Cancer CRCdb

TF information

TF name:	RREB1
TF family:	zf-C2H2
Ensembl gene ID:	ENSG00000124782
Ensembl protein ID:	ENSP00000420519, ENSP00000369270, ENSP00000419511, ENSP00000369265, ENSP00000420299, ENSP00000305560, ENSP00000335574, ENSP00000483108
Entrez gene ID:	6239

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of RREB1 in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_02_021	Cell line	Colon	V429	0.96367829345633
Sample_02_095	Cell line	Mammary Gland	MDA-MB-468	1
Sample_02_114	Cell line	Mammary Gland	CAL51	0.36683417085427
Sample_02_168	Cell line	Prostate	LNCaP	0.21292775665399
Sample_02_184	Cell line	Skin	SKMEL30	0.61414790996785
Sample_02_192	Cell line	Stomach	MKN45	0.66666666666667
Sample_02_199	Cell line	Stomach	KATO3	0.66666666666667
Sample_02_205	Tissue	Stomach	Gastric_Primary_Sample_T	0.83703703703704
Sample_02_236	Cell line	Colon	V206	1
Sample_02_237	Cell line	Colon	V389	1
Sample_02_241	Cell line	Colon	V456	1
Sample_02_242	Cell line	Colon	V481	1
Sample_02_354	Cell line	Colon	Colo205	0.90990990990991
Sample_02_356	Cell line	Colon	Sw480	0.41935483870968
Sample_02_358	Cell line	Colon	LS180	0.35900473933649
Sample_02_359	Cell line	Colon	Colo741	0.39759036144578
Sample_02_403	Cell line	Mammary Gland	T-47D_untreat	0.77272727272727
Sample_02_404	Cell line	Mammary Gland	ZR-75-1_2	0.34712230215827
Sample_02_424	Cell line	Colon	SW620	0.27536231884058

RREB1 distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name
Sample_02_021	Colon	Cell line	V429
Sample_02_095	Mammary Gland	Cell line	MDA-MB-468
Sample_02_168	Prostate	Cell line	LNCaP
Sample_02_184	Skin	Cell line	SKMEL30
Sample_02_192	Stomach	Cell line	MKN45
Sample_02_199	Stomach	Cell line	KATO3
Sample_02_205	Stomach	Tissue	Gastric_Primary_Sample_T
Sample_02_236	Colon	Cell line	V206
Sample_02_237	Colon	Cell line	V389
Sample_02_241	Colon	Cell line	V456
Sample_02_242	Colon	Cell line	V481
Sample_02_358	Colon	Cell line	LS180
Sample_02_403	Mammary Gland	Cell line	T-47D_untreat

