Cancer CRCdb

TF information

TF name:	SP2
TF family:	zf-C2H2
Ensembl gene ID:	ENSG00000167182
Ensembl protein ID:	ENSP00000365931
Entrez gene ID:	6668

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of SP2 in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_02_095	Cell line	Mammary Gland	MDA-MB-468	1
Sample_02_404	Cell line	Mammary Gland	ZR-75-1_2	0.54676258992806

SP2 distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name
Sample_02_095	Mammary Gland	Cell line	MDA-MB-468
Sample_02_404	Mammary Gland	Cell line	ZR-75-1_2

SP2 distribution in all CRCs

Genomic distribution of SEs associated with SP2

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Mutation of SP2

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of SP2

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
rs774644043	chr17	46002386	46002386	G	A	exonic	SP2	nonsynonymous	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr17	45994334	45994334	G	C	exonic	SP2	nonsynonymous	LUSC\|1\|178\|0.00562
rs771830248	chr17	46005104	46005104	G	A	exonic	SP2	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr17	45993797	45993797	C	T	exonic	SP2	synonymous	BLCA\|1\|396\|0.00253
-	chr17	45994011	45994011	A	C	exonic	SP2	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr17	45992745	45992745	C	A	exonic	SP2	synonymous	BLCA\|1\|396\|0.00253
-	chr17	46002882	46002882	C	T	exonic	SP2	synonymous	SKCM\|1\|368\|0.00272
-	chr17	46002859	46002859	A	C	exonic	SP2	synonymous	PAAD\|1\|185\|0.00541
rs75562971	chr17	46005109	46005109	C	T	exonic	SP2	synonymous	LUSC\|1\|178\|0.00562
-	chr17	45994443	45994443	C	T	exonic	SP2	stopgain	BLCA\|1\|396\|0.00253
rs759132721	chr17	45994349	45994349	-	C	exonic	SP2	frameshift	KIPAN\|2\|799\|0.00250,KIRC\|2\|451\|0.00443
-	chr17	45993951	45993951	T	C	exonic	SP2	nonsynonymous	TGCT\|1\|155\|0.00645
-	chr17	45994066	45994066	T	C	exonic	SP2	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr17	45993647	45993647	C	G	exonic	SP2	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr17	45994224	45994224	G	A	exonic	SP2	nonsynonymous	CESC\|1\|194\|0.00515
rs374244316	chr17	45993997	45993997	C	T	exonic	SP2	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr17	45994350	45994350	C	-	exonic	SP2	frameshift	LIHC\|1\|373\|0.00268,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	46000417	46000417	C	G	exonic	SP2	synonymous	KICH\|1\|66\|0.01515,KIPAN\|1\|799\|0.00125
-	chr17	46002810	46002810	G	A	exonic	SP2	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	45994184	45994184	G	A	exonic	SP2	synonymous	LUAD\|1\|543\|0.00184,SKCM\|1\|368\|0.00272
-	chr17	45993838	45993838	C	T	exonic	SP2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr17	45993744	45993744	G	A	exonic	SP2	nonsynonymous	UCEC\|1\|248\|0.00403
rs138122841	chr17	46002400	46002400	C	T	exonic	SP2	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	45993786	45993786	C	G	exonic	SP2	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
rs758493874	chr17	46000338	46000338	G	A	exonic	SP2	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr17	46002387	46002387	G	A	exonic	SP2	nonsynonymous	SKCM\|1\|368\|0.00272
