Cancer CRCdb

TF information

TF name:	YY1
TF family:	zf-C2H2
Ensembl gene ID:	ENSG00000100811
Ensembl protein ID:	ENSP00000262238, ENSP00000452225
Entrez gene ID:	7528

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of YY1 in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_01_001	Cell line	Prostate	22Rv1	0.47457627118644
Sample_02_029	Cell line	Colorectal	LS174T	0.5
Sample_02_069	Cell line	Brain	SF268	0.030534351145038
Sample_02_242	Cell line	Colon	V481	0.52771902839198
Sample_02_354	Cell line	Colon	Colo205	0.59459459459459
Sample_02_358	Cell line	Colon	LS180	0.17140600315956
Sample_02_361	Cell line	Colon	HT29_DMSO	0.29911504424779

YY1 distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name
Sample_01_001	Prostate	Cell line	22Rv1
Sample_02_354	Colon	Cell line	Colo205

YY1 distribution in all CRCs

Genomic distribution of SEs associated with YY1

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Mutation of YY1

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of YY1

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr14	100728701	100728701	C	T	exonic	YY1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr14	100705845	100705845	G	T	exonic	YY1	synonymous	LIHC\|1\|373\|0.00268
rs748178185	chr14	100706003	100706003	G	A	exonic	YY1	nonsynonymous	ESCA\|1\|185\|0.00541,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr14	100705951	100705951	G	T	exonic	YY1	stopgain	SARC\|1\|247\|0.00405
-	chr14	100728792	100728792	A	-	exonic	YY1	frameshift	SKCM\|1\|368\|0.00272
-	chr14	100743870	100743870	A	G	exonic	YY1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr14	100743846	100743846	G	T	exonic	YY1	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189,LUAD\|1\|543\|0.00184,SKCM\|1\|368\|0.00272,THCA\|1\|504\|0.00198
-	chr14	100742844	100742844	C	G	exonic	YY1	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr14	100706061	100706061	C	T	exonic	YY1	synonymous	HNSC\|1\|512\|0.00195
-	chr14	100742831	100742831	G	T	exonic	YY1	nonsynonymous	SARC\|1\|247\|0.00405
-	chr14	100728643	100728643	-	A	exonic	YY1	frameshift	ESCA\|1\|185\|0.00541,PAAD\|1\|185\|0.00541,STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr14	100742864	100742864	G	T	exonic	YY1	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr14	100705962	100705962	C	T	exonic	YY1	synonymous	CESC\|1\|194\|0.00515
-	chr14	100742955	100742955	A	C	exonic	YY1	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr14	100728767	100728767	A	G	exonic	YY1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs377175446	chr14	100728656	100728656	T	C	exonic	YY1	nonsynonymous	HNSC\|1\|512\|0.00195
rs759536629	chr14	100728644	100728644	A	-	exonic	YY1	frameshift	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr14	100706005	100706005	G	A	exonic	YY1	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr14	100741061	100741061	A	G	exonic	YY1	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr14	100743822	100743822	A	G	exonic	YY1	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr14	100705714	100705714	G	T	exonic	YY1	stopgain	BLCA\|1\|396\|0.00253
-	chr14	100705584	100705584	G	A	exonic	YY1	nonsynonymous	PRAD\|1\|499\|0.00200
-	chr14	100705746	100705749	CGGT	-	exonic	YY1	frameshift	HNSC\|1\|512\|0.00195
-	chr14	100705709	100705710	AG	-	exonic	YY1	frameshift	BLCA\|1\|396\|0.00253,LUAD\|1\|543\|0.00184,PAAD\|6\|185\|0.03243,PCPG\|1\|184\|0.00543
-	chr14	100706146	100706146	G	A	exonic	YY1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr14	100705804	100705804	C	G	exonic	YY1	nonsynonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr14	100728689	100728689	T	C	exonic	YY1	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr14	100705969	100705969	C	G	exonic	YY1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr14	100705835	100705835	C	G	exonic	YY1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr14	100705717	100705717	G	T	exonic	YY1	stopgain	PAAD\|1\|185\|0.00541
-	chr14	100743853	100743853	C	T	exonic	YY1	synonymous	HNSC\|2\|512\|0.00391
-	chr14	100728746	100728746	C	T	exonic	YY1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr14	100728670	100728670	G	C	exonic	YY1	nonsynonymous	SARC\|1\|247\|0.00405
-	chr14	100728701	100728701	C	G	exonic	YY1	stopgain	BLCA\|1\|396\|0.00253
-	chr14	100705789	100705790	CA	-	exonic	YY1	frameshift	ACC\|1\|90\|0.01111,LUAD\|2\|543\|0.00368,SKCM\|2\|368\|0.00543,UCEC\|2\|248\|0.00806
-	chr14	100743827	100743827	G	A	exonic	YY1	nonsynonymous	HNSC\|1\|512\|0.00195,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr14	100728666	100728666	G	C	exonic	YY1	nonsynonymous	CESC\|1\|194\|0.00515
-	chr14	100728716	100728716	C	T	exonic	YY1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr14	100705865	100705865	C	-	exonic	YY1	frameshift	UCEC\|1\|248\|0.00403
-	chr14	100741090	100741090	C	T	exonic	YY1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr14	100741052	100741052	T	-	exonic	YY1	frameshift	SKCM\|1\|368\|0.00272

