Cancer CRCdb

TF information

TF name:	BHLHE40
TF family:	bHLH
Ensembl gene ID:	ENSG00000134107
Ensembl protein ID:	ENSP00000256495
Entrez gene ID:	8553

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of BHLHE40 in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_01_046	Cell line	Mammary Gland	MCF-7	0.8
Sample_02_007	Other	Cervical	cervical-cancer_vector	0.10927152317881
Sample_02_021	Cell line	Colon	V429	0.31363505332949
Sample_02_069	Cell line	Brain	SF268	0.51145038167939
Sample_02_080	Cell line	Lung	Calu-3	0.31818181818182
Sample_02_095	Cell line	Mammary Gland	MDA-MB-468	0.89299610894942
Sample_02_096	Cell line	Mammary Gland	ZR-75-1_1	0.96739130434783
Sample_02_161	Cell line	Brain	U87	0.4
Sample_02_166	Cell line	Mammary Gland	HCC1954_Parental	0.476
Sample_02_168	Cell line	Prostate	LNCaP	0.24714828897338
Sample_02_179	Cell line	Urinary bladder	T24	0.27586206896552
Sample_02_180	Cell line	Human melanoma	CJM	0.09375
Sample_02_181	Cell line	Human melanoma	COLO679	0.16053333333333
Sample_02_182	Cell line	Human melanoma	LOX-IMVI	0.23563218390805
Sample_02_183	Cell line	Skin	SKMEL2	0.30769230769231
Sample_02_184	Cell line	Skin	SKMEL30	0.14469453376206
Sample_02_188	Cell line	Stomach	MKN1	0.5
Sample_02_191	Cell line	Stomach	SNU719	0.28571428571429
Sample_02_192	Cell line	Stomach	MKN45	0.5
Sample_02_205	Tissue	Stomach	Gastric_Primary_Sample_T	0.16296296296296
Sample_02_208	Cell line	Stomach	YCC3	0.25
Sample_02_219	Cell line	Mammary Gland	MDA-MB-231	0.25490196078431
Sample_02_236	Cell line	Colon	V206	0.37060041407867
Sample_02_237	Cell line	Colon	V389	0.46221240566906
Sample_02_241	Cell line	Colon	V456	0.23476297968397
Sample_02_242	Cell line	Colon	V481	0.39453951163238
Sample_02_267	Cell line	Kidney	786-O	0.6
Sample_02_268	Cell line	Kidney	A-498	0.24238508399483
Sample_02_280	Cell line	Mammary Gland	SUM159_DMSO_24h	0.35
Sample_02_285	Cell line	Liver	HuH7_untreat	0.22299651567944
Sample_02_323	Cell line	Colon	RKO	0.45
Sample_02_354	Cell line	Colon	Colo205	0.42192192192192
Sample_02_356	Cell line	Colon	Sw480	0.32258064516129
Sample_02_358	Cell line	Colon	LS180	0.37756714060032
Sample_02_395	Cell line	Mammary Gland	BT-549	0.27328671328671
Sample_02_413	Tissue	Brain	GBM_2493	0.082417582417582
Sample_02_424	Cell line	Colon	SW620	0.21739130434783
Sample_02_430	Cell line	Kidney	12364284	0.46428571428571

BHLHE40 distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name
Sample_01_046	Mammary Gland	Cell line	MCF-7
Sample_02_069	Brain	Cell line	SF268
Sample_02_095	Mammary Gland	Cell line	MDA-MB-468
Sample_02_096	Mammary Gland	Cell line	ZR-75-1_1
Sample_02_236	Colon	Cell line	V206
Sample_02_237	Colon	Cell line	V389
Sample_02_267	Kidney	Cell line	786-O
Sample_02_395	Mammary Gland	Cell line	BT-549
Sample_02_430	Kidney	Cell line	12364284

