Cancer CRCdb

TF information

TF name:	SREBF2
TF family:	bHLH
Ensembl gene ID:	ENSG00000198911
Ensembl protein ID:	ENSP00000395728, ENSP00000484441, ENSP00000354476
Entrez gene ID:	6721

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of SREBF2 in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_02_183	Cell line	Skin	SKMEL2	0.20512820512821
Sample_02_237	Cell line	Colon	V389	0.19223265230996
Sample_02_242	Cell line	Colon	V481	0.3045247708774
Sample_02_296	Cell line	Neuroblastoma	CLB-BER-Lud	0.096403978576894
Sample_02_304	Cell line	Neuroblastoma	N206	0.063858695652174
Sample_02_312	Cell line	Neuroblastoma	SK-N-BE_2-C	0.14893617021277
Sample_02_322	Cell line	Colon	Caco-2	0.84253028263795
Sample_02_354	Cell line	Colon	Colo205	0.45495495495495
Sample_02_355	Cell line	Colon	HCT15	0.2797619047619
Sample_02_424	Cell line	Colon	SW620	0.47826086956522

SREBF2 distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name
Sample_02_322	Colon	Cell line	Caco-2

SREBF2 distribution in all CRCs

Genomic distribution of SEs associated with SREBF2

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Mutation of SREBF2

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of SREBF2

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr22	42273342	42273342	C	G	exonic	SREBF2	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr22	42273258	42273258	C	T	exonic	SREBF2	nonsynonymous	BRCA\|1\|982\|0.00102
rs760365601	chr22	42271636	42271636	-	C	exonic	SREBF2	frameshift	BRCA\|1\|982\|0.00102,KIPAN\|10\|799\|0.01252,KIRC\|10\|451\|0.02217,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs372007376	chr22	42301503	42301503	C	T	exonic	SREBF2	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr22	42293159	42293159	G	T	exonic	SREBF2	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr22	42266899	42266899	G	T	exonic	SREBF2	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr22	42293128	42293128	C	T	exonic	SREBF2	synonymous	SKCM\|1\|368\|0.00272
-	chr22	42262839	42262839	G	A	exonic	SREBF2	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr22	42262950	42262951	CA	-	exonic	SREBF2	frameshift	ESCA\|1\|185\|0.00541,HNSC\|1\|512\|0.00195,PAAD\|11\|185\|0.05946,PCPG\|1\|184\|0.00543,PRAD\|2\|499\|0.00401,SKCM\|2\|368\|0.00543,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253,THCA\|1\|504\|0.00198,THYM\|2\|123\|0.01626
-	chr22	42264617	42264617	C	A	exonic	SREBF2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr22	42293161	42293161	C	T	exonic	SREBF2	synonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr22	42269953	42269953	A	T	exonic	SREBF2	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr22	42263037	42263037	A	G	exonic	SREBF2	synonymous	COAD\|2\|367\|0.00545,COADREAD\|2\|489\|0.00409
-	chr22	42293125	42293125	C	-	exonic	SREBF2	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs755066563	chr22	42266998	42266998	G	A	exonic	SREBF2	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr22	42271662	42271662	C	A	exonic	SREBF2	synonymous	UCEC\|1\|248\|0.00403
-	chr22	42269984	42269984	C	A	exonic	SREBF2	synonymous	UCEC\|1\|248\|0.00403
rs756793996	chr22	42280955	42280955	C	T	exonic	SREBF2	synonymous	SKCM\|1\|368\|0.00272
-	chr22	42276875	42276875	G	T	exonic	SREBF2	nonsynonymous	UCEC\|1\|248\|0.00403
rs753385840	chr22	42300961	42300961	C	T	exonic	SREBF2	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr22	42290843	42290843	C	T	exonic	SREBF2	synonymous	BRCA\|1\|982\|0.00102
-	chr22	42267031	42267031	C	T	exonic	SREBF2	stopgain	CESC\|1\|194\|0.00515
rs764977781	chr22	42289188	42289188	G	A	exonic	SREBF2	nonsynonymous	ESCA\|1\|185\|0.00541,UCEC\|1\|248\|0.00403
-	chr22	42264700	42264700	C	T	exonic	SREBF2	synonymous	UCEC\|1\|248\|0.00403
-	chr22	42267008	42267008	C	T	exonic	SREBF2	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr22	42289166	42289166	A	T	exonic	SREBF2	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr22	42294718	42294718	G	T	exonic	SREBF2	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr22	42264771	42264771	C	A	exonic	SREBF2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs748435330	chr22	42271622	42271622	A	G	exonic	SREBF2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr22	42276884	42276884	C	T	exonic	SREBF2	synonymous	LUAD\|1\|543\|0.00184
-	chr22	42273399	42273399	G	A	exonic	SREBF2	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr22	42269825	42269825	C	T	exonic	SREBF2	synonymous	COAD\|2\|367\|0.00545,COADREAD\|2\|489\|0.00409
-	chr22	42263062	42263062	-	C	exonic	SREBF2	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr22	42276780	42276780	C	A	exonic	SREBF2	nonsynonymous	SARC\|1\|247\|0.00405
-	chr22	42289183	42289183	C	T	exonic	SREBF2	synonymous	SKCM\|2\|368\|0.00543
-	chr22	42245950	42245950	-	GATCGAGA	intronic	SREBF2	unknown	-
-	chr22	42273351	42273351	A	G	exonic	SREBF2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr22	42266928	42266928	C	T	exonic	SREBF2	synonymous	SKCM\|1\|368\|0.00272
-	chr22	42294721	42294721	G	A	exonic	SREBF2	nonsynonymous	CESC\|1\|194\|0.00515
