TF information
| TF name: | TCF7 |
| TF family: | HMG |
| Ensembl gene ID: | ENSG00000081059 |
| Ensembl protein ID: | ENSP00000378472, ENSP00000429547, ENSP00000429935, ENSP00000367822, ENSP00000378469, ENSP00000340347, ENSP00000429178, ENSP00000427968, ENSP00000430179 |
| Entrez gene ID: | 6932 |
| Database name | Link | Database name | Link |
| NCBI Gene: |  |
Genecards: |  |
| Uniprot: |  |
Wikipedia: |  |
| Cosmic 3D: |  |
Geneontology: |  |
| CCLE: |  |
Frequency of TCF7 in all biosamples
| Sample ID | Biosample type | Tissue type | Biosample name | TF Frequency |
|---|---|---|---|---|
| Sample_02_354 | Cell line | Colon | Colo205 | 0.97747747747748 |
TCF7 distribution in samples’ most representative CRC
| Sample ID | Tissue type | Biosample type | Biosample name |
|---|---|---|---|
| Sample_02_354 | Colon | Cell line | Colo205 |
TCF7 distribution in all CRCs
Genomic distribution of SEs associated with TCF7
Genomic distribution of SEs associated with TF
Figure legend:
Genomic distribution of SEs associated with TF: It can roughly understand the genomic regions of SEs associated with TF, and help to carry out the next analysis, such as knocking down the experiment.
What is important information?
The yellow box can be thought of as the common genomic regions that regulates the SEs associated with TF. For example, if a knockdown experiment is performed on this region, then theoretically, the expression of the TF will be greatly reduced.
| Database name | Link |
|---|---|
| Cosmic: |  |
| Cosmic cell lines: |  |
| Depmap: |  |
TCGA somatic mutations and clinical variants of TCF7
| rsID | Chr | Start | Stop | Ref | Alt | Gene_region | Gene_symble | Effect | TCGA_Occurrence |
|---|---|---|---|---|---|---|---|---|---|
| rs775076567 | chr5 | 133473798 | 133473798 | G | A | exonic | TCF7 | nonsynonymous | COAD|1|367|0.00272,COADREAD|2|489|0.00409,PAAD|1|185|0.00541,READ|1|122|0.00820,UCEC|1|248|0.00403 |
| rs552034914 | chr5 | 133451702 | 133451702 | A | C | exonic | TCF7 | nonsynonymous | KIPAN|1|799|0.00125,KIRC|1|451|0.00222 |
| - | chr5 | 133477961 | 133477961 | G | T | exonic | TCF7 | nonsynonymous | BRCA|1|982|0.00102 |
| - | chr5 | 133473792 | 133473792 | C | T | exonic | TCF7 | nonsynonymous | BLCA|1|396|0.00253 |
| - | chr5 | 133478563 | 133478563 | C | T | exonic | TCF7 | synonymous | BLCA|1|396|0.00253 |
| - | chr5 | 133451662 | 133451662 | C | A | exonic | TCF7 | nonsynonymous | BRCA|1|982|0.00102 |
| - | chr5 | 133474706 | 133474706 | G | A | exonic | TCF7 | synonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr5 | 133478709 | 133478709 | A | T | exonic | TCF7 | nonsynonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr5 | 133451530 | 133451530 | A | T | UTR5 | TCF7 | unknown | BLCA|1|396|0.00253 |
| rs765049839 | chr5 | 133473797 | 133473797 | C | T | exonic | TCF7 | synonymous | BRCA|1|982|0.00102,ESCA|1|185|0.00541 |
| rs754914783 | chr5 | 133479303 | 133479303 | G | A | exonic | TCF7 | synonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr5 | 133451600 | 133451600 | G | A | exonic | TCF7 | nonsynonymous | PRAD|1|499|0.00200 |
| - | chr5 | 133473755 | 133473755 | G | T | exonic | TCF7 | nonsynonymous | LUAD|1|543|0.00184 |
| - | chr5 | 133478506 | 133478506 | A | G | exonic | TCF7 | nonsynonymous | UCEC|1|248|0.00403 |
