Cancer CRCdb

TF information

TF name:	HNF1A
TF family:	Homeobox
Ensembl gene ID:	ENSG00000135100
Ensembl protein ID:	ENSP00000443112, ENSP00000438804, ENSP00000257555, ENSP00000476181
Entrez gene ID:	6927

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of HNF1A in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_01_001	Cell line	Prostate	22Rv1	0.33414043583535
Sample_02_236	Cell line	Colon	V206	0.91511387163561
Sample_02_237	Cell line	Colon	V389	0.97110252162709
Sample_02_241	Cell line	Colon	V456	0.87923250564334
Sample_02_242	Cell line	Colon	V481	0.4499455232968
Sample_02_285	Cell line	Liver	HuH7_untreat	0.49128919860627
Sample_02_322	Cell line	Colon	Caco-2	0.06864064602961
Sample_02_354	Cell line	Colon	Colo205	0.80930930930931
Sample_02_358	Cell line	Colon	LS180	0.90955766192733

HNF1A distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name
Sample_02_236	Colon	Cell line	V206
Sample_02_237	Colon	Cell line	V389
Sample_02_241	Colon	Cell line	V456
Sample_02_354	Colon	Cell line	Colo205
Sample_02_358	Colon	Cell line	LS180

HNF1A distribution in all CRCs

Genomic distribution of SEs associated with HNF1A

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Mutation of HNF1A

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of HNF1A

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr12	121435420	121435420	A	G	exonic	HNF1A	nonsynonymous	ESCA\|1\|185\|0.00541
rs772756175	chr12	121435350	121435350	C	T	exonic	HNF1A	synonymous	PRAD\|1\|499\|0.00200
-	chr12	121432128	121432128	G	A	exonic	HNF1A	nonsynonymous	SKCM\|1\|368\|0.00272
rs570915522	chr12	121432114	121432114	C	T	exonic	HNF1A	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs766191969	chr12	121432116	121432116	-	C	exonic	HNF1A	frameshift	BRCA\|2\|982\|0.00204
-	chr12	121431465	121431465	C	T	exonic	HNF1A	synonymous	SKCM\|1\|368\|0.00272
-	chr12	121434601	121434601	G	A	intronic	HNF1A	unknown	SARC\|1\|247\|0.00405
-	chr12	121426820	121426820	C	T	exonic	HNF1A	stopgain	LIHC\|1\|373\|0.00268
-	chr12	121431506	121431506	A	G	exonic	HNF1A	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr12	121426785	121426785	G	T	exonic	HNF1A	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr12	121432064	121432064	C	T	exonic	HNF1A	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr12	121434128	121434128	C	T	exonic	HNF1A	nonsynonymous	SKCM\|2\|368\|0.00543
rs774996577	chr12	121426649	121426649	C	T	exonic	HNF1A	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr12	121431498	121431498	G	A	exonic	HNF1A	synonymous	SKCM\|1\|368\|0.00272
-	chr12	121416712	121416714	GGA	-	exonic	HNF1A	nonframeshift	LIHC\|1\|373\|0.00268
-	chr12	121426802	121426802	T	C	exonic	HNF1A	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs766982432	chr12	121432118	121432118	C	-	exonic	HNF1A	frameshift	COAD\|2\|367\|0.00545,COADREAD\|2\|489\|0.00409,ESCA\|1\|185\|0.00541,STAD\|4\|395\|0.01013,STES\|4\|395\|0.01013
-	chr12	121416768	121416768	A	G	exonic	HNF1A	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr12	121438866	121438866	A	G	splicing	HNF1A	splicing	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr12	121431330	121431330	C	T	exonic	HNF1A	synonymous	HNSC\|1\|512\|0.00195
-	chr12	121434399	121434399	G	A	exonic	HNF1A	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr12	121416631	121416631	G	A	exonic	HNF1A	synonymous	SKCM\|1\|368\|0.00272
-	chr12	121426813	121426813	C	G	exonic	HNF1A	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr12	121431453	121431453	G	C	exonic	HNF1A	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr12	121431429	121431429	G	A	exonic	HNF1A	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr12	121435510	121435510	G	T	intronic	HNF1A	unknown	ESCA\|1\|185\|0.00541