rs764970167	chr17	45994016	45994016	C	T	exonic	SP2	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr17	46002461	46002461	T	C	splicing	SP2	splicing	UCEC\|1\|248\|0.00403
-	chr17	46000463	46000463	A	-	exonic	SP2	frameshift	ESCA\|1\|185\|0.00541
-	chr17	45993695	45993695	C	G	exonic	SP2	nonsynonymous	CESC\|1\|194\|0.00515
-	chr17	45993627	45993627	C	A	exonic	SP2	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr17	45993940	45993940	C	-	exonic	SP2	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs756490026	chr17	45994483	45994483	C	T	exonic	SP2	nonsynonymous	PRAD\|1\|499\|0.00200
-	chr17	45994392	45994392	C	T	exonic	SP2	stopgain	UCEC\|1\|248\|0.00403
-	chr17	46000473	46000473	C	G	exonic	SP2	stopgain	HNSC\|1\|512\|0.00195
rs775954063	chr17	45993853	45993853	A	G	exonic	SP2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	46000545	46000545	C	T	exonic	SP2	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr17	45993977	45993977	G	T	exonic	SP2	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr17	45994216	45994216	C	A	exonic	SP2	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr17	46000337	46000337	C	T	exonic	SP2	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr17	45994052	45994052	T	G	exonic	SP2	synonymous	BRCA\|1\|982\|0.00102
-	chr17	45993545	45993545	C	G	exonic	SP2	synonymous	PRAD\|1\|499\|0.00200
-	chr17	45993626	45993626	A	C	exonic	SP2	synonymous	BRCA\|1\|982\|0.00102
rs750001387	chr17	45994113	45994113	G	A	exonic	SP2	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr17	46002805	46002805	C	T	exonic	SP2	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr17	45993740	45993740	G	C	exonic	SP2	synonymous	LUAD\|1\|543\|0.00184
-	chr17	45994489	45994489	C	A	exonic	SP2	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr17	46000404	46000404	C	T	exonic	SP2	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr17	45994416	45994416	G	A	exonic	SP2	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr17	45993964	45993964	C	A	exonic	SP2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs773392267	chr17	46000540	46000540	G	A	exonic	SP2	synonymous	BLCA\|2\|396\|0.00505
-	chr17	46002397	46002397	G	A	exonic	SP2	synonymous	PRAD\|1\|499\|0.00200
-	chr17	45994345	45994345	T	G	exonic	SP2	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr17	45994098	45994098	A	G	exonic	SP2	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr17	46000487	46000487	C	T	exonic	SP2	stopgain	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr17	45993881	45993881	A	G	exonic	SP2	synonymous	UCEC\|1\|248\|0.00403
-	chr17	45994141	45994141	-	C	exonic	SP2	frameshift	KIPAN\|4\|799\|0.00501,KIRC\|4\|451\|0.00887,LUAD\|1\|543\|0.00184
rs1130932	chr17	46002744	46002744	G	T	exonic	SP2	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs763819687	chr17	45994101	45994101	G	A	exonic	SP2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr17	46002417	46002417	G	A	exonic	SP2	nonsynonymous	LUAD\|2\|543\|0.00368
-	chr17	45994401	45994401	C	T	exonic	SP2	nonsynonymous	ACC\|1\|90\|0.01111
-	chr17	45994157	45994157	G	T	exonic	SP2	synonymous	CESC\|1\|194\|0.00515
-	chr17	46000381	46000381	C	-	exonic	SP2	frameshift	LUAD\|1\|543\|0.00184
-	chr17	45993703	45993703	C	T	exonic	SP2	nonsynonymous	CESC\|1\|194\|0.00515