RREB1 distribution in all CRCs

Genomic distribution of SEs associated with RREB1

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Mutation of RREB1

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of RREB1

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr6	7230609	7230609	C	T	exonic	RREB1	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs756205550	chr6	7229303	7229303	C	T	exonic	RREB1	nonsynonymous	PRAD\|1\|499\|0.00200,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253,UCEC\|1\|248\|0.00403
-	chr6	7230677	7230677	G	T	exonic	RREB1	nonsynonymous	OV\|1\|469\|0.00213
rs200032827	chr6	7231821	7231821	C	T	exonic	RREB1	synonymous	LUSC\|1\|178\|0.00562
-	chr6	7230971	7230971	C	T	exonic	RREB1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr6	7229324	7229324	T	G	exonic	RREB1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr6	7211126	7211126	G	A	exonic	RREB1	nonsynonymous	SKCM\|1\|368\|0.00272
rs781269289	chr6	7229286	7229286	C	T	exonic	RREB1	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs758391187	chr6	7211105	7211105	G	A	exonic	RREB1	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
rs116295722	chr6	7231736	7231736	G	T	exonic	RREB1	nonsynonymous	DLBC\|1\|48\|0.02083
-	chr6	7231086	7231086	C	A	exonic	RREB1	synonymous	LUAD\|1\|543\|0.00184
-	chr6	7211110	7211110	C	T	exonic	RREB1	stopgain	LUAD\|1\|543\|0.00184,PAAD\|1\|185\|0.00541
rs745990582	chr6	7231916	7231916	C	T	exonic	RREB1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,LUSC\|1\|178\|0.00562
-	chr6	7211167	7211167	G	A	exonic	RREB1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	7230553	7230553	G	C	exonic	RREB1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr6	7247005	7247005	C	T	exonic	RREB1	nonsynonymous	KICH\|1\|66\|0.01515,KIPAN\|1\|799\|0.00125
-	chr6	7229781	7229781	G	A	exonic	RREB1	synonymous	BLCA\|1\|396\|0.00253
-	chr6	7229901	7229901	G	C	exonic	RREB1	synonymous	GBMLGG\|3\|820\|0.00366,LGG\|3\|530\|0.00566,PRAD\|2\|499\|0.00401,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	7230630	7230630	T	C	exonic	RREB1	synonymous	BLCA\|1\|396\|0.00253
-	chr6	7229720	7229725	CGGCCA	-	exonic	RREB1	nonframeshift	BLCA\|2\|396\|0.00505
-	chr6	7211829	7211829	T	G	exonic	RREB1	synonymous	BRCA\|1\|982\|0.00102
-	chr6	7226887	7226887	C	G	exonic	RREB1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	7231272	7231272	T	G	exonic	RREB1	synonymous	OV\|1\|469\|0.00213
-	chr6	7229269	7229269	C	T	exonic	RREB1	stopgain	PAAD\|1\|185\|0.00541
rs200867216	chr6	7247354	7247354	C	T	exonic	RREB1	synonymous	LUSC\|1\|178\|0.00562
-	chr6	7187819	7187819	T	G	intronic	RREB1	unknown	CESC\|1\|194\|0.00515
-	chr6	7229349	7229349	G	A	exonic	RREB1	synonymous	LUAD\|1\|543\|0.00184
rs751045274	chr6	7230849	7230849	T	C	exonic	RREB1	synonymous	SKCM\|1\|368\|0.00272
rs139799223	chr6	7229400	7229400	C	T	exonic	RREB1	synonymous	SKCM\|1\|368\|0.00272
-	chr6	7232097	7232097	C	-	exonic	RREB1	frameshift	LIHC\|1\|373\|0.00268
-	chr6	7231535	7231535	T	C	exonic	RREB1	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr6	7211914	7211914	A	G	exonic	RREB1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	7246768	7246768	G	T	exonic	RREB1	nonsynonymous	ESCA\|1\|185\|0.00541
rs781624746	chr6	7231795	7231795	C	T	exonic	RREB1	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr6	7231151	7231151	C	T	exonic	RREB1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs201769527	chr6	7247268	7247268	C	T	exonic	RREB1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr6	7247285	7247285	C	T	exonic	RREB1	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs146641651	chr6	7231972	7231972	G	A	exonic	RREB1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	7231542	7231542	G	T	exonic	RREB1	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr6	7211050	7211071	CATGAGAAGGACCCTAACAGTG	-	exonic	RREB1	frameshift	HNSC\|1\|512\|0.00195