-	chr12	121416852	121416852	C	A	exonic	HNF1A	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr12	121432043	121432043	G	A	exonic	HNF1A	nonsynonymous	HNSC\|1\|512\|0.00195
rs2259820	chr12	121435342	121435342	C	T	exonic	HNF1A	synonymous	DLBC\|2\|48\|0.04167
-	chr12	121426687	121426687	C	A	exonic	HNF1A	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr12	121426736	121426736	C	T	exonic	HNF1A	nonsynonymous	KICH\|1\|66\|0.01515,KIPAN\|1\|799\|0.00125
-	chr12	121416899	121416899	T	A	splicing	HNF1A	splicing	LIHC\|1\|373\|0.00268
rs375702866	chr12	121438947	121438947	C	T	exonic	HNF1A	synonymous	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr12	121437343	121437343	C	T	exonic	HNF1A	stopgain	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr12	121431360	121431360	G	T	exonic	HNF1A	nonsynonymous	UCEC\|1\|248\|0.00403
rs201934320	chr12	121426830	121426830	C	T	exonic	HNF1A	nonsynonymous	SKCM\|1\|368\|0.00272
rs55834942	chr12	121437114	121437114	G	A	exonic	HNF1A	synonymous	DLBC\|3\|48\|0.06250
-	chr12	121438965	121438965	C	T	exonic	HNF1A	synonymous	CESC\|1\|194\|0.00515
-	chr12	121437070	121437070	G	A	splicing	HNF1A	splicing	LIHC\|1\|373\|0.00268
-	chr12	121434205	121434205	G	C	exonic	HNF1A	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr12	121434166	121434166	C	-	exonic	HNF1A	frameshift	LIHC\|1\|373\|0.00268
-	chr12	121426669	121426669	G	T	exonic	HNF1A	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr12	121416664	121416664	T	C	exonic	HNF1A	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr12	121426771	121426771	G	A	exonic	HNF1A	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr12	121434630	121434630	-	CATTCAT	intronic	HNF1A	unknown	OV\|1\|469\|0.00213
-	chr12	121431424	121431424	T	A	exonic	HNF1A	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr12	121416572	121416744	ATGGTTTCTAAACTGAGCCAGCTGCAGACGGAGCTCCTGGCGGCCCTGCTCGAGTCAGGGCTGAGCAAAGAGGCACTGATCCAGGCACTGGGTGAGCCGGGGCCCTACCTCCTGGCTGGAGAAGGCCCCCTGGACAAGGGGGAGTCCTGCGGCGGCGGTCGAGGGGAGCTGGC	-	exonic	HNF1A	frameshift	-
-	chr12	121416797	121416797	G	A	exonic	HNF1A	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr12	121434448	121434448	C	T	exonic	HNF1A	synonymous	SKCM\|1\|368\|0.00272
rs371807951	chr12	121435468	121435468	G	A	exonic	HNF1A	nonsynonymous	HNSC\|1\|512\|0.00195
rs762703502	chr12	121432115	121432115	G	-	exonic	HNF1A	frameshift	COAD\|4\|367\|0.01090,COADREAD\|4\|489\|0.00818,HNSC\|1\|512\|0.00195,SKCM\|1\|368\|0.00272,STAD\|4\|395\|0.01013,STES\|4\|395\|0.01013,UCEC\|2\|248\|0.00806
-	chr12	121416684	121416684	T	C	exonic	HNF1A	nonsynonymous	LIHC\|1\|373\|0.00268
rs2464196	chr12	121435427	121435427	G	A	exonic	HNF1A	nonsynonymous	DLBC\|2\|48\|0.04167
-	chr12	121426634	121426634	A	G	splicing	HNF1A	splicing	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr12	121431351	121431351	G	A	exonic	HNF1A	synonymous	SKCM\|1\|368\|0.00272
-	chr12	121434172	121434172	G	T	exonic	HNF1A	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr12	121416718	121416718	C	T	exonic	HNF1A	synonymous	SKCM\|1\|368\|0.00272
-	chr12	121434164	121434164	C	T	exonic	HNF1A	nonsynonymous	LIHC\|1\|373\|0.00268
rs56348580	chr12	121432117	121432117	G	C	exonic	HNF1A	synonymous	DLBC\|3\|48\|0.06250
-	chr12	121432014	121432014	T	A	exonic	HNF1A	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr12	121426701	121426701	G	T	exonic	HNF1A	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
rs201694197	chr12	121435467	121435467	C	T	exonic	HNF1A	synonymous	HNSC\|1\|512\|0.00195
-	chr12	121434148	121434148	C	T	exonic	HNF1A	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr12	121434482	121434482	C	A	exonic	HNF1A	nonsynonymous	LUAD\|1\|543\|0.00184
rs1169289	chr12	121416622	121416622	C	G	exonic	HNF1A	synonymous	DLBC\|2\|48\|0.04167
-	chr12	121426777	121426777	G	A	exonic	HNF1A	synonymous	HNSC\|2\|512\|0.00391