-	chr22	42299024	42299024	C	T	exonic	SREBF2	synonymous	UCS\|1\|57\|0.01754
rs200493376	chr22	42280874	42280874	C	T	exonic	SREBF2	synonymous	LIHC\|1\|373\|0.00268
-	chr22	42273340	42273340	T	G	exonic	SREBF2	synonymous	UCS\|1\|57\|0.01754
-	chr22	42262990	42262990	G	T	exonic	SREBF2	stopgain	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr22	42273401	42273401	C	T	exonic	SREBF2	nonsynonymous	UCEC\|1\|248\|0.00403
rs143287516	chr22	42273265	42273265	G	A	exonic	SREBF2	synonymous	PCPG\|1\|184\|0.00543
-	chr22	42266912	42266914	TCA	-	exonic	SREBF2	nonframeshift	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
rs375253567	chr22	42294664	42294664	A	G	exonic	SREBF2	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr22	42269973	42269973	A	G	exonic	SREBF2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr22	42274026	42274026	G	A	exonic	SREBF2	nonsynonymous	LAML\|1\|197\|0.00508
-	chr22	42263176	42263176	C	G	exonic	SREBF2	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr22	42262940	42262940	G	A	exonic	SREBF2	nonsynonymous	BLCA\|1\|396\|0.00253
rs369078163	chr22	42263058	42263058	G	A	exonic	SREBF2	synonymous	UCEC\|1\|248\|0.00403
-	chr22	42262864	42262864	G	C	exonic	SREBF2	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr22	42264729	42264729	G	C	exonic	SREBF2	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr22	42262866	42262866	A	-	exonic	SREBF2	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr22	42273239	42273239	G	-	exonic	SREBF2	frameshift	BLCA\|1\|396\|0.00253
-	chr22	42264622	42264622	G	A	exonic	SREBF2	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr22	42262852	42262852	A	G	exonic	SREBF2	nonsynonymous	LUSC\|1\|178\|0.00562
rs778847006	chr22	42271413	42271413	C	T	exonic	SREBF2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253,UCEC\|1\|248\|0.00403
-	chr22	42271599	42271599	G	T	exonic	SREBF2	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr22	42263110	42263110	C	T	exonic	SREBF2	nonsynonymous	SKCM\|2\|368\|0.00543
-	chr22	42269866	42269866	T	C	exonic	SREBF2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr22	42263286	42263286	T	C	splicing	SREBF2	splicing	SKCM\|1\|368\|0.00272
rs781475168	chr22	42263150	42263150	C	T	exonic	SREBF2	nonsynonymous	SKCM\|2\|368\|0.00543
rs755835024	chr22	42262990	42262990	G	A	exonic	SREBF2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs767557693	chr22	42269956	42269956	G	A	exonic	SREBF2	nonsynonymous	HNSC\|1\|512\|0.00195,UCEC\|1\|248\|0.00403
rs201061816	chr22	42276902	42276902	G	C	exonic	SREBF2	synonymous	BRCA\|1\|982\|0.00102
-	chr22	42263147	42263147	G	A	exonic	SREBF2	nonsynonymous	PRAD\|1\|499\|0.00200
-	chr22	42289163	42289163	C	A	exonic	SREBF2	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr22	42271554	42271554	A	-	exonic	SREBF2	frameshift	ACC\|1\|90\|0.01111
-	chr22	42276762	42276762	G	A	exonic	SREBF2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr22	42296418	42296418	C	T	exonic	SREBF2	synonymous	SKCM\|1\|368\|0.00272
-	chr22	42245950	42245950	-	GATCGAGT	intronic	SREBF2	unknown	-
-	chr22	42266914	42266914	A	T	exonic	SREBF2	nonsynonymous	LUAD\|2\|543\|0.00368
-	chr22	42289198	42289198	C	T	exonic	SREBF2	synonymous	TGCT\|1\|155\|0.00645
rs745588418	chr22	42266957	42266957	G	A	exonic	SREBF2	nonsynonymous	PAAD\|1\|185\|0.00541
rs781489533	chr22	42271552	42271552	C	T	exonic	SREBF2	synonymous	SKCM\|1\|368\|0.00272
-	chr22	42293062	42293062	C	T	exonic	SREBF2	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr22	42271711	42271711	C	G	exonic	SREBF2	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr22	42271637	42271637	C	-	exonic	SREBF2	frameshift	PAAD\|3\|185\|0.01622,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr22	42299067	42299067	T	C	exonic	SREBF2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr22	42276798	42276798	G	A	exonic	SREBF2	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr22	42289201	42289201	C	-	exonic	SREBF2	frameshift	STAD\|3\|395\|0.00759,STES\|3\|395\|0.00759
-	chr22	42262982	42262982	G	A	exonic	SREBF2	nonsynonymous	THCA\|1\|504\|0.00198
-	chr22	42262951	42262951	A	G	exonic	SREBF2	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr22	42262934	42262934	G	T	exonic	SREBF2	nonsynonymous	UCEC\|1\|248\|0.00403
rs146289041	chr22	42273334	42273334	C	T	exonic	SREBF2	synonymous	SKCM\|1\|368\|0.00272
rs373113186	chr22	42263232	42263232	G	A	exonic	SREBF2	synonymous	BLCA\|1\|396\|0.00253
-	chr22	42273324	42273324	C	T	exonic	SREBF2	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr22	42274004	42274004	T	-	exonic	SREBF2	frameshift	ESCA\|1\|185\|0.00541
-	chr22	42262853	42262853	-	T	exonic	SREBF2	frameshift	ACC\|1\|90\|0.01111
-	chr22	42276720	42276720	G	T	exonic	SREBF2	stopgain	KIPAN\|2\|799\|0.00250,KIRC\|2\|451\|0.00443
rs753747422	chr22	42276779	42276779	A	G	exonic	SREBF2	synonymous	SARC\|1\|247\|0.00405
