Cancer CRCdb

TF information

TF name:	TCF7L2
TF family:	HMG
Ensembl gene ID:	ENSG00000148737
Ensembl protein ID:	ENSP00000435694, ENSP00000348274, ENSP00000440547, ENSP00000344823, ENSP00000443883, ENSP00000487507, ENSP00000277945, ENSP00000444972, ENSP00000446172, ENSP00000446238, ENSP00000358402, ENSP00000490260, ENSP00000347949, ENSP00000443626, ENSP00000358404, ENSP00000486891
Entrez gene ID:	6934

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of TCF7L2 in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_02_007	Other	Cervical	cervical-cancer_vector	0.21192052980132
Sample_02_021	Cell line	Colon	V429	0.50821562409916
Sample_02_180	Cell line	Human melanoma	CJM	0.0390625
Sample_02_181	Cell line	Human melanoma	COLO679	0.0256
Sample_02_205	Tissue	Stomach	Gastric_Primary_Sample_T	1
Sample_02_220	Cell line	Brain	BE2C_1	0.025641025641026
Sample_02_236	Cell line	Colon	V206	0.59627329192547
Sample_02_237	Cell line	Colon	V389	0.51768820173017
Sample_02_241	Cell line	Colon	V456	0.65462753950339
Sample_02_242	Cell line	Colon	V481	0.48666923027623
Sample_02_267	Cell line	Kidney	786-O	1
Sample_02_268	Cell line	Kidney	A-498	0.94646483293336
Sample_02_312	Cell line	Neuroblastoma	SK-N-BE_2-C	0.25531914893617
Sample_02_314	Cell line	Neuroblastoma	SK-N-FI	0.08641975308642
Sample_02_338	Cell line	Neuroblastoma	BE2	0.044117647058824
Sample_02_354	Cell line	Colon	Colo205	0.47447447447447
Sample_02_361	Cell line	Colon	HT29_DMSO	1
Sample_02_406	Cell line	Mammary Gland	ZR-75-30_parental	0.17391304347826
Sample_02_424	Cell line	Colon	SW620	0.78260869565217

TCF7L2 distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name
Sample_02_021	Colon	Cell line	V429
Sample_02_205	Stomach	Tissue	Gastric_Primary_Sample_T
Sample_02_267	Kidney	Cell line	786-O
Sample_02_268	Kidney	Cell line	A-498
Sample_02_354	Colon	Cell line	Colo205
Sample_02_361	Colon	Cell line	HT29_DMSO
Sample_02_424	Colon	Cell line	SW620

