TF information
| TF name: | IRF1 |
| TF family: | IRF |
| Ensembl gene ID: | ENSG00000125347 |
| Ensembl protein ID: | ENSP00000480887, ENSP00000405655, ENSP00000473661, ENSP00000392455, ENSP00000384406, ENSP00000245414, ENSP00000396318 |
| Entrez gene ID: | 3659 |
| Database name | Link | Database name | Link |
| NCBI Gene: |  |
Genecards: |  |
| Uniprot: |  |
Wikipedia: |  |
| Cosmic 3D: |  |
Geneontology: |  |
| CCLE: |  |
Frequency of IRF1 in all biosamples
| Sample ID | Biosample type | Tissue type | Biosample name | TF Frequency |
|---|---|---|---|---|
| Sample_02_095 | Cell line | Mammary Gland | MDA-MB-468 | 1 |
| Sample_02_166 | Cell line | Mammary Gland | HCC1954_Parental | 0.904 |
| Sample_02_179 | Cell line | Urinary bladder | T24 | 0.4367816091954 |
| Sample_02_237 | Cell line | Colon | V389 | 0.70804343824775 |
| Sample_02_242 | Cell line | Colon | V481 | 1 |
| Sample_02_361 | Cell line | Colon | HT29_DMSO | 0.56106194690265 |
| Sample_02_395 | Cell line | Mammary Gland | BT-549 | 0.29874125874126 |
| Sample_02_430 | Cell line | Kidney | 12364284 | 0.53571428571429 |
IRF1 distribution in samples’ most representative CRC
| Sample ID | Tissue type | Biosample type | Biosample name |
|---|---|---|---|
| Sample_02_095 | Mammary Gland | Cell line | MDA-MB-468 |
| Sample_02_179 | Urinary bladder | Cell line | T24 |
| Sample_02_237 | Colon | Cell line | V389 |
| Sample_02_242 | Colon | Cell line | V481 |
| Sample_02_361 | Colon | Cell line | HT29_DMSO |
IRF1 distribution in all CRCs
Genomic distribution of SEs associated with IRF1
Genomic distribution of SEs associated with TF
Figure legend:
Genomic distribution of SEs associated with TF: It can roughly understand the genomic regions of SEs associated with TF, and help to carry out the next analysis, such as knocking down the experiment.
What is important information?
The yellow box can be thought of as the common genomic regions that regulates the SEs associated with TF. For example, if a knockdown experiment is performed on this region, then theoretically, the expression of the TF will be greatly reduced.
| Database name | Link |
|---|---|
| Cosmic: |  |
| Cosmic cell lines: |  |
| Depmap: |  |
TCGA somatic mutations and clinical variants of IRF1
| rsID | Chr | Start | Stop | Ref | Alt | Gene_region | Gene_symble | Effect | TCGA_Occurrence |
|---|---|---|---|---|---|---|---|---|---|
| - | chr5 | 131819656 | 131819656 | G | T | exonic | IRF1 | nonsynonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr5 | 131825132 | 131825132 | C | G | exonic | IRF1 | nonsynonymous | CESC|1|194|0.00515 |
| - | chr5 | 131820153 | 131820153 | C | T | exonic | IRF1 | nonsynonymous | HNSC|2|512|0.00391 |
| - | chr5 | 131822801 | 131822801 | T | - | exonic | IRF1 | frameshift | PAAD|1|185|0.00541 |
| - | chr5 | 131819736 | 131819736 | G | A | exonic | IRF1 | synonymous | HNSC|2|512|0.00391 |
| - | chr5 | 131823654 | 131823654 | C | T | exonic | IRF1 | nonsynonymous | SKCM|1|368|0.00272 |