-	chr12	121437302	121437302	C	G	exonic	HNF1A	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr12	121435299	121435299	G	C	exonic	HNF1A	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr12	121431982	121431982	G	A	exonic	HNF1A	synonymous	BLCA\|1\|396\|0.00253
-	chr12	121431417	121431417	C	A	exonic	HNF1A	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr12	121438773	121438773	G	A	intronic	HNF1A	unknown	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr12	121432189	121432189	C	G	exonic	HNF1A	synonymous	ESCA\|1\|185\|0.00541
-	chr12	121431342	121431342	G	A	exonic	HNF1A	synonymous	SKCM\|1\|368\|0.00272
rs113111047	chr12	121434647	121434647	A	T	intronic	HNF1A	unknown	ESCA\|1\|185\|0.00541
-	chr12	121431983	121431983	A	G	exonic	HNF1A	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr12	121432065	121432065	G	T	exonic	HNF1A	nonsynonymous	SARC\|1\|247\|0.00405
-	chr12	121432060	121432060	C	T	exonic	HNF1A	synonymous	BLCA\|2\|396\|0.00505
-	chr12	121431483	121431483	A	G	exonic	HNF1A	synonymous	COAD\|1\|367\|0.00272,COADREAD\|2\|489\|0.00409,READ\|1\|122\|0.00820
-	chr12	121434449	121434449	A	T	exonic	HNF1A	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr12	121432002	121432002	A	G	exonic	HNF1A	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs769086289	chr12	121431481	121431481	C	T	exonic	HNF1A	stopgain	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr12	121416794	121416794	G	A	exonic	HNF1A	nonsynonymous	SARC\|1\|247\|0.00405
rs368683806	chr12	121434479	121434479	G	A	exonic	HNF1A	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr12	121434696	121434696	T	A	intronic	HNF1A	unknown	BRCA\|1\|982\|0.00102
-	chr12	121431369	121431369	-	G	exonic	HNF1A	frameshift	KICH\|1\|66\|0.01515,KIPAN\|1\|799\|0.00125
-	chr12	121434389	121434389	G	A	exonic	HNF1A	nonsynonymous	BLCA\|1\|396\|0.00253
rs763412043	chr12	121434123	121434123	C	T	exonic	HNF1A	synonymous	PRAD\|2\|499\|0.00401,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs144674840	chr12	121437365	121437365	C	T	exonic	HNF1A	nonsynonymous	PRAD\|1\|499\|0.00200
-	chr12	121434367	121434367	C	-	exonic	HNF1A	frameshift	COAD\|2\|367\|0.00545,COADREAD\|2\|489\|0.00409
rs760640415	chr12	121432086	121432086	G	A	exonic	HNF1A	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr12	121438965	121438965	C	A	exonic	HNF1A	synonymous	BLCA\|1\|396\|0.00253
-	chr12	121437400	121437400	C	T	exonic	HNF1A	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr12	121416653	121416653	C	T	exonic	HNF1A	stopgain	SKCM\|1\|368\|0.00272
-	chr12	121434594	121434594	A	G	intronic	HNF1A	unknown	SKCM\|1\|368\|0.00272
-	chr12	121437209	121437209	C	T	intronic	HNF1A	unknown	ESCA\|1\|185\|0.00541
-	chr12	121432067	121432067	C	A	exonic	HNF1A	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr12	121437354	121437354	C	T	exonic	HNF1A	synonymous	LUAD\|1\|543\|0.00184
-	chr12	121437168	121437168	G	A	exonic	HNF1A	synonymous	SKCM\|1\|368\|0.00272
-	chr12	121437150	121437150	C	T	exonic	HNF1A	synonymous	SKCM\|1\|368\|0.00272
-	chr12	121434405	121434405	A	G	exonic	HNF1A	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr12	121426712	121426712	G	A	exonic	HNF1A	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr12	121434162	121434162	G	T	exonic	HNF1A	synonymous	LIHC\|1\|373\|0.00268
-	chr12	121435406	121435406	T	C	exonic	HNF1A	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr12	121437158	121437158	T	C	exonic	HNF1A	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
rs757068809	chr12	121434170	121434170	C	T	exonic	HNF1A	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr12	121431395	121431395	G	A	exonic	HNF1A	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr12	121437175	121437175	C	T	exonic	HNF1A	nonsynonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
