TF information

TF name: FOXA1
TF family: Fork_head
Ensembl gene ID: ENSG00000129514
Ensembl protein ID: ENSP00000250448
Entrez gene ID: 3169
Database name Link Database name Link
NCBI Gene: Genecards:
Uniprot: Wikipedia:
Cosmic 3D: Geneontology:
CCLE:

Frequency of FOXA1 in all biosamples
Sample ID Biosample type Tissue type Biosample name TF Frequency
Sample_01_022Cell lineProstateC4-2B0.61904761904762
Sample_01_046Cell lineMammary GlandMCF-70.5
Sample_01_068Cell lineProstate: derived from metastatic site: vertebral metastasisVCaP0.63013698630137
Sample_02_021Cell lineColonV4290.59469587777457
Sample_02_029Cell lineColorectalLS174T0.66666666666667
Sample_02_079Cell lineMammary GlandT-47D_10.66666666666667
Sample_02_080Cell lineLungCalu-31
Sample_02_095Cell lineMammary GlandMDA-MB-4680.31984435797665
Sample_02_096Cell lineMammary GlandZR-75-1_11
Sample_02_115Cell lineMammary GlandMCF-71
Sample_02_164Cell lineLungH2087_Parental0.46666666666667
Sample_02_166Cell lineMammary GlandHCC1954_Parental0.6
Sample_02_168Cell lineProstateLNCaP1
Sample_02_227Cell lineOesophagusTE70.6
Sample_02_237Cell lineColonV3890.63821093318609
Sample_02_242Cell lineColonV4810.39684676023842
Sample_02_285Cell lineLiverHuH7_untreat0.66202090592334
Sample_02_322Cell lineColonCaco-20.31493943472409
Sample_02_355Cell lineColonHCT150.51190476190476
Sample_02_358Cell lineColonLS1800.61571879936809
Sample_02_361Cell lineColonHT29_DMSO0.39823008849558
Sample_02_394Cell lineMammary GlandT-47D_20.53846153846154
Sample_02_403Cell lineMammary GlandT-47D_untreat1
Sample_02_404Cell lineMammary GlandZR-75-1_20.9136690647482

FOXA1 distribution in samples’ most representative CRC
Sample ID Tissue type Biosample type Biosample name
Sample_01_022ProstateCell lineC4-2B
Sample_01_046Mammary GlandCell lineMCF-7
Sample_01_068Prostate: derived from metastatic site: vertebral metastasisCell lineVCaP
Sample_02_021ColonCell lineV429
Sample_02_029ColorectalCell lineLS174T
Sample_02_080LungCell lineCalu-3
Sample_02_096Mammary GlandCell lineZR-75-1_1
Sample_02_115Mammary GlandCell lineMCF-7
Sample_02_168ProstateCell lineLNCaP
Sample_02_227OesophagusCell lineTE7
Sample_02_237ColonCell lineV389
Sample_02_285LiverCell lineHuH7_untreat
Sample_02_355ColonCell lineHCT15
Sample_02_358ColonCell lineLS180
Sample_02_403Mammary GlandCell lineT-47D_untreat
Sample_02_404Mammary GlandCell lineZR-75-1_2

FOXA1 distribution in all CRCs
Biosample type
Biosample name
Sample ID

Genomic distribution of SEs associated with FOXA1
Download

Mutation of FOXA1
Database name Link
gnomAD: gnomAD
ExAC: ExAC
ICGC:
Database name Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of FOXA1