TCF7L2 distribution in all CRCs

Genomic distribution of SEs associated with TCF7L2

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Mutation of TCF7L2

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of TCF7L2

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr10	114903722	114903722	T	G	exonic	TCF7L2	stopgain	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr10	114905824	114905824	C	T	exonic	TCF7L2	synonymous	SKCM\|1\|368\|0.00272
-	chr10	114911545	114911545	A	G	exonic	TCF7L2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr10	114710585	114710585	G	T	exonic	TCF7L2	stopgain	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr10	114919708	114919708	C	T	exonic	TCF7L2	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr10	114911576	114911576	G	T	exonic	TCF7L2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr10	114710667	114710667	A	G	exonic	TCF7L2	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr10	114912149	114912149	C	T	exonic	TCF7L2	stopgain	COAD\|1\|367\|0.00272,COADREAD\|2\|489\|0.00409,READ\|1\|122\|0.00820
-	chr10	114918429	114918429	A	G	exonic	TCF7L2	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr10	114905802	114905802	G	C	exonic	TCF7L2	nonsynonymous	LUAD\|1\|543\|0.00184
rs765693671	chr10	114925428	114925428	C	T	exonic	TCF7L2	synonymous	SKCM\|1\|368\|0.00272
-	chr10	114849161	114849161	C	-	exonic	TCF7L2	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr10	114925464	114925464	C	T	exonic	TCF7L2	synonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
rs761028094	chr10	114925566	114925566	C	T	exonic	TCF7L2	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr10	114710596	114710597	GG	-	exonic	TCF7L2	frameshift	UCEC\|1\|248\|0.00403
-	chr10	114910812	114910812	C	T	exonic	TCF7L2	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr10	114849235	114849235	A	T	exonic	TCF7L2	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr10	114925398	114925398	G	T	exonic	TCF7L2	synonymous	LUAD\|1\|543\|0.00184
rs768298443	chr10	114710691	114710691	C	A	exonic	TCF7L2	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr10	114920422	114920422	C	T	exonic	TCF7L2	stopgain	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr10	114905790	114905790	C	T	exonic	TCF7L2	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr10	114920450	114920450	G	C	exonic	TCF7L2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr10	114911553	114911553	C	A	exonic	TCF7L2	nonsynonymous	COAD\|2\|367\|0.00545,COADREAD\|2\|489\|0.00409,UCEC\|1\|248\|0.00403
-	chr10	114912186	114912186	C	T	exonic	TCF7L2	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs368142604	chr10	114925476	114925476	G	A	exonic	TCF7L2	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr10	114849256	114849256	G	A	exonic	TCF7L2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr10	114925636	114925636	A	G	exonic	TCF7L2	nonsynonymous	HNSC\|1\|512\|0.00195
rs766727892	chr10	114910866	114910866	G	A	exonic	TCF7L2	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr10	114925334	114925334	G	A	exonic	TCF7L2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr10	114905821	114905821	C	A	exonic	TCF7L2	stopgain	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr10	114905822	114905822	C	G	exonic	TCF7L2	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr10	114910865	114910865	C	T	exonic	TCF7L2	synonymous	CESC\|1\|194\|0.00515,UCEC\|1\|248\|0.00403
-	chr10	114724315	114724315	C	T	exonic	TCF7L2	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr10	114912183	114912183	C	T	exonic	TCF7L2	nonsynonymous	SARC\|1\|247\|0.00405
rs373202228	chr10	114919707	114919707	G	A	exonic	TCF7L2	synonymous	HNSC\|1\|512\|0.00195
-	chr10	114799814	114799814	G	A	exonic	TCF7L2	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr10	114925530	114925530	C	A	exonic	TCF7L2	synonymous	TGCT\|1\|155\|0.00645
rs778855667	chr10	114900984	114900984	C	-	exonic	TCF7L2	frameshift	COAD\|2\|367\|0.00545,COADREAD\|2\|489\|0.00409,LIHC\|1\|373\|0.00268
-	chr10	114799871	114799871	C	T	exonic	TCF7L2	nonsynonymous	SKCM\|1\|368\|0.00272
rs750909665	chr10	114710732	114710732	G	T	intronic	TCF7L2	unknown	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs369602107	chr10	114903764	114903764	G	A	exonic	TCF7L2	synonymous	PRAD\|1\|499\|0.00200
rs750351798	chr10	114900993	114900993	G	A	exonic	TCF7L2	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr10	114903697	114903697	C	T	exonic	TCF7L2	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr10	114903763	114903763	C	T	exonic	TCF7L2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr10	114710997	114710997	G	C	exonic	TCF7L2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs758342453	chr10	114925501	114925501	G	A	exonic	TCF7L2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr10	114911628	114911628	G	T	exonic	TCF7L2	nonsynonymous	LUSC\|1\|178\|0.00562
rs776719680	chr10	114901057	114901057	G	A	exonic	TCF7L2	nonsynonymous	UCEC\|1\|248\|0.00403
