TF name: | PITX1 |
TF family: | Homeobox |
Ensembl gene ID: | ENSG00000069011 |
Ensembl protein ID: | ENSP00000451199, ENSP00000423624, ENSP00000427542, ENSP00000265340, ENSP00000422908 |
Entrez gene ID: | 5307 |
Sample ID | Biosample type | Tissue type | Biosample name | TF Frequency |
---|---|---|---|---|
Sample_02_021 | Cell line | Colon | V429 | 0.26578264629576 |
Sample_02_241 | Cell line | Colon | V456 | 0.28781038374718 |
Sample_02_242 | Cell line | Colon | V481 | 0.2423572389925 |
Sample_02_354 | Cell line | Colon | Colo205 | 0.45345345345345 |
Sample ID | Tissue type | Biosample type | Biosample name |
---|
rsID | Chr | Start | Stop | Ref | Alt | Gene_region | Gene_symble | Effect | TCGA_Occurrence |
---|---|---|---|---|---|---|---|---|---|
- | chr5 | 134364847 | 134364847 | - | A | exonic | PITX1 | frameshift | HNSC|1|512|0.00195 |
rs775755663 | chr5 | 134364727 | 134364727 | C | T | exonic | PITX1 | nonsynonymous | LUAD|1|543|0.00184 |
rs779923896 | chr5 | 134367190 | 134367190 | G | A | exonic | PITX1 | nonsynonymous | PRAD|1|499|0.00200 |
- | chr5 | 134367076 | 134367076 | T | C | exonic | PITX1 | nonsynonymous | KIPAN|1|799|0.00125,KIRP|1|282|0.00355 |
- | chr5 | 134364717 | 134364717 | C | T | exonic | PITX1 | nonsynonymous | UCEC|1|248|0.00403 |
rs773259804 | chr5 | 134364888 | 134364888 | C | T | exonic | PITX1 | nonsynonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
- | chr5 | 134364975 | 134364975 | G | T | exonic | PITX1 | nonsynonymous | LUSC|1|178|0.00562 |
- | chr5 | 134367042 | 134367042 | T | C | exonic | PITX1 | nonsynonymous | GBMLGG|1|820|0.00122,LGG|1|530|0.00189 |
- | chr5 | 134365003 | 134365003 | G | A | exonic | PITX1 | synonymous | HNSC|1|512|0.00195 |
- | chr5 | 134364901 | 134364901 | G | T | exonic | PITX1 | stopgain | LUAD|2|543|0.00368 |
- | chr5 | 134364949 | 134364949 | C | - | exonic | PITX1 | frameshift | UCEC|1|248|0.00403 |
rs146204449 | chr5 | 134364763 | 134364763 | G | C | exonic | PITX1 | synonymous | CESC|1|194|0.00515 |
rs140746945 | chr5 | 134364489 | 134364489 | C | T | exonic | PITX1 | nonsynonymous | LUAD|2|543|0.00368 |
- | chr5 | 134364715 | 134364715 | G | T | exonic | PITX1 | synonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
- | chr5 | 134364795 | 134364795 | G | C | exonic | PITX1 | nonsynonymous | LIHC|1|373|0.00268 |
rs772730554 | chr5 | 134364505 | 134364505 | C | T | exonic | PITX1 | synonymous | HNSC|1|512|0.00195 |
rs757231285 | chr5 | 134364640 | 134364640 | C | T | exonic | PITX1 | synonymous | COADREAD|1|489|0.00204,READ|1|122|0.00820 |
- | chr5 | 134367105 | 134367106 | TT | - | exonic | PITX1 | frameshift | BRCA|2|982|0.00204 |
- | chr5 | 134364650 | 134364650 | G | A | exonic | PITX1 | nonsynonymous | UCEC|1|248|0.00403 |
- | chr5 | 134364669 | 134364669 | T | C | exonic | PITX1 | nonsynonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
- | chr5 | 134364978 | 134364978 | - | A | exonic | PITX1 | stopgain | STAD|1|395|0.00253,STES|1|395|0.00253 |
- | chr5 | 134364975 | 134364975 | G | A | exonic | PITX1 | nonsynonymous | UCEC|1|248|0.00403 |
- | chr5 | 134367090 | 134367090 | C | T | exonic | PITX1 | nonsynonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
- | chr5 | 134364969 | 134364969 | G | A | exonic | PITX1 | nonsynonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
- | chr5 | 134369448 | 134369448 | G | C | exonic | PITX1 | nonsynonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