rs751449138	chr12	121432117	121432117	-	C	exonic	HNF1A	frameshift	KIPAN\|2\|799\|0.00250,KIRC\|2\|451\|0.00443,LUAD\|1\|543\|0.00184
-	chr12	121426770	121426770	T	C	exonic	HNF1A	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs199511735	chr12	121437180	121437180	G	A	exonic	HNF1A	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr12	121439044	121439044	G	T	UTR3	HNF1A	unknown	ESCA\|1\|185\|0.00541
-	chr12	121437368	121437368	-	C	exonic	HNF1A	frameshift	KICH\|1\|66\|0.01515,KIPAN\|1\|799\|0.00125
rs758875084	chr12	121434487	121434487	T	A	exonic	HNF1A	synonymous	HNSC\|2\|512\|0.00391
rs193922580	chr12	121435391	121435391	C	T	exonic	HNF1A	nonsynonymous	SKCM\|1\|368\|0.00272
rs760910961	chr12	121426657	121426657	G	A	exonic	HNF1A	synonymous	SKCM\|1\|368\|0.00272
-	chr12	121416709	121416709	G	A	exonic	HNF1A	synonymous	SKCM\|1\|368\|0.00272
-	chr12	121432040	121432040	C	G	exonic	HNF1A	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr12	121438953	121438953	C	A	exonic	HNF1A	synonymous	HNSC\|2\|512\|0.00391
-	chr12	121431496	121431496	G	A	exonic	HNF1A	nonsynonymous	SKCM\|1\|368\|0.00272
rs139016696	chr12	121426650	121426650	G	A	exonic	HNF1A	nonsynonymous	BLCA\|1\|396\|0.00253,UCEC\|1\|248\|0.00403
rs774637975	chr12	121416600	121416600	C	T	exonic	HNF1A	nonsynonymous	PRAD\|1\|499\|0.00200
-	chr12	121435302	121435302	T	G	exonic	HNF1A	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr12	121437163	121437163	G	A	exonic	HNF1A	nonsynonymous	UCEC\|1\|248\|0.00403
rs137853244	chr12	121426700	121426700	C	T	exonic	HNF1A	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr12	121416806	121416806	G	A	exonic	HNF1A	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr12	121431475	121431475	G	A	exonic	HNF1A	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr12	121437184	121437184	A	G	exonic	HNF1A	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr12	121431999	121431999	C	G	exonic	HNF1A	stopgain	ESCA\|1\|185\|0.00541
-	chr12	121431321	121431321	A	G	splicing	HNF1A	splicing	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr12	121416810	121416810	A	G	exonic	HNF1A	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr12	121416877	121416877	C	A	exonic	HNF1A	synonymous	LUSC\|1\|178\|0.00562
rs753998395	chr12	121426701	121426701	G	A	exonic	HNF1A	nonsynonymous	UCEC\|1\|248\|0.00403
rs549471872	chr12	121434120	121434120	C	T	exonic	HNF1A	synonymous	OV\|1\|469\|0.00213
-	chr12	121416639	121416639	A	-	exonic	HNF1A	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr12	121434799	121434799	A	T	intronic	HNF1A	unknown	SARC\|1\|247\|0.00405
-	chr12	121416883	121416883	G	A	exonic	HNF1A	synonymous	HNSC\|1\|512\|0.00195
-	chr12	121431482	121431482	G	A	exonic	HNF1A	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr12	121438927	121438927	-	T	exonic	HNF1A	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr12	121426689	121426689	A	G	exonic	HNF1A	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
rs776169793	chr12	121435308	121435308	G	A	exonic	HNF1A	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs773895173	chr12	121437383	121437383	G	A	exonic	HNF1A	nonsynonymous	OV\|1\|469\|0.00213
-	chr12	121416586	121416586	G	C	exonic	HNF1A	synonymous	BLCA\|1\|396\|0.00253
-	chr12	121426788	121426788	C	A	exonic	HNF1A	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr12	121426774	121426774	G	A	exonic	HNF1A	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr12	121431449	121431449	A	G	exonic	HNF1A	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr12	121434509	121434509	A	C	exonic	HNF1A	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
rs193922576	chr12	121434361	121434361	C	-	exonic	HNF1A	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253

