Cancer CRCdb

TF information

TF name:	TEAD1
TF family:	TEA
Ensembl gene ID:	ENSG00000187079
Ensembl protein ID:	ENSP00000334754, ENSP00000435977, ENSP00000435233, ENSP00000432587, ENSP00000491500
Entrez gene ID:	7003

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of TEAD1 in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_02_007	Other	Cervical	cervical-cancer_vector	0.34437086092715
Sample_02_069	Cell line	Brain	SF268	0.12213740458015
Sample_02_164	Cell line	Lung	H2087_Parental	0.25
Sample_02_180	Cell line	Human melanoma	CJM	0.203125
Sample_02_181	Cell line	Human melanoma	COLO679	0.464
Sample_02_182	Cell line	Human melanoma	LOX-IMVI	0.25287356321839
Sample_02_183	Cell line	Skin	SKMEL2	0.8974358974359
Sample_02_205	Tissue	Stomach	Gastric_Primary_Sample_T	0.16296296296296
Sample_02_219	Cell line	Mammary Gland	MDA-MB-231	0.37254901960784
Sample_02_237	Cell line	Colon	V389	0.33539480949752
Sample_02_241	Cell line	Colon	V456	0.51467268623025
Sample_02_242	Cell line	Colon	V481	0.61363199384734
Sample_02_258	Other	Lung	NCI-H1299_EGFP-NEO_reporter_cells_DMSO	0.19111111111111
Sample_02_268	Cell line	Kidney	A-498	0.40889791397452
Sample_02_296	Cell line	Neuroblastoma	CLB-BER-Lud	0.3787299158378
Sample_02_298	Cell line	Neuroblastoma	CLB-GA	0.31506849315068
Sample_02_299	Cell line	Neuroblastoma	CLB-MA	0.36930455635492
Sample_02_300	Cell line	Neuroblastoma	CLB-PE	0.14102564102564
Sample_02_303	Cell line	Neuroblastoma	LAN1	0.34285714285714
Sample_02_309	Cell line	Neuroblastoma	SJNB6	0.42654028436019
Sample_02_310	Cell line	Neuroblastoma	SJNB8	0.41284403669725
Sample_02_311	Cell line	Neuroblastoma	SK-N-AS	0.24675324675325
Sample_02_312	Cell line	Neuroblastoma	SK-N-BE_2-C	0.77659574468085
Sample_02_313	Cell line	Neuroblastoma	SK-N-DZ	0.19305019305019
Sample_02_318	Cell line	Neuroblastoma	NB69	0.359375
Sample_02_322	Cell line	Colon	Caco-2	0.49528936742934
Sample_02_323	Cell line	Colon	RKO	0.8
Sample_02_354	Cell line	Colon	Colo205	0.61861861861862
Sample_02_357	Cell line	Colon	Colo320	1
Sample_02_359	Cell line	Colon	Colo741	0.41867469879518
Sample_02_361	Cell line	Colon	HT29_DMSO	0.47787610619469
Sample_02_424	Cell line	Colon	SW620	1
Sample_02_430	Cell line	Kidney	12364284	0.71428571428571

TEAD1 distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name
Sample_02_164	Lung	Cell line	H2087_Parental
Sample_02_181	Human melanoma	Cell line	COLO679
Sample_02_183	Skin	Cell line	SKMEL2
Sample_02_242	Colon	Cell line	V481
Sample_02_296	Neuroblastoma	Cell line	CLB-BER-Lud
Sample_02_298	Neuroblastoma	Cell line	CLB-GA
Sample_02_309	Neuroblastoma	Cell line	SJNB6
Sample_02_310	Neuroblastoma	Cell line	SJNB8
Sample_02_312	Neuroblastoma	Cell line	SK-N-BE_2-C
Sample_02_322	Colon	Cell line	Caco-2
Sample_02_323	Colon	Cell line	RKO
Sample_02_357	Colon	Cell line	Colo320
Sample_02_359	Colon	Cell line	Colo741
Sample_02_424	Colon	Cell line	SW620
Sample_02_430	Kidney	Cell line	12364284