| - | chr5 | 131822699 | 131822699 | G | T | exonic | IRF1 | stopgain | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr5 | 131822538 | 131822538 | T | C | splicing | IRF1 | splicing | HNSC|1|512|0.00195 |
| - | chr5 | 131820066 | 131820066 | C | G | exonic | IRF1 | nonsynonymous | HNSC|2|512|0.00391 |
| - | chr5 | 131822339 | 131822339 | G | A | exonic | IRF1 | nonsynonymous | BRCA|1|982|0.00102 |
| - | chr5 | 131825083 | 131825083 | C | A | splicing | IRF1 | splicing | DLBC|1|48|0.02083 |
| - | chr5 | 131821402 | 131821402 | G | A | exonic | IRF1 | nonsynonymous | GBM|1|290|0.00345,GBMLGG|1|820|0.00122 |
| - | chr5 | 131825088 | 131825088 | T | G | exonic | IRF1 | nonsynonymous | DLBC|1|48|0.02083 |
| - | chr5 | 131819745 | 131819745 | C | A | exonic | IRF1 | nonsynonymous | GBMLGG|1|820|0.00122,LGG|1|530|0.00189 |
| - | chr5 | 131822682 | 131822682 | G | T | exonic | IRF1 | synonymous | UCEC|1|248|0.00403 |
| - | chr5 | 131822017 | 131822017 | G | A | exonic | IRF1 | nonsynonymous | THCA|1|504|0.00198 |
| - | chr5 | 131819732 | 131819732 | C | T | exonic | IRF1 | nonsynonymous | HNSC|2|512|0.00391 |
| - | chr5 | 131822793 | 131822793 | C | G | exonic | IRF1 | nonsynonymous | LUAD|1|543|0.00184 |
| - | chr5 | 131825176 | 131825176 | C | T | splicing | IRF1 | splicing | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr5 | 131822771 | 131822771 | T | C | exonic | IRF1 | nonsynonymous | COADREAD|1|489|0.00204,READ|1|122|0.00820 |
| - | chr5 | 131823647 | 131823647 | C | T | exonic | IRF1 | nonsynonymous | BRCA|1|982|0.00102 |
| - | chr5 | 131823709 | 131823709 | C | G | exonic | IRF1 | nonsynonymous | CESC|1|194|0.00515 |
| - | chr5 | 131820129 | 131820129 | C | G | exonic | IRF1 | nonsynonymous | CESC|1|194|0.00515 |
| - | chr5 | 131822029 | 131822029 | T | A | exonic | IRF1 | nonsynonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr5 | 131820190 | 131820190 | C | A | splicing | IRF1 | splicing | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr5 | 131820191 | 131820191 | T | C | splicing | IRF1 | splicing | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr5 | 131821980 | 131821980 | G | T | exonic | IRF1 | stopgain | ESCA|1|185|0.00541 |
| rs768359746 | chr5 | 131822063 | 131822063 | G | A | exonic | IRF1 | synonymous | HNSC|1|512|0.00195 |
| rs759014983 | chr5 | 131822766 | 131822766 | G | A | exonic | IRF1 | nonsynonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr5 | 131825149 | 131825149 | T | C | exonic | IRF1 | nonsynonymous | DLBC|1|48|0.02083 |
| - | chr5 | 131822507 | 131822507 | - | A | exonic | IRF1 | stopgain | THYM|1|123|0.00813 |
| - | chr5 | 131821943 | 131821943 | C | G | exonic | IRF1 | nonsynonymous | UCEC|1|248|0.00403 |
| - | chr5 | 131819667 | 131819667 | G | C | exonic | IRF1 | nonsynonymous | BLCA|1|396|0.00253 |
| rs201186445 | chr5 | 131820175 | 131820175 | C | T | exonic | IRF1 | synonymous | PAAD|1|185|0.00541 |
| - | chr5 | 131823676 | 131823676 | C | T | exonic | IRF1 | synonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr5 | 131825243 | 131825243 | A | C | intronic | IRF1 | unknown | BRCA|1|982|0.00102 |
