BRCA|1|982|0.00102
-chr6135539839135539839GCUTR3MYBunknown ESCA|1|185|0.00541
-chr6135539112135539112CAexonicMYBsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr6135511466135511466GAexonicMYBnonsynonymous COADREAD|1|489|0.00204,ESCA|1|185|0.00541,READ|1|122|0.00820
-chr6135516964135516964GTexonicMYBnonsynonymous LUSC|1|178|0.00562
-chr6135515004135515004CTexonicMYBnonsynonymous GBMLGG|1|820|0.00122,LGG|1|530|0.00189
-chr6135539912135539912T-UTR3MYBunknown THYM|1|123|0.00813
-chr6135517079135517079CTexonicMYBnonsynonymous SKCM|1|368|0.00272
rs540205784chr6135516936135516936CTexonicMYBsynonymous SKCM|1|368|0.00272
-chr6135513605135513605CTexonicMYBnonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr6135515024135515036AATGTCCCTCAGC-exonicMYBframeshift BRCA|1|982|0.00102
-chr6135516956135516956GAexonicMYBnonsynonymous UCEC|1|248|0.00403
-chr6135518263135518263GCexonicMYBnonsynonymous CESC|1|194|0.00515
-chr6135515551135515551CTexonicMYBnonsynonymous UCEC|1|248|0.00403
-chr6135521538135521538GTexonicMYBnonsynonymous LUAD|1|543|0.00184
-chr6135507133135507133GCexonicMYBnonsynonymous LUSC|1|178|0.00562
-chr6135520132135520132TAexonicMYBsynonymous LUAD|1|543|0.00184
-chr6135507043135507043-AexonicMYBframeshift BRCA|1|982|0.00102
-chr6135515583135515583ATexonicMYBsynonymous LUAD|1|543|0.00184
rs750351406chr6135516913135516913GAexonicMYBnonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr6135507100135507100GTexonicMYBnonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr6135507145135507145GTexonicMYBnonsynonymous LUSC|1|178|0.00562
-chr6135518328135518328TCexonicMYBnonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr6135521533135521533CAexonicMYBnonsynonymous SKCM|1|368|0.00272
-chr6135521543135521543TGexonicMYBnonsynonymous BLCA|1|396|0.00253
-chr6135518382135518382GTexonicMYBnonsynonymous PAAD|1|185|0.00541
rs778686623chr6135511348135511348TCexonicMYBsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr6135507076135507076AGexonicMYBnonsynonymous LIHC|1|373|0.00268
-chr6135511293135511293CTexonicMYBnonsynonymous ESCA|1|185|0.00541
-chr6135518269135518269GAexonicMYBsynonymous UCEC|1|248|0.00403
-chr6135515008135515008ACexonicMYBnonsynonymous ESCA|1|185|0.00541
-chr6135511379135511379GCexonicMYBnonsynonymous BLCA|1|396|0.00253
-chr6135521439135521439CTexonicMYBsynonymous LUAD|1|543|0.00184
-chr6135513630135513630CTexonicMYBsynonymous SKCM|1|368|0.00272
-chr6135539487135539487AGUTR3MYBunknown CESC|1|194|0.00515
-chr6135511361135511361CTexonicMYBnonsynonymous BRCA|1|982|0.00102
-chr6135539519135539519C-UTR3MYBunknown CESC|1|194|0.00515
-chr6135510957135510957GAexonicMYBnonsynonymous HNSC|1|512|0.00195
rs55983257chr6135518458135518458GAexonicMYBsynonymous ESCA|1|185|0.00541,GBMLGG|1|820|0.00122,LGG|1|530|0.00189,UCEC|1|248|0.00403
-chr6135521286135521286CGexonicMYBnonsynonymous HNSC|1|512|0.00195
-chr6135517008135517008GAexonicMYBsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr6135524361135524361CAexonicMYBnonsynonymous UCEC|1|248|0.00403
-chr6135539216135539216CAUTR3MYBunknown ESCA|1|185|0.00541
-chr6135518428135518428CTexonicMYBsynonymous SKCM|1|368|0.00272
rs113182184chr6135521495135521495GAexonicMYBnonsynonymous BLCA|1|396|0.00253