rsID Chr Start Stop Ref Alt Gene_region Gene_symble Effect TCGA_Occurrence
-chr143806120338061208GCGGCG-exonicFOXA1nonframeshift PRAD|1|499|0.00200
rs764130009chr143806152138061521GAexonicFOXA1synonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr143806122538061225TAexonicFOXA1nonsynonymous BRCA|1|982|0.00102
-chr143806190438061904CTexonicFOXA1nonsynonymous GBM|1|290|0.00345,GBMLGG|1|820|0.00122
-chr143806181238061812CTexonicFOXA1nonsynonymous BLCA|1|396|0.00253
-chr143806187738061877GAexonicFOXA1synonymous PRAD|1|499|0.00200
-chr143806146838061468GAexonicFOXA1nonsynonymous HNSC|1|512|0.00195
-chr143806413838064138CGexonicFOXA1nonsynonymous TGCT|1|155|0.00645
-chr143806075438060754T-exonicFOXA1frameshift BRCA|1|982|0.00102
-chr143806119138061191GTexonicFOXA1nonsynonymous PRAD|1|499|0.00200
-chr143806434938064350CG-upstreamFOXA1unknown ESCA|1|185|0.00541,SARC|1|247|0.00405
-chr143806163238061632CTexonicFOXA1synonymous COADREAD|1|489|0.00204,READ|1|122|0.00820
-chr143806113238061155CCGCTGCCCCCGCTTCCGCTCCCG-exonicFOXA1nonframeshift PRAD|1|499|0.00200
-chr143806162738061627GTexonicFOXA1nonsynonymous TGCT|1|155|0.00645
-chr143806121038061236AAGTAGCAGCCGTTCTCGAACATGTTG-exonicFOXA1nonframeshift -
-chr143806186638061866CTexonicFOXA1nonsynonymous BLCA|2|396|0.00505
-chr143806155838061558GAexonicFOXA1nonsynonymous UCEC|1|248|0.00403
-chr143806153138061531GAexonicFOXA1nonsynonymous BRCA|1|982|0.00102
-chr143806075938060762CTCC-exonicFOXA1frameshift BLCA|1|396|0.00253
-chr143806159238061592CTexonicFOXA1nonsynonymous PAAD|1|185|0.00541
-chr143806089738060897GAexonicFOXA1synonymous GBM|1|290|0.00345,GBMLGG|1|820|0.00122
-chr143806168838061688CTexonicFOXA1nonsynonymous GBM|1|290|0.00345,GBMLGG|1|820|0.00122
-chr143806120238061202-CGGCexonicFOXA1frameshift PRAD|1|499|0.00200
-chr143806190638061907GA-exonicFOXA1frameshift STAD|1|395|0.00253,STES|1|395|0.00253
-chr143806074738060747-TexonicFOXA1frameshift BRCA|1|982|0.00102
-chr143806116838061168-CexonicFOXA1frameshift BLCA|1|396|0.00253
-chr143806141038061410C-exonicFOXA1frameshift BRCA|1|982|0.00102
-chr143806174738061747GTexonicFOXA1nonsynonymous SKCM|1|368|0.00272
-chr143806124038061240GAexonicFOXA1nonsynonymous BRCA|3|982|0.00305
-chr143806146138061461GCexonicFOXA1nonsynonymous BRCA|4|982|0.00407,LUAD|6|543|0.01105
-chr143806185738061857-AexonicFOXA1frameshift BLCA|1|396|0.00253
-chr143806120838061208GAexonicFOXA1nonsynonymous PRAD|1|499|0.00200
-chr143806123038061237CATGTTGC-exonicFOXA1frameshift PRAD|1|499|0.00200
-chr143806127938061279TAexonicFOXA1nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr143806122138061228GTTCTCGA-exonicFOXA1frameshift PRAD|1|499|0.00200
-chr143806119238061192AGexonicFOXA1nonsynonymous PRAD|1|499|0.00200
-chr143806151438061514CTexonicFOXA1nonsynonymous SARC|1|247|0.00405
rs201428590chr143806148538061485GAexonicFOXA1synonymous UCEC|1|248|0.00403
-chr143806120938061229CAAGTAGCAGCCGTTCTCGAA-exonicFOXA1nonframeshift -
-chr143806125038061250GAexonicFOXA1nonsynonymous BRCA|1|982|0.00102,PRAD|2|499|0.00401
-chr143806058738060587CAexonicFOXA1nonsynonymous GBMLGG|1|820|0.00122,LGG|1|530|0.00189
-chr143806123438061241TTGCCGGA-exonicFOXA1frameshift PRAD|1|499|0.00200
-chr143806126638061266GAexonicFOXA1synonymous GBMLGG|1|820|0.00122,LGG|1|530|0.00189
-chr143806122438061228CTCGA-exonicFOXA1frameshift PRAD|3|499|0.00601
-chr143806414738064147CTexonicFOXA1nonsynonymous LUAD|1|543|0.00184
-chr143806123138061231ATexonicFOXA1nonsynonymous PRAD|1|499|0.00200
-chr143806082538060825CTexonicFOXA1synonymous BLCA|1|396|0.00253
-chr143806072138060721G-exonicFOXA1frameshift PRAD|1|499|0.00200
-chr143806122938061229ACexonicFOXA1nonsynonymous PRAD|2|499|0.00401
-chr143806121038061240AAGTAGCAGCCGTTCTCGAACATGTTGCCGG-exonicFOXA1frameshift -
-chr143806151638061516-GCexonicFOXA1frameshift PRAD|1|499|0.00200
-chr143806124838061248GCexonicFOXA1nonsynonymous BRCA|1|982|0.00102
-chr143806190738061907AGexonicFOXA1nonsynonymous UCEC|1|248|0.00403
-chr143806131738061317GTexonicFOXA1nonsynonymous BLCA|1|396|0.00253
-chr143806122538061242TCGAACATGTTGCCGGAG-exonicFOXA1nonframeshift -
-chr143806122438061229CTCGAA-exonicFOXA1nonframeshift -
-chr143806146338061463TCexonicFOXA1nonsynonymous BRCA|2|982|0.00204
-chr143806062738060627GAexonicFOXA1synonymous LUAD|1|543|0.00184
-chr143806122638061228CGA-exonicFOXA1nonframeshift BRCA|1|982|0.00102
-chr143806410838064108CTexonicFOXA1nonsynonymous SKCM|1|368|0.00272
rs777922164chr143806416338064163CTexonicFOXA1synonymous BLCA|1|396|0.00253
-chr143806131238061312TCexonicFOXA1nonsynonymous BRCA|1|982|0.00102,PRAD|1|499|0.00200