BHLHE40 distribution in all CRCs

Genomic distribution of SEs associated with BHLHE40

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Mutation of BHLHE40

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of BHLHE40

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr3	5024755	5024755	G	A	exonic	BHLHE40	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr3	5025075	5025075	G	T	exonic	BHLHE40	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr3	5024704	5024704	G	T	exonic	BHLHE40	nonsynonymous	ESCA\|1\|185\|0.00541
rs767694119	chr3	5024984	5024984	C	T	exonic	BHLHE40	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr3	5025131	5025131	A	T	exonic	BHLHE40	synonymous	LUAD\|1\|543\|0.00184
-	chr3	5022090	5022090	-	A	exonic	BHLHE40	frameshift	BRCA\|2\|982\|0.00204
-	chr3	5024874	5024874	G	A	exonic	BHLHE40	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr3	5025139	5025139	C	T	exonic	BHLHE40	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr3	5025373	5025373	A	C	exonic	BHLHE40	nonsynonymous	UCEC\|1\|248\|0.00403
rs908078	chr3	5024771	5024771	T	C	exonic	BHLHE40	synonymous	ACC\|1\|90\|0.01111
-	chr3	5022085	5022085	A	G	exonic	BHLHE40	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr3	5025282	5025282	C	T	exonic	BHLHE40	nonsynonymous	SKCM\|1\|368\|0.00272
rs141865687	chr3	5025027	5025027	G	A	exonic	BHLHE40	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr3	5025203	5025203	C	T	exonic	BHLHE40	synonymous	BLCA\|1\|396\|0.00253
-	chr3	5025316	5025316	C	T	exonic	BHLHE40	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr3	5025346	5025346	-	C	exonic	BHLHE40	frameshift	KIPAN\|2\|799\|0.00250,KIRC\|2\|451\|0.00443
-	chr3	5025196	5025196	-	A	exonic	BHLHE40	frameshift	UCEC\|1\|248\|0.00403
-	chr3	5025108	5025108	C	G	exonic	BHLHE40	nonsynonymous	OV\|1\|469\|0.00213
-	chr3	5025110	5025110	C	T	exonic	BHLHE40	synonymous	ESCA\|1\|185\|0.00541
-	chr3	5025187	5025187	T	C	exonic	BHLHE40	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr3	5025186	5025186	G	C	exonic	BHLHE40	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr3	5024990	5024990	-	C	exonic	BHLHE40	frameshift	LUAD\|2\|543\|0.00368
-	chr3	5024904	5024904	A	T	exonic	BHLHE40	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr3	5024970	5024970	A	C	exonic	BHLHE40	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr3	5025367	5025367	C	T	exonic	BHLHE40	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr3	5022091	5022091	A	C	exonic	BHLHE40	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr3	5024644	5024644	C	T	exonic	BHLHE40	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr3	5024760	5024760	C	G	exonic	BHLHE40	nonsynonymous	LUAD\|2\|543\|0.00368
-	chr3	5021412	5021412	G	A	exonic	BHLHE40	synonymous	BRCA\|1\|982\|0.00102
rs772064940	chr3	5025010	5025010	G	A	exonic	BHLHE40	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr3	5025163	5025163	G	A	exonic	BHLHE40	nonsynonymous	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr3	5024938	5024938	G	A	exonic	BHLHE40	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr3	5025274	5025274	A	C	exonic	BHLHE40	nonsynonymous	KICH\|1\|66\|0.01515,KIPAN\|1\|799\|0.00125
-	chr3	5024941	5024941	G	A	exonic	BHLHE40	nonsynonymous	PCPG\|1\|184\|0.00543
-	chr3	5024875	5024875	G	A	exonic	BHLHE40	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr3	5025334	5025334	C	T	exonic	BHLHE40	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr3	5024544	5024544	G	A	exonic	BHLHE40	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr3	5022090	5022090	T	G	exonic	BHLHE40	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr3	5025281	5025281	C	T	exonic	BHLHE40	synonymous	CESC\|1\|194\|0.00515
-	chr3	5024815	5024815	C	T	exonic	BHLHE40	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr3	5023160	5023160	G	A	exonic	BHLHE40	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs776429558	chr3	5024963	5024963	C	T	exonic	BHLHE40	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr3	5025243	5025243	G	T	exonic	BHLHE40	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr3	5023178	5023178	C	T	exonic	BHLHE40	synonymous	SKCM\|1\|368\|0.00272
-	chr3	5023083	5023083	G	T	exonic	BHLHE40	nonsynonymous	LUSC\|1\|178\|0.00562
rs763465378	chr3	5023150	5023150	T	C	exonic	BHLHE40	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr3	5022016	5022016	G	A	exonic	BHLHE40	nonsynonymous	BLCA\|1\|396\|0.00253
rs773058967	chr3	5024967	5024967	G	A	exonic	BHLHE40	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr3	5024807	5024807	C	A	exonic	BHLHE40	synonymous	BLCA\|1\|396\|0.00253
-	chr3	5024806	5024806	T	A	exonic	BHLHE40	nonsynonymous	BLCA\|1\|396\|0.00253
rs755711001	chr3	5025215	5025215	C	T	exonic	BHLHE40	synonymous	UCEC\|1\|248\|0.00403
-	chr3	5025019	5025019	T	C	exonic	BHLHE40	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr3	5024744	5024744	G	A	exonic	BHLHE40	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr3	5025300	5025300	C	T	exonic	BHLHE40	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr3	5025133	5025133	C	T	exonic	BHLHE40	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs749055581	chr3	5025226	5025226	C	G	exonic	BHLHE40	nonsynonymous	CESC\|1\|194\|0.00515
rs201524353	chr3	5025216	5025216	G	A	exonic	BHLHE40	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr3	5023179	5023179	C	T	exonic	BHLHE40	synonymous	SKCM\|1\|368\|0.00272
-	chr3	5025136	5025136	C	A	exonic	BHLHE40	nonsynonymous	PRAD\|1\|499\|0.00200