| rs373409914 | chr5 | 133473836 | 133473836 | G | A | exonic | TCF7 | synonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr5 | 133478560 | 133478560 | A | T | exonic | TCF7 | nonsynonymous | PAAD|1|185|0.00541 |
| - | chr5 | 133473800 | 133473800 | A | G | exonic | TCF7 | synonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr5 | 133478723 | 133478723 | G | A | exonic | TCF7 | nonsynonymous | BRCA|1|982|0.00102 |
| - | chr5 | 133451706 | 133451706 | C | T | exonic | TCF7 | synonymous | SKCM|1|368|0.00272 |
| - | chr5 | 133451703 | 133451703 | C | - | exonic | TCF7 | frameshift | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| rs774858813 | chr5 | 133481907 | 133481907 | A | G | UTR3 | TCF7 | unknown | UCS|1|57|0.01754 |
| - | chr5 | 133481949 | 133481949 | - | A | exonic | TCF7 | frameshift | BLCA|1|396|0.00253 |
| rs570365840 | chr5 | 133451714 | 133451714 | A | T | exonic | TCF7 | nonsynonymous | LIHC|1|373|0.00268 |
| - | chr5 | 133473785 | 133473785 | - | T | exonic | TCF7 | frameshift | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr5 | 133473765 | 133473765 | C | - | exonic | TCF7 | frameshift | COAD|2|367|0.00545,COADREAD|2|489|0.00409,STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr5 | 133477951 | 133477951 | - | C | exonic | TCF7 | frameshift | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| rs373163251 | chr5 | 133479302 | 133479302 | C | T | exonic | TCF7 | nonsynonymous | UCEC|1|248|0.00403 |
| rs369717473 | chr5 | 133481935 | 133481935 | G | A | exonic | TCF7 | nonsynonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr5 | 133477960 | 133477960 | - | G | exonic | TCF7 | frameshift | HNSC|1|512|0.00195 |
| - | chr5 | 133473787 | 133473789 | TCT | - | exonic | TCF7 | nonframeshift | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr5 | 133478495 | 133478495 | T | C | exonic | TCF7 | nonsynonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr5 | 133478442 | 133478442 | G | T | exonic | TCF7 | nonsynonymous | LUSC|1|178|0.00562 |
| - | chr5 | 133451679 | 133451679 | - | C | exonic | TCF7 | frameshift | LUAD|3|543|0.00552 |
| rs765208997 | chr5 | 133480540 | 133480540 | G | A | exonic | TCF7 | synonymous | UCEC|1|248|0.00403 |
| - | chr5 | 133482071 | 133482071 | T | C | UTR3 | TCF7 | unknown | LUAD|1|543|0.00184 |
| rs764132346 | chr5 | 133478778 | 133478778 | C | T | exonic | TCF7 | nonsynonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr5 | 133480499 | 133480499 | C | T | exonic | TCF7 | nonsynonymous | LIHC|1|373|0.00268 |
| - | chr5 | 133473780 | 133473780 | C | T | exonic | TCF7 | nonsynonymous | SKCM|1|368|0.00272 |
| - | chr5 | 133481891 | 133481891 | G | A | splicing | TCF7 | splicing | LIHC|1|373|0.00268 |
| - | chr5 | 133477913 | 133477913 | C | G | exonic | TCF7 | nonsynonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr5 | 133473817 | 133473817 | A | T | exonic | TCF7 | nonsynonymous | SKCM|1|368|0.00272 |
| rs757866191 | chr5 | 133473769 | 133473769 | C | A | exonic | TCF7 | nonsynonymous | LIHC|1|373|0.00268 |
| rs143237515 | chr5 | 133477985 | 133477985 | G | A | exonic | TCF7 | nonsynonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr5 | 133478792 | 133478792 | G | A | splicing | TCF7 | splicing | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr5 | 133478537 | 133478538 | AG | - | exonic | TCF7 | frameshift | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr5 | 133478730 | 133478730 | C | T | exonic | TCF7 | nonsynonymous | COADREAD|1|489|0.00204,READ|1|122|0.00820 |