-chr143806173738061737GAexonicFOXA1synonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr143806130438061304CTexonicFOXA1nonsynonymous UCEC|1|248|0.00403
-chr143806091438060914GAexonicFOXA1nonsynonymous SKCM|1|368|0.00272
-chr143806415238064152CAexonicFOXA1nonsynonymous LUAD|1|543|0.00184
-chr143806122338061223T-exonicFOXA1frameshift BRCA|1|982|0.00102
-chr143806162338061623GAexonicFOXA1synonymous PRAD|2|499|0.00401
-chr143806177638061776CAexonicFOXA1synonymous LUAD|1|543|0.00184
rs752035534chr143806066938060669GAexonicFOXA1synonymous GBM|1|290|0.00345,GBMLGG|1|820|0.00122
rs141004703chr143806061738060617CTexonicFOXA1nonsynonymous ESCA|1|185|0.00541
rs201419897chr143806170538061705CGexonicFOXA1nonsynonymous PRAD|2|499|0.00401
-chr143806143238061432GAexonicFOXA1nonsynonymous UCEC|1|248|0.00403
-chr143806070238060702GAexonicFOXA1synonymous PRAD|1|499|0.00200
-chr143806117838061178GTexonicFOXA1nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
rs112819884chr143806154738061547GCexonicFOXA1nonsynonymous ACC|1|90|0.01111
-chr143806066738060667CGexonicFOXA1nonsynonymous GBMLGG|1|820|0.00122,LGG|1|530|0.00189
-chr143806191738061917CGsplicingFOXA1splicing HNSC|1|512|0.00195
-chr143806134438061344CTexonicFOXA1synonymous UCEC|1|248|0.00403
-chr143806122038061228CGTTCTCGA-exonicFOXA1nonframeshift PRAD|1|499|0.00200
-chr143806123138061231AGexonicFOXA1nonsynonymous PRAD|2|499|0.00401
-chr143806122238061245TTCTCGAACATGTTGCCGGAGTCC-exonicFOXA1nonframeshift -
-chr143806057238060572ACexonicFOXA1stoploss PRAD|1|499|0.00200
-chr143806123438061244TTGCCGGAGTC-exonicFOXA1frameshift PRAD|1|499|0.00200
-chr143806165438061654CTexonicFOXA1nonsynonymous GBMLGG|1|820|0.00122,LGG|1|530|0.00189
-chr143806122538061228TCGA-exonicFOXA1frameshift BRCA|1|982|0.00102
-chr143806119438061194GTexonicFOXA1synonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr143806135138061351CTexonicFOXA1nonsynonymous UCEC|1|248|0.00403
-chr143806151538061515GAexonicFOXA1synonymous GBM|1|290|0.00345,GBMLGG|1|820|0.00122
-chr143806134238061351TTCTGCCAGC-exonicFOXA1frameshift BLCA|1|396|0.00253
-chr143806063538060635GCexonicFOXA1nonsynonymous GBM|1|290|0.00345,GBMLGG|1|820|0.00122
rs867072933chr143806064838060648CTexonicFOXA1synonymous HNSC|1|512|0.00195
rs771653601chr143806151738061517CTexonicFOXA1nonsynonymous LUSC|1|178|0.00562
-chr143806137538061375GAexonicFOXA1nonsynonymous BLCA|1|396|0.00253
-chr143806155238061552GAexonicFOXA1nonsynonymous GBMLGG|1|820|0.00122,LGG|1|530|0.00189
-chr143806183438061834GAexonicFOXA1nonsynonymous PAAD|1|185|0.00541
-chr143806132938061329GCexonicFOXA1nonsynonymous PRAD|1|499|0.00200
-chr143806158538061585TCexonicFOXA1nonsynonymous SKCM|1|368|0.00272
-chr143806141438061414GAexonicFOXA1nonsynonymous HNSC|1|512|0.00195
-chr143806185538061862TTCATGGA-exonicFOXA1frameshift BLCA|1|396|0.00253
-chr143806122138061225GTTCT-exonicFOXA1frameshift PRAD|1|499|0.00200
-chr143806124338061243TAexonicFOXA1nonsynonymous PRAD|1|499|0.00200
-chr143806119338061193ATexonicFOXA1nonsynonymous BRCA|1|982|0.00102
-chr143806119238061192ACexonicFOXA1nonsynonymous PRAD|1|499|0.00200
-chr143806134738061347CAexonicFOXA1nonsynonymous BRCA|1|982|0.00102
-chr143806120138061243TGGCGGCGCAAGTAGCAGCCGTTCTCGAACATGTTGCCGGAGT-exonicFOXA1frameshift -
-chr143806122338061228TCTCGA-exonicFOXA1nonframeshift PRAD|3|499|0.00601
-chr143806131338061313CTexonicFOXA1nonsynonymous BLCA|1|396|0.00253,BRCA|2|982|0.00204,PRAD|1|499|0.00200
rs774644296chr143806089438060894CTexonicFOXA1synonymous LUAD|1|543|0.00184
-chr143806126338061263G-exonicFOXA1frameshift BLCA|1|396|0.00253
-chr143806062038060620GAexonicFOXA1nonsynonymous HNSC|1|512|0.00195
-chr143806183238061832TCexonicFOXA1nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr143806122138061232GTTCTCGAACAT-exonicFOXA1nonframeshift -
-chr143806120138061202TG-exonicFOXA1frameshift PRAD|1|499|0.00200
-chr143806121338061213TGexonicFOXA1nonsynonymous BRCA|1|982|0.00102
-chr143806191038061910AGexonicFOXA1nonsynonymous LIHC|1|373|0.00268
-chr143806152738061527GAexonicFOXA1synonymous GBM|1|290|0.00345,GBMLGG|1|820|0.00122,UCEC|1|248|0.00403
-chr143806122238061222TAexonicFOXA1nonsynonymous BRCA|1|982|0.00102
-chr143806090638060906GTexonicFOXA1nonsynonymous TGCT|1|155|0.00645
-chr143806120838061208GCexonicFOXA1nonsynonymous PRAD|1|499|0.00200
-chr143806121538061235GCAGCCGTTCTCGAACATGTT-exonicFOXA1nonframeshift -
-chr143806057338060573G-exonicFOXA1frameshift BLCA|2|396|0.00505
-chr143806157438061574T-exonicFOXA1frameshift BLCA|1|396|0.00253
-chr143806161038061610GAexonicFOXA1synonymous LUAD|1|543|0.00184
-chr143806078838060788ATexonicFOXA1nonsynonymous KIPAN|1|799|0.00125,KIRP|1|282|0.00355

