Cancer CRCdb

TF information

TF name:	ELF1
TF family:	ETS
Ensembl gene ID:	ENSG00000120690
Ensembl protein ID:	ENSP00000489586, ENSP00000486912, ENSP00000239882
Entrez gene ID:	1997

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of ELF1 in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_02_205	Tissue	Stomach	Gastric_Primary_Sample_T	0.37037037037037
Sample_02_236	Cell line	Colon	V206	0.1304347826087
Sample_02_242	Cell line	Colon	V481	0.2340895981542
Sample_02_322	Cell line	Colon	Caco-2	0.40511440107672
Sample_02_354	Cell line	Colon	Colo205	0.30630630630631

ELF1 distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name
Sample_02_205	Stomach	Tissue	Gastric_Primary_Sample_T
Sample_02_322	Colon	Cell line	Caco-2

ELF1 distribution in all CRCs

Genomic distribution of SEs associated with ELF1

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Mutation of ELF1

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of ELF1

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr13	41524010	41524010	T	A	exonic	ELF1	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr13	41515288	41515288	G	A	exonic	ELF1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr13	41507962	41507962	G	A	exonic	ELF1	stopgain	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr13	41515228	41515228	G	A	exonic	ELF1	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
rs368030828	chr13	41533025	41533025	T	C	exonic	ELF1	nonsynonymous	HNSC\|1\|512\|0.00195
rs540284464	chr13	41508066	41508066	A	G	exonic	ELF1	nonsynonymous	LAML\|1\|197\|0.00508
rs749880705	chr13	41507956	41507956	G	A	exonic	ELF1	stopgain	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr13	41517240	41517240	G	A	exonic	ELF1	synonymous	BLCA\|1\|396\|0.00253
-	chr13	41507882	41507882	C	T	exonic	ELF1	synonymous	DLBC\|1\|48\|0.02083
-	chr13	41507915	41507915	G	T	exonic	ELF1	synonymous	LUAD\|1\|543\|0.00184
-	chr13	41517129	41517129	G	T	exonic	ELF1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr13	41507961	41507961	T	A	exonic	ELF1	nonsynonymous	LUAD\|2\|543\|0.00368
-	chr13	41525513	41525513	G	T	exonic	ELF1	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr13	41515376	41515376	G	A	exonic	ELF1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs528981271	chr13	41533046	41533046	A	G	exonic	ELF1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr13	41533074	41533074	G	C	exonic	ELF1	nonsynonymous	BRCA\|1\|982\|0.00102,HNSC\|1\|512\|0.00195
-	chr13	41507845	41507845	G	C	exonic	ELF1	nonsynonymous	UCS\|1\|57\|0.01754
-	chr13	41523981	41523981	G	A	exonic	ELF1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr13	41533123	41533123	-	A	exonic	ELF1	frameshift	BRCA\|1\|982\|0.00102
-	chr13	41508157	41508157	G	T	exonic	ELF1	nonsynonymous	PRAD\|1\|499\|0.00200
-	chr13	41515310	41515310	G	A	exonic	ELF1	nonsynonymous	LUAD\|2\|543\|0.00368
rs760051911	chr13	41556139	41556139	C	T	exonic	ELF1	nonsynonymous	BLCA\|1\|396\|0.00253,UCEC\|1\|248\|0.00403
-	chr13	41525494	41525494	G	-	exonic	ELF1	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs370759144	chr13	41533078	41533078	G	A	exonic	ELF1	synonymous	LUSC\|1\|178\|0.00562
-	chr13	41533055	41533055	G	C	exonic	ELF1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr13	41525466	41525466	T	A	exonic	ELF1	synonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr13	41507750	41507750	G	A	exonic	ELF1	synonymous	BLCA\|2\|396\|0.00505
rs1056820	chr13	41515286	41515286	T	A	exonic	ELF1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr13	41515075	41515075	G	T	exonic	ELF1	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr13	41515206	41515206	C	T	exonic	ELF1	synonymous	THYM\|1\|123\|0.00813
rs750744628	chr13	41515327	41515327	G	A	exonic	ELF1	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr13	41556170	41556170	C	G	exonic	ELF1	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr13	41508066	41508066	A	T	exonic	ELF1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs766946264	chr13	41507949	41507949	G	A	exonic	ELF1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,PAAD\|1\|185\|0.00541
-	chr13	41533125	41533125	C	T	exonic	ELF1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr13	41507884	41507884	G	C	exonic	ELF1	nonsynonymous	LUAD\|6\|543\|0.01105
-	chr13	41525483	41525483	G	A	exonic	ELF1	synonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr13	41556123	41556123	C	T	exonic	ELF1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr13	41508052	41508052	G	A	exonic	ELF1	nonsynonymous	SKCM\|2\|368\|0.00543
rs538458962	chr13	41507803	41507803	G	A	exonic	ELF1	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr13	41533103	41533103	C	A	exonic	ELF1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr13	41556143	41556143	A	G	exonic	ELF1	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr13	41517220	41517220	G	T	exonic	ELF1	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr13	41517101	41517101	C	T	exonic	ELF1	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr13	41515219	41515219	G	C	exonic	ELF1	stopgain	BRCA\|2\|982\|0.00204
