Cancer CRCdb

TF information

TF name:	SRF
TF family:	SRF
Ensembl gene ID:	ENSG00000112658
Ensembl protein ID:	ENSP00000265354
Entrez gene ID:	6722

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of SRF in all biosamples

Download

Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_02_021	Cell line	Colon	V429	0.016431248198328
Sample_02_241	Cell line	Colon	V456	0.098194130925508
Sample_02_242	Cell line	Colon	V481	0.032301480484522
Sample_02_354	Cell line	Colon	Colo205	0.56756756756757

SRF distribution in samples’ most representative CRC

Download

Sample ID	Tissue type	Biosample type	Biosample name

SRF distribution in all CRCs

Genomic distribution of SEs associated with SRF

Download

Mutation of SRF

Download

Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of SRF

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
rs761821794	chr6	43146043	43146043	G	A	exonic	SRF	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr6	43143444	43143450	GACACAC	-	exonic	SRF	frameshift	SARC\|1\|247\|0.00405
-	chr6	43141726	43141726	C	A	exonic	SRF	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr6	43144316	43144316	A	G	exonic	SRF	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr6	43146905	43146905	G	A	exonic	SRF	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr6	43139845	43139845	A	C	exonic	SRF	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr6	43141721	43141721	C	T	exonic	SRF	nonsynonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr6	43139486	43139487	GC	-	exonic	SRF	frameshift	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189,SKCM\|1\|368\|0.00272
-	chr6	43144302	43144302	G	T	exonic	SRF	nonsynonymous	OV\|1\|469\|0.00213
-	chr6	43143662	43143662	-	G	exonic	SRF	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs778816086	chr6	43143635	43143635	G	C	exonic	SRF	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr6	43143694	43143694	C	T	exonic	SRF	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr6	43143452	43143452	G	A	exonic	SRF	synonymous	HNSC\|1\|512\|0.00195
-	chr6	43141825	43141825	G	A	exonic	SRF	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr6	43141698	43141698	G	C	exonic	SRF	nonsynonymous	BRCA\|1\|982\|0.00102
rs140883192	chr6	43146105	43146105	G	T	exonic	SRF	synonymous	DLBC\|1\|48\|0.02083
-	chr6	43141802	43141802	C	G	exonic	SRF	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr6	43146097	43146097	C	T	exonic	SRF	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr6	43146615	43146615	C	A	exonic	SRF	nonsynonymous	LUSC\|1\|178\|0.00562
rs142020494	chr6	43141605	43141605	G	A	exonic	SRF	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	43144299	43144299	C	T	exonic	SRF	synonymous	SKCM\|1\|368\|0.00272
-	chr6	43143531	43143531	C	T	exonic	SRF	stopgain	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
rs760243435	chr6	43146877	43146877	C	T	exonic	SRF	synonymous	SKCM\|1\|368\|0.00272
-	chr6	43143591	43143591	G	A	exonic	SRF	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	43143699	43143699	A	G	exonic	SRF	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs757850825	chr6	43146098	43146098	C	G	exonic	SRF	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr6	43144291	43144295	GCAGT	-	exonic	SRF	frameshift	PAAD\|1\|185\|0.00541
-	chr6	43141756	43141756	G	A	exonic	SRF	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	43146557	43146557	G	A	exonic	SRF	synonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr6	43146564	43146564	C	T	exonic	SRF	synonymous	SKCM\|1\|368\|0.00272
-	chr6	43143550	43143550	C	G	exonic	SRF	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr6	43143453	43143453	A	-	exonic	SRF	frameshift	SARC\|1\|247\|0.00405
-	chr6	43144302	43144302	G	A	exonic	SRF	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr6	43143627	43143627	G	A	exonic	SRF	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr6	43146121	43146121	G	A	exonic	SRF	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	43141804	43141804	G	T	exonic	SRF	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr6	43143632	43143632	G	A	exonic	SRF	synonymous	CESC\|1\|194\|0.00515
-	chr6	43141677	43141677	G	C	exonic	SRF	synonymous	BRCA\|1\|982\|0.00102
-	chr6	43139653	43139653	G	A	exonic	SRF	nonsynonymous	ACC\|1\|90\|0.01111
rs537102728	chr6	43146057	43146057	G	A	exonic	SRF	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr6	43141795	43141795	G	A	exonic	SRF	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr6	43146124	43146124	C	T	exonic	SRF	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr6	43144340	43144340	C	T	exonic	SRF	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr6	43144380	43144380	C	T	exonic	SRF	synonymous	HNSC\|1\|512\|0.00195

