Cancer CRCdb

TF information

TF name:	IRF2
TF family:	IRF
Ensembl gene ID:	ENSG00000168310
Ensembl protein ID:	ENSP00000425037, ENSP00000427204, ENSP00000422860, ENSP00000424552, ENSP00000377218
Entrez gene ID:	3660

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of IRF2 in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_01_001	Cell line	Prostate	22Rv1	0.58353510895884
Sample_02_095	Cell line	Mammary Gland	MDA-MB-468	0.61167315175097
Sample_02_204	Cell line	Stomach	IM95	0.77272727272727
Sample_02_236	Cell line	Colon	V206	0.65631469979296
Sample_02_237	Cell line	Colon	V389	0.51205595435303
Sample_02_242	Cell line	Colon	V481	0.15298340062808
Sample_02_322	Cell line	Colon	Caco-2	0.069986541049798
Sample_02_354	Cell line	Colon	Colo205	0.13663663663664

IRF2 distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name
Sample_01_001	Prostate	Cell line	22Rv1
Sample_02_204	Stomach	Cell line	IM95
Sample_02_236	Colon	Cell line	V206

IRF2 distribution in all CRCs

Genomic distribution of SEs associated with IRF2

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Mutation of IRF2

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of IRF2

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr4	185339812	185339812	T	A	exonic	IRF2	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr4	185320164	185320164	C	T	exonic	IRF2	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr4	185340657	185340657	A	G	exonic	IRF2	synonymous	LIHC\|1\|373\|0.00268
-	chr4	185320141	185320141	C	T	exonic	IRF2	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr4	185339800	185339800	C	G	exonic	IRF2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253,UCEC\|1\|248\|0.00403
-	chr4	185310022	185310022	A	C	exonic	IRF2	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr4	185310037	185310037	G	C	exonic	IRF2	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr4	185310027	185310027	G	A	exonic	IRF2	nonsynonymous	SKCM\|2\|368\|0.00543
rs142409473	chr4	185350153	185350153	C	T	exonic	IRF2	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr4	185350107	185350137	CATACACCCACCCTGACCCACTCACCTTGTT	-	exonic	IRF2	nonframeshift	SARC\|1\|247\|0.00405
-	chr4	185320135	185320135	C	T	exonic	IRF2	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr4	185309954	185309954	C	T	exonic	IRF2	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr4	185340688	185340688	G	A	exonic	IRF2	nonsynonymous	ACC\|1\|90\|0.01111,COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,LIHC\|1\|373\|0.00268,STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr4	185339341	185339341	C	T	exonic	IRF2	nonsynonymous	ACC\|1\|90\|0.01111
-	chr4	185339701	185339701	G	A	exonic	IRF2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr4	185320161	185320161	T	G	exonic	IRF2	nonsynonymous	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
rs759970386	chr4	185350181	185350181	T	C	exonic	IRF2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr4	185310048	185310048	C	A	exonic	IRF2	nonsynonymous	LUAD\|2\|543\|0.00368
rs776694126	chr4	185340717	185340717	C	T	exonic	IRF2	synonymous	PAAD\|1\|185\|0.00541
-	chr4	185340707	185340707	-	A	exonic	IRF2	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr4	185339750	185339750	C	A	exonic	IRF2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr4	185340702	185340702	G	A	exonic	IRF2	synonymous	UCEC\|1\|248\|0.00403
-	chr4	185309930	185309930	G	A	exonic	IRF2	synonymous	SKCM\|1\|368\|0.00272
-	chr4	185329430	185329430	C	T	splicing	IRF2	splicing	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr4	185329312	185329312	C	T	exonic	IRF2	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr4	185350182	185350182	C	A	exonic	IRF2	stopgain	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs753833490	chr4	185309971	185309971	G	A	exonic	IRF2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,LIHC\|1\|373\|0.00268
-	chr4	185350199	185350199	C	T	exonic	IRF2	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr4	185329364	185329364	C	G	exonic	IRF2	synonymous	BLCA\|1\|396\|0.00253
rs148758064	chr4	185339801	185339801	G	A	exonic	IRF2	synonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189,UCEC\|1\|248\|0.00403
-	chr4	185329386	185329386	C	-	exonic	IRF2	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr4	185340638	185340638	A	G	exonic	IRF2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,OV\|1\|469\|0.00213
-	chr4	185329341	185329341	T	-	exonic	IRF2	frameshift	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
rs868855868	chr4	185340674	185340674	A	C	exonic	IRF2	nonsynonymous	TGCT\|1\|155\|0.00645
-	chr4	185339758	185339758	T	-	exonic	IRF2	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr4	185320077	185320077	G	A	exonic	IRF2	nonsynonymous	BLCA\|1\|396\|0.00253
rs754089440	chr4	185310216	185310216	C	T	exonic	IRF2	nonsynonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr4	185309983	185309983	C	T	exonic	IRF2	nonsynonymous	HNSC\|1\|512\|0.00195