-	chr13	41515109	41515109	T	C	exonic	ELF1	nonsynonymous	HNSC\|2\|512\|0.00391
rs7799	chr13	41533052	41533052	T	C	exonic	ELF1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs750270245	chr13	41517272	41517272	T	C	exonic	ELF1	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr13	41508072	41508072	G	-	exonic	ELF1	frameshift	UCEC\|1\|248\|0.00403
-	chr13	41507921	41507921	-	C	exonic	ELF1	frameshift	LIHC\|1\|373\|0.00268
rs772172636	chr13	41517096	41517096	T	C	exonic	ELF1	synonymous	UCEC\|1\|248\|0.00403
-	chr13	41518040	41518040	C	A	exonic	ELF1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr13	41515309	41515309	G	A	exonic	ELF1	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr13	41515284	41515284	T	A	exonic	ELF1	synonymous	ACC\|1\|90\|0.01111
-	chr13	41523943	41523943	T	-	exonic	ELF1	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,LIHC\|2\|373\|0.00536,PAAD\|1\|185\|0.00541
-	chr13	41515396	41515396	G	A	exonic	ELF1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr13	41525519	41525519	C	T	exonic	ELF1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr13	41517143	41517143	C	A	exonic	ELF1	nonsynonymous	LUAD\|1\|543\|0.00184
rs759798230	chr13	41507679	41507679	T	C	exonic	ELF1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr13	41508027	41508027	T	C	exonic	ELF1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr13	41517086	41517086	A	G	splicing	ELF1	splicing	UCEC\|1\|248\|0.00403
-	chr13	41508024	41508024	A	C	exonic	ELF1	nonsynonymous	CESC\|1\|194\|0.00515
-	chr13	41515415	41515415	T	G	exonic	ELF1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr13	41507906	41507906	C	A	exonic	ELF1	nonsynonymous	LUSC\|1\|178\|0.00562
rs140646954	chr13	41515330	41515330	C	T	exonic	ELF1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr13	41515340	41515340	G	A	exonic	ELF1	stopgain	ESCA\|1\|185\|0.00541
rs138109960	chr13	41523980	41523980	G	A	exonic	ELF1	nonsynonymous	SKCM\|1\|368\|0.00272
rs751355911	chr13	41556167	41556167	G	A	exonic	ELF1	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr13	41508159	41508159	A	T	exonic	ELF1	nonsynonymous	OV\|1\|469\|0.00213
-	chr13	41507720	41507720	C	A	exonic	ELF1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr13	41507736	41507736	G	C	exonic	ELF1	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr13	41515417	41515417	A	-	exonic	ELF1	frameshift	COAD\|2\|367\|0.00545,COADREAD\|2\|489\|0.00409
-	chr13	41550351	41591525	AGGCACACTGTGAAAAGTTTCTAACCATAAATTAAGATGTTTGGACTGATAATGAAGTCAAGAGAATCTGTTAAAAGTTTTGGTACACTCTACTGCTCTAGAACACCTCCTCTTCTTCATCTGTCAGATAAACTAGATCCTCCTTTGAGATCCAGTTCAACTTCCATGGTGAAGCATTCCCAAAGTTGCAGTGCAGTCAATGGCTCCATTCTCAGTATCCACAGCACTTTGCATTTATCTGTGTTACATTGAATA	-	exonic	ELF1	frameshift	-
-	chr13	41556277	41556277	A	-	UTR5	ELF1	unknown	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr13	41515124	41515124	C	T	exonic	ELF1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr13	41517240	41517240	G	T	exonic	ELF1	synonymous	BRCA\|1\|982\|0.00102
rs865878592	chr13	41515153	41515153	T	C	exonic	ELF1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr13	41517154	41517154	G	A	exonic	ELF1	nonsynonymous	BRCA\|1\|982\|0.00102
rs776686002	chr13	41507794	41507794	G	A	exonic	ELF1	stopgain	BLCA\|1\|396\|0.00253
-	chr13	41515131	41515131	A	T	exonic	ELF1	synonymous	SKCM\|1\|368\|0.00272
-	chr13	41515065	41515065	C	G	exonic	ELF1	nonsynonymous	BRCA\|2\|982\|0.00204
-	chr13	41515451	41515451	G	A	exonic	ELF1	stopgain	BLCA\|1\|396\|0.00253
-	chr13	41515071	41515071	G	C	exonic	ELF1	synonymous	BRCA\|1\|982\|0.00102
-	chr13	41517138	41517138	C	T	exonic	ELF1	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr13	41532987	41532988	CA	-	exonic	ELF1	frameshift	PAAD\|1\|185\|0.00541
-	chr13	41533092	41533092	G	A	exonic	ELF1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr13	41525489	41525489	G	A	exonic	ELF1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr13	41515130	41515130	C	G	exonic	ELF1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr13	41517221	41517221	G	C	exonic	ELF1	nonsynonymous	OV\|1\|469\|0.00213
-	chr13	41525537	41525537	C	A	exonic	ELF1	stopgain	UCEC\|1\|248\|0.00403
-	chr13	41533090	41533090	G	C	exonic	ELF1	synonymous	BLCA\|1\|396\|0.00253
-	chr13	41517266	41517266	G	T	exonic	ELF1	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr13	41507734	41507734	T	C	exonic	ELF1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr13	41507924	41507924	C	G	exonic	ELF1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr13	41518058	41518058	C	A	exonic	ELF1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr13	41517197	41517197	G	A	exonic	ELF1	stopgain	HNSC\|1\|512\|0.00195
-	chr13	41523989	41523989	G	A	exonic	ELF1	nonsynonymous	PAAD\|1\|185\|0.00541