Disease information of BHLHE40

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
BHLHE40	Bipolar Disorder	F03	Mental or Behavioral Dysfunction	CTD_human;PSYGENET
BHLHE40	Depression, Bipolar	F03	Mental or Behavioral Dysfunction	CTD_human
BHLHE40	Glioblastoma	C04	Neoplastic Process	CTD_human
BHLHE40	Manic Disorder	F03	Mental or Behavioral Dysfunction	CTD_human
BHLHE40	Schizophrenia	F03	Mental or Behavioral Dysfunction	PSYGENET
BHLHE40	Myocardial Ischemia	C14	Disease or Syndrome	CTD_human
BHLHE40	Giant Cell Glioblastoma	C04	Neoplastic Process	CTD_human
BHLHE40	Manic	F03	Mental or Behavioral Dysfunction	CTD_human
BHLHE40	Delayed Sleep Phase Syndrome	C10;C24;F03	Disease or Syndrome	CTD_human
BHLHE40	Nonorganic Sleep Wake Cycle Disorders	C10;C24;F03	Mental or Behavioral Dysfunction	CTD_human
BHLHE40	Advanced Sleep Phase Syndrome	C10;C24;F03	Disease or Syndrome	CTD_human
BHLHE40	Non-24 Hour Sleep-Wake Disorder	C10;C24;F03	Mental or Behavioral Dysfunction	CTD_human
BHLHE40	Shift-Work Sleep Disorder	C10;C24;F03	Mental or Behavioral Dysfunction	CTD_human
BHLHE40	Sleep Disorders, Circadian Rhythm	C10;C24;F03	Pathologic Function	CTD_human
BHLHE40	Glioblastoma Multiforme	C04	Neoplastic Process	CTD_human

Pathway associated with BHLHE40

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number
pathway0000316	BMAL1:CLOCK,NPAS2 activates circadian gene expression	reactome	42	282
pathway0000432	Circadian rhythm pathway	pid	17	64
pathway0000752	Fanconi anemia pathway	pid	48	794
pathway0001021	HIF-1-alpha transcription factor network	pid	67	420
pathway0001022	HIF-2-alpha transcription factor network	pid	34	119
pathway0002614	Circadian rhythm - mammal	kegg	19	111
pathway0002768	Hs_Heart_Development_WP1591_90186	wikipathways	28	78

Go term information of BHLHE40

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GO_term_name	GO_term_type	TF_name
GO_PHOTOPERIODISM	BP	BHLHE40
GO_ENTRAINMENT_OF_CIRCADIAN_CLOCK_BY_PHOTOPERIOD	BP	BHLHE40
GO_CIRCADIAN_REGULATION_OF_GENE_EXPRESSION	BP	BHLHE40
GO_ENTRAINMENT_OF_CIRCADIAN_CLOCK	BP	BHLHE40
GO_BHLH_TRANSCRIPTION_FACTOR_BINDING	MF	BHLHE40
GO_TRANSCRIPTION_FACTOR_ACTIVITY_RNA_POLYMERASE_II_DISTAL_ENHANCER_SEQUENCE_SPECIFIC_BINDING	MF	BHLHE40
GO_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_ACTIVITY_SEQUENCE_SPECIFIC_DNA_BINDING	MF	BHLHE40
GO_E_BOX_BINDING	MF	BHLHE40
GO_ACTIVATING_TRANSCRIPTION_FACTOR_BINDING	MF	BHLHE40
GO_RNA_POLYMERASE_II_ACTIVATING_TRANSCRIPTION_FACTOR_BINDING	MF	BHLHE40
GO_TRANSCRIPTION_COREPRESSOR_ACTIVITY	MF	BHLHE40
GO_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_BINDING	MF	BHLHE40

Survival analysis of BHLHE40

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of BHLHE40

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)