TF information

TF name: IRX3
TF family: Homeobox
Ensembl gene ID: ENSG00000177508
Ensembl protein ID: ENSP00000331608
Entrez gene ID: 79191
Database name Link Database name Link
NCBI Gene: Genecards:
Uniprot: Wikipedia:
Cosmic 3D: Geneontology:
CCLE:

Frequency of IRX3 in all biosamples
Sample ID Biosample type Tissue type Biosample name TF Frequency
Sample_02_095Cell lineMammary GlandMDA-MB-4680.47743190661479
Sample_02_115Cell lineMammary GlandMCF-70.4
Sample_02_394Cell lineMammary GlandT-47D_20.23076923076923
Sample_02_404Cell lineMammary GlandZR-75-1_20.20863309352518

IRX3 distribution in samples’ most representative CRC
Sample ID Tissue type Biosample type Biosample name
Sample_02_115Mammary GlandCell lineMCF-7

IRX3 distribution in all CRCs
Biosample type
Biosample name
Sample ID

Genomic distribution of SEs associated with IRX3
Download

Mutation of IRX3
Database name Link
gnomAD: gnomAD
ExAC: ExAC
ICGC:
Database name Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of IRX3

rsID Chr Start Stop Ref Alt Gene_region Gene_symble Effect TCGA_Occurrence
-chr165431927354319273CTexonicIRX3nonsynonymous UCEC|1|248|0.00403
-chr165431931954319319GAexonicIRX3synonymous UCS|1|57|0.01754
-chr165431899054318990AGexonicIRX3nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr165431880854318808-GexonicIRX3frameshift PAAD|1|185|0.00541
-chr165431818754318187GCexonicIRX3synonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr165431936954319369GCexonicIRX3nonsynonymous PRAD|1|499|0.00200
rs748254948chr165431902854319028AGexonicIRX3synonymous BLCA|1|396|0.00253
rs151141618chr165431912854319128CTexonicIRX3nonsynonymous UCEC|1|248|0.00403
-chr165431763054317630CTexonicIRX3nonsynonymous PAAD|1|185|0.00541
rs761463912chr165431908654319086-CexonicIRX3frameshift STAD|1|395|0.00253,STES|1|395|0.00253,THYM|1|123|0.00813
-chr165431943154319431C-exonicIRX3frameshift BRCA|1|982|0.00102
-chr165431880054318800CTexonicIRX3synonymous SKCM|1|368|0.00272
rs1450355chr165431852854318528AGexonicIRX3nonsynonymous ACC|21|90|0.23333
-chr165431909354319093CAexonicIRX3nonsynonymous LUAD|1|543|0.00184
-chr165431912954319129CTexonicIRX3nonsynonymous TGCT|1|155|0.00645
-chr165431906154319061-CexonicIRX3frameshift LUAD|2|543|0.00368
-chr165431937754319377GAexonicIRX3nonsynonymous UCEC|1|248|0.00403
-chr165431909054319090CAexonicIRX3nonsynonymous LUAD|1|543|0.00184
-chr165431765354317653CAsplicingIRX3splicing STAD|1|395|0.00253,STES|1|395|0.00253
-chr165431941454319414C-exonicIRX3frameshift BRCA|1|982|0.00102
-chr165431761754317617GAexonicIRX3nonsynonymous UCEC|2|248|0.00806
-chr165431913254319132CTexonicIRX3nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
rs376056612chr165431946154319461GAexonicIRX3nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr165431908754319087C-exonicIRX3frameshift COADREAD|1|489|0.00204,READ|1|122|0.00820,STAD|1|395|0.00253,STES|1|395|0.00253
-chr165431925954319259GAexonicIRX3synonymous BLCA|1|396|0.00253
-chr165431763354317633CAexonicIRX3nonsynonymous UCEC|1|248|0.00403
-chr165431897554318975GAexonicIRX3nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204,STAD|1|395|0.00253,STES|1|395|0.00253
-chr165431920754319207GCexonicIRX3nonsynonymous LUSC|1|178|0.00562
-chr165431906854319068CTexonicIRX3nonsynonymous LUAD|1|543|0.00184
-chr165431929454319294TCexonicIRX3nonsynonymous KIPAN|1|799|0.00125,KIRC|1|451|0.00222
-chr165431906854319068C-exonicIRX3frameshift STAD|1|395|0.00253,STES|1|395|0.00253
-chr165431940554319405GAexonicIRX3nonsynonymous PRAD|1|499|0.00200
-chr165431896454318964CTexonicIRX3nonsynonymous LUAD|1|543|0.00184
-chr165431815954318159GAexonicIRX3nonsynonymous LUSC|1|178|0.00562
rs567541390chr165431884154318841CAexonicIRX3nonsynonymous KICH|1|66|0.01515,KIPAN|1|799|0.00125
-chr165431815754318157CAsplicingIRX3splicing LUAD|1|543|0.00184
-chr165431919254319192CTexonicIRX3nonsynonymous LUAD|1|543|0.00184
-chr165431849854318498G-exonicIRX3frameshift THCA|1|504|0.00198
-chr165431861354318614CG-exonicIRX3frameshift THYM|1|123|0.00813
-chr165431821254318212GAexonicIRX3nonsynonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr165431853454318534GCexonicIRX3nonsynonymous LIHC|1|373|0.00268
-chr165431900754319007CTexonicIRX3synonymous STAD|1|395|0.00253,STES|1|395|0.00253
-chr165431940254319402GAexonicIRX3nonsynonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr165431910554319105CGexonicIRX3nonsynonymous OV|1|469|0.00213
-chr165431918754319187CTexonicIRX3synonymous HNSC|1|512|0.00195
-chr165431934954319349CTexonicIRX3synonymous COAD|1|367|0.00272,COADREAD|1|489|0.00204
-chr165431898254318982CAexonicIRX3nonsynonymous LUAD|2|543|0.00368
-chr165431935554319355GCexonicIRX3synonymous HNSC|1|512|0.00195
-chr165431904654319046GAexonicIRX3synonymous SKCM|1|368|0.00272
-chr165431896954318969CTexonicIRX3nonsynonymous COADREAD|1|489|0.00204,READ|1|122|0.00820

Disease information of IRX3
TF_name Disease_name Disease_class Disease_semantic_type TF_disease_source
IRX3 Lung diseases C08 Disease or Syndrome CTD_human

Pathway associated with IRX3
pathway_ID pathway_name pathway_source gene_number edge_number

Go term information of IRX3
GO_term_name GO_term_type TF_name
GO_NEGATIVE_REGULATION_OF_NEURON_DIFFERENTIATION BP IRX3
GO_LOOP_OF_HENLE_DEVELOPMENT BP IRX3
GO_POSITIVE_REGULATION_OF_NEURON_DIFFERENTIATION BP IRX3
GO_PROXIMAL_DISTAL_PATTERN_FORMATION BP IRX3
GO_RENAL_TUBULE_DEVELOPMENT BP IRX3
GO_SEGMENT_SPECIFICATION BP IRX3
GO_TUBE_FORMATION BP IRX3
GO_TUBE_MORPHOGENESIS BP IRX3
GO_NEPHRON_TUBULE_FORMATION BP IRX3
GO_NEURON_PART CC IRX3

Survival analysis of IRX3



Calculate the hazards ratio based on Cox PH Model.
Add the 95% CI as dotted line.

Expression of IRX3