| rs766182177 | chr5 | 133479299 | 133479299 | G | A | exonic | TCF7 | nonsynonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr5 | 133474713 | 133474713 | C | A | exonic | TCF7 | nonsynonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr5 | 133451705 | 133451705 | C | T | exonic | TCF7 | nonsynonymous | SKCM|1|368|0.00272 |
| rs760014270 | chr5 | 133451688 | 133451688 | G | A | exonic | TCF7 | synonymous | BRCA|1|982|0.00102 |
| rs771602751 | chr5 | 133473764 | 133473764 | - | C | exonic | TCF7 | frameshift | COAD|2|367|0.00545,COADREAD|2|489|0.00409,HNSC|1|512|0.00195,KIPAN|8|799|0.01001,KIRC|8|451|0.01774,LUAD|2|543|0.00368,STAD|1|395|0.00253,STES|1|395|0.00253 |
| rs561867522 | chr5 | 133473773 | 133473773 | C | T | exonic | TCF7 | synonymous | ESCA|1|185|0.00541 |
| - | chr5 | 133477984 | 133477984 | C | G | exonic | TCF7 | nonsynonymous | LUAD|2|543|0.00368 |
| - | chr5 | 133451660 | 133451660 | A | T | exonic | TCF7 | nonsynonymous | HNSC|1|512|0.00195 |
| - | chr5 | 133451043 | 133451043 | T | - | exonic | TCF7 | frameshift | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr5 | 133482119 | 133482119 | C | G | UTR3 | TCF7 | unknown | BLCA|1|396|0.00253 |
| rs768845581 | chr5 | 133480497 | 133480497 | C | T | exonic | TCF7 | nonsynonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204,STAD|1|395|0.00253,STES|1|395|0.00253 |
| rs377581629 | chr5 | 133481970 | 133481970 | G | A | exonic | TCF7 | synonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr5 | 133479286 | 133479287 | AA | - | exonic | TCF7 | frameshift | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr5 | 133478466 | 133478466 | G | T | exonic | TCF7 | nonsynonymous | COADREAD|1|489|0.00204,READ|1|122|0.00820 |
| - | chr5 | 133481891 | 133481891 | G | T | splicing | TCF7 | splicing | HNSC|1|512|0.00195 |
| rs140392908 | chr5 | 133451023 | 133451023 | G | A | exonic | TCF7 | synonymous | SKCM|1|368|0.00272 |
| TF_name | Disease_name | Disease_class | Disease_semantic_type | TF_disease_source |
|---|---|---|---|---|
| TCF7 | Crohn Disease | C06 | Disease or Syndrome | CTD_human |
| TCF7 | Lupus Erythematosus, Systemic | C17;C20 | Disease or Syndrome | CTD_human |
| TCF7 | Crohn's disease of large bowel | C06 | Disease or Syndrome | CTD_human |
| TCF7 | Libman-Sacks Disease | C17;C20 | Disease or Syndrome | CTD_human |
| TCF7 | Crohn's disease of the ileum | C06 | Disease or Syndrome | CTD_human |
| TCF7 | Regional enteritis | C06 | Disease or Syndrome | CTD_human |
| TCF7 | IIeocolitis | C06 | Disease or Syndrome | CTD_human |
| pathway_ID | pathway_name | pathway_source | gene_number | edge_number |
|---|---|---|---|---|
| pathway0000309 | Binding of TCF/LEF:CTNNB1 to target gene promoters | reactome | 7 | 20 |
| pathway0000355 | Canonical Wnt signaling pathway ( C. elegans endoderm induction Wnt signaling pathway Diagram ) | inoh | 56 | 519 |
| pathway0000356 | Canonical Wnt signaling pathway ( Canonical Wnt signaling pathway Diagram ) | inoh | 56 | 519 |
| pathway0000357 | Canonical Wnt signaling pathway ( Drosophila Wingless/Wnt signaling pathway Diagram ) | inoh | 56 | 519 |
| pathway0000358 | Canonical Wnt signaling pathway ( Mammalian Wnt signaling pathway Diagram ) | inoh | 56 | 519 |