rs751985080	chr6	7229265	7229265	C	T	exonic	RREB1	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	7230522	7230522	C	T	exonic	RREB1	synonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr6	7231050	7231050	C	A	exonic	RREB1	synonymous	UCEC\|1\|248\|0.00403
rs371044808	chr6	7231823	7231823	G	A	exonic	RREB1	nonsynonymous	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr6	7232112	7232112	C	T	exonic	RREB1	synonymous	HNSC\|1\|512\|0.00195
-	chr6	7229845	7229845	C	T	exonic	RREB1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	7229776	7229776	C	T	exonic	RREB1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr6	7229368	7229368	G	T	exonic	RREB1	stopgain	PAAD\|1\|185\|0.00541
-	chr6	7226816	7226816	C	T	exonic	RREB1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|2\|489\|0.00409,READ\|1\|122\|0.00820
-	chr6	7230384	7230384	C	T	exonic	RREB1	synonymous	OV\|1\|469\|0.00213,SKCM\|1\|368\|0.00272
-	chr6	7231394	7231394	C	T	exonic	RREB1	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr6	7229614	7229614	C	G	exonic	RREB1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr6	7230602	7230602	T	C	exonic	RREB1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	7211055	7211055	G	A	exonic	RREB1	synonymous	BLCA\|1\|396\|0.00253
-	chr6	7230907	7230907	C	T	exonic	RREB1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr6	7229784	7229784	C	T	exonic	RREB1	synonymous	HNSC\|1\|512\|0.00195
-	chr6	7230131	7230131	G	A	exonic	RREB1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	7189439	7189439	A	G	exonic	RREB1	synonymous	BRCA\|1\|982\|0.00102
-	chr6	7230139	7230139	G	T	exonic	RREB1	stopgain	LUAD\|1\|543\|0.00184
-	chr6	7246876	7246876	A	G	exonic	RREB1	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr6	7231938	7231938	C	T	exonic	RREB1	synonymous	THCA\|1\|504\|0.00198
-	chr6	7232090	7232090	G	T	exonic	RREB1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr6	7229427	7229427	C	T	exonic	RREB1	synonymous	SKCM\|1\|368\|0.00272
rs370083804	chr6	7229401	7229401	G	A	exonic	RREB1	nonsynonymous	UCEC\|1\|248\|0.00403
rs144915615	chr6	7211817	7211817	C	T	exonic	RREB1	synonymous	UCEC\|1\|248\|0.00403
-	chr6	7230732	7230732	G	T	exonic	RREB1	synonymous	LUAD\|1\|543\|0.00184
-	chr6	7211929	7211929	G	A	exonic	RREB1	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr6	7230078	7230078	G	A	exonic	RREB1	synonymous	PRAD\|1\|499\|0.00200
-	chr6	7182181	7182181	G	C	exonic	RREB1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr6	7230308	7230308	G	A	exonic	RREB1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	7230144	7230144	C	T	exonic	RREB1	synonymous	SKCM\|1\|368\|0.00272
-	chr6	7230408	7230408	G	T	exonic	RREB1	synonymous	LIHC\|1\|373\|0.00268
-	chr6	7231301	7231301	A	T	exonic	RREB1	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
rs376220493	chr6	7231628	7231628	C	T	exonic	RREB1	nonsynonymous	KICH\|1\|66\|0.01515,KIPAN\|1\|799\|0.00125
-	chr6	7229752	7229752	C	T	exonic	RREB1	synonymous	CESC\|1\|194\|0.00515
-	chr6	7231912	7231912	A	G	exonic	RREB1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr6	7247433	7247433	C	T	exonic	RREB1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs747053131	chr6	7229901	7229901	G	A	exonic	RREB1	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	7247294	7247294	G	T	exonic	RREB1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr6	7230564	7230564	G	T	exonic	RREB1	synonymous	HNSC\|1\|512\|0.00195
-	chr6	7229536	7229536	C	T	exonic	RREB1	stopgain	BLCA\|2\|396\|0.00505
rs747673605	chr6	7229470	7229470	G	A	exonic	RREB1	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr6	7230870	7230870	G	T	exonic	RREB1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr6	7230637	7230637	C	T	exonic	RREB1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr6	7231040	7231040	C	T	exonic	RREB1	nonsynonymous	SKCM\|2\|368\|0.00543