Disease information of SP2

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source

Pathway associated with SP2

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number
pathway0000317	BMP receptor signaling	pid	42	280
pathway0000377	Caspase Cascade in Apoptosis	pid	57	396
pathway0000492	Coregulation of Androgen receptor activity	pid	61	268
pathway0000639	Drosophila Toll-like receptor signaling ( Drosophila Toll-like receptor signaling )	inoh	236	3833
pathway0000794	Ficolins bind to repetitive carbohydrate structures on the target cell surface	reactome	5	8
pathway0000968	Golgi Cisternae Pericentriolar Stack Reorganization	reactome	14	54
pathway0001033	HIV-1 Nef: Negative effector of Fas and TNF-alpha	pid	33	281
pathway0001150	Initial triggering of complement	reactome	31	260
pathway0001261	Lectin pathway of complement activation	reactome	6	10
pathway0001387	Mitotic Prometaphase	reactome	87	3744
pathway0001430	NADE modulates death signalling	reactome	6	14
pathway0001465	Negative regulation of MAPK pathway	reactome	38	287
pathway0001503	NOD1/2 Signaling Pathway	reactome	31	245
pathway0001582	p73 transcription factor network	pid	80	478
pathway0001789	RAF-independent MAPK1/3 activation	reactome	13	25
pathway0001830	Regulation of cytoplasmic and nuclear SMAD2/3 signaling	pid	20	69
pathway0001862	Regulation of TNFR1 signaling	reactome	31	297
pathway0001867	Regulation of TP53 Degradation	reactome	35	257
pathway0001869	Release of Hh-Np from the secreting cell	reactome	8	19
pathway0001879	Resolution of Sister Chromatid Cohesion	reactome	100	4864
pathway0001894	RHO GTPases Activate Formins	reactome	114	4108
pathway0001934	Role of Abl in Robo-Slit signaling	reactome	9	32
pathway0002249	TNFalpha	netpath	274	5236
pathway0002250	TNFR1-induced NFkappaB signaling pathway	reactome	26	269
pathway0002251	TNFR1-induced proapoptotic signaling	reactome	13	64
pathway0002271	TP53 Regulates Transcription of Caspase Activators and Caspases	reactome	12	33
pathway0002456	XBP1(S) activates chaperone genes	reactome	53	101
pathway0002562	MAPK signaling pathway	kegg	264	4851
pathway0002600	Complement and coagulation cascades	kegg	69	338
pathway0002654	Staphylococcus aureus infection	kegg	54	192
pathway0002686	Hs_Tryptophan_metabolism_WP465_85055	wikipathways	45	103
pathway0002719	Hs_Apoptosis_WP254_88977	wikipathways	31	127
pathway0002734	Hs_Apoptosis_Modulation_and_Signaling_WP1772_91293	wikipathways	71	522
pathway0002825	Hs_Gene_regulatory_network_modelling_somitogenesis_WP2854_87527	wikipathways	12	26