Disease information of FOXA1
TF_name Disease_name Disease_class Disease_semantic_type TF_disease_source
FOXA1 Malignant neoplasm of breast C04;C17 Neoplastic Process CGI;CTD_human
FOXA1 Adenocarcinoma of prostate Neoplastic Process CGI
FOXA1 Fatty Liver C06 Disease or Syndrome CTD_human
FOXA1 Prostatic Neoplasms C04;C12 Neoplastic Process CTD_human
FOXA1 Malignant neoplasm of prostate C04;C12 Neoplastic Process CTD_human
FOXA1 Neoplasm of uncertain or unknown behavior of breast Neoplastic Process CGI
FOXA1 Breast Carcinoma C04;C17 Neoplastic Process CGI;CTD_human
FOXA1 Breast adenocarcinoma Neoplastic Process CGI
FOXA1 Mammary Neoplasms, Human C04;C17 Neoplastic Process CTD_human
FOXA1 Mammary Neoplasms C04;C17 Neoplastic Process CTD_human
FOXA1 Steatohepatitis C06 Disease or Syndrome CTD_human

Pathway associated with FOXA1
pathway_ID pathway_name pathway_source gene_number edge_number
pathway0000824 FOXA1 transcription factor network pid 45 204
pathway0000825 FOXA2 and FOXA3 transcription factor networks pid 45 202
pathway0002740 Hs_Endoderm_Differentiation_WP2853_88152 wikipathways 62 260