rs754945001	chr6	7231195	7231195	G	A	exonic	RREB1	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr6	7249158	7249158	T	G	exonic	RREB1	nonsynonymous	CHOL\|1\|35\|0.02857
rs182302012	chr6	7231125	7231125	C	T	exonic	RREB1	synonymous	SKCM\|1\|368\|0.00272
-	chr6	7231430	7231430	C	T	exonic	RREB1	nonsynonymous	BLCA\|1\|396\|0.00253,LUAD\|1\|543\|0.00184
-	chr6	7248752	7248752	C	G	exonic	RREB1	nonsynonymous	OV\|1\|469\|0.00213
-	chr6	7240812	7240812	A	G	exonic	RREB1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	7231751	7231751	C	T	exonic	RREB1	nonsynonymous	OV\|1\|469\|0.00213
rs750751724	chr6	7229956	7229956	C	T	exonic	RREB1	synonymous	UCEC\|1\|248\|0.00403
rs745668051	chr6	7230059	7230059	G	A	exonic	RREB1	nonsynonymous	PRAD\|1\|499\|0.00200
-	chr6	7240690	7240690	T	G	exonic	RREB1	nonsynonymous	UCS\|1\|57\|0.01754
rs767996104	chr6	7248956	7248956	A	G	exonic	RREB1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr6	7229882	7229882	C	T	exonic	RREB1	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr6	7229354	7229354	C	T	exonic	RREB1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr6	7231437	7231437	C	A	exonic	RREB1	synonymous	LIHC\|1\|373\|0.00268
-	chr6	7249195	7249198	GGAG	-	exonic	RREB1	frameshift	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr6	7231215	7231215	G	T	exonic	RREB1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr6	7248826	7248826	G	C	exonic	RREB1	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr6	7231198	7231198	G	T	exonic	RREB1	nonsynonymous	LUSC\|1\|178\|0.00562
rs146203523	chr6	7231482	7231482	G	A	exonic	RREB1	synonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
rs750223399	chr6	7230882	7230882	C	T	exonic	RREB1	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs766290053	chr6	7230282	7230282	G	T	exonic	RREB1	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr6	7247378	7247378	G	T	exonic	RREB1	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr6	7229380	7229380	G	A	exonic	RREB1	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr6	7231266	7231266	T	A	exonic	RREB1	synonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr6	7230314	7230314	A	G	exonic	RREB1	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr6	7231086	7231086	C	T	exonic	RREB1	synonymous	SKCM\|1\|368\|0.00272
rs138539147	chr6	7229727	7229727	C	T	exonic	RREB1	synonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr6	7231149	7231149	C	T	exonic	RREB1	synonymous	SKCM\|1\|368\|0.00272
-	chr6	7230164	7230164	A	T	exonic	RREB1	nonsynonymous	UCS\|1\|57\|0.01754
-	chr6	7231723	7231723	G	T	exonic	RREB1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr6	7229268	7229268	G	T	exonic	RREB1	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr6	7211092	7211092	T	C	exonic	RREB1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr6	7229527	7229527	C	T	exonic	RREB1	stopgain	BLCA\|1\|396\|0.00253,SKCM\|1\|368\|0.00272
-	chr6	7229933	7229933	C	T	exonic	RREB1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr6	7211052	7211052	T	G	exonic	RREB1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr6	7230227	7230227	G	T	exonic	RREB1	nonsynonymous	LUAD\|1\|543\|0.00184
rs756644282	chr6	7247274	7247274	G	A	exonic	RREB1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr6	7248924	7248924	C	T	exonic	RREB1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	7230393	7230393	C	T	exonic	RREB1	synonymous	BLCA\|1\|396\|0.00253
-	chr6	7182219	7182219	G	A	exonic	RREB1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	7187719	7187719	G	T	exonic	RREB1	nonsynonymous	CHOL\|1\|35\|0.02857
rs746694845	chr6	7211139	7211139	C	T	exonic	RREB1	synonymous	UCEC\|1\|248\|0.00403