rs190966900	chr10	114901060	114901060	G	A	exonic	TCF7L2	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr10	114910854	114910854	C	T	exonic	TCF7L2	stopgain	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr10	114925643	114925643	A	G	exonic	TCF7L2	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr10	114849161	114849161	C	G	exonic	TCF7L2	nonsynonymous	OV\|1\|469\|0.00213
-	chr10	114911638	114911638	C	A	exonic	TCF7L2	synonymous	THCA\|1\|504\|0.00198
-	chr10	114799860	114799860	G	A	exonic	TCF7L2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr10	114911560	114911560	T	C	exonic	TCF7L2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr10	114901015	114901015	G	T	exonic	TCF7L2	stopgain	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr10	114910775	114910775	C	T	exonic	TCF7L2	synonymous	HNSC\|1\|512\|0.00195
rs771614599	chr10	114925413	114925413	G	A	exonic	TCF7L2	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs200865074	chr10	114724358	114724358	C	T	exonic	TCF7L2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs758558518	chr10	114925317	114925317	A	G	exonic	TCF7L2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr10	114912183	114912183	C	A	exonic	TCF7L2	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr10	114910883	114910883	G	A	splicing	TCF7L2	splicing	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr10	114910867	114910867	G	A	exonic	TCF7L2	nonsynonymous	PCPG\|1\|184\|0.00543
-	chr10	114901075	114901075	G	A	exonic	TCF7L2	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
rs772550681	chr10	114901029	114901029	G	A	exonic	TCF7L2	synonymous	LIHC\|1\|373\|0.00268
-	chr10	114901043	114901043	C	T	exonic	TCF7L2	nonsynonymous	SKCM\|1\|368\|0.00272
rs769309826	chr10	114925542	114925542	C	T	exonic	TCF7L2	synonymous	ESCA\|1\|185\|0.00541
rs573425555	chr10	114925412	114925412	C	T	exonic	TCF7L2	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr10	114901049	114901049	-	A	exonic	TCF7L2	frameshift	COADREAD\|3\|489\|0.00613,READ\|3\|122\|0.02459
-	chr10	114903757	114903757	C	T	exonic	TCF7L2	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr10	114925715	114925715	C	A	exonic	TCF7L2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr10	114925411	114925411	C	T	exonic	TCF7L2	nonsynonymous	SKCM\|1\|368\|0.00272
rs367884505	chr10	114905797	114905797	G	A	exonic	TCF7L2	synonymous	SKCM\|1\|368\|0.00272
-	chr10	114911586	114911586	C	A	exonic	TCF7L2	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr10	114911516	114911517	AG	-	exonic	TCF7L2	frameshift	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
rs760999129	chr10	114925398	114925398	G	A	exonic	TCF7L2	synonymous	BLCA\|1\|396\|0.00253,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr10	114925681	114925681	G	T	exonic	TCF7L2	nonsynonymous	LUAD\|4\|543\|0.00737
-	chr10	114911564	114911564	T	G	exonic	TCF7L2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr10	114724335	114724335	C	T	exonic	TCF7L2	synonymous	LUSC\|1\|178\|0.00562
-	chr10	114925695	114925695	C	T	exonic	TCF7L2	synonymous	SKCM\|1\|368\|0.00272
-	chr10	114925315	114925315	-	G	exonic	TCF7L2	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr10	114905778	114905780	AAC	-	exonic	TCF7L2	nonframeshift	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr10	114710681	114710681	C	G	exonic	TCF7L2	nonsynonymous	CESC\|1\|194\|0.00515
-	chr10	114849212	114849212	C	T	exonic	TCF7L2	synonymous	ESCA\|1\|185\|0.00541
rs780509521	chr10	114925329	114925329	C	T	exonic	TCF7L2	nonsynonymous	PRAD\|1\|499\|0.00200
-	chr10	114920390	114920390	C	A	exonic	TCF7L2	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
rs756433967	chr10	114849205	114849205	-	C	exonic	TCF7L2	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr10	114925707	114925707	G	A	exonic	TCF7L2	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs368592547	chr10	114901025	114901025	C	T	exonic	TCF7L2	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr10	114919691	114919691	C	G	exonic	TCF7L2	nonsynonymous	BLCA\|1\|396\|0.00253
rs12359833	chr10	114919695	114919695	G	A	exonic	TCF7L2	synonymous	BLCA\|1\|396\|0.00253
-	chr10	114911604	114911604	G	A	exonic	TCF7L2	synonymous	ESCA\|1\|185\|0.00541
rs745872748	chr10	114925317	114925317	A	-	exonic	TCF7L2	frameshift	BRCA\|2\|982\|0.00204,COAD\|8\|367\|0.02180,COADREAD\|8\|489\|0.01636,GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
rs565119818	chr10	114911613	114911613	C	T	exonic	TCF7L2	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr10	114925318	114925318	A	C	exonic	TCF7L2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr10	114900983	114900983	-	C	exonic	TCF7L2	frameshift	UCS\|1\|57\|0.01754
-	chr10	114912175	114912175	C	A	exonic	TCF7L2	synonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr10	114905796	114905796	C	T	exonic	TCF7L2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr10	114799863	114799863	C	A	exonic	TCF7L2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr10	114911632	114911632	C	T	exonic	TCF7L2	nonsynonymous	UCEC\|1\|248\|0.00403