-	chr22	42269988	42269988	G	A	exonic	SREBF2	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr22	42264749	42264749	C	T	exonic	SREBF2	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr22	42293062	42293062	C	A	exonic	SREBF2	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr22	42280950	42280950	G	C	exonic	SREBF2	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr22	42269979	42269979	A	G	exonic	SREBF2	nonsynonymous	LIHC\|1\|373\|0.00268
rs766904764	chr22	42281016	42281016	G	A	splicing	SREBF2	splicing	BRCA\|1\|982\|0.00102
-	chr22	42263103	42263103	C	T	exonic	SREBF2	synonymous	SKCM\|1\|368\|0.00272
rs781174022	chr22	42274013	42274013	C	T	exonic	SREBF2	synonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr22	42273963	42273963	G	C	exonic	SREBF2	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr22	42266953	42266953	G	C	exonic	SREBF2	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr22	42267007	42267007	A	C	exonic	SREBF2	nonsynonymous	BRCA\|1\|982\|0.00102
rs760768724	chr22	42294733	42294733	C	T	exonic	SREBF2	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr22	42264652	42264652	C	T	exonic	SREBF2	synonymous	SKCM\|1\|368\|0.00272
-	chr22	42289217	42289217	T	-	exonic	SREBF2	frameshift	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr22	42266958	42266958	C	T	exonic	SREBF2	synonymous	LIHC\|1\|373\|0.00268
-	chr22	42262964	42262964	G	A	exonic	SREBF2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs141892188	chr22	42276824	42276824	C	T	exonic	SREBF2	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs140257167	chr22	42245928	42245928	-	TCAGGAGATCGAGACCA	intronic	SREBF2	unknown	-
-	chr22	42290837	42290837	G	A	exonic	SREBF2	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr22	42269951	42269951	G	T	exonic	SREBF2	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr22	42266924	42266924	A	T	exonic	SREBF2	nonsynonymous	HNSC\|1\|512\|0.00195
rs760363309	chr22	42276858	42276858	G	A	exonic	SREBF2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr22	42271369	42271369	C	G	exonic	SREBF2	nonsynonymous	OV\|1\|469\|0.00213
-	chr22	42269825	42269825	C	G	exonic	SREBF2	synonymous	OV\|1\|469\|0.00213
-	chr22	42271676	42271676	C	G	exonic	SREBF2	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr22	42281013	42281013	G	T	exonic	SREBF2	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
rs199689929	chr22	42273418	42273418	C	T	exonic	SREBF2	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs370413839	chr22	42296467	42296467	G	A	exonic	SREBF2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs774875916	chr22	42300952	42300952	G	A	exonic	SREBF2	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr22	42273293	42273293	C	T	exonic	SREBF2	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
rs760693739	chr22	42269974	42269974	A	G	exonic	SREBF2	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
rs747929744	chr22	42289229	42289229	C	T	exonic	SREBF2	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr22	42299078	42299078	A	G	exonic	SREBF2	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs377649542	chr22	42276853	42276853	G	A	exonic	SREBF2	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
rs867776373	chr22	42280888	42280888	C	T	exonic	SREBF2	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
rs769759580	chr22	42276831	42276831	C	T	exonic	SREBF2	nonsynonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr22	42293166	42293166	G	T	splicing	SREBF2	splicing	TGCT\|1\|155\|0.00645
rs778125858	chr22	42276929	42276929	C	T	exonic	SREBF2	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs757074741	chr22	42300914	42300914	C	T	exonic	SREBF2	synonymous	LUSC\|1\|178\|0.00562
-	chr22	42264705	42264705	G	A	exonic	SREBF2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,HNSC\|1\|512\|0.00195
-	chr22	42245927	42245927	-	TCAGGAGATCGAGACCA	intronic	SREBF2	unknown	-
rs780320915	chr22	42271431	42271431	C	T	exonic	SREBF2	synonymous	UCEC\|1\|248\|0.00403
-	chr22	42276872	42276872	C	T	exonic	SREBF2	synonymous	SKCM\|1\|368\|0.00272
-	chr22	42280846	42280846	G	T	exonic	SREBF2	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr22	42290890	42290890	T	C	exonic	SREBF2	nonsynonymous	DLBC\|1\|48\|0.02083
-	chr22	42263244	42263244	G	A	exonic	SREBF2	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr22	42263157	42263157	C	T	exonic	SREBF2	synonymous	UCEC\|1\|248\|0.00403
-	chr22	42264696	42264696	A	T	exonic	SREBF2	nonsynonymous	PRAD\|1\|499\|0.00200
-	chr22	42269955	42269955	C	T	exonic	SREBF2	stopgain	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr22	42290907	42290907	A	T	exonic	SREBF2	stopgain	LUSC\|1\|178\|0.00562
-	chr22	42269859	42269859	G	C	exonic	SREBF2	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr22	42273946	42273946	G	T	exonic	SREBF2	nonsynonymous	LIHC\|1\|373\|0.00268
rs2229439	chr22	42271363	42271363	G	A	exonic	SREBF2	nonsynonymous	LUAD\|3\|543\|0.00552
-	chr22	42269900	42269900	G	T	exonic	SREBF2	nonsynonymous	SKCM\|1\|368\|0.00272
rs776255333	chr22	42271668	42271668	T	C	exonic	SREBF2	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs147075621	chr22	42263057	42263057	C	T	exonic	SREBF2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr22	42274097	42274097	C	T	exonic	SREBF2	synonymous	SKCM\|1\|368\|0.00272