-	chr6	7249005	7249005	C	G	exonic	RREB1	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr6	7231121	7231121	G	A	exonic	RREB1	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
rs375275893	chr6	7231010	7231010	C	T	exonic	RREB1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr6	7229937	7229937	G	T	exonic	RREB1	synonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr6	7230225	7230225	C	T	exonic	RREB1	synonymous	DLBC\|1\|48\|0.02083
-	chr6	7231632	7231632	T	G	exonic	RREB1	synonymous	SKCM\|1\|368\|0.00272
-	chr6	7229630	7229630	G	T	exonic	RREB1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs374502214	chr6	7248820	7248820	C	T	exonic	RREB1	synonymous	SKCM\|1\|368\|0.00272
-	chr6	7246910	7246910	C	T	exonic	RREB1	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	7211836	7211836	G	A	exonic	RREB1	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr6	7230488	7230488	G	A	exonic	RREB1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr6	7231900	7231900	A	G	exonic	RREB1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr6	7230402	7230402	G	T	exonic	RREB1	synonymous	BLCA\|1\|396\|0.00253
-	chr6	7247315	7247315	C	T	exonic	RREB1	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs778172996	chr6	7230854	7230854	C	T	exonic	RREB1	nonsynonymous	SARC\|1\|247\|0.00405
rs760414247	chr6	7229769	7229769	G	A	exonic	RREB1	synonymous	HNSC\|1\|512\|0.00195
-	chr6	7232080	7232080	C	T	exonic	RREB1	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr6	7247180	7247180	-	C	exonic	RREB1	frameshift	BRCA\|2\|982\|0.00204
-	chr6	7248780	7248780	C	G	exonic	RREB1	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr6	7229617	7229617	G	T	exonic	RREB1	nonsynonymous	LUAD\|1\|543\|0.00184
rs201015406	chr6	7231817	7231817	G	T	exonic	RREB1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr6	7230237	7230237	G	A	exonic	RREB1	synonymous	HNSC\|1\|512\|0.00195
-	chr6	7231902	7231902	C	G	exonic	RREB1	synonymous	SKCM\|1\|368\|0.00272
rs756923290	chr6	7230726	7230726	G	C	exonic	RREB1	synonymous	BRCA\|1\|982\|0.00102
rs756773469	chr6	7230407	7230407	C	T	exonic	RREB1	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr6	7230280	7230280	C	T	exonic	RREB1	stopgain	ESCA\|1\|185\|0.00541
-	chr6	7232077	7232077	C	-	exonic	RREB1	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	7248772	7248772	C	T	exonic	RREB1	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	7240690	7240690	T	A	exonic	RREB1	stopgain	PRAD\|1\|499\|0.00200
-	chr6	7240706	7240706	T	A	exonic	RREB1	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr6	7232113	7232113	C	T	exonic	RREB1	synonymous	HNSC\|1\|512\|0.00195
rs142150270	chr6	7229544	7229544	C	T	exonic	RREB1	synonymous	SKCM\|1\|368\|0.00272
-	chr6	7229828	7229828	C	T	exonic	RREB1	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr6	7230183	7230183	G	C	exonic	RREB1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr6	7230840	7230840	G	C	exonic	RREB1	synonymous	OV\|1\|469\|0.00213
rs370598103	chr6	7231322	7231322	C	T	exonic	RREB1	nonsynonymous	SKCM\|1\|368\|0.00272
rs763437605	chr6	7231588	7231588	G	A	exonic	RREB1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	7230298	7230298	G	C	exonic	RREB1	nonsynonymous	LUAD\|2\|543\|0.00368
-	chr6	7229722	7229722	G	A	exonic	RREB1	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr6	7231407	7231407	C	T	exonic	RREB1	synonymous	TGCT\|1\|155\|0.00645
-	chr6	7248754	7248754	A	G	exonic	RREB1	synonymous	COADREAD\|2\|489\|0.00409,READ\|2\|122\|0.01639
-	chr6	7229287	7229287	-	CAC	exonic	RREB1	nonframeshift	PAAD\|1\|185\|0.00541
-	chr6	7230383	7230383	C	T	exonic	RREB1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr6	7182305	7182305	G	A	exonic	RREB1	nonsynonymous	BLCA\|1\|396\|0.00253