Go term information of SP2

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GO_term_name	GO_term_type	TF_name
GO_CIRCADIAN_RHYTHM	BP	SP2
GO_PLATELET_DERIVED_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY	BP	SP2
GO_REGULATION_OF_T_CELL_RECEPTOR_SIGNALING_PATHWAY	BP	SP2
GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS	BP	SP2
GO_REGULATION_OF_G_PROTEIN_COUPLED_RECEPTOR_PROTEIN_SIGNALING_PATHWAY	BP	SP2
GO_REGULATION_OF_CELL_ACTIVATION	BP	SP2
GO_CHROMOSOME_ORGANIZATION	BP	SP2
GO_NEGATIVE_REGULATION_OF_MAP_KINASE_ACTIVITY	BP	SP2
GO_REGULATION_OF_ANTIGEN_RECEPTOR_MEDIATED_SIGNALING_PATHWAY	BP	SP2
GO_NEGATIVE_REGULATION_OF_ERK1_AND_ERK2_CASCADE	BP	SP2
GO_LENS_FIBER_CELL_DIFFERENTIATION	BP	SP2
GO_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE_BY_P53_CLASS_MEDIATOR	BP	SP2
GO_MICROTUBULE_POLYMERIZATION_OR_DEPOLYMERIZATION	BP	SP2
GO_REGULATION_OF_SKELETAL_MUSCLE_TISSUE_DEVELOPMENT	BP	SP2
GO_INTERMEDIATE_FILAMENT_BASED_PROCESS	BP	SP2
GO_NEGATIVE_REGULATION_OF_ADAPTIVE_IMMUNE_RESPONSE	BP	SP2
GO_IRE1_MEDIATED_UNFOLDED_PROTEIN_RESPONSE	BP	SP2
GO_DEVELOPMENTAL_PROGRAMMED_CELL_DEATH	BP	SP2
GO_POSITIVE_REGULATION_OF_SKELETAL_MUSCLE_TISSUE_DEVELOPMENT	BP	SP2
GO_POSITIVE_REGULATION_OF_NEURON_DEATH	BP	SP2
GO_IMMUNE_SYSTEM_PROCESS	BP	SP2
GO_NEGATIVE_REGULATION_OF_KINASE_ACTIVITY	BP	SP2
GO_MICROTUBULE_ANCHORING	BP	SP2
GO_CELLULAR_RESPONSE_TO_UV	BP	SP2
GO_PHOTOPERIODISM	BP	SP2
GO_REGULATION_OF_DEVELOPMENTAL_GROWTH	BP	SP2
GO_PROTEIN_MATURATION	BP	SP2
GO_CELLULAR_RESPONSE_TO_LIGHT_STIMULUS	BP	SP2
GO_REGULATION_OF_KINASE_ACTIVITY	BP	SP2
GO_POSITIVE_REGULATION_OF_MITOTIC_CELL_CYCLE	BP	SP2
GO_PLASMA_MEMBRANE_ORGANIZATION	BP	SP2
GO_NEGATIVE_REGULATION_OF_ADHERENS_JUNCTION_ORGANIZATION	BP	SP2
GO_NEGATIVE_REGULATION_OF_CELL_CELL_ADHESION	BP	SP2
GO_ENTRAINMENT_OF_CIRCADIAN_CLOCK_BY_PHOTOPERIOD	BP	SP2
GO_REGULATION_OF_INTRACELLULAR_STEROID_HORMONE_RECEPTOR_SIGNALING_PATHWAY	BP	SP2
GO_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY	BP	SP2
GO_ADAPTIVE_IMMUNE_RESPONSE_BASED_ON_SOMATIC_RECOMBINATION_OF_IMMUNE_RECEPTORS_BUILT_FROM_IMMUNOGLOBULIN_SUPERFAMILY_DOMAINS	BP	SP2
GO_REGULATION_OF_CELL_JUNCTION_ASSEMBLY	BP	SP2
GO_NEGATIVE_REGULATION_OF_CELL_JUNCTION_ASSEMBLY	BP	SP2
GO_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_IN_RESPONSE_TO_DNA_DAMAGE	BP	SP2
GO_MICROTUBULE_NUCLEATION	BP	SP2