Disease information of ELF1

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source

Pathway associated with ELF1

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number
pathway0000178	Angiopoietin receptor Tie2-mediated signaling	pid	50	441
pathway0000187	AP-1 transcription factor network	pid	71	659
pathway0001122	IL2 signaling events mediated by STAT5	pid	30	232
pathway0001604	PDGF signaling pathway	panther	113	1684
pathway0001857	Regulation of retinoblastoma protein	pid	67	718

Go term information of ELF1

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GO_term_name	GO_term_type	TF_name
GO_REGULATION_OF_T_CELL_RECEPTOR_SIGNALING_PATHWAY	BP	ELF1
GO_REGULATION_OF_ANTIGEN_RECEPTOR_MEDIATED_SIGNALING_PATHWAY	BP	ELF1
GO_MRNA_SPLICE_SITE_SELECTION	BP	ELF1
GO_REGULATION_OF_IMMUNE_RESPONSE	BP	ELF1
GO_POSTTRANSCRIPTIONAL_REGULATION_OF_GENE_EXPRESSION	BP	ELF1
GO_NEGATIVE_REGULATION_OF_T_CELL_RECEPTOR_SIGNALING_PATHWAY	BP	ELF1
GO_REGULATION_OF_MULTICELLULAR_ORGANISM_GROWTH	BP	ELF1
GO_RNA_SPLICING_VIA_TRANSESTERIFICATION_REACTIONS	BP	ELF1
GO_GENE_SILENCING	BP	ELF1
GO_POSITIVE_REGULATION_OF_GROWTH	BP	ELF1
GO_POSTTRANSCRIPTIONAL_GENE_SILENCING	BP	ELF1
GO_NEGATIVE_REGULATION_OF_ANTIGEN_RECEPTOR_MEDIATED_SIGNALING_PATHWAY	BP	ELF1
GO_MULTICELLULAR_ORGANISM_REPRODUCTION	BP	ELF1
GO_POSITIVE_REGULATION_OF_MULTICELLULAR_ORGANISM_GROWTH	BP	ELF1
GO_RNA_INTERFERENCE	BP	ELF1
GO_REGULATION_OF_RNA_SPLICING	BP	ELF1
GO_TRANSLATION_INITIATION_FACTOR_BINDING	MF	ELF1
GO_TRANSCRIPTIONAL_ACTIVATOR_ACTIVITY_RNA_POLYMERASE_II_CORE_PROMOTER_PROXIMAL_REGION_SEQUENCE_SPECIFIC_BINDING	MF	ELF1
GO_TRANSLATION_REGULATOR_ACTIVITY	MF	ELF1
GO_TRANSLATION_REPRESSOR_ACTIVITY	MF	ELF1
GO_TRANSLATION_REGULATOR_ACTIVITY_NUCLEIC_ACID_BINDING	MF	ELF1

Survival analysis of ELF1

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of ELF1

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)