| pathway0000359 | Canonical Wnt signaling pathway ( Xenopus axis formation Wnt signaling pathway Diagram ) | inoh | 56 | 519 |
| pathway0000549 | Deactivation of the beta-catenin transactivating complex | reactome | 42 | 236 |
| pathway0001078 | ID | netpath | 38 | 213 |
| pathway0001315 | Mammalian Wnt signaling pathway ( Mammalian Wnt signaling pathway Diagram ) | inoh | 49 | 453 |
| pathway0001876 | Repression of WNT target genes | reactome | 14 | 68 |
| pathway0002046 | Signaling with Wnt (Canonical) ( C. elegans endoderm induction Wnt signaling pathway Diagram ) | inoh | 47 | 421 |
| pathway0002047 | Signaling with Wnt (Canonical) ( Canonical Wnt signaling pathway Diagram ) | inoh | 47 | 421 |
| pathway0002048 | Signaling with Wnt (Canonical) ( Drosophila Wingless/Wnt signaling pathway Diagram ) | inoh | 47 | 421 |
| pathway0002049 | Signaling with Wnt (Canonical) ( Mammalian Wnt signaling pathway Diagram ) | inoh | 47 | 421 |
| pathway0002050 | Signaling with Wnt (Canonical) ( Xenopus axis formation Wnt signaling pathway Diagram ) | inoh | 47 | 421 |
| pathway0002051 | Signaling with Wnt (Mammal) ( Mammalian Wnt signaling pathway Diagram ) | inoh | 47 | 421 |
| pathway0002052 | Signaling with Wnt (Xenopus) ( Xenopus axis formation Wnt signaling pathway Diagram ) | inoh | 19 | 46 |
| pathway0002053 | Signaling without Wnt (Canonical) ( C. elegans endoderm induction Wnt signaling pathway Diagram ) | inoh | 8 | 26 |
| pathway0002054 | Signaling without Wnt (Canonical) ( Canonical Wnt signaling pathway Diagram ) | inoh | 8 | 26 |
| pathway0002055 | Signaling without Wnt (Canonical) ( Drosophila Wingless/Wnt signaling pathway Diagram ) | inoh | 8 | 26 |
| pathway0002056 | Signaling without Wnt (Canonical) ( Mammalian Wnt signaling pathway Diagram ) | inoh | 8 | 26 |
| pathway0002057 | Signaling without Wnt (Canonical) ( Xenopus axis formation Wnt signaling pathway Diagram ) | inoh | 8 | 26 |
| pathway0002058 | Signaling without Wnt (Mammal) ( Mammalian Wnt signaling pathway Diagram ) | inoh | 8 | 26 |
| pathway0002181 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) | reactome | 20 | 41 |
| pathway0002393 | Validated transcriptional targets of deltaNp63 isoforms | pid | 47 | 101 |
| pathway0002587 | Wnt signaling pathway | kegg | 135 | 1586 |
| pathway0002597 | Adherens junction | kegg | 70 | 644 |
| pathway0002627 | Melanogenesis | kegg | 100 | 1225 |
| pathway0002656 | Pathways in cancer | kegg | 321 | 8293 |
| pathway0002657 | Colorectal cancer | kegg | 63 | 642 |
| pathway0002660 | Endometrial cancer | kegg | 52 | 567 |
| pathway0002662 | Prostate cancer | kegg | 85 | 1261 |
| pathway0002668 | Acute myeloid leukemia | kegg | 53 | 562 |
| pathway0002677 | Arrhythmogenic right ventricular cardiomyopathy (ARVC) | kegg | 71 | 760 |
| pathway0002755 | Hs_White_fat_cell_differentiation_WP3946_90940 | wikipathways | 30 | 59 |
| pathway0002826 | Hs_Mesodermal_Commitment_Pathway_WP2857_87780 | wikipathways | 47 | 175 |
| pathway0002841 | Hs_Ectoderm_Differentiation_WP2858_89329 | wikipathways | 56 | 137 |
| GO_term_name | GO_term_type | TF_name |
|---|---|---|
| GO_LEUKOCYTE_ACTIVATION | BP | TCF7 |
| GO_REGULATION_OF_EPITHELIAL_CELL_APOPTOTIC_PROCESS | BP | TCF7 |
| GO_REGULATION_OF_PROTEIN_BINDING | BP | TCF7 |