GO_PROTEIN_MODIFICATION_BY_SMALL_PROTEIN_REMOVAL	BP	SP2
GO_NEGATIVE_REGULATION_OF_MAPK_CASCADE	BP	SP2
GO_REGULATION_OF_EXTRACELLULAR_MATRIX_ORGANIZATION	BP	SP2
GO_NEGATIVE_REGULATION_OF_PROTEIN_CATABOLIC_PROCESS	BP	SP2
GO_REGULATION_OF_EXTRACELLULAR_MATRIX_ASSEMBLY	BP	SP2
GO_REGULATION_OF_GROWTH	BP	SP2
GO_HISTONE_DEUBIQUITINATION	BP	SP2
GO_B_CELL_MEDIATED_IMMUNITY	BP	SP2
GO_NEGATIVE_REGULATION_OF_CELL_SUBSTRATE_ADHESION	BP	SP2
GO_REGULATION_OF_CIRCADIAN_RHYTHM	BP	SP2
GO_AGING	BP	SP2
GO_NEGATIVE_REGULATION_OF_WOUND_HEALING	BP	SP2
GO_NEGATIVE_REGULATION_OF_T_CELL_RECEPTOR_SIGNALING_PATHWAY	BP	SP2
GO_COMPLEMENT_ACTIVATION	BP	SP2
GO_NEGATIVE_REGULATION_OF_CELL_MATRIX_ADHESION	BP	SP2
GO_REGULATION_OF_MICROTUBULE_POLYMERIZATION	BP	SP2
GO_REGULATION_OF_INTRACELLULAR_ESTROGEN_RECEPTOR_SIGNALING_PATHWAY	BP	SP2
GO_DNA_REPAIR	BP	SP2
GO_SIGNAL_TRANSDUCTION_IN_RESPONSE_TO_DNA_DAMAGE	BP	SP2
GO_REGULATION_OF_ADHERENS_JUNCTION_ORGANIZATION	BP	SP2
GO_CELL_MATURATION	BP	SP2
GO_APOPTOTIC_SIGNALING_PATHWAY	BP	SP2
GO_POSITIVE_REGULATION_OF_CELL_ADHESION	BP	SP2
GO_EXIT_FROM_MITOSIS	BP	SP2
GO_G1_DNA_DAMAGE_CHECKPOINT	BP	SP2
GO_POSITIVE_REGULATION_OF_IMMUNE_SYSTEM_PROCESS	BP	SP2
GO_NEGATIVE_REGULATION_OF_ACTIN_FILAMENT_BUNDLE_ASSEMBLY	BP	SP2
GO_REGULATION_OF_CELL_GROWTH	BP	SP2
GO_POSITIVE_REGULATION_OF_EXTRACELLULAR_MATRIX_ORGANIZATION	BP	SP2
GO_POSITIVE_REGULATION_OF_EXOCYTOSIS	BP	SP2
GO_REGULATION_OF_CELL_CYCLE_G1_S_PHASE_TRANSITION	BP	SP2
GO_MITOTIC_NUCLEAR_DIVISION	BP	SP2
GO_MULTICELLULAR_ORGANISM_GROWTH	BP	SP2
GO_SIGNAL_TRANSDUCTION_IN_ABSENCE_OF_LIGAND	BP	SP2
GO_NEGATIVE_REGULATION_OF_MITOTIC_CELL_CYCLE	BP	SP2
GO_GASTRULATION	BP	SP2
GO_REGULATION_OF_LYMPHOCYTE_MEDIATED_IMMUNITY	BP	SP2
GO_RESPONSE_TO_RADIATION	BP	SP2
GO_MITOTIC_DNA_INTEGRITY_CHECKPOINT	BP	SP2
GO_MITOTIC_SPINDLE_ORGANIZATION	BP	SP2
GO_ENDODERM_DEVELOPMENT	BP	SP2
GO_ENTRAINMENT_OF_CIRCADIAN_CLOCK	BP	SP2
GO_POSITIVE_REGULATION_OF_CELL_DEATH	BP	SP2
GO_NEGATIVE_REGULATION_OF_SKELETAL_MUSCLE_TISSUE_DEVELOPMENT	BP	SP2
GO_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY	BP	SP2
GO_GROWTH	BP	SP2
GO_NEGATIVE_REGULATION_OF_CATALYTIC_ACTIVITY	BP	SP2
GO_MITOTIC_CELL_CYCLE_CHECKPOINT	BP	SP2
GO_REGULATION_OF_GASTRULATION	BP	SP2
GO_PROTEIN_K48_LINKED_DEUBIQUITINATION	BP	SP2
GO_TRANSFORMING_GROWTH_FACTOR_BETA_RECEPTOR_SIGNALING_PATHWAY	BP	SP2
GO_RHYTHMIC_BEHAVIOR	BP	SP2
GO_REGULATION_OF_T_CELL_MEDIATED_IMMUNITY	BP	SP2
