TF information
| TF name: | FOSL1 |
| TF family: | TF_bZIP |
| Ensembl gene ID: | ENSG00000175592 |
| Ensembl protein ID: | ENSP00000310170 |
| Entrez gene ID: | 8061 |
| Database name | Link | Database name | Link |
| NCBI Gene: |  |
Genecards: |  |
| Uniprot: |  |
Wikipedia: |  |
| Cosmic 3D: |  |
Geneontology: |  |
| CCLE: |  |
Frequency of FOSL1 in all biosamples
| Sample ID | Biosample type | Tissue type | Biosample name | TF Frequency |
|---|---|---|---|---|
| Sample_02_021 | Cell line | Colon | V429 | 0.034015566445662 |
| Sample_02_116 | Cell line | Mammary Gland | MDA-MB-231_untreat | 0.33333333333333 |
| Sample_02_161 | Cell line | Brain | U87 | 1 |
| Sample_02_164 | Cell line | Lung | H2087_Parental | 0.016666666666667 |
| Sample_02_182 | Cell line | Human melanoma | LOX-IMVI | 0.10632183908046 |
| Sample_02_199 | Cell line | Stomach | KATO3 | 0.33333333333333 |
| Sample_02_219 | Cell line | Mammary Gland | MDA-MB-231 | 0.72549019607843 |
| Sample_02_241 | Cell line | Colon | V456 | 0.1038374717833 |
| Sample_02_258 | Other | Lung | NCI-H1299_EGFP-NEO_reporter_cells_DMSO | 0.0088888888888889 |
| Sample_02_268 | Cell line | Kidney | A-498 | 0.21100239985232 |
| Sample_02_317 | Cell line | Neuroblastoma | GICAN | 0.37837837837838 |
| Sample_02_323 | Cell line | Colon | RKO | 0.65 |
| Sample_02_354 | Cell line | Colon | Colo205 | 0.19069069069069 |
| Sample_02_356 | Cell line | Colon | Sw480 | 0.012903225806452 |
| Sample_02_358 | Cell line | Colon | LS180 | 0.022511848341232 |
| Sample_02_359 | Cell line | Colon | Colo741 | 0.066265060240964 |
| Sample_02_395 | Cell line | Mammary Gland | BT-549 | 0.19188811188811 |
| Sample_02_406 | Cell line | Mammary Gland | ZR-75-30_parental | 0.34782608695652 |
FOSL1 distribution in samples’ most representative CRC
| Sample ID | Tissue type | Biosample type | Biosample name |
|---|---|---|---|
| Sample_02_161 | Brain | Cell line | U87 |
FOSL1 distribution in all CRCs
Genomic distribution of SEs associated with FOSL1
Genomic distribution of SEs associated with TF
Figure legend:
Genomic distribution of SEs associated with TF: It can roughly understand the genomic regions of SEs associated with TF, and help to carry out the next analysis, such as knocking down the experiment.
What is important information?
The yellow box can be thought of as the common genomic regions that regulates the SEs associated with TF. For example, if a knockdown experiment is performed on this region, then theoretically, the expression of the TF will be greatly reduced.
| Database name | Link |
|---|---|
| Cosmic: |  |
| Cosmic cell lines: |  |
| Depmap: |  |
TCGA somatic mutations and clinical variants of FOSL1
| rsID | Chr | Start | Stop | Ref | Alt | Gene_region | Gene_symble | Effect | TCGA_Occurrence |
|---|---|---|---|---|---|---|---|---|---|
| - | chr11 | 65660543 | 65660543 | A | - | exonic | FOSL1 | frameshift | HNSC|1|512|0.00195 |
| - | chr11 | 65660434 | 65660434 | C | T | exonic | FOSL1 | nonsynonymous | LUSC|1|178|0.00562 |
| - | chr11 | 65660629 | 65660629 | C | - | exonic | FOSL1 | frameshift | ESCA|1|185|0.00541,STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr11 | 65660407 | 65660407 | C | A | exonic | FOSL1 | stopgain | LUAD|1|543|0.00184 |
| - | chr11 | 65664290 | 65664290 | G | A | exonic | FOSL1 | nonsynonymous | BLCA|1|396|0.00253 |
| - | chr11 | 65664331 | 65664331 | G | A | exonic | FOSL1 | synonymous | LUSC|1|178|0.00562 |
| - | chr11 | 65661581 | 65661581 | C | T | exonic | FOSL1 | synonymous | COADREAD|1|489|0.00204,READ|1|122|0.00820 |
| - | chr11 | 65660431 | 65660431 | G | T | exonic | FOSL1 | nonsynonymous | HNSC|1|512|0.00195 |
| - | chr11 | 65664372 | 65664372 | T | A | exonic | FOSL1 | nonsynonymous | LUAD|1|543|0.00184 |