| - | chr5 | 131822746 | 131822746 | C | A | exonic | IRF1 | synonymous | GBMLGG|1|820|0.00122,LGG|1|530|0.00189 |
| rs769107060 | chr5 | 131822515 | 131822515 | C | T | exonic | IRF1 | nonsynonymous | GBMLGG|1|820|0.00122,LGG|1|530|0.00189 |
| - | chr5 | 131823680 | 131823680 | G | A | exonic | IRF1 | nonsynonymous | GBMLGG|1|820|0.00122,LGG|1|530|0.00189 |
| - | chr5 | 131821409 | 131821409 | C | T | splicing | IRF1 | splicing | PAAD|1|185|0.00541 |
| - | chr5 | 131822820 | 131822820 | G | A | exonic | IRF1 | stopgain | HNSC|1|512|0.00195 |
| - | chr5 | 131820178 | 131820178 | C | A | exonic | IRF1 | nonsynonymous | GBMLGG|1|820|0.00122,LGG|1|530|0.00189 |
| - | chr5 | 131822653 | 131822653 | C | G | exonic | IRF1 | nonsynonymous | LUSC|1|178|0.00562 |
| - | chr5 | 131825125 | 131825125 | T | G | exonic | IRF1 | nonsynonymous | LIHC|1|373|0.00268 |
| - | chr5 | 131821389 | 131821389 | C | T | exonic | IRF1 | synonymous | KIPAN|1|799|0.00125,KIRC|1|451|0.00222 |
| - | chr5 | 131820150 | 131820150 | C | G | exonic | IRF1 | nonsynonymous | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| - | chr5 | 131820142 | 131820142 | C | - | exonic | IRF1 | frameshift | COAD|1|367|0.00272,COADREAD|1|489|0.00204 |
| rs756898983 | chr5 | 131819646 | 131819646 | C | T | exonic | IRF1 | synonymous | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr5 | 131825157 | 131825157 | C | A | exonic | IRF1 | nonsynonymous | SKCM|1|368|0.00272 |
| - | chr5 | 131822005 | 131822005 | A | - | exonic | IRF1 | frameshift | STAD|1|395|0.00253,STES|1|395|0.00253 |
| - | chr5 | 131823640 | 131823640 | G | A | exonic | IRF1 | synonymous | CESC|1|194|0.00515 |
| - | chr5 | 131819709 | 131819709 | G | C | exonic | IRF1 | synonymous | HNSC|1|512|0.00195 |
| - | chr5 | 131820143 | 131820143 | C | T | exonic | IRF1 | nonsynonymous | HNSC|2|512|0.00391 |
| - | chr5 | 131825145 | 131825145 | C | T | exonic | IRF1 | nonsynonymous | HNSC|2|512|0.00391 |
| TF_name | Disease_name | Disease_class | Disease_semantic_type | TF_disease_source |
|---|---|---|---|---|
| IRF1 | Cytopenia | Pathologic Function | GENOMICS_ENGLAND | |
| IRF1 | Lung Neoplasms | C04;C08 | Neoplastic Process | CTD_human |
| IRF1 | Malignant neoplasm of stomach | C04;C06 | Neoplastic Process | CGI;CTD_human |
| IRF1 | Stomach Neoplasms | C04;C06 | Neoplastic Process | CGI;CTD_human |
| IRF1 | Cerebrovascular accident | C10;C14 | Disease or Syndrome | CTD_human |
| IRF1 | Injuries, Acute Brain | C10;C26 | Injury or Poisoning | CTD_human |
| IRF1 | Myocardial Ischemia | C14 | Disease or Syndrome | CTD_human |
| IRF1 | Benign neoplasm of stomach | Neoplastic Process | CGI | |
| IRF1 | Carcinoma in situ of stomach | Neoplastic Process | CGI | |
| IRF1 | Congenital anemia | Disease or Syndrome | GENOMICS_ENGLAND | |
| IRF1 | Malignant neoplasm of lung | C04;C08 | Neoplastic Process | CTD_human |
| IRF1 | Brain Injuries | C10;C26 | Injury or Poisoning | CTD_human |
| IRF1 | Brain Lacerations | C10;C26 | Injury or Poisoning | CTD_human |
| IRF1 | Brain Injuries, Focal | C10;C26 | Injury or Poisoning | CTD_human |