TEAD1 distribution in all CRCs

Genomic distribution of SEs associated with TEAD1

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Mutation of TEAD1

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of TEAD1

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr11	12904610	12904610	A	G	exonic	TEAD1	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr11	12785959	12785959	A	T	exonic	TEAD1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr11	12785963	12785963	G	C	exonic	TEAD1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr11	12923629	12923629	C	A	exonic	TEAD1	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr11	12883843	12883843	G	C	exonic	TEAD1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr11	12903493	12903493	C	-	exonic	TEAD1	frameshift	LUAD\|1\|543\|0.00184
-	chr11	12923603	12923603	C	A	exonic	TEAD1	synonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr11	12946585	12946585	G	A	exonic	TEAD1	nonsynonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr11	12886424	12886424	C	T	exonic	TEAD1	nonsynonymous	CESC\|1\|194\|0.00515,SKCM\|1\|368\|0.00272
-	chr11	12883805	12883805	G	T	exonic	TEAD1	stopgain	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs373835493	chr11	12901217	12901217	G	A	intronic	TEAD1	unknown	PRAD\|1\|499\|0.00200
rs548044773	chr11	12901314	12901314	C	T	exonic	TEAD1	synonymous	SKCM\|1\|368\|0.00272,UCEC\|1\|248\|0.00403
-	chr11	12785928	12785928	A	G	exonic	TEAD1	nonsynonymous	THCA\|1\|504\|0.00198
-	chr11	12901270	12901270	G	T	exonic	TEAD1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr11	12883850	12883850	A	G	exonic	TEAD1	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr11	12958691	12958691	C	G	exonic	TEAD1	synonymous	BLCA\|1\|396\|0.00253
-	chr11	12923586	12923586	C	T	exonic	TEAD1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr11	12902559	12902559	C	T	exonic	TEAD1	nonsynonymous	KIPAN\|2\|799\|0.00250,KIRC\|2\|451\|0.00443
-	chr11	12904613	12904613	A	G	exonic	TEAD1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr11	12886385	12886385	G	A	exonic	TEAD1	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr11	12958748	12958748	T	A	exonic	TEAD1	synonymous	SKCM\|1\|368\|0.00272
-	chr11	12901370	12901370	C	T	exonic	TEAD1	nonsynonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr11	12951826	12951826	G	C	exonic	TEAD1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr11	12903467	12903467	C	A	exonic	TEAD1	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr11	12904607	12904607	G	A	exonic	TEAD1	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr11	12946524	12946524	G	T	exonic	TEAD1	nonsynonymous	PRAD\|1\|499\|0.00200
-	chr11	12923632	12923632	A	-	exonic	TEAD1	frameshift	ACC\|1\|90\|0.01111
-	chr11	12904597	12904597	T	C	exonic	TEAD1	synonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
rs377174338	chr11	12785801	12785801	G	A	exonic	TEAD1	nonsynonymous	OV\|1\|469\|0.00213
rs867734243	chr11	12883845	12883845	C	T	exonic	TEAD1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr11	12923642	12923642	C	A	exonic	TEAD1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr11	12901223	12901223	T	C	intronic	TEAD1	unknown	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr11	12958680	12958680	G	A	exonic	TEAD1	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr11	12902571	12902571	A	-	exonic	TEAD1	frameshift	BRCA\|3\|982\|0.00305
-	chr11	12923583	12923583	T	-	exonic	TEAD1	frameshift	THCA\|1\|504\|0.00198
-	chr11	12785961	12785961	C	G	exonic	TEAD1	stopgain	BRCA\|1\|982\|0.00102
rs752862372	chr11	12901386	12901386	G	A	exonic	TEAD1	synonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189,LUAD\|1\|543\|0.00184
-	chr11	12903501	12903501	C	T	exonic	TEAD1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr11	12785940	12785940	G	A	exonic	TEAD1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs374937210	chr11	12901216	12901216	C	T	intronic	TEAD1	unknown	PAAD\|1\|185\|0.00541,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr11	12901332	12901332	T	A	exonic	TEAD1	synonymous	BLCA\|1\|396\|0.00253
-	chr11	12946496	12946496	-	T	exonic	TEAD1	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr11	12923582	12923582	A	C	exonic	TEAD1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr11	12883803	12883803	A	G	exonic	TEAD1	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr11	12901304	12901304	C	G	exonic	TEAD1	stopgain	CESC\|1\|194\|0.00515
-	chr11	12946588	12946588	G	C	exonic	TEAD1	nonsynonymous	BLCA\|2\|396\|0.00505
rs368869959	chr11	12923504	12923504	C	T	exonic	TEAD1	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs763864290	chr11	12904622	12904622	C	T	exonic	TEAD1	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr11	12951768	12951768	C	T	exonic	TEAD1	synonymous	SKCM\|1\|368\|0.00272
-	chr11	12923662	12923664	TGA	-	splicing	TEAD1	unknown	SKCM\|1\|368\|0.00272
rs200089160	chr11	12923645	12923645	C	T	exonic	TEAD1	synonymous	SKCM\|1\|368\|0.00272
-	chr11	12886397	12886397	A	G	exonic	TEAD1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr11	12902599	12902599	G	C	splicing	TEAD1	splicing	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr11	12785897	12785897	G	A	exonic	TEAD1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr11	12904600	12904600	C	T	exonic	TEAD1	synonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr11	12901337	12901337	A	T	exonic	TEAD1	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr11	12923610	12923610	G	T	exonic	TEAD1	stopgain	CESC\|1\|194\|0.00515

Disease information of TEAD1

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
TEAD1	SVEINSSON CHORIORETINAL ATROPHY	C11;C16	Disease or Syndrome	CTD_human;ORPHANET;UNIPROT

Pathway associated with TEAD1

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number
pathway0002460	YAP1- and WWTR1 (TAZ)-stimulated gene expression	reactome	29	144
pathway0002826	Hs_Mesodermal_Commitment_Pathway_WP2857_87780	wikipathways	47	175

Go term information of TEAD1

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GO_term_name	GO_term_type	TF_name
GO_HIPPO_SIGNALING	BP	TEAD1
GO_POSITIVE_REGULATION_OF_PRI_MIRNA_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER	BP	TEAD1
GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER	BP	TEAD1
GO_REGULATION_OF_PRI_MIRNA_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER	BP	TEAD1

Survival analysis of TEAD1

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of TEAD1

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)