rs780527620	chr6	7230953	7230953	C	T	exonic	RREB1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr6	7231875	7231875	C	T	exonic	RREB1	synonymous	SKCM\|1\|368\|0.00272,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	7229455	7229455	G	C	exonic	RREB1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr6	7249029	7249029	A	G	exonic	RREB1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr6	7231105	7231105	C	T	exonic	RREB1	synonymous	SKCM\|1\|368\|0.00272
-	chr6	7230570	7230570	C	-	exonic	RREB1	frameshift	PAAD\|1\|185\|0.00541
-	chr6	7229573	7229573	C	T	exonic	RREB1	nonsynonymous	HNSC\|1\|512\|0.00195
rs778865424	chr6	7248912	7248912	G	A	exonic	RREB1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr6	7247375	7247375	G	C	exonic	RREB1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr6	7189549	7189549	T	C	exonic	RREB1	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr6	7230223	7230223	G	A	exonic	RREB1	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr6	7230628	7230628	C	T	exonic	RREB1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr6	7229815	7229815	G	T	exonic	RREB1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr6	7230136	7230136	A	G	exonic	RREB1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr6	7229879	7229879	G	T	exonic	RREB1	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr6	7248771	7248771	G	A	exonic	RREB1	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr6	7240734	7240734	G	C	exonic	RREB1	nonsynonymous	LUAD\|4\|543\|0.00737
-	chr6	7226828	7226828	-	G	exonic	RREB1	frameshift	PAAD\|1\|185\|0.00541
-	chr6	7247181	7247181	C	-	exonic	RREB1	frameshift	UCS\|1\|57\|0.01754
-	chr6	7229492	7229492	A	G	exonic	RREB1	nonsynonymous	LUAD\|1\|543\|0.00184
rs769663945	chr6	7230666	7230666	C	T	exonic	RREB1	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	7229363	7229363	G	A	exonic	RREB1	nonsynonymous	HNSC\|1\|512\|0.00195
rs140980354	chr6	7229595	7229595	C	T	exonic	RREB1	synonymous	PAAD\|1\|185\|0.00541
-	chr6	7231404	7231404	C	T	exonic	RREB1	synonymous	BLCA\|1\|396\|0.00253
-	chr6	7246974	7246974	G	A	exonic	RREB1	nonsynonymous	PAAD\|1\|185\|0.00541
rs201588284	chr6	7189437	7189437	G	A	exonic	RREB1	nonsynonymous	DLBC\|1\|48\|0.02083,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	7229250	7229250	G	A	exonic	RREB1	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	7240715	7240715	A	G	exonic	RREB1	nonsynonymous	OV\|1\|469\|0.00213
rs751013989	chr6	7229879	7229879	G	A	exonic	RREB1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr6	7231362	7231362	C	T	exonic	RREB1	synonymous	THCA\|1\|504\|0.00198
-	chr6	7230611	7230611	A	G	exonic	RREB1	nonsynonymous	PRAD\|1\|499\|0.00200
rs771534976	chr6	7230732	7230732	G	A	exonic	RREB1	synonymous	HNSC\|1\|512\|0.00195
rs759101444	chr6	7226757	7226757	G	A	exonic	RREB1	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	7229365	7229365	C	T	exonic	RREB1	stopgain	PAAD\|1\|185\|0.00541
-	chr6	7230385	7230385	G	A	exonic	RREB1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	7231393	7231393	T	A	exonic	RREB1	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr6	7231254	7231254	A	T	exonic	RREB1	synonymous	LUAD\|1\|543\|0.00184
rs138181401	chr6	7226755	7226755	G	A	exonic	RREB1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	7230453	7230453	C	T	exonic	RREB1	synonymous	SKCM\|1\|368\|0.00272
-	chr6	7231669	7231669	A	G	exonic	RREB1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr6	7230362	7230362	A	T	exonic	RREB1	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr6	7230981	7230981	G	T	exonic	RREB1	synonymous	ESCA\|1\|185\|0.00541,LUAD\|1\|543\|0.00184
rs770296374	chr6	7230036	7230036	G	T	exonic	RREB1	synonymous	LUAD\|1\|543\|0.00184
-	chr6	7189489	7189489	C	G	exonic	RREB1	nonsynonymous	CESC\|1\|194\|0.00515
-	chr6	7229506	7229506	C	T	exonic	RREB1	stopgain	BLCA\|2\|396\|0.00505,SKCM\|1\|368\|0.00272