| rs564101721 | chr11 | 65660583 | 65660583 | C | T | exonic | FOSL1 | nonsynonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr11 | 65660497 | 65660497 | G | T | exonic | FOSL1 | nonsynonymous | ESCA|1|185|0.00541 |
| - | chr11 | 65664377 | 65664377 | G | T | exonic | FOSL1 | nonsynonymous | LUAD|1|543|0.00184 |
| - | chr11 | 65660428 | 65660428 | G | A | exonic | FOSL1 | nonsynonymous | UCEC|1|248|0.00403 |
| - | chr11 | 65664326 | 65664326 | C | A | exonic | FOSL1 | nonsynonymous | BLCA|1|396|0.00253 |
| - | chr11 | 65664342 | 65664342 | G | A | exonic | FOSL1 | nonsynonymous | UCEC|1|248|0.00403 |
| - | chr11 | 65660427 | 65660427 | C | G | exonic | FOSL1 | nonsynonymous | HNSC|1|512|0.00195 |
| - | chr11 | 65664318 | 65664318 | C | A | exonic | FOSL1 | nonsynonymous | CHOL|1|35|0.02857 |
| - | chr11 | 65661489 | 65661489 | T | A | exonic | FOSL1 | nonsynonymous | PAAD|1|185|0.00541 |
| - | chr11 | 65660635 | 65660635 | C | A | exonic | FOSL1 | stopgain | BLCA|1|396|0.00253 |
| rs763454407 | chr11 | 65660407 | 65660407 | C | T | exonic | FOSL1 | nonsynonymous | UCEC|1|248|0.00403 |
| - | chr11 | 65664461 | 65664461 | G | - | exonic | FOSL1 | frameshift | LUAD|1|543|0.00184 |
| TF_name | Disease_name | Disease_class | Disease_semantic_type | TF_disease_source |
|---|
| pathway_ID | pathway_name | pathway_source | gene_number | edge_number |
|---|---|---|---|---|
| pathway0000187 | AP-1 transcription factor network | pid | 71 | 659 |
| pathway0000343 | Calcineurin-regulated NFAT-dependent transcription in lymphocytes | pid | 50 | 304 |
| pathway0000347 | Calcium signaling in the CD4+ TCR pathway | pid | 29 | 153 |
| pathway0000634 | Downstream signaling in nave CD8+ T cells | pid | 69 | 708 |
| pathway0000895 | Gene expression of IL2 by AP-1 ( CD4 T cell receptor signaling (JNK cascade) ) | inoh | 5 | 10 |
| pathway0000896 | Gene expression of IL2 by AP-1 ( CD4 T cell receptor signaling ) | inoh | 5 | 10 |
| pathway0001230 | JNK cascade ( CD4 T cell receptor signaling (JNK cascade) ) | inoh | 12 | 48 |
| pathway0001231 | JNK cascade ( CD4 T cell receptor signaling ) | inoh | 10 | 35 |
| pathway0002217 | TGF-beta signaling pathway | panther | 88 | 1636 |
| pathway0002390 | Validated targets of C-MYC transcriptional activation | pid | 80 | 573 |
| pathway0002392 | Validated transcriptional targets of AP1 family members Fra1 and Fra2 | pid | 37 | 165 |
| GO_term_name | GO_term_type | TF_name |
|---|---|---|
| GO_RESPONSE_TO_ORGANOPHOSPHORUS | BP | FOSL1 |
| GO_RESPONSE_TO_STEROID_HORMONE | BP | FOSL1 |
| GO_POSITIVE_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_INITIATION | BP | FOSL1 |
| GO_CELLULAR_RESPONSE_TO_EXTRACELLULAR_STIMULUS | BP | FOSL1 |
| GO_RESPONSE_TO_GRAVITY | BP | FOSL1 |
| GO_PLACENTA_BLOOD_VESSEL_DEVELOPMENT | BP | FOSL1 |
| GO_IN_UTERO_EMBRYONIC_DEVELOPMENT | BP | FOSL1 |
| GO_RESPONSE_TO_CAMP | BP | FOSL1 |
| GO_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_INITIATION | BP | FOSL1 |
| GO_RESPONSE_TO_ORGANIC_CYCLIC_COMPOUND | BP | FOSL1 |
| GO_REGULATION_OF_PROTEIN_COMPLEX_ASSEMBLY | BP | FOSL1 |
| GO_POSITIVE_REGULATION_OF_CELL_DEATH | BP | FOSL1 |
| GO_POSITIVE_REGULATION_OF_PROTEIN_COMPLEX_ASSEMBLY | BP | FOSL1 |
| GO_RESPONSE_TO_CORTICOSTERONE | BP | FOSL1 |
| GO_FEMALE_GAMETE_GENERATION | BP | FOSL1 |
| GO_DEVELOPMENTAL_PROCESS_INVOLVED_IN_REPRODUCTION | BP | FOSL1 |
| GO_RESPONSE_TO_MINERALOCORTICOID | BP | FOSL1 |
| GO_PLACENTA_DEVELOPMENT | BP | FOSL1 |
| GO_CELLULAR_DEFENSE_RESPONSE | BP | FOSL1 |
| GO_RESPONSE_TO_PURINE_CONTAINING_COMPOUND | BP | FOSL1 |
| GO_RESPONSE_TO_HYDROGEN_PEROXIDE | BP | FOSL1 |
| GO_SYNAPSE | CC | FOSL1 |
| GO_PRESYNAPTIC_MEMBRANE | CC | FOSL1 |
| GO_TRANSCRIPTIONAL_ACTIVATOR_ACTIVITY_RNA_POLYMERASE_II_TRANSCRIPTION_REGULATORY_REGION_SEQUENCE_SPECIFIC_BINDING | MF | FOSL1 |