Disease information of SREBF2

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
SREBF2	Malignant neoplasm of breast	C04;C17	Neoplastic Process	UNIPROT
SREBF2	Hypercholesterolemia, Familial	C16;C18	Disease or Syndrome	GENOMICS_ENGLAND
SREBF2	Insulin Resistance	C18	Pathologic Function	CTD_human
SREBF2	Kidney Failure, Chronic	C12;C13	Disease or Syndrome	CTD_human
SREBF2	Malignant neoplasm of stomach	C04;C06	Neoplastic Process	CTD_human
SREBF2	Schizophrenia	F03	Mental or Behavioral Dysfunction	PSYGENET
SREBF2	Stomach Neoplasms	C04;C06	Neoplastic Process	CTD_human
SREBF2	Cataract	C11	Acquired Abnormality	GENOMICS_ENGLAND
SREBF2	Disease Exacerbation	C23	Finding	CTD_human
SREBF2	Insulin Sensitivity	C18	Pathologic Function	CTD_human
SREBF2	Hereditary Diffuse Gastric Cancer	C04;C06	Neoplastic Process	CTD_human
SREBF2	Liver carcinoma	C04;C06	Neoplastic Process	CTD_human
SREBF2	Intellectual Disability	C10;C23;F01;F03	Mental or Behavioral Dysfunction	GENOMICS_ENGLAND