rs534110993	chr10	114925492	114925492	G	A	exonic	TCF7L2	nonsynonymous	PRAD\|1\|499\|0.00200
-	chr10	114905824	114905824	C	A	exonic	TCF7L2	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs572431965	chr10	114910882	114910882	C	T	exonic	TCF7L2	nonsynonymous	UCEC\|1\|248\|0.00403
rs769592153	chr10	114925316	114925316	-	A	exonic	TCF7L2	frameshift	COAD\|4\|367\|0.01090,COADREAD\|4\|489\|0.00818,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253,THCA\|1\|504\|0.00198
-	chr10	114849213	114849213	T	C	exonic	TCF7L2	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr10	114918424	114918424	A	T	splicing	TCF7L2	splicing	LUAD\|6\|543\|0.01105
-	chr10	114724346	114724346	C	T	exonic	TCF7L2	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr10	114905822	114905822	C	A	exonic	TCF7L2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,OV\|1\|469\|0.00213
-	chr10	114912156	114912156	T	G	exonic	TCF7L2	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
rs776801596	chr10	114912121	114912121	G	A	exonic	TCF7L2	synonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820,UCS\|1\|57\|0.01754
-	chr10	114912120	114912120	C	T	exonic	TCF7L2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr10	114903766	114903766	T	G	exonic	TCF7L2	nonsynonymous	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr10	114905797	114905797	G	T	exonic	TCF7L2	synonymous	LUAD\|1\|543\|0.00184
-	chr10	114910795	114910795	A	T	exonic	TCF7L2	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr10	114919686	114919686	C	T	exonic	TCF7L2	synonymous	UCS\|1\|57\|0.01754
rs575072438	chr10	114912130	114912130	C	T	exonic	TCF7L2	synonymous	UCEC\|1\|248\|0.00403
-	chr10	114925494	114925494	C	-	exonic	TCF7L2	frameshift	PRAD\|1\|499\|0.00200
rs762217447	chr10	114920412	114920412	C	T	exonic	TCF7L2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs773530340	chr10	114925397	114925397	C	T	exonic	TCF7L2	nonsynonymous	UCEC\|1\|248\|0.00403
rs747875356	chr10	114901026	114901026	G	A	exonic	TCF7L2	synonymous	UCEC\|1\|248\|0.00403
-	chr10	114711348	114711348	C	G	exonic	TCF7L2	synonymous	ACC\|1\|90\|0.01111,BLCA\|1\|396\|0.00253
-	chr10	114849293	114849293	T	C	exonic	TCF7L2	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr10	114849206	114849206	C	-	exonic	TCF7L2	frameshift	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr10	114925622	114925622	C	-	exonic	TCF7L2	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr10	114903687	114903687	C	T	exonic	TCF7L2	nonsynonymous	SKCM\|2\|368\|0.00543
-	chr10	114912188	114912188	C	T	exonic	TCF7L2	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr10	114799868	114799868	-	AC	exonic	TCF7L2	frameshift	CESC\|1\|194\|0.00515
-	chr10	114917784	114917785	AG	-	exonic	TCF7L2	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr10	114925434	114925434	C	T	exonic	TCF7L2	synonymous	SKCM\|1\|368\|0.00272
-	chr10	114900993	114900993	G	T	exonic	TCF7L2	synonymous	BLCA\|1\|396\|0.00253
-	chr10	114920401	114920401	C	T	exonic	TCF7L2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs768101780	chr10	114925402	114925402	C	-	exonic	TCF7L2	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr10	114920394	114920394	G	A	exonic	TCF7L2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr10	114711350	114711350	C	A	exonic	TCF7L2	stopgain	ACC\|1\|90\|0.01111
-	chr10	114901068	114901068	C	A	exonic	TCF7L2	synonymous	CHOL\|1\|35\|0.02857
-	chr10	114925376	114925376	C	G	exonic	TCF7L2	stopgain	LUAD\|1\|543\|0.00184
-	chr10	114711317	114711317	T	C	exonic	TCF7L2	nonsynonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr10	114920448	114920448	C	A	exonic	TCF7L2	stopgain	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr10	114710569	114710569	G	A	exonic	TCF7L2	synonymous	BLCA\|1\|396\|0.00253
rs767830105	chr10	114920413	114920413	G	A	exonic	TCF7L2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs758190471	chr10	114849224	114849224	T	C	exonic	TCF7L2	synonymous	BRCA\|1\|982\|0.00102
-	chr10	114918464	114918464	C	T	exonic	TCF7L2	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr10	114925333	114925333	C	A	exonic	TCF7L2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr10	114901063	114901063	G	T	exonic	TCF7L2	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr10	114925333	114925333	C	T	exonic	TCF7L2	nonsynonymous	COAD\|2\|367\|0.00545,COADREAD\|3\|489\|0.00613,READ\|1\|122\|0.00820,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr10	114849277	114849277	T	C	exonic	TCF7L2	nonsynonymous	BRCA\|1\|982\|0.00102,SKCM\|1\|368\|0.00272
rs756595480	chr10	114710508	114710508	A	-	UTR5	TCF7L2	unknown	ESCA\|1\|185\|0.00541
-	chr10	114710655	114710655	C	T	exonic	TCF7L2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr10	114920402	114920402	G	A	exonic	TCF7L2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr10	114903693	114903693	C	T	exonic	TCF7L2	nonsynonymous	THCA\|1\|504\|0.00198

