TF information
| TF name: | ZIC2 |
| TF family: | zf-C2H2 |
| Ensembl gene ID: | ENSG00000043355 |
| Ensembl protein ID: | ENSP00000365514 |
| Entrez gene ID: | 7546 |
| Database name | Link | Database name | Link |
| NCBI Gene: |  |
Genecards: |  |
| Uniprot: |  |
Wikipedia: |  |
| Cosmic 3D: |  |
Geneontology: |  |
| CCLE: |  |
Frequency of ZIC2 in all biosamples
| Sample ID | Biosample type | Tissue type | Biosample name | TF Frequency |
|---|---|---|---|---|
| Sample_02_007 | Other | Cervical | cervical-cancer_vector | 0.24503311258278 |
| Sample_02_236 | Cell line | Colon | V206 | 0.045548654244306 |
| Sample_02_242 | Cell line | Colon | V481 | 0.088444529898097 |
| Sample_02_258 | Other | Lung | NCI-H1299_EGFP-NEO_reporter_cells_DMSO | 0.25555555555556 |
| Sample_02_354 | Cell line | Colon | Colo205 | 0.12462462462462 |
| Sample_02_355 | Cell line | Colon | HCT15 | 0.14880952380952 |
| Sample_02_395 | Cell line | Mammary Gland | BT-549 | 0.048391608391608 |
| Sample_02_413 | Tissue | Brain | GBM_2493 | 0.37362637362637 |
ZIC2 distribution in samples’ most representative CRC
| Sample ID | Tissue type | Biosample type | Biosample name |
|---|---|---|---|
| Sample_02_413 | Brain | Tissue | GBM_2493 |
ZIC2 distribution in all CRCs
Genomic distribution of SEs associated with ZIC2
Genomic distribution of SEs associated with TF
Figure legend:
Genomic distribution of SEs associated with TF: It can roughly understand the genomic regions of SEs associated with TF, and help to carry out the next analysis, such as knocking down the experiment.
What is important information?
The yellow box can be thought of as the common genomic regions that regulates the SEs associated with TF. For example, if a knockdown experiment is performed on this region, then theoretically, the expression of the TF will be greatly reduced.
| Database name | Link |
|---|---|
| Cosmic: |  |
| Cosmic cell lines: |  |
| Depmap: |  |
TCGA somatic mutations and clinical variants of ZIC2
| rsID | Chr | Start | Stop | Ref | Alt | Gene_region | Gene_symble | Effect | TCGA_Occurrence |
|---|---|---|---|---|---|---|---|---|---|
| - | chr13 | 100635342 | 100635342 | A | C | exonic | ZIC2 | nonsynonymous | SKCM|1|368|0.00272 |
| - | chr13 | 100635317 | 100635317 | C | T | exonic | ZIC2 | synonymous | SKCM|1|368|0.00272 |
| - | chr13 | 100635045 | 100635045 | T | - | exonic | ZIC2 | frameshift | PAAD|3|185|0.01622 |
| - | chr13 | 100635301 | 100635301 | C | T | exonic | ZIC2 | nonsynonymous | LUSC|1|178|0.00562 |
| - | chr13 | 100637890 | 100637890 | G | T | exonic | ZIC2 | nonsynonymous | THCA|1|504|0.00198 |
| - | chr13 | 100634395 | 100634396 | CG | - | exonic | ZIC2 | frameshift | HNSC|1|512|0.00195,PRAD|1|499|0.00200,THCA|1|504|0.00198 |
| rs752861140 | chr13 | 100637594 | 100637594 | G | A | exonic | ZIC2 | synonymous | ESCA|1|185|0.00541 |
| - | chr13 | 100635355 | 100635355 | G | T | exonic | ZIC2 | nonsynonymous | LUAD|1|543|0.00184 |
| - | chr13 | 100635121 | 100635121 | A | G | exonic | ZIC2 | nonsynonymous | HNSC|1|512|0.00195 |
| - | chr13 | 100637327 | 100637327 | C | A | exonic | ZIC2 | synonymous | LUSC|1|178|0.00562 |
| - | chr13 | 100637333 | 100637333 | G | A | exonic | ZIC2 | synonymous | BLCA|2|396|0.00505 |
| - | chr13 | 100635372 | 100635372 | A | G | exonic | ZIC2 | nonsynonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| rs774529965 | chr13 | 100634920 | 100634920 | G | C | exonic | ZIC2 | nonsynonymous | BLCA|1|396|0.00253 |
| - | chr13 | 100637592 | 100637592 | C | A | exonic | ZIC2 | nonsynonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr13 | 100637717 | 100637717 | G | A | exonic | ZIC2 | synonymous | BLCA|1|396|0.00253 |
| - | chr13 | 100635045 | 100635045 | T | C | exonic | ZIC2 | nonsynonymous | TGCT|1|155|0.00645 |