| IRF1 | Neoplasm of uncertain or unknown behavior of stomach | Neoplastic Process | CGI | |
| IRF1 | Stomach Carcinoma | Neoplastic Process | CGI;UNIPROT | |
| IRF1 | Acute Cerebrovascular Accidents | C10;C14 | Disease or Syndrome | CTD_human |
| IRF1 | Hereditary Diffuse Gastric Cancer | C04;C06 | Neoplastic Process | CTD_human |
| IRF1 | GASTRIC CANCER, INTESTINAL | Neoplastic Process | UNIPROT |
| pathway_ID | pathway_name | pathway_source | gene_number | edge_number |
|---|---|---|---|---|
| pathway0000916 | Glucocorticoid receptor regulatory network | pid | 85 | 876 |
| pathway0001079 | IFN-gamma pathway | pid | 43 | 345 |
| pathway0001117 | IL12 signaling mediated by STAT4 | pid | 33 | 229 |
| pathway0001131 | IL6-mediated signaling events | pid | 48 | 426 |
| pathway0001180 | Interferon alpha/beta signaling | reactome | 67 | 378 |
| pathway0001861 | Regulation of Telomerase | pid | 70 | 708 |
| pathway0002282 | TRAF6 mediated IRF7 activation | reactome | 33 | 184 |
| pathway0002655 | Hepatitis C | kegg | 134 | 1627 |
| pathway0002686 | Hs_Tryptophan_metabolism_WP465_85055 | wikipathways | 45 | 103 |
| GO_term_name | GO_term_type | TF_name |
|---|---|---|
| GO_REGULATION_OF_INTERFERON_BETA_PRODUCTION | BP | IRF1 |
| GO_REGULATION_OF_ALPHA_BETA_T_CELL_ACTIVATION | BP | IRF1 |
| GO_REGULATION_OF_ADAPTIVE_IMMUNE_RESPONSE | BP | IRF1 |
| GO_ALPHA_BETA_T_CELL_DIFFERENTIATION | BP | IRF1 |
| GO_CYTOKINE_MEDIATED_SIGNALING_PATHWAY | BP | IRF1 |
| GO_RESPONSE_TO_INTERFERON_BETA | BP | IRF1 |
| GO_REGULATION_OF_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY | BP | IRF1 |
| GO_POSITIVE_REGULATION_OF_INTERLEUKIN_12_PRODUCTION | BP | IRF1 |
| GO_CELLULAR_RESPONSE_TO_INTERFERON_GAMMA | BP | IRF1 |
| GO_POSITIVE_REGULATION_OF_INTERFERON_BETA_PRODUCTION | BP | IRF1 |
| GO_REGULATION_OF_RESPONSE_TO_STRESS | BP | IRF1 |
| GO_REGULATION_OF_LYMPHOCYTE_DIFFERENTIATION | BP | IRF1 |
| GO_REGULATION_OF_REGULATORY_T_CELL_DIFFERENTIATION | BP | IRF1 |
| GO_REGULATION_OF_T_CELL_DIFFERENTIATION | BP | IRF1 |
| GO_INTERFERON_GAMMA_MEDIATED_SIGNALING_PATHWAY | BP | IRF1 |
| GO_REGULATION_OF_CYTOKINE_BIOSYNTHETIC_PROCESS | BP | IRF1 |
| GO_NEGATIVE_REGULATION_OF_T_CELL_DIFFERENTIATION | BP | IRF1 |
| GO_REGULATION_OF_CELL_ADHESION | BP | IRF1 |
| GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER | BP | IRF1 |
| GO_NEGATIVE_REGULATION_OF_CELL_ADHESION | BP | IRF1 |
| GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_DIFFERENTIATION | BP | IRF1 |
| GO_T_CELL_DIFFERENTIATION | BP | IRF1 |
| GO_CELLULAR_RESPONSE_TO_MECHANICAL_STIMULUS | BP | IRF1 |
| GO_REGULATION_OF_ALPHA_BETA_T_CELL_PROLIFERATION | BP | IRF1 |
| GO_REGULATION_OF_TYPE_I_INTERFERON_PRODUCTION | BP | IRF1 |
| GO_CELL_CYCLE_PROCESS | BP | IRF1 |
| GO_HEMOSTASIS | BP | IRF1 |
| GO_CELLULAR_RESPONSE_TO_INTERFERON_BETA | BP | IRF1 |
| GO_REGULATION_OF_INTERLEUKIN_12_PRODUCTION | BP | IRF1 |
| GO_NEGATIVE_REGULATION_OF_LYMPHOCYTE_DIFFERENTIATION | BP | IRF1 |
| GO_TRANSCRIPTIONAL_ACTIVATOR_ACTIVITY_RNA_POLYMERASE_II_CORE_PROMOTER_PROXIMAL_REGION_SEQUENCE_SPECIFIC_BINDING | MF | IRF1 |