Disease information of TCF7L2

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
TCF7L2	Adenocarcinoma	C04	Neoplastic Process	CTD_human
TCF7L2	Bipolar Disorder	F03	Mental or Behavioral Dysfunction	PSYGENET
TCF7L2	Malignant tumor of colon	C04;C06	Neoplastic Process	CTD_human
TCF7L2	Colonic Neoplasms	C04;C06	Neoplastic Process	CTD_human
TCF7L2	Colorectal Carcinoma	C04;C06	Neoplastic Process	CTD_human
TCF7L2	Colorectal Neoplasms	C04;C06	Neoplastic Process	CTD_human
TCF7L2	Coronary heart disease	C14	Disease or Syndrome	CTD_human
TCF7L2	Diabetes Mellitus, Non-Insulin-Dependent	C18;C19	Disease or Syndrome	CTD_human
TCF7L2	Hyperplasia	C23	Pathologic Function	CTD_human
TCF7L2	Schizoaffective Disorder	F03	Mental or Behavioral Dysfunction	PSYGENET
TCF7L2	Schizophrenia	F03	Mental or Behavioral Dysfunction	PSYGENET
TCF7L2	Juvenile-Onset Still Disease	C05;C17;C20	Disease or Syndrome	CTD_human
TCF7L2	Adenocarcinoma, Basal Cell	C04	Neoplastic Process	CTD_human
TCF7L2	Adenocarcinoma, Oxyphilic	C04	Neoplastic Process	CTD_human
TCF7L2	Carcinoma, Cribriform	C04	Neoplastic Process	CTD_human
TCF7L2	Carcinoma, Granular Cell	C04	Neoplastic Process	CTD_human
TCF7L2	Adenocarcinoma, Tubular	C04	Neoplastic Process	CTD_human
TCF7L2	Colorectal Cancer	C04;C06	Neoplastic Process	CTD_human;UNIPROT
TCF7L2	Neurodevelopmental Disorders	F03	Mental or Behavioral Dysfunction	CTD_human
TCF7L2	Juvenile arthritis	C05;C17;C20	Disease or Syndrome	CTD_human
TCF7L2	Juvenile psoriatic arthritis	C05;C17;C20	Disease or Syndrome	CTD_human