Pathway associated with SREBF2

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number
pathway0000069	Activation of gene expression by SREBF (SREBP)	reactome	42	266
pathway0001828	Regulation of cholesterol biosynthesis by SREBP (SREBF)	reactome	15	53
pathway0002719	Hs_Apoptosis_WP254_88977	wikipathways	31	127
pathway0002806	Hs_Sterol_Regulatory_Element-Binding_Proteins_(SREBP)_signalling_WP1982_90425	wikipathways	15	31

Go term information of SREBF2

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GO_term_name	GO_term_type	TF_name
GO_REGULATION_OF_PROTEIN_TARGETING_TO_MITOCHONDRION	BP	SREBF2
GO_REGULATION_OF_LIPID_STORAGE	BP	SREBF2
GO_REGULATION_OF_CHOLESTEROL_HOMEOSTASIS	BP	SREBF2
GO_CELLULAR_RESPONSE_TO_EXTERNAL_STIMULUS	BP	SREBF2
GO_RESPONSE_TO_FLUID_SHEAR_STRESS	BP	SREBF2
GO_REGULATION_OF_RESPONSE_TO_EXTRACELLULAR_STIMULUS	BP	SREBF2
GO_CELLULAR_RESPONSE_TO_FLUID_SHEAR_STRESS	BP	SREBF2
GO_REGULATION_OF_CHOLESTEROL_EFFLUX	BP	SREBF2
GO_POSITIVE_REGULATION_OF_CYTOPLASMIC_TRANSPORT	BP	SREBF2
GO_REGULATION_OF_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_MITOCHONDRION	BP	SREBF2
GO_RESPONSE_TO_LOW_DENSITY_LIPOPROTEIN_PARTICLE	BP	SREBF2
GO_REGULATION_OF_MITOPHAGY	BP	SREBF2
GO_REGULATION_OF_STEROL_TRANSPORT	BP	SREBF2
GO_RESPONSE_TO_LIPOPROTEIN_PARTICLE	BP	SREBF2
GO_NEGATIVE_REGULATION_OF_LIPID_TRANSPORT	BP	SREBF2
GO_CELLULAR_RESPONSE_TO_STARVATION	BP	SREBF2
GO_REGULATION_OF_CHOLESTEROL_STORAGE	BP	SREBF2
GO_NEGATIVE_REGULATION_OF_STEROL_TRANSPORT	BP	SREBF2
GO_POSITIVE_REGULATION_OF_LIPID_STORAGE	BP	SREBF2
GO_STEROL_METABOLIC_PROCESS	BP	SREBF2
GO_NEGATIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER	BP	SREBF2
GO_RESPONSE_TO_LAMINAR_FLUID_SHEAR_STRESS	BP	SREBF2
GO_INTRACELLULAR_VESICLE	CC	SREBF2
GO_ER_TO_GOLGI_TRANSPORT_VESICLE_MEMBRANE	CC	SREBF2
GO_TRANSPORT_VESICLE_MEMBRANE	CC	SREBF2
GO_TRANSCRIPTIONAL_REPRESSOR_ACTIVITY_RNA_POLYMERASE_II_TRANSCRIPTION_REGULATORY_REGION_SEQUENCE_SPECIFIC_BINDING	MF	SREBF2
GO_PROTEIN_C_TERMINUS_BINDING	MF	SREBF2
GO_E_BOX_BINDING	MF	SREBF2
GO_TRANSCRIPTIONAL_REPRESSOR_ACTIVITY_RNA_POLYMERASE_II_CORE_PROMOTER_PROXIMAL_REGION_SEQUENCE_SPECIFIC_BINDING	MF	SREBF2
GO_INTRAMOLECULAR_OXIDOREDUCTASE_ACTIVITY_TRANSPOSING_C_C_BONDS	MF	SREBF2
GO_INTRAMOLECULAR_OXIDOREDUCTASE_ACTIVITY	MF	SREBF2

Survival analysis of SREBF2

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of SREBF2

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)