GO_HISTONE_UBIQUITINATION	BP	SP2
GO_NEGATIVE_REGULATION_OF_LYMPHOCYTE_MEDIATED_IMMUNITY	BP	SP2
GO_REGULATION_OF_DEPHOSPHORYLATION	BP	SP2
GO_MICROTUBULE_ORGANIZING_CENTER_ORGANIZATION	BP	SP2
GO_REGULATION_OF_LEUKOCYTE_MEDIATED_IMMUNITY	BP	SP2
GO_NEGATIVE_REGULATION_OF_CELL_CYCLE_PHASE_TRANSITION	BP	SP2
GO_NEGATIVE_REGULATION_OF_CELL_CYCLE_G1_S_PHASE_TRANSITION	BP	SP2
GO_NEGATIVE_REGULATION_OF_T_CELL_MEDIATED_IMMUNITY	BP	SP2
GO_DEPHOSPHORYLATION	BP	SP2
GO_HUMORAL_IMMUNE_RESPONSE_MEDIATED_BY_CIRCULATING_IMMUNOGLOBULIN	BP	SP2
GO_POSITIVE_REGULATION_OF_EPITHELIAL_CELL_MIGRATION	BP	SP2
GO_NEGATIVE_REGULATION_OF_CELL_ACTIVATION	BP	SP2
GO_SMOOTHENED_SIGNALING_PATHWAY	BP	SP2
GO_NEGATIVE_REGULATION_OF_STRESS_FIBER_ASSEMBLY	BP	SP2
GO_POSITIVE_REGULATION_OF_PROTEOLYSIS	BP	SP2
GO_ENDODERM_FORMATION	BP	SP2
GO_NEGATIVE_REGULATION_OF_ANTIGEN_RECEPTOR_MEDIATED_SIGNALING_PATHWAY	BP	SP2
GO_NEGATIVE_REGULATION_OF_MUSCLE_TISSUE_DEVELOPMENT	BP	SP2
GO_DNA_INTEGRITY_CHECKPOINT	BP	SP2
GO_PROTEIN_K63_LINKED_DEUBIQUITINATION	BP	SP2
GO_NEGATIVE_REGULATION_OF_ERAD_PATHWAY	BP	SP2
GO_REGULATION_OF_EXTRACELLULAR_MATRIX_DISASSEMBLY	BP	SP2
GO_ESTABLISHMENT_OR_MAINTENANCE_OF_CELL_POLARITY	BP	SP2
GO_CELL_CYCLE_CHECKPOINT	BP	SP2
GO_EPITHELIAL_CELL_DIFFERENTIATION	BP	SP2
GO_EXECUTION_PHASE_OF_APOPTOSIS	BP	SP2
GO_POSITIVE_REGULATION_OF_EMBRYONIC_DEVELOPMENT	BP	SP2
GO_HISTONE_H4_ACETYLATION	BP	SP2
GO_INACTIVATION_OF_MAPK_ACTIVITY	BP	SP2
GO_POSITIVE_REGULATION_OF_SECRETION	BP	SP2
GO_POSITIVE_REGULATION_OF_DEPHOSPHORYLATION	BP	SP2
GO_NEGATIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER	BP	SP2
GO_RESPONSE_TO_LIGHT_STIMULUS	BP	SP2
GO_RESPONSE_TO_MECHANICAL_STIMULUS	BP	SP2
GO_POSITIVE_REGULATION_OF_NEURON_APOPTOTIC_PROCESS	BP	SP2
GO_REGULATION_OF_ERAD_PATHWAY	BP	SP2
GO_DEVELOPMENTAL_MATURATION	BP	SP2
GO_NEGATIVE_REGULATION_OF_PROTEIN_MODIFICATION_PROCESS	BP	SP2
GO_BIOLOGICAL_ADHESION	BP	SP2
GO_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_SIGNALING_PATHWAY	BP	SP2
GO_MICROTUBULE_POLYMERIZATION	BP	SP2
GO_RESPONSE_TO_TOPOLOGICALLY_INCORRECT_PROTEIN	BP	SP2
GO_LENS_FIBER_CELL_DEVELOPMENT	BP	SP2
GO_NEGATIVE_REGULATION_OF_HOMOTYPIC_CELL_CELL_ADHESION	BP	SP2
GO_LENS_DEVELOPMENT_IN_CAMERA_TYPE_EYE	BP	SP2
GO_NEGATIVE_REGULATION_OF_PROTEIN_SERINE_THREONINE_KINASE_ACTIVITY	BP	SP2
GO_IMMUNE_EFFECTOR_PROCESS	BP	SP2
GO_REGULATION_OF_STEM_CELL_DIFFERENTIATION	BP	SP2