Disease information of MYB
TF_name Disease_name Disease_class Disease_semantic_type TF_disease_source
MYB Asthma C08;C20 Disease or Syndrome CTD_human
MYB Adenoid Cystic Carcinoma C04 Neoplastic Process CTD_human
MYB Glioma C04 Neoplastic Process CTD_human
MYB Acute Basophilic Leukemia C04 Neoplastic Process ORPHANET
MYB mixed gliomas C04 Neoplastic Process CTD_human
MYB Malignant Glioma C04 Neoplastic Process CTD_human
MYB Precursor T-Cell Lymphoblastic Leukemia-Lymphoma C04;C15;C20 Neoplastic Process CTD_human;ORPHANET
MYB Angiocentric glioma Neoplastic Process ORPHANET

Pathway associated with MYB
pathway_ID pathway_name pathway_source gene_number edge_number
pathway0000648 E2F transcription factor network pid 77 897
pathway0000862 G0 and Early G1 reactome 25 194
pathway0001121 IL2 signaling events mediated by PI3K pid 38 397
pathway0001127 IL4-mediated signaling events pid 66 512
pathway0001516 Notch-mediated HES/HEY network pid 48 337
pathway0001666 PIWI-interacting RNA (piRNA) biogenesis reactome 29 127
pathway0001690 Polo-like kinase mediated events reactome 16 71
pathway0002110 Striated Muscle Contraction reactome 34 537
pathway0002676 Hypertrophic cardiomyopathy (HCM) kegg 78 912
pathway0002697 Hs_miRNAs_involved_in_DNA_damage_response_WP1545_84697 wikipathways 30 76
pathway0002703 Hs_Gastric_Cancer_Network_1_WP2361_86831 wikipathways 26 52
pathway0002747 Hs_Neural_Crest_Differentiation_WP2064_79263 wikipathways 40 129
pathway0002773 Hs_Energy_Metabolism_WP1541_91584 wikipathways 13 34
pathway0002774 Hs_Heme_Biosynthesis_WP561_89918 wikipathways 5 3