Disease information of SRF

Download

TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
SRF	Malignant Neoplasms	C04	Neoplastic Process	CTD_human
SRF	Fetal Alcohol Syndrome	C13;C16;C25	Disease or Syndrome	PSYGENET
SRF	HIV Infections	C02;C20	Disease or Syndrome	CTD_human
SRF	Neoplasms	C04	Neoplastic Process	CTD_human
SRF	Benign Neoplasm	C04	Neoplastic Process	CTD_human
SRF	Fetal Alcohol Spectrum Disorders	C13;C16;C25	Congenital Abnormality; Disease or Syndrome	PSYGENET
SRF	HIV Coinfection	C02;C20	Disease or Syndrome	CTD_human

Pathway associated with SRF

Download

pathway_ID	pathway_name	pathway_source	gene_number	edge_number
pathway0001572	p38 MAPK pathway	panther	31	137
pathway0001574	p38 signaling mediated by MAPKAP kinases	pid	21	107
pathway0001605	PDGFR-alpha signaling pathway	pid	22	96
pathway0002340	Trk receptor signaling mediated by the MAPK pathway	pid	34	175
pathway0002743	Hs_VEGFA-VEGFR2_Signaling_Pathway_WP3888_90000	wikipathways	153	1949
pathway0002750	Hs_Serotonin_Receptor_4-6-7_and_NR3C_Signaling_WP734_74438	wikipathways	15	37
pathway0002826	Hs_Mesodermal_Commitment_Pathway_WP2857_87780	wikipathways	47	175
pathway0002834	Hs_Serotonin_Receptor_2_and_ELK-SRF-GATA4_signaling_WP732_80010	wikipathways	13	27