Go term information of FOXA1
GO_term_name GO_term_type TF_name
GO_LUNG_EPITHELIUM_DEVELOPMENT BP FOXA1
GO_PROSTATE_GLAND_MORPHOGENESIS BP FOXA1
GO_EPITHELIAL_TUBE_BRANCHING_INVOLVED_IN_LUNG_MORPHOGENESIS BP FOXA1
GO_REGULATION_OF_CELL_CELL_ADHESION_MEDIATED_BY_CADHERIN BP FOXA1
GO_NEGATIVE_REGULATION_OF_STEM_CELL_DIFFERENTIATION BP FOXA1
GO_LUNG_CELL_DIFFERENTIATION BP FOXA1
GO_POSITIVE_REGULATION_OF_NEURON_DIFFERENTIATION BP FOXA1
GO_LUNG_MORPHOGENESIS BP FOXA1
GO_REGULATION_OF_HORMONE_LEVELS BP FOXA1
GO_POSITIVE_REGULATION_OF_INTRACELLULAR_STEROID_HORMONE_RECEPTOR_SIGNALING_PATHWAY BP FOXA1
GO_NEURAL_TUBE_DEVELOPMENT BP FOXA1
GO_NEGATIVE_REGULATION_OF_EPITHELIAL_TO_MESENCHYMAL_TRANSITION BP FOXA1
GO_REGULATION_OF_INTRACELLULAR_ESTROGEN_RECEPTOR_SIGNALING_PATHWAY BP FOXA1
GO_CHROMATIN_MODIFICATION BP FOXA1
GO_NEURON_FATE_SPECIFICATION BP FOXA1
GO_DORSAL_VENTRAL_NEURAL_TUBE_PATTERNING BP FOXA1
GO_REGULATION_OF_SMOOTHENED_SIGNALING_PATHWAY BP FOXA1
GO_CARBOHYDRATE_HOMEOSTASIS BP FOXA1
GO_POSITIVE_REGULATION_OF_CELL_CELL_ADHESION BP FOXA1
GO_TUBE_MORPHOGENESIS BP FOXA1
GO_DOPAMINERGIC_NEURON_DIFFERENTIATION BP FOXA1
GO_NEURON_FATE_COMMITMENT BP FOXA1
GO_CELL_FATE_SPECIFICATION BP FOXA1
GO_EPITHELIAL_CELL_DIFFERENTIATION_INVOLVED_IN_PROSTATE_GLAND_DEVELOPMENT BP FOXA1
GO_POSITIVE_REGULATION_OF_SMOOTHENED_SIGNALING_PATHWAY BP FOXA1
GO_POSITIVE_REGULATION_OF_CELL_DIFFERENTIATION BP FOXA1
GO_PROSTATE_GLAND_DEVELOPMENT BP FOXA1
GO_PROSTATE_GLANDULAR_ACINUS_DEVELOPMENT BP FOXA1
GO_RESPONSE_TO_ALCOHOL BP FOXA1
GO_EPITHELIAL_CELL_MATURATION BP FOXA1
GO_REGULATION_OF_MITOTIC_CELL_CYCLE BP FOXA1
GO_NEURAL_TUBE_PATTERNING BP FOXA1
GO_REGULATION_OF_EPITHELIAL_TO_MESENCHYMAL_TRANSITION BP FOXA1
GO_LUNG_ALVEOLUS_DEVELOPMENT BP FOXA1
GO_GLANDULAR_EPITHELIAL_CELL_DIFFERENTIATION BP FOXA1
GO_MICROVILLUS CC FOXA1
GO_TRANSCRIPTION_FACTOR_ACTIVITY_RNA_POLYMERASE_II_CORE_PROMOTER_PROXIMAL_REGION_SEQUENCE_SPECIFIC_BINDING MF FOXA1

Survival analysis of FOXA1



Calculate the hazards ratio based on Cox PH Model.
Add the 95% CI as dotted line.

Expression of FOXA1