-	chr6	7247187	7247187	G	A	exonic	RREB1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr6	7211150	7211150	-	A	exonic	RREB1	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	7211090	7211090	C	T	exonic	RREB1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr6	7182158	7182158	C	A	exonic	RREB1	stopgain	PAAD\|1\|185\|0.00541
-	chr6	7230370	7230370	G	A	exonic	RREB1	nonsynonymous	UCEC\|1\|248\|0.00403
rs9502564	chr6	7230680	7230680	G	T	exonic	RREB1	nonsynonymous	ACC\|11\|90\|0.12222,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	7230365	7230365	A	C	exonic	RREB1	nonsynonymous	SKCM\|2\|368\|0.00543
-	chr6	7231269	7231269	T	C	exonic	RREB1	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	7189542	7189542	G	T	exonic	RREB1	nonsynonymous	CHOL\|1\|35\|0.02857,KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr6	7230591	7230591	C	G	exonic	RREB1	synonymous	LAML\|1\|197\|0.00508
-	chr6	7231221	7231221	G	A	exonic	RREB1	synonymous	HNSC\|2\|512\|0.00391
-	chr6	7232026	7232026	C	T	exonic	RREB1	synonymous	PAAD\|1\|185\|0.00541
rs770076990	chr6	7246811	7246811	G	A	exonic	RREB1	synonymous	UCEC\|1\|248\|0.00403
rs753387864	chr6	7230996	7230996	C	T	exonic	RREB1	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs756143736	chr6	7231533	7231533	C	T	exonic	RREB1	synonymous	LUAD\|1\|543\|0.00184
-	chr6	7226815	7226815	C	T	exonic	RREB1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr6	7189489	7189489	C	T	exonic	RREB1	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr6	7247318	7247318	C	T	exonic	RREB1	synonymous	PAAD\|1\|185\|0.00541
rs149124719	chr6	7182150	7182150	G	A	exonic	RREB1	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	7211077	7211077	G	A	exonic	RREB1	nonsynonymous	UCEC\|1\|248\|0.00403
rs115093903	chr6	7231280	7231280	T	C	exonic	RREB1	nonsynonymous	DLBC\|1\|48\|0.02083
rs759718934	chr6	7230050	7230050	C	T	exonic	RREB1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	7229398	7229398	G	A	exonic	RREB1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	7231750	7231750	T	C	exonic	RREB1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr6	7229820	7229820	A	C	exonic	RREB1	synonymous	BRCA\|1\|982\|0.00102
rs780237679	chr6	7226853	7226853	G	A	exonic	RREB1	synonymous	BRCA\|1\|982\|0.00102
-	chr6	7231372	7231372	C	T	exonic	RREB1	synonymous	SKCM\|1\|368\|0.00272
rs187908583	chr6	7246994	7246994	C	T	exonic	RREB1	synonymous	DLBC\|1\|48\|0.02083
-	chr6	7246803	7246803	G	T	exonic	RREB1	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr6	7229257	7229257	T	C	exonic	RREB1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr6	7231129	7231129	G	T	exonic	RREB1	stopgain	LUAD\|1\|543\|0.00184
-	chr6	7240815	7240815	T	A	exonic	RREB1	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr6	7248826	7248826	G	A	exonic	RREB1	synonymous	BLCA\|1\|396\|0.00253
rs147699375	chr6	7231194	7231194	C	T	exonic	RREB1	synonymous	UCEC\|1\|248\|0.00403
-	chr6	7248872	7248872	G	A	exonic	RREB1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr6	7246965	7246965	A	G	exonic	RREB1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr6	7229251	7229251	C	T	exonic	RREB1	nonsynonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	7229899	7229899	A	T	exonic	RREB1	nonsynonymous	LUAD\|2\|543\|0.00368
rs754554711	chr6	7230884	7230884	C	T	exonic	RREB1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr6	7226816	7226816	C	A	exonic	RREB1	nonsynonymous	OV\|1\|469\|0.00213
-	chr6	7182252	7182252	C	A	exonic	RREB1	nonsynonymous	CESC\|1\|194\|0.00515
-	chr6	7211137	7211137	C	G	exonic	RREB1	nonsynonymous	LUAD\|1\|543\|0.00184
rs374868150	chr6	7232039	7232039	G	A	exonic	RREB1	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr6	7240823	7240823	C	T	exonic	RREB1	nonsynonymous	SKCM\|1\|368\|0.00272
rs765867404	chr6	7231959	7231959	C	T	exonic	RREB1	synonymous	BLCA\|1\|396\|0.00253