Go term information of SRF

Download

GO_term_name	GO_term_type	TF_name
GO_MEMORY	BP	SRF
GO_ACTIN_FILAMENT_BUNDLE_ORGANIZATION	BP	SRF
GO_MYELOID_CELL_HOMEOSTASIS	BP	SRF
GO_CORONARY_VASCULATURE_DEVELOPMENT	BP	SRF
GO_HEART_TRABECULA_MORPHOGENESIS	BP	SRF
GO_MYELOID_CELL_DEVELOPMENT	BP	SRF
GO_REGULATION_OF_SMOOTH_MUSCLE_CELL_DIFFERENTIATION	BP	SRF
GO_SMOOTH_MUSCLE_CELL_DIFFERENTIATION	BP	SRF
GO_THYMIC_T_CELL_SELECTION	BP	SRF
GO_MATURATION_OF_SSU_RRNA	BP	SRF
GO_POSITIVE_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_INITIATION	BP	SRF
GO_ERYTHROCYTE_HOMEOSTASIS	BP	SRF
GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_INITIATION_FROM_RNA_POLYMERASE_II_PROMOTER	BP	SRF
GO_APICAL_JUNCTION_ASSEMBLY	BP	SRF
GO_CELLULAR_RESPONSE_TO_CARBOHYDRATE_STIMULUS	BP	SRF
GO_CELL_MIGRATION_INVOLVED_IN_SPROUTING_ANGIOGENESIS	BP	SRF
GO_PRIMITIVE_STREAK_FORMATION	BP	SRF
GO_CONTRACTILE_ACTIN_FILAMENT_BUNDLE_ASSEMBLY	BP	SRF
GO_REGULATION_OF_CELLULAR_COMPONENT_SIZE	BP	SRF
GO_REGULATION_OF_SMOOTH_MUSCLE_CONTRACTION	BP	SRF
GO_LUNG_MORPHOGENESIS	BP	SRF
GO_BONE_CELL_DEVELOPMENT	BP	SRF
GO_THYMUS_DEVELOPMENT	BP	SRF
GO_CELL_MATRIX_ADHESION	BP	SRF
GO_TISSUE_HOMEOSTASIS	BP	SRF
GO_ARTERY_DEVELOPMENT	BP	SRF
GO_CARDIAC_MYOFIBRIL_ASSEMBLY	BP	SRF
GO_VASCULAR_SMOOTH_MUSCLE_CELL_DIFFERENTIATION	BP	SRF
GO_BLASTOCYST_FORMATION	BP	SRF
GO_REGULATION_OF_WATER_LOSS_VIA_SKIN	BP	SRF
GO_CELLULAR_SENESCENCE	BP	SRF
GO_SARCOMERE_ORGANIZATION	BP	SRF
GO_LEUKOCYTE_DIFFERENTIATION	BP	SRF
GO_GASTRULATION_WITH_MOUTH_FORMING_SECOND	BP	SRF
GO_HEMATOPOIETIC_STEM_CELL_DIFFERENTIATION	BP	SRF
GO_REGULATION_OF_SYNAPSE_STRUCTURE_OR_ACTIVITY	BP	SRF
GO_CELL_SUBSTRATE_ADHESION	BP	SRF
GO_FOREBRAIN_CELL_MIGRATION	BP	SRF
GO_CELL_MOTILITY	BP	SRF
GO_AORTA_DEVELOPMENT	BP	SRF
GO_SPECIFICATION_OF_SYMMETRY	BP	SRF
GO_ENDOTHELIAL_CELL_MIGRATION	BP	SRF
GO_EMBRYO_DEVELOPMENT	BP	SRF
GO_EPITHELIAL_CELL_CELL_ADHESION	BP	SRF
GO_POSITIVE_REGULATION_OF_MUSCLE_CONTRACTION	BP	SRF
GO_BLOOD_VESSEL_ENDOTHELIAL_CELL_MIGRATION	BP	SRF
GO_REGULATION_OF_ANATOMICAL_STRUCTURE_SIZE	BP	SRF
GO_PATTERNING_OF_BLOOD_VESSELS	BP	SRF
GO_BONE_DEVELOPMENT	BP	SRF
GO_SMOOTH_MUSCLE_TISSUE_DEVELOPMENT	BP	SRF
GO_THYMOCYTE_AGGREGATION	BP	SRF
GO_LONG_TERM_SYNAPTIC_DEPRESSION	BP	SRF
GO_ARTERY_MORPHOGENESIS	BP	SRF
GO_SPROUTING_ANGIOGENESIS	BP	SRF
GO_HIPPOCAMPUS_DEVELOPMENT	BP	SRF
GO_POSITIVE_REGULATION_OF_FILOPODIUM_ASSEMBLY	BP	SRF
GO_NEGATIVE_REGULATION_OF_SYNAPTIC_TRANSMISSION	BP	SRF
GO_EYELID_DEVELOPMENT_IN_CAMERA_TYPE_EYE	BP	SRF
GO_POSITIVE_REGULATION_OF_SMOOTH_MUSCLE_CONTRACTION	BP	SRF
GO_POSITIVE_REGULATION_OF_CELL_GROWTH	BP	SRF
GO_POSITIVE_REGULATION_OF_PRI_MIRNA_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER	BP	SRF
GO_TISSUE_MIGRATION	BP	SRF
GO_PLATELET_MORPHOGENESIS	BP	SRF