Disease information of YY1

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
YY1	Malignant Neoplasms	C04	Neoplastic Process	CTD_human
YY1	Uterine Cervical Neoplasm	C04;C13	Neoplastic Process	CTD_human
YY1	HIV Infections	C02;C20	Disease or Syndrome	CTD_human
YY1	Profound Mental Retardation	C10;C23;F01;F03	Mental or Behavioral Dysfunction	CTD_human
YY1	Mental Retardation, Psychosocial	C10;C23;F01;F03	Mental or Behavioral Dysfunction	CTD_human
YY1	Neoplasms	C04	Neoplastic Process	CTD_human
YY1	Benign Neoplasm	C04	Neoplastic Process	CTD_human
YY1	Disease Exacerbation	C23	Finding	CTD_human
YY1	Mental deficiency	C10;C23;F01;F03	Mental or Behavioral Dysfunction	CTD_human
YY1	Intellectual Disability	C10;C23;F01;F03	Mental or Behavioral Dysfunction	CTD_human;GENOMICS_ENGLAND
YY1	cervical cancer	C04;C13	Neoplastic Process	CTD_human
YY1	GABRIELE-DE VRIES SYNDROME		Disease or Syndrome	ORPHANET;UNIPROT
YY1	HIV Coinfection	C02;C20	Disease or Syndrome	CTD_human

Pathway associated with YY1

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number
pathway0000616	DNA Damage Recognition in GG-NER	reactome	38	547

Go term information of YY1

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GO_term_name	GO_term_type	TF_name
GO_RESPONSE_TO_UV_C	BP	YY1
GO_CELLULAR_RESPONSE_TO_UV	BP	YY1
GO_CELLULAR_RESPONSE_TO_LIGHT_STIMULUS	BP	YY1
GO_MULTICELLULAR_ORGANISM_REPRODUCTION	BP	YY1
GO_RESPONSE_TO_LIGHT_STIMULUS	BP	YY1
GO_CELLULAR_RESPONSE_TO_ABIOTIC_STIMULUS	BP	YY1
GO_DNA_METABOLIC_PROCESS	BP	YY1
GO_INO80_TYPE_COMPLEX	CC	YY1
GO_SWI_SNF_SUPERFAMILY_TYPE_COMPLEX	CC	YY1
GO_NUCLEAR_CHROMATIN	CC	YY1
GO_DNA_HELICASE_COMPLEX	CC	YY1
GO_NUCLEAR_MATRIX	CC	YY1
GO_SMAD_BINDING	MF	YY1
GO_DNA_SECONDARY_STRUCTURE_BINDING	MF	YY1
GO_TRANSCRIPTIONAL_REPRESSOR_ACTIVITY_RNA_POLYMERASE_II_TRANSCRIPTION_REGULATORY_REGION_SEQUENCE_SPECIFIC_BINDING	MF	YY1
GO_FOUR_WAY_JUNCTION_DNA_BINDING	MF	YY1
GO_TRANSCRIPTIONAL_REPRESSOR_ACTIVITY_RNA_POLYMERASE_II_CORE_PROMOTER_PROXIMAL_REGION_SEQUENCE_SPECIFIC_BINDING	MF	YY1

Survival analysis of YY1

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of YY1

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)