Go term information of MYB
GO_term_name GO_term_type TF_name
GO_POSITIVE_REGULATION_OF_GENE_EXPRESSION_EPIGENETIC BP MYB
GO_CARDIAC_CHAMBER_MORPHOGENESIS BP MYB
GO_ACTIN_MYOSIN_FILAMENT_SLIDING BP MYB
GO_CELLULAR_RESPONSE_TO_EXTRACELLULAR_STIMULUS BP MYB
GO_REGULATION_OF_T_HELPER_CELL_DIFFERENTIATION BP MYB
GO_CIRCADIAN_REGULATION_OF_GENE_EXPRESSION BP MYB
GO_POSITIVE_REGULATION_OF_HISTONE_H3_K4_METHYLATION BP MYB
GO_ACTIN_FILAMENT_BASED_MOVEMENT BP MYB
GO_MICROTUBULE_CYTOSKELETON_ORGANIZATION BP MYB
GO_CELLULAR_RESPIRATION BP MYB
GO_REGULATION_OF_STRIATED_MUSCLE_CONTRACTION BP MYB
GO_MITOTIC_SPINDLE_ASSEMBLY BP MYB
GO_VENTRICULAR_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT BP MYB
GO_CARDIAC_VENTRICLE_MORPHOGENESIS BP MYB
GO_POSITIVE_REGULATION_OF_CD4_POSITIVE_ALPHA_BETA_T_CELL_ACTIVATION BP MYB
GO_REGULATION_OF_ALPHA_BETA_T_CELL_DIFFERENTIATION BP MYB
GO_CARDIAC_MUSCLE_TISSUE_MORPHOGENESIS BP MYB
GO_MUSCLE_ORGAN_MORPHOGENESIS BP MYB
GO_REGULATION_OF_HISTONE_H3_K9_METHYLATION BP MYB
GO_REGULATION_OF_CD4_POSITIVE_ALPHA_BETA_T_CELL_ACTIVATION BP MYB
GO_POSITIVE_REGULATION_OF_CHROMATIN_MODIFICATION BP MYB
GO_REGULATION_OF_T_CELL_DIFFERENTIATION BP MYB
GO_DNA_BIOSYNTHETIC_PROCESS BP MYB
GO_POSITIVE_REGULATION_OF_T_HELPER_CELL_DIFFERENTIATION BP MYB
GO_ACTIN_MEDIATED_CELL_CONTRACTION BP MYB
GO_POSITIVE_REGULATION_OF_LYMPHOCYTE_DIFFERENTIATION BP MYB
GO_REGULATION_OF_HISTONE_H3_K4_METHYLATION BP MYB
GO_REGULATION_OF_ANOIKIS BP MYB
GO_NEGATIVE_REGULATION_OF_CYTOSKELETON_ORGANIZATION BP MYB
GO_CELLULAR_RESPONSE_TO_STARVATION BP MYB
GO_POSITIVE_REGULATION_OF_PROTEIN_MODIFICATION_PROCESS BP MYB
GO_MUSCLE_SYSTEM_PROCESS BP MYB
GO_SPINDLE_ASSEMBLY BP MYB
GO_POSITIVE_REGULATION_OF_HISTONE_METHYLATION BP MYB
GO_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_BY_P53_CLASS_MEDIATOR BP MYB
GO_REGULATION_OF_CELL_ADHESION BP MYB
GO_REGULATION_OF_ACTIN_FILAMENT_BASED_MOVEMENT BP MYB
GO_CELLULAR_RESPONSE_TO_GLUCOSE_STARVATION BP MYB
GO_POSITIVE_REGULATION_OF_ALPHA_BETA_T_CELL_DIFFERENTIATION BP MYB
GO_POSITIVE_REGULATION_OF_IMMUNE_RESPONSE BP MYB
GO_POSITIVE_REGULATION_OF_ATPASE_ACTIVITY BP MYB
GO_POSITIVE_REGULATION_OF_ALPHA_BETA_T_CELL_ACTIVATION BP MYB
GO_MUSCLE_MYOSIN_COMPLEX CC MYB
GO_ACTIN_CYTOSKELETON CC MYB
GO_MYOFILAMENT CC MYB
GO_MYOSIN_FILAMENT CC MYB
GO_CONTRACTILE_FIBER CC MYB
GO_MYOSIN_COMPLEX CC MYB
GO_A_BAND CC MYB
GO_MYOSIN_II_COMPLEX CC MYB
GO_DNA_POLYMERASE_ACTIVITY MF MYB
GO_CORE_PROMOTER_BINDING MF MYB
GO_ATPASE_ACTIVATOR_ACTIVITY MF MYB
GO_REGULATORY_REGION_NUCLEIC_ACID_BINDING MF MYB
GO_TRANSCRIPTIONAL_ACTIVATOR_ACTIVITY_RNA_POLYMERASE_II_TRANSCRIPTION_REGULATORY_REGION_SEQUENCE_SPECIFIC_BINDING MF MYB
GO_ATPASE_REGULATOR_ACTIVITY MF MYB
GO_STRUCTURAL_CONSTITUENT_OF_MUSCLE MF MYB
GO_MYOSIN_HEAVY_CHAIN_BINDING MF MYB
GO_TRANSCRIPTIONAL_ACTIVATOR_ACTIVITY_RNA_POLYMERASE_II_CORE_PROMOTER_PROXIMAL_REGION_SEQUENCE_SPECIFIC_BINDING MF MYB
GO_TITIN_BINDING MF MYB
GO_DNA_DIRECTED_DNA_POLYMERASE_ACTIVITY MF MYB
GO_NUCLEOTIDYLTRANSFERASE_ACTIVITY MF MYB

Survival analysis of MYB



Calculate the hazards ratio based on Cox PH Model.
Add the 95% CI as dotted line.

Expression of MYB