Pathway associated with TCF7L2

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number
pathway0000309	Binding of TCF/LEF:CTNNB1 to target gene promoters	reactome	7	20
pathway0000355	Canonical Wnt signaling pathway ( C. elegans endoderm induction Wnt signaling pathway Diagram )	inoh	56	519
pathway0000356	Canonical Wnt signaling pathway ( Canonical Wnt signaling pathway Diagram )	inoh	56	519
pathway0000357	Canonical Wnt signaling pathway ( Drosophila Wingless/Wnt signaling pathway Diagram )	inoh	56	519
pathway0000358	Canonical Wnt signaling pathway ( Mammalian Wnt signaling pathway Diagram )	inoh	56	519
pathway0000359	Canonical Wnt signaling pathway ( Xenopus axis formation Wnt signaling pathway Diagram )	inoh	56	519
pathway0000549	Deactivation of the beta-catenin transactivating complex	reactome	42	236
pathway0001078	ID	netpath	38	213
pathway0001315	Mammalian Wnt signaling pathway ( Mammalian Wnt signaling pathway Diagram )	inoh	49	453
pathway0001876	Repression of WNT target genes	reactome	14	68
pathway0002046	Signaling with Wnt (Canonical) ( C. elegans endoderm induction Wnt signaling pathway Diagram )	inoh	47	421
pathway0002047	Signaling with Wnt (Canonical) ( Canonical Wnt signaling pathway Diagram )	inoh	47	421
pathway0002048	Signaling with Wnt (Canonical) ( Drosophila Wingless/Wnt signaling pathway Diagram )	inoh	47	421
pathway0002049	Signaling with Wnt (Canonical) ( Mammalian Wnt signaling pathway Diagram )	inoh	47	421
pathway0002050	Signaling with Wnt (Canonical) ( Xenopus axis formation Wnt signaling pathway Diagram )	inoh	47	421
pathway0002051	Signaling with Wnt (Mammal) ( Mammalian Wnt signaling pathway Diagram )	inoh	47	421
pathway0002052	Signaling with Wnt (Xenopus) ( Xenopus axis formation Wnt signaling pathway Diagram )	inoh	19	46
pathway0002053	Signaling without Wnt (Canonical) ( C. elegans endoderm induction Wnt signaling pathway Diagram )	inoh	8	26
pathway0002054	Signaling without Wnt (Canonical) ( Canonical Wnt signaling pathway Diagram )	inoh	8	26
pathway0002055	Signaling without Wnt (Canonical) ( Drosophila Wingless/Wnt signaling pathway Diagram )	inoh	8	26
pathway0002056	Signaling without Wnt (Canonical) ( Mammalian Wnt signaling pathway Diagram )	inoh	8	26
pathway0002057	Signaling without Wnt (Canonical) ( Xenopus axis formation Wnt signaling pathway Diagram )	inoh	8	26
pathway0002058	Signaling without Wnt (Mammal) ( Mammalian Wnt signaling pathway Diagram )	inoh	8	26
pathway0002181	Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	reactome	20	41
pathway0002597	Adherens junction	kegg	70	644
pathway0002657	Colorectal cancer	kegg	63	642
pathway0002660	Endometrial cancer	kegg	52	567
pathway0002668	Acute myeloid leukemia	kegg	53	562
pathway0002677	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	kegg	71	760