Disease information of RREB1

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
RREB1	DiGeorge Syndrome	C05;C14;C15;C16;C19	Disease or Syndrome	ORPHANET
RREB1	Shprintzen syndrome	C05;C14;C15;C16;C19	Disease or Syndrome	ORPHANET
RREB1	Asymmetric crying face association	C07;C10;C23	Disease or Syndrome	ORPHANET
RREB1	CONOTRUNCAL ANOMALY FACE SYNDROME	C05;C14;C15;C16;C19	Disease or Syndrome	ORPHANET
RREB1	22q11 Deletion Syndrome	C05;C14;C15;C16;C19	Disease or Syndrome	ORPHANET
RREB1	22q11 partial monosomy syndrome		Disease or Syndrome	ORPHANET

Pathway associated with RREB1

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number

Go term information of RREB1

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GO_term_name	GO_term_type	TF_name
GO_REGULATION_OF_MAMMARY_GLAND_EPITHELIAL_CELL_PROLIFERATION	BP	RREB1
GO_POSITIVE_REGULATION_OF_SUBSTRATE_ADHESION_DEPENDENT_CELL_SPREADING	BP	RREB1
GO_REGULATION_OF_SUBSTRATE_ADHESION_DEPENDENT_CELL_SPREADING	BP	RREB1
GO_REGULATION_OF_CELL_SUBSTRATE_ADHESION	BP	RREB1
GO_POSITIVE_REGULATION_OF_WOUND_HEALING	BP	RREB1
GO_REGULATION_OF_LAMELLIPODIUM_ORGANIZATION	BP	RREB1
GO_POSITIVE_REGULATION_OF_EPITHELIAL_CELL_MIGRATION	BP	RREB1
GO_POSITIVE_REGULATION_OF_LAMELLIPODIUM_ORGANIZATION	BP	RREB1
GO_POSITIVE_REGULATION_OF_CELL_SUBSTRATE_ADHESION	BP	RREB1
GO_POSITIVE_REGULATION_OF_CELL_MORPHOGENESIS_INVOLVED_IN_DIFFERENTIATION	BP	RREB1
GO_NUCLEAR_SPECK	CC	RREB1
GO_CORE_PROMOTER_BINDING	MF	RREB1
GO_DOUBLE_STRANDED_DNA_BINDING	MF	RREB1
GO_RNA_POLYMERASE_II_CORE_PROMOTER_SEQUENCE_SPECIFIC_DNA_BINDING	MF	RREB1
GO_CORE_PROMOTER_SEQUENCE_SPECIFIC_DNA_BINDING	MF	RREB1

Survival analysis of RREB1

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of RREB1

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)