rs865781754	chr4	185310135	185310135	C	T	exonic	IRF2	nonsynonymous	GBMLGG\|1\|820\|0.00122,HNSC\|1\|512\|0.00195,LGG\|1\|530\|0.00189,PAAD\|1\|185\|0.00541,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr4	185310092	185310092	G	-	exonic	IRF2	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr4	185340650	185340650	G	C	exonic	IRF2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr4	185339806	185339806	T	C	exonic	IRF2	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr4	185340660	185340660	T	C	exonic	IRF2	synonymous	HNSC\|1\|512\|0.00195
-	chr4	185339727	185339727	A	C	exonic	IRF2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr4	185339858	185339858	C	A	exonic	IRF2	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr4	185340714	185340715	CT	-	exonic	IRF2	frameshift	ACC\|1\|90\|0.01111,UCS\|1\|57\|0.01754
-	chr4	185339823	185339823	-	T	exonic	IRF2	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr4	185320123	185320123	C	-	exonic	IRF2	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr4	185340636	185340636	C	A	exonic	IRF2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr4	185310172	185310172	T	C	exonic	IRF2	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr4	185329416	185329416	T	A	exonic	IRF2	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr4	185311904	185311904	C	G	splicing	IRF2	splicing	HNSC\|1\|512\|0.00195
-	chr4	185309962	185309962	C	T	exonic	IRF2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,DLBC\|1\|48\|0.02083,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr4	185320176	185320176	G	A	exonic	IRF2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr4	185320215	185320222	AGATGGGA	-	exonic	IRF2	frameshift	OV\|1\|469\|0.00213
-	chr4	185320192	185320192	C	A	exonic	IRF2	stopgain	LIHC\|1\|373\|0.00268
-	chr4	185320080	185320080	G	A	exonic	IRF2	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr4	185340707	185340707	G	-	exonic	IRF2	frameshift	PRAD\|1\|499\|0.00200
-	chr4	185339369	185339369	T	A	splicing	IRF2	splicing	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr4	185311898	185311898	C	T	exonic	IRF2	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr4	185350194	185350194	G	A	exonic	IRF2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs779259983	chr4	185311894	185311894	G	A	exonic	IRF2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr4	185309973	185309973	G	A	exonic	IRF2	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr4	185340707	185340707	G	A	exonic	IRF2	stopgain	SKCM\|1\|368\|0.00272
rs758246792	chr4	185320124	185320124	C	T	exonic	IRF2	synonymous	LUSC\|1\|178\|0.00562,UCEC\|1\|248\|0.00403
rs767335959	chr4	185329382	185329382	A	G	exonic	IRF2	synonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr4	185339729	185339729	C	A	exonic	IRF2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr4	185329365	185329365	G	A	exonic	IRF2	nonsynonymous	PAAD\|1\|185\|0.00541,UCEC\|1\|248\|0.00403
-	chr4	185309950	185309950	T	C	exonic	IRF2	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr4	185339717	185339717	C	A	exonic	IRF2	nonsynonymous	KICH\|1\|66\|0.01515,KIPAN\|1\|799\|0.00125
-	chr4	185339323	185339323	T	A	exonic	IRF2	stopgain	LIHC\|1\|373\|0.00268
-	chr4	185340623	185340623	C	T	exonic	IRF2	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr4	185320087	185320087	G	C	exonic	IRF2	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr4	185339814	185339814	G	A	exonic	IRF2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253,UCEC\|1\|248\|0.00403
-	chr4	185340655	185340655	G	A	exonic	IRF2	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr4	185339859	185339859	T	G	exonic	IRF2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr4	185339800	185339800	C	T	exonic	IRF2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr4	185340682	185340682	C	G	exonic	IRF2	nonsynonymous	CESC\|1\|194\|0.00515
-	chr4	185339324	185339324	G	C	exonic	IRF2	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr4	185320141	185320141	C	G	exonic	IRF2	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr4	185339790	185339790	G	A	exonic	IRF2	nonsynonymous	HNSC\|2\|512\|0.00391
-	chr4	185320153	185320153	C	G	exonic	IRF2	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr4	185310142	185310142	G	A	exonic	IRF2	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr4	185339723	185339723	G	A	exonic	IRF2	synonymous	UCEC\|1\|248\|0.00403
-	chr4	185339692	185339692	T	A	exonic	IRF2	stopgain	OV\|1\|469\|0.00213
-	chr4	185320225	185320225	G	A	exonic	IRF2	stopgain	UCEC\|1\|248\|0.00403

Disease information of IRF2

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
IRF2	Liver carcinoma	C04;C06	Neoplastic Process	CTD_human

Pathway associated with IRF2

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number
pathway0001180	Interferon alpha/beta signaling	reactome	67	378
pathway0002282	TRAF6 mediated IRF7 activation	reactome	33	184
pathway0002748	Hs_Inflammatory_Response_Pathway_WP453_80206	wikipathways	6	5
pathway0002815	Hs_Type_II_interferon_signaling_(IFNG)_WP619_71168	wikipathways	10	14

Go term information of IRF2

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GO_term_name	GO_term_type	TF_name
GO_INTERFERON_GAMMA_MEDIATED_SIGNALING_PATHWAY	BP	IRF2
GO_NEGATIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER	BP	IRF2

Survival analysis of IRF2

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of IRF2

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)