| - | chr13 | 100635181 | 100635181 | C | T | exonic | ZIC2 | nonsynonymous | BLCA|1|396|0.00253 |
| - | chr13 | 100637229 | 100637229 | G | A | exonic | ZIC2 | nonsynonymous | HNSC|1|512|0.00195 |
| - | chr13 | 100637318 | 100637318 | C | T | exonic | ZIC2 | synonymous | PAAD|1|185|0.00541 |
| - | chr13 | 100637299 | 100637299 | C | A | exonic | ZIC2 | nonsynonymous | PAAD|1|185|0.00541 |
| - | chr13 | 100634871 | 100634871 | G | T | exonic | ZIC2 | nonsynonymous | LUAD|1|543|0.00184 |
| - | chr13 | 100635062 | 100635062 | G | C | exonic | ZIC2 | synonymous | PAAD|1|185|0.00541 |
| rs746858832 | chr13 | 100637612 | 100637612 | C | T | exonic | ZIC2 | synonymous | SKCM|1|368|0.00272 |
| - | chr13 | 100635322 | 100635322 | G | A | exonic | ZIC2 | nonsynonymous | KIPAN|1|799|0.00125,KIRP|1|282|0.00355 |
| - | chr13 | 100637340 | 100637340 | A | T | exonic | ZIC2 | nonsynonymous | BLCA|1|396|0.00253 |
| - | chr13 | 100635375 | 100635375 | C | T | exonic | ZIC2 | nonsynonymous | SKCM|1|368|0.00272 |
| - | chr13 | 100635191 | 100635191 | C | G | exonic | ZIC2 | nonsynonymous | ESCA|1|185|0.00541 |
| - | chr13 | 100635374 | 100635374 | C | T | exonic | ZIC2 | synonymous | SKCM|1|368|0.00272 |
| - | chr13 | 100635185 | 100635185 | G | A | exonic | ZIC2 | synonymous | SARC|1|247|0.00405 |
| - | chr13 | 100634891 | 100634891 | G | A | exonic | ZIC2 | synonymous | SKCM|1|368|0.00272 |
| - | chr13 | 100637337 | 100637337 | C | A | exonic | ZIC2 | nonsynonymous | BLCA|1|396|0.00253 |
| - | chr13 | 100637292 | 100637292 | G | A | exonic | ZIC2 | nonsynonymous | HNSC|1|512|0.00195 |
| rs765615222 | chr13 | 100637680 | 100637680 | A | G | exonic | ZIC2 | nonsynonymous | KIPAN|1|799|0.00125,KIRP|1|282|0.00355 |
| - | chr13 | 100634942 | 100634942 | G | A | exonic | ZIC2 | synonymous | GBM|1|290|0.00345,GBMLGG|1|820|0.00122 |
| - | chr13 | 100635006 | 100635006 | G | A | exonic | ZIC2 | nonsynonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| rs370011753 | chr13 | 100635025 | 100635025 | A | G | exonic | ZIC2 | nonsynonymous | THCA|1|504|0.00198 |
| - | chr13 | 100635354 | 100635354 | C | T | exonic | ZIC2 | nonsynonymous | GBMLGG|1|820|0.00122,LGG|1|530|0.00189,STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr13 | 100635308 | 100635308 | G | C | exonic | ZIC2 | nonsynonymous | BLCA|1|396|0.00253 |
| - | chr13 | 100634965 | 100634965 | C | A | exonic | ZIC2 | nonsynonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr13 | 100637597 | 100637597 | G | A | exonic | ZIC2 | synonymous | LUSC|1|178|0.00562 |
| - | chr13 | 100635350 | 100635350 | C | T | exonic | ZIC2 | synonymous | HNSC|1|512|0.00195 |
| - | chr13 | 100635244 | 100635244 | G | C | exonic | ZIC2 | nonsynonymous | HNSC|2|512|0.00391 |
| - | chr13 | 100637238 | 100637238 | C | T | exonic | ZIC2 | nonsynonymous | UCEC|1|248|0.00403 |
| - | chr13 | 100637349 | 100637349 | C | T | exonic | ZIC2 | nonsynonymous | CESC|1|194|0.00515 |
| - | chr13 | 100637726 | 100637726 | G | T | exonic | ZIC2 | synonymous | GBMLGG|1|820|0.00122,LGG|1|530|0.00189,LIHC|1|373|0.00268,PAAD|1|185|0.00541 |
| - | chr13 | 100635186 | 100635186 | G | A | exonic | ZIC2 | nonsynonymous | SARC|1|247|0.00405 |
| - | chr13 | 100635131 | 100635131 | G | A | exonic | ZIC2 | synonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr13 | 100637931 | 100637931 | G | C | exonic | ZIC2 | nonsynonymous | HNSC|1|512|0.00195 |
| - | chr13 | 100635292 | 100635292 | G | A | exonic | ZIC2 | nonsynonymous | PAAD|1|185|0.00541 |
| - | chr13 | 100634887 | 100634887 | G | A | exonic | ZIC2 | nonsynonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr13 | 100637226 | 100637226 | G | C | exonic | ZIC2 | nonsynonymous | CESC|1|194|0.00515 |