Go term information of TCF7L2

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GO_term_name	GO_term_type	TF_name
GO_REGULATION_OF_EPITHELIAL_CELL_APOPTOTIC_PROCESS	BP	TCF7L2
GO_REGULATION_OF_PROTEIN_BINDING	BP	TCF7L2
GO_POSITIVE_REGULATION_OF_EPITHELIAL_TO_MESENCHYMAL_TRANSITION	BP	TCF7L2
GO_POSITIVE_REGULATION_OF_BINDING	BP	TCF7L2
GO_REGULATION_OF_CELL_MORPHOGENESIS_INVOLVED_IN_DIFFERENTIATION	BP	TCF7L2
GO_NON_CANONICAL_WNT_SIGNALING_PATHWAY	BP	TCF7L2
GO_REGULATION_OF_PROTEIN_EXPORT_FROM_NUCLEUS	BP	TCF7L2
GO_WNT_SIGNALING_PATHWAY_CALCIUM_MODULATING_PATHWAY	BP	TCF7L2
GO_NEGATIVE_REGULATION_OF_SEQUENCE_SPECIFIC_DNA_BINDING_TRANSCRIPTION_FACTOR_ACTIVITY	BP	TCF7L2
GO_PANCREAS_DEVELOPMENT	BP	TCF7L2
GO_NEGATIVE_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY	BP	TCF7L2
GO_REGULATION_OF_GLYCOPROTEIN_METABOLIC_PROCESS	BP	TCF7L2
GO_NEGATIVE_REGULATION_OF_EPITHELIAL_CELL_APOPTOTIC_PROCESS	BP	TCF7L2
GO_CANONICAL_WNT_SIGNALING_PATHWAY	BP	TCF7L2
GO_MYOBLAST_DIFFERENTIATION	BP	TCF7L2
GO_REGULATION_OF_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY	BP	TCF7L2
GO_POSITIVE_REGULATION_OF_HORMONE_SECRETION	BP	TCF7L2
GO_NEGATIVE_REGULATION_OF_CANONICAL_WNT_SIGNALING_PATHWAY	BP	TCF7L2
GO_POSITIVE_REGULATION_OF_GLYCOPROTEIN_METABOLIC_PROCESS	BP	TCF7L2
GO_FAT_CELL_DIFFERENTIATION	BP	TCF7L2
GO_REGULATION_OF_SMOOTH_MUSCLE_CELL_PROLIFERATION	BP	TCF7L2
GO_POSITIVE_REGULATION_OF_PROTEIN_KINASE_B_SIGNALING	BP	TCF7L2
GO_CELL_FATE_COMMITMENT	BP	TCF7L2
GO_NEGATIVE_REGULATION_OF_APOPTOTIC_SIGNALING_PATHWAY	BP	TCF7L2
GO_REGULATION_OF_CELL_DEATH	BP	TCF7L2
GO_REGULATION_OF_PROTEIN_KINASE_B_SIGNALING	BP	TCF7L2
GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_STIMULUS	BP	TCF7L2
GO_REGULATION_OF_HORMONE_METABOLIC_PROCESS	BP	TCF7L2
GO_POSITIVE_REGULATION_OF_PROTEIN_EXPORT_FROM_NUCLEUS	BP	TCF7L2
GO_BETA_CATENIN_TCF_COMPLEX_ASSEMBLY	BP	TCF7L2
GO_REGULATION_OF_SULFUR_METABOLIC_PROCESS	BP	TCF7L2
GO_MUSCLE_CELL_DIFFERENTIATION	BP	TCF7L2
GO_POSITIVE_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION	BP	TCF7L2
GO_POSITIVE_REGULATION_OF_CELL_MORPHOGENESIS_INVOLVED_IN_DIFFERENTIATION	BP	TCF7L2
GO_REGULATION_OF_STEM_CELL_DIFFERENTIATION	BP	TCF7L2
GO_CHROMATIN	CC	TCF7L2
GO_RNA_POLYMERASE_II_REPRESSING_TRANSCRIPTION_FACTOR_BINDING	MF	TCF7L2
GO_REPRESSING_TRANSCRIPTION_FACTOR_BINDING	MF	TCF7L2
GO_GAMMA_CATENIN_BINDING	MF	TCF7L2
GO_ARMADILLO_REPEAT_DOMAIN_BINDING	MF	TCF7L2

Survival analysis of TCF7L2

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of TCF7L2

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)