- | chr5 | 134364509 | 134364509 | C | T | exonic | PITX1 | nonsynonymous | SKCM|1|368|0.00272 |
- | chr5 | 134364708 | 134364708 | C | T | exonic | PITX1 | nonsynonymous | BRCA|1|982|0.00102 |
rs761995125 | chr5 | 134364859 | 134364859 | G | A | exonic | PITX1 | synonymous | GBMLGG|1|820|0.00122,LGG|1|530|0.00189 |
- | chr5 | 134364919 | 134364919 | G | A | exonic | PITX1 | synonymous | UCEC|1|248|0.00403 |
- | chr5 | 134364547 | 134364547 | G | A | exonic | PITX1 | synonymous | HNSC|1|512|0.00195 |
rs569223515 | chr5 | 134364829 | 134364829 | G | A | exonic | PITX1 | synonymous | SKCM|1|368|0.00272 |
- | chr5 | 134364577 | 134364577 | G | C | exonic | PITX1 | nonsynonymous | HNSC|1|512|0.00195 |
rs139844695 | chr5 | 134367153 | 134367153 | G | A | exonic | PITX1 | nonsynonymous | GBMLGG|1|820|0.00122,LGG|1|530|0.00189 |
- | chr5 | 134364558 | 134364558 | G | T | exonic | PITX1 | synonymous | CESC|1|194|0.00515 |
- | chr5 | 134364608 | 134364608 | G | C | exonic | PITX1 | nonsynonymous | CESC|1|194|0.00515 |
- | chr5 | 134364688 | 134364688 | G | T | exonic | PITX1 | synonymous | HNSC|1|512|0.00195 |
- | chr5 | 134367188 | 134367188 | G | A | exonic | PITX1 | synonymous | UCEC|1|248|0.00403 |
- | chr5 | 134364843 | 134364843 | G | T | exonic | PITX1 | nonsynonymous | LUAD|1|543|0.00184 |
rs61751190 | chr5 | 134364535 | 134364535 | C | G | exonic | PITX1 | synonymous | TGCT|1|155|0.00645 |
rs753029316 | chr5 | 134366998 | 134366998 | C | T | exonic | PITX1 | nonsynonymous | LUAD|1|543|0.00184 |
- | chr5 | 134364925 | 134364925 | C | T | exonic | PITX1 | synonymous | BLCA|1|396|0.00253 |
- | chr5 | 134364597 | 134364597 | C | T | exonic | PITX1 | nonsynonymous | OV|1|469|0.00213,STAD|1|395|0.00253,STES|1|395|0.00253 |
- | chr5 | 134364803 | 134364803 | G | A | exonic | PITX1 | nonsynonymous | SKCM|1|368|0.00272 |
- | chr5 | 134367080 | 134367080 | G | A | exonic | PITX1 | synonymous | SKCM|1|368|0.00272 |
- | chr5 | 134364788 | 134364788 | G | A | exonic | PITX1 | nonsynonymous | SKCM|2|368|0.00543 |
TF_name | Disease_name | Disease_class | Disease_semantic_type | TF_disease_source |
---|---|---|---|---|
PITX1 | Autistic Disorder | F03 | Mental or Behavioral Dysfunction | CTD_human |
PITX1 | Congenital clubfoot | C05;C16 | Congenital Abnormality | CTD_human;UNIPROT |
PITX1 | Polydactyly | C05;C16 | Congenital Abnormality | GENOMICS_ENGLAND |
PITX1 | Testicular Germ Cell Tumor | C04;C12;C19 | Neoplastic Process | CTD_human |
PITX1 | LAURIN-SANDROW SYNDROME | C05;C16 | Disease or Syndrome | ORPHANET |
PITX1 | Synostosis, Carpal, with Dysplastic Elbow Joints and Brachydactyly | C05;C16 | Disease or Syndrome | CTD_human;ORPHANET |
PITX1 | Radial club hand | Congenital Abnormality | GENOMICS_ENGLAND |
pathway_ID | pathway_name | pathway_source | gene_number | edge_number |
---|
GO_term_name | GO_term_type | TF_name |
---|---|---|
GO_CARTILAGE_DEVELOPMENT | BP | PITX1 |
GO_HINDLIMB_MORPHOGENESIS | BP | PITX1 |
GO_PITUITARY_GLAND_DEVELOPMENT | BP | PITX1 |
GO_MYOBLAST_DIFFERENTIATION | BP | PITX1 |
GO_EMBRYONIC_HINDLIMB_MORPHOGENESIS | BP | PITX1 |
GO_ENDOCRINE_SYSTEM_DEVELOPMENT | BP | PITX1 |
GO_TRANSCRIPTION_FACTOR_ACTIVITY_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_BINDING | MF | PITX1 |
GO_TRANSCRIPTIONAL_REPRESSOR_ACTIVITY_RNA_POLYMERASE_II_ACTIVATING_TRANSCRIPTION_FACTOR_BINDING | MF | PITX1 |
GO_TRANSCRIPTIONAL_REPRESSOR_ACTIVITY_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_BINDING | MF | PITX1 |
GO_RNA_POLYMERASE_II_TRANSCRIPTION_FACTOR_BINDING | MF | PITX1 |