| - | chr13 | 100634697 | 100634697 | G | - | exonic | ZIC2 | frameshift | ESCA|1|185|0.00541 |
| - | chr13 | 100634935 | 100634935 | C | A | exonic | ZIC2 | stopgain | UCS|1|57|0.01754 |
| - | chr13 | 100637296 | 100637296 | A | T | exonic | ZIC2 | nonsynonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr13 | 100635007 | 100635007 | - | CA | exonic | ZIC2 | frameshift | ESCA|1|185|0.00541 |
| rs781077990 | chr13 | 100637714 | 100637714 | A | T | exonic | ZIC2 | synonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr13 | 100635129 | 100635129 | A | C | exonic | ZIC2 | nonsynonymous | SKCM|1|368|0.00272 |
| - | chr13 | 100635009 | 100635010 | CA | - | exonic | ZIC2 | frameshift | BRCA|2|982|0.00204,GBMLGG|1|820|0.00122,HNSC|1|512|0.00195,LGG|1|530|0.00189,LUAD|5|543|0.00921,PAAD|7|185|0.03784,PCPG|1|184|0.00543,PRAD|1|499|0.00200,STAD|2|395|0.00506,STES|2|395|0.00506,THCA|1|504|0.00198 |
| rs755198296 | chr13 | 100637593 | 100637593 | C | T | exonic | ZIC2 | nonsynonymous | LUAD|4|543|0.00737 |
| - | chr13 | 100635217 | 100635217 | A | G | exonic | ZIC2 | nonsynonymous | GBMLGG|1|820|0.00122,LGG|1|530|0.00189 |
| - | chr13 | 100637905 | 100637905 | T | - | exonic | ZIC2 | frameshift | STAD|2|395|0.00506,STES|2|395|0.00506 |
| - | chr13 | 100635069 | 100635069 | T | C | exonic | ZIC2 | nonsynonymous | HNSC|1|512|0.00195 |
| - | chr13 | 100635004 | 100635006 | CGG | - | exonic | ZIC2 | nonframeshift | BRCA|1|982|0.00102 |
| rs780880109 | chr13 | 100635173 | 100635173 | A | G | exonic | ZIC2 | synonymous | PRAD|1|499|0.00200 |
| - | chr13 | 100637729 | 100637729 | T | G | exonic | ZIC2 | synonymous | THCA|1|504|0.00198 |
| - | chr13 | 100634397 | 100634397 | G | A | exonic | ZIC2 | nonsynonymous | BLCA|1|396|0.00253 |
| - | chr13 | 100637338 | 100637338 | C | A | exonic | ZIC2 | nonsynonymous | BLCA|1|396|0.00253 |
| TF_name | Disease_name | Disease_class | Disease_semantic_type | TF_disease_source |
|---|---|---|---|---|
| ZIC2 | Diastematomyelia | C10;C16 | Congenital Abnormality | CTD_human |
| ZIC2 | Hydrocephalus | C10 | Disease or Syndrome | GENOMICS_ENGLAND |
| ZIC2 | Neural Tube Defects | C10;C16 | Congenital Abnormality | CTD_human |
| ZIC2 | Neurenteric Cyst | C10;C16 | Congenital Abnormality | CTD_human |
| ZIC2 | Prostatic Neoplasms | C04;C12 | Neoplastic Process | CTD_human |
| ZIC2 | Schizophrenia | F03 | Mental or Behavioral Dysfunction | PSYGENET |
| ZIC2 | Holoprosencephaly | C05;C10;C16 | Congenital Abnormality | GENOMICS_ENGLAND |
| ZIC2 | Tethered Cord Syndrome | C10;C16 | Disease or Syndrome | CTD_human |
| ZIC2 | Iniencephaly | C10;C16 | Congenital Abnormality | CTD_human |
| ZIC2 | Craniorachischisis | C10;C16 | Congenital Abnormality | CTD_human |
| ZIC2 | Exencephaly | C10;C16 | Congenital Abnormality | CTD_human |
| ZIC2 | Spinal Cord Myelodysplasia | C10;C16 | Congenital Abnormality | CTD_human |
| ZIC2 | Malignant neoplasm of prostate | C04;C12 | Neoplastic Process | CTD_human |
| ZIC2 | Lobar Holoprosencephaly | C05;C10;C16 | Congenital Abnormality | ORPHANET |
| ZIC2 | Alobar Holoprosencephaly | C05;C10;C16 | Congenital Abnormality | ORPHANET |
| ZIC2 | Acrania | C10;C16 | Congenital Abnormality | CTD_human |
| ZIC2 | Semilobar Holoprosencephaly | C05;C10;C16 | Congenital Abnormality | ORPHANET |
| ZIC2 | HOLOPROSENCEPHALY 5 | C05;C10;C16 | Disease or Syndrome | CTD_human;UNIPROT |
| ZIC2 | Intellectual Disability | C10;C23;F01;F03 | Mental or Behavioral Dysfunction | GENOMICS_ENGLAND |
| pathway_ID | pathway_name | pathway_source | gene_number | edge_number |
|---|---|---|---|---|
| pathway0002590 | Hedgehog signaling pathway | kegg | 53 | 285 |
| GO_term_name | GO_term_type | TF_name |
|---|---|---|
| GO_STRUCTURE_SPECIFIC_DNA_BINDING | MF | ZIC2 |