GO_SAGA_COMPLEX	CC	SP2
GO_CHROMOSOME_CENTROMERIC_REGION	CC	SP2
GO_CYTOPLASMIC_REGION	CC	SP2
GO_MITOTIC_SPINDLE	CC	SP2
GO_CELL_PROJECTION_MEMBRANE	CC	SP2
GO_TRANSFERASE_COMPLEX	CC	SP2
GO_INTERMEDIATE_FILAMENT	CC	SP2
GO_CELL_CORTEX_REGION	CC	SP2
GO_AXONAL_GROWTH_CONE	CC	SP2
GO_LEADING_EDGE_MEMBRANE	CC	SP2
GO_EXTRINSIC_COMPONENT_OF_ORGANELLE_MEMBRANE	CC	SP2
GO_MICROTUBULE_PLUS_END	CC	SP2
GO_SAGA_TYPE_COMPLEX	CC	SP2
GO_RUFFLE_MEMBRANE	CC	SP2
GO_CONDENSED_CHROMOSOME_CENTROMERIC_REGION	CC	SP2
GO_SPINDLE_MICROTUBULE	CC	SP2
GO_MICROTUBULE_END	CC	SP2
GO_CELL_CORTEX	CC	SP2
GO_RUFFLE	CC	SP2
GO_CYTOPLASMIC_MICROTUBULE	CC	SP2
GO_BASAL_PART_OF_CELL	CC	SP2
GO_ACETYLTRANSFERASE_COMPLEX	CC	SP2
GO_MITOGEN_ACTIVATED_PROTEIN_KINASE_BINDING	MF	SP2
GO_PEPTIDASE_ACTIVITY	MF	SP2
GO_CYSTEINE_TYPE_PEPTIDASE_ACTIVITY	MF	SP2
GO_COMPLEMENT_BINDING	MF	SP2
GO_CYCLIN_BINDING	MF	SP2
GO_PROTEIN_DIMERIZATION_ACTIVITY	MF	SP2
GO_KINASE_BINDING	MF	SP2
GO_THIOLESTER_HYDROLASE_ACTIVITY	MF	SP2
GO_CALCIUM_DEPENDENT_PROTEIN_BINDING	MF	SP2
GO_STRUCTURAL_CONSTITUENT_OF_EYE_LENS	MF	SP2
GO_GLYCOSAMINOGLYCAN_BINDING	MF	SP2
GO_PROTEIN_SERINE_THREONINE_PHOSPHATASE_ACTIVITY	MF	SP2
GO_H4_HISTONE_ACETYLTRANSFERASE_ACTIVITY	MF	SP2
GO_INSULIN_LIKE_GROWTH_FACTOR_BINDING	MF	SP2
GO_PROTEIN_COMPLEX_BINDING	MF	SP2
GO_PROTEIN_TYROSINE_SERINE_THREONINE_PHOSPHATASE_ACTIVITY	MF	SP2
GO_ATPASE_BINDING	MF	SP2
GO_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY	MF	SP2
GO_SUMO_BINDING	MF	SP2
GO_PEPTIDE_N_ACETYLTRANSFERASE_ACTIVITY	MF	SP2
GO_INTEGRIN_BINDING	MF	SP2
GO_THIOL_DEPENDENT_UBIQUITIN_SPECIFIC_PROTEASE_ACTIVITY	MF	SP2
GO_PROTEIN_TYROSINE_PHOSPHATASE_ACTIVITY	MF	SP2
GO_MAP_KINASE_PHOSPHATASE_ACTIVITY	MF	SP2
GO_UBIQUITIN_LIKE_PROTEIN_LIGASE_BINDING	MF	SP2
GO_BETA_AMYLOID_BINDING	MF	SP2
GO_TRANSCRIPTION_FACTOR_ACTIVITY_PROTEIN_BINDING	MF	SP2
GO_LIGAND_DEPENDENT_NUCLEAR_RECEPTOR_TRANSCRIPTION_COACTIVATOR_ACTIVITY	MF	SP2
GO_RNA_POLYMERASE_II_ACTIVATING_TRANSCRIPTION_FACTOR_BINDING	MF	SP2
GO_PROTEIN_TYROSINE_KINASE_BINDING	MF	SP2
GO_P53_BINDING	MF	SP2
GO_UBIQUITIN_LIKE_PROTEIN_SPECIFIC_PROTEASE_ACTIVITY	MF	SP2
GO_OPSONIN_BINDING	MF	SP2
GO_CYSTEINE_TYPE_ENDOPEPTIDASE_ACTIVITY_INVOLVED_IN_APOPTOTIC_PROCESS	MF	SP2

Survival analysis of SP2

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of SP2

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)