Disease information of HNF1A

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
HNF1A	Renal Cell Carcinoma	C04;C12;C13	Neoplastic Process	CTD_human
HNF1A	Coronary heart disease	C14	Disease or Syndrome	CTD_human
HNF1A	Diabetes Mellitus, Insulin-Dependent	C18;C19;C20	Disease or Syndrome	CTD_human
HNF1A	Diabetes Mellitus, Non-Insulin-Dependent	C18;C19	Disease or Syndrome	CTD_human
HNF1A	Hyperinsulinism	C18	Disease or Syndrome	GENOMICS_ENGLAND
HNF1A	Hypoglycemia	C18	Disease or Syndrome	CTD_human
HNF1A	Diabetes, Autoimmune	C18;C19;C20	Disease or Syndrome	CTD_human
HNF1A	Hepatocellular Adenoma	C04;C06	Neoplastic Process	CGI
HNF1A	Fasting Hypoglycemia	C18	Disease or Syndrome	CTD_human
HNF1A	Reactive hypoglycemia	C18	Disease or Syndrome	CTD_human
HNF1A	Conventional (Clear Cell) Renal Cell Carcinoma	C04;C12;C13	Neoplastic Process	CGI;CTD_human
HNF1A	Maturity onset diabetes mellitus in young	C18;C19	Disease or Syndrome	ORPHANET
HNF1A	Brittle diabetes	C18;C19;C20	Disease or Syndrome	CTD_human
HNF1A	Chromophobe Renal Cell Carcinoma	C04;C12;C13	Neoplastic Process	CTD_human;ORPHANET
HNF1A	Sarcomatoid Renal Cell Carcinoma	C04;C12;C13	Neoplastic Process	CTD_human
HNF1A	Collecting Duct Carcinoma of the Kidney	C04;C12;C13	Neoplastic Process	CTD_human
HNF1A	Papillary Renal Cell Carcinoma	C04;C12;C13	Neoplastic Process	CTD_human
HNF1A	MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 3 (disorder)	C18;C19	Disease or Syndrome	CTD_human;UNIPROT
HNF1A	Hepatic Adenomas, Familial	C04;C06	Disease or Syndrome	CTD_human
HNF1A	Liver carcinoma	C04;C06	Neoplastic Process	CGI;UNIPROT
HNF1A	DIABETES MELLITUS, INSULIN-DEPENDENT, 20 (disorder)	C18;C19;C20	Disease or Syndrome	CTD_human;UNIPROT
HNF1A	Diabetes Mellitus, Ketosis-Prone	C18;C19;C20	Disease or Syndrome	CTD_human
HNF1A	Hyperinsulinism due to HNF1A deficiency		Disease or Syndrome	ORPHANET
HNF1A	Clear cell papillary renal cell carcinoma		Neoplastic Process	ORPHANET

Pathway associated with HNF1A

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number
pathway0000825	FOXA2 and FOXA3 transcription factor networks	pid	45	202
pathway0001132	IL6	netpath	85	1335
pathway0001714	Presenilin action in Notch and Wnt signaling	pid	46	287
pathway0001834	Regulation of gene expression in beta cells	reactome	17	54
pathway0002631	Maturity onset diabetes of the young	kegg	25	76

Go term information of HNF1A

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GO_term_name	GO_term_type	TF_name
GO_AMIDE_TRANSPORT	BP	HNF1A
GO_PROTEIN_SECRETION	BP	HNF1A
GO_POSITIVE_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_INITIATION	BP	HNF1A
GO_INSULIN_SECRETION	BP	HNF1A
GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_INITIATION_FROM_RNA_POLYMERASE_II_PROMOTER	BP	HNF1A
GO_HORMONE_TRANSPORT	BP	HNF1A
GO_POSITIVE_REGULATION_OF_BIOSYNTHETIC_PROCESS	BP	HNF1A
GO_PEPTIDE_SECRETION	BP	HNF1A
GO_GLUCOSE_IMPORT	BP	HNF1A
GO_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_INITIATION	BP	HNF1A
GO_MONOSACCHARIDE_TRANSPORT	BP	HNF1A
GO_CARBOHYDRATE_HOMEOSTASIS	BP	HNF1A
GO_RENAL_ABSORPTION	BP	HNF1A
GO_KIDNEY_MORPHOGENESIS	BP	HNF1A
GO_PEPTIDE_TRANSPORT	BP	HNF1A
GO_RENAL_SYSTEM_PROCESS	BP	HNF1A
GO_REGULATION_OF_TRANSCRIPTION_INITIATION_FROM_RNA_POLYMERASE_II_PROMOTER	BP	HNF1A
GO_IDENTICAL_PROTEIN_BINDING	MF	HNF1A

Survival analysis of HNF1A

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of HNF1A

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)