GO_MYOBLAST_DIFFERENTIATION	BP	SRF
GO_RIBOSOMAL_SMALL_SUBUNIT_BIOGENESIS	BP	SRF
GO_TRABECULA_MORPHOGENESIS	BP	SRF
GO_LEARNING	BP	SRF
GO_MORPHOGENESIS_OF_AN_EPITHELIAL_SHEET	BP	SRF
GO_CARDIAC_MUSCLE_CELL_DIFFERENTIATION	BP	SRF
GO_POSITIVE_T_CELL_SELECTION	BP	SRF
GO_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_INITIATION	BP	SRF
GO_ACTOMYOSIN_STRUCTURE_ORGANIZATION	BP	SRF
GO_MYOFIBRIL_ASSEMBLY	BP	SRF
GO_CARDIOBLAST_DIFFERENTIATION	BP	SRF
GO_FACE_DEVELOPMENT	BP	SRF
GO_MEGAKARYOCYTE_DEVELOPMENT	BP	SRF
GO_POSITIVE_REGULATION_OF_AXON_EXTENSION	BP	SRF
GO_BICELLULAR_TIGHT_JUNCTION_ASSEMBLY	BP	SRF
GO_MULTICELLULAR_ORGANISMAL_WATER_HOMEOSTASIS	BP	SRF
GO_LONG_TERM_MEMORY	BP	SRF
GO_CELL_MORPHOGENESIS_INVOLVED_IN_DIFFERENTIATION	BP	SRF
GO_NEURON_MIGRATION	BP	SRF
GO_TRACHEA_DEVELOPMENT	BP	SRF
GO_EMBRYONIC_MORPHOGENESIS	BP	SRF
GO_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT	BP	SRF
GO_RESPONSE_TO_CARBOHYDRATE	BP	SRF
GO_CELLULAR_RESPONSE_TO_NUTRIENT	BP	SRF
GO_CELLULAR_GLUCOSE_HOMEOSTASIS	BP	SRF
GO_OLFACTORY_LOBE_DEVELOPMENT	BP	SRF
GO_MRNA_TRANSCRIPTION	BP	SRF
GO_MEGAKARYOCYTE_DIFFERENTIATION	BP	SRF
GO_CELL_AGING	BP	SRF
GO_HEART_TRABECULA_FORMATION	BP	SRF
GO_ANTERIOR_POSTERIOR_AXIS_SPECIFICATION	BP	SRF
GO_MUSCLE_CELL_CELLULAR_HOMEOSTASIS	BP	SRF
GO_CELL_PROJECTION_ORGANIZATION	BP	SRF
GO_TRABECULA_FORMATION	BP	SRF
GO_STEM_CELL_DIFFERENTIATION	BP	SRF
GO_REGULATION_OF_CELL_PROJECTION_ASSEMBLY	BP	SRF
GO_TROPHECTODERMAL_CELL_DIFFERENTIATION	BP	SRF
GO_CELL_CELL_JUNCTION_ASSEMBLY	BP	SRF
GO_REGULATION_OF_EXTENT_OF_CELL_GROWTH	BP	SRF
GO_EPITHELIAL_STRUCTURE_MAINTENANCE	BP	SRF
GO_ANGIOGENESIS_INVOLVED_IN_WOUND_HEALING	BP	SRF
GO_REGULATION_OF_PRI_MIRNA_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER	BP	SRF
GO_SKIN_DEVELOPMENT	BP	SRF
GO_MESODERM_DEVELOPMENT	BP	SRF
GO_ANGIOGENESIS	BP	SRF
GO_BRANCHING_MORPHOGENESIS_OF_AN_EPITHELIAL_TUBE	BP	SRF
GO_AORTA_MORPHOGENESIS	BP	SRF
GO_REGULATION_OF_FILOPODIUM_ASSEMBLY	BP	SRF
GO_EMBRYONIC_HEART_TUBE_MORPHOGENESIS	BP	SRF
GO_CIRCULATORY_SYSTEM_DEVELOPMENT	BP	SRF
GO_ERYTHROCYTE_DEVELOPMENT	BP	SRF
GO_THYROID_GLAND_DEVELOPMENT	BP	SRF
GO_POSITIVE_REGULATION_OF_AXONOGENESIS	BP	SRF
GO_T_CELL_SELECTION	BP	SRF
GO_CARDIAC_CELL_DEVELOPMENT	BP	SRF
GO_REGULATION_OF_TRANSCRIPTION_INITIATION_FROM_RNA_POLYMERASE_II_PROMOTER	BP	SRF
GO_MRNA_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER	BP	SRF
GO_90S_PRERIBOSOME	CC	SRF
GO_HISTONE_DEACETYLASE_BINDING	MF	SRF
GO_REGULATORY_REGION_NUCLEIC_ACID_BINDING	MF	SRF
GO_TRANSCRIPTION_FACTOR_ACTIVITY_RNA_POLYMERASE_II_CORE_PROMOTER_SEQUENCE_SPECIFIC	MF	SRF

Survival analysis of SRF

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of SRF

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)