| GO_POSITIVE_REGULATION_OF_EPITHELIAL_TO_MESENCHYMAL_TRANSITION | BP | TCF7 |
| GO_RESPONSE_TO_INTERLEUKIN_4 | BP | TCF7 |
| GO_POSITIVE_REGULATION_OF_BINDING | BP | TCF7 |
| GO_REGULATION_OF_CELL_MORPHOGENESIS_INVOLVED_IN_DIFFERENTIATION | BP | TCF7 |
| GO_NON_CANONICAL_WNT_SIGNALING_PATHWAY | BP | TCF7 |
| GO_ALPHA_BETA_T_CELL_DIFFERENTIATION | BP | TCF7 |
| GO_REGULATION_OF_PROTEIN_EXPORT_FROM_NUCLEUS | BP | TCF7 |
| GO_NEURAL_TUBE_DEVELOPMENT | BP | TCF7 |
| GO_WNT_SIGNALING_PATHWAY_CALCIUM_MODULATING_PATHWAY | BP | TCF7 |
| GO_WNT_SIGNALING_PATHWAY | BP | TCF7 |
| GO_NEGATIVE_REGULATION_OF_SEQUENCE_SPECIFIC_DNA_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY | BP | TCF7 |
| GO_PANCREAS_DEVELOPMENT | BP | TCF7 |
| GO_CELLULAR_RESPONSE_TO_INTERLEUKIN_4 | BP | TCF7 |
| GO_SOMATIC_CELL_DNA_RECOMBINATION | BP | TCF7 |
| GO_EMBRYONIC_DIGESTIVE_TRACT_MORPHOGENESIS | BP | TCF7 |
| GO_NEGATIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY | BP | TCF7 |
| GO_REGULATION_OF_GLYCOPROTEIN_METABOLIC_PROCESS | BP | TCF7 |
| GO_NEGATIVE_REGULATION_OF_EPITHELIAL_CELL_APOPTOTIC_PROCESS | BP | TCF7 |
| GO_LYMPHOCYTE_ACTIVATION | BP | TCF7 |
| GO_CANONICAL_WNT_SIGNALING_PATHWAY | BP | TCF7 |
| GO_EMBRYONIC_DIGESTIVE_TRACT_DEVELOPMENT | BP | TCF7 |
| GO_MYOBLAST_DIFFERENTIATION | BP | TCF7 |
| GO_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY | BP | TCF7 |
| GO_DIGESTIVE_TRACT_MORPHOGENESIS | BP | TCF7 |
| GO_POSITIVE_REGULATION_OF_HORMONE_SECRETION | BP | TCF7 |
| GO_SOMATIC_DIVERSIFICATION_OF_IMMUNE_RECEPTORS | BP | TCF7 |
| GO_NEGATIVE_REGULATION_OF_CANONICAL_WNT_SIGNALING_PATHWAY | BP | TCF7 |
| GO_POSITIVE_REGULATION_OF_GLYCOPROTEIN_METABOLIC_PROCESS | BP | TCF7 |
| GO_FAT_CELL_DIFFERENTIATION | BP | TCF7 |
| GO_ALPHA_BETA_T_CELL_ACTIVATION | BP | TCF7 |
| GO_REGULATION_OF_SMOOTH_MUSCLE_CELL_PROLIFERATION | BP | TCF7 |
| GO_SEX_DIFFERENTIATION | BP | TCF7 |
| GO_POSITIVE_REGULATION_OF_PROTEIN_KINASE_B_SIGNALING | BP | TCF7 |
| GO_CELL_FATE_COMMITMENT | BP | TCF7 |
| GO_NEGATIVE_REGULATION_OF_APOPTOTIC_SIGNALING_PATHWAY | BP | TCF7 |
| GO_REGULATION_OF_CELL_DEATH | BP | TCF7 |
| GO_REGULATION_OF_PROTEIN_KINASE_B_SIGNALING | BP | TCF7 |
| GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_STIMULUS | BP | TCF7 |
| GO_REGULATION_OF_HORMONE_METABOLIC_PROCESS | BP | TCF7 |
| GO_POSITIVE_REGULATION_OF_PROTEIN_EXPORT_FROM_NUCLEUS | BP | TCF7 |
| GO_BETA_CATENIN_TCF_COMPLEX_ASSEMBLY | BP | TCF7 |
| GO_REGULATION_OF_SULFUR_METABOLIC_PROCESS | BP | TCF7 |
| GO_GENITALIA_DEVELOPMENT | BP | TCF7 |
| GO_MUSCLE_CELL_DIFFERENTIATION | BP | TCF7 |
| GO_EMBRYONIC_ORGAN_DEVELOPMENT | BP | TCF7 |
| GO_T_CELL_DIFFERENTIATION | BP | TCF7 |
| GO_POSITIVE_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION | BP | TCF7 |
| GO_V_D_J_RECOMBINATION | BP | TCF7 |
| GO_POSITIVE_REGULATION_OF_CELL_MORPHOGENESIS_INVOLVED_IN_DIFFERENTIATION | BP | TCF7 |
| GO_REGULATION_OF_STEM_CELL_DIFFERENTIATION | BP | TCF7 |
| GO_CHROMATIN | CC | TCF7 |
| GO_TRANSCRIPTION_FACTOR_COMPLEX | CC | TCF7 |
| GO_NUCLEAR_EUCHROMATIN | CC | TCF7 |
| GO_EUCHROMATIN | CC | TCF7 |
| GO_BETA_CATENIN_BINDING | MF | TCF7 |
| GO_RNA_POLYMERASE_II_REPRESSING_TRANSCRIPTION_FACTOR_BINDING | MF | TCF7 |
| GO_REPRESSING_TRANSCRIPTION_FACTOR_BINDING | MF | TCF7 |
| GO_GAMMA_CATENIN_BINDING | MF | TCF7 |
| GO_ARMADILLO_REPEAT_DOMAIN_BINDING | MF | TCF7 |