Cancer CRCdb

TF information

TF name:	MYCN
TF family:	bHLH
Ensembl gene ID:	ENSG00000134323
Ensembl protein ID:	ENSP00000281043, ENSP00000491476
Entrez gene ID:	4613

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of MYCN in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_02_095	Cell line	Mammary Gland	MDA-MB-468	0.3988326848249

MYCN distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name

MYCN distribution in all CRCs

Genomic distribution of SEs associated with MYCN

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Mutation of MYCN

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of MYCN

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr2	16085827	16085827	C	T	exonic	MYCN	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr2	16086192	16086192	G	A	exonic	MYCN	synonymous	SKCM\|2\|368\|0.00543
-	chr2	16085863	16085863	C	A	exonic	MYCN	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr2	16082333	16082333	C	G	exonic	MYCN	nonsynonymous	BLCA\|2\|396\|0.00505
-	chr2	16082485	16082485	G	T	exonic	MYCN	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr2	16082320	16082320	C	G	exonic	MYCN	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs752702966	chr2	16085916	16085916	C	T	exonic	MYCN	synonymous	SKCM\|1\|368\|0.00272
rs144939456	chr2	16085728	16085728	C	T	exonic	MYCN	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|2\|489\|0.00409,PAAD\|1\|185\|0.00541,READ\|1\|122\|0.00820
-	chr2	16086025	16086025	T	A	exonic	MYCN	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr2	16082320	16082320	-	G	exonic	MYCN	frameshift	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr2	16085917	16085917	C	A	exonic	MYCN	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr2	16082548	16082548	C	T	exonic	MYCN	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr2	16082453	16082453	C	A	exonic	MYCN	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs780080562	chr2	16082313	16082313	-	C	exonic	MYCN	frameshift	BRCA\|2\|982\|0.00204
-	chr2	16086111	16086111	T	A	exonic	MYCN	stopgain	SKCM\|1\|368\|0.00272
-	chr2	16086001	16086001	C	T	exonic	MYCN	nonsynonymous	PRAD\|1\|499\|0.00200
-	chr2	16082194	16082194	G	T	exonic	MYCN	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr2	16085886	16085886	G	T	exonic	MYCN	synonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr2	16085834	16085834	C	T	exonic	MYCN	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr2	16085893	16085893	C	T	exonic	MYCN	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr2	16085670	16085670	G	A	exonic	MYCN	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr2	16082936	16082936	G	T	exonic	MYCN	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr2	16082314	16082314	C	-	exonic	MYCN	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,STAD\|5\|395\|0.01266,STES\|5\|395\|0.01266
-	chr2	16086157	16086157	G	A	exonic	MYCN	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr2	16082258	16082258	A	G	exonic	MYCN	synonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr2	16082542	16082542	G	T	exonic	MYCN	nonsynonymous	BLCA\|1\|396\|0.00253
rs755948961	chr2	16085739	16085739	C	T	exonic	MYCN	synonymous	SKCM\|1\|368\|0.00272
-	chr2	16086058	16086058	G	C	exonic	MYCN	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr2	16085831	16085831	C	T	exonic	MYCN	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr2	16082735	16082735	C	T	exonic	MYCN	synonymous	HNSC\|1\|512\|0.00195
-	chr2	16082189	16082189	G	A	exonic	MYCN	nonsynonymous	LUSC\|1\|178\|0.00562
rs773995882	chr2	16082556	16082556	G	A	exonic	MYCN	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr2	16085942	16085942	G	A	exonic	MYCN	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
rs760276350	chr2	16085898	16085898	G	T	exonic	MYCN	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr2	16082272	16082272	A	-	exonic	MYCN	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr2	16082705	16082705	C	T	exonic	MYCN	synonymous	LIHC\|1\|373\|0.00268
-	chr2	16085691	16085691	C	T	exonic	MYCN	synonymous	BLCA\|1\|396\|0.00253
rs868623724	chr2	16082199	16082199	T	A	exonic	MYCN	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr2	16082291	16082291	C	T	exonic	MYCN	synonymous	BLCA\|2\|396\|0.00505
-	chr2	16085778	16085778	G	T	exonic	MYCN	synonymous	LUAD\|1\|543\|0.00184
-	chr2	16082277	16082277	G	A	exonic	MYCN	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr2	16082244	16082244	G	C	exonic	MYCN	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr2	16082270	16082270	C	T	exonic	MYCN	synonymous	LUAD\|2\|543\|0.00368
rs753698437	chr2	16085955	16085955	G	A	exonic	MYCN	synonymous	ESCA\|1\|185\|0.00541
rs751918450	chr2	16082519	16082519	C	T	exonic	MYCN	synonymous	LUSC\|1\|178\|0.00562
-	chr2	16082321	16082321	G	-	exonic	MYCN	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr2	16085898	16085898	G	A	exonic	MYCN	synonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr2	16085828	16085828	C	T	exonic	MYCN	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr2	16085904	16085904	G	A	exonic	MYCN	synonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
rs774985441	chr2	16085786	16085786	A	G	exonic	MYCN	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr2	16085953	16085953	T	A	exonic	MYCN	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr2	16082732	16082732	G	T	exonic	MYCN	synonymous	BLCA\|1\|396\|0.00253
-	chr2	16086128	16086128	C	T	exonic	MYCN	nonsynonymous	CESC\|1\|194\|0.00515
-	chr2	16082186	16082186	G	A	exonic	MYCN	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr2	16082317	16082317	C	A	exonic	MYCN	nonsynonymous	COAD\|2\|367\|0.00545,COADREAD\|2\|489\|0.00409
-	chr2	16086094	16086094	A	-	exonic	MYCN	frameshift	PAAD\|1\|185\|0.00541
-	chr2	16086175	16086175	C	G	exonic	MYCN	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr2	16085981	16085981	A	G	exonic	MYCN	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr2	16082395	16082395	A	T	exonic	MYCN	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr2	16085807	16085807	A	G	exonic	MYCN	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr2	16082311	16082311	C	T	exonic	MYCN	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr2	16086029	16086029	T	C	exonic	MYCN	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr2	16085781	16085781	C	T	exonic	MYCN	synonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr2	16082739	16082739	G	C	exonic	MYCN	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr2	16086021	16086021	C	T	exonic	MYCN	synonymous	SKCM\|1\|368\|0.00272
-	chr2	16086120	16086120	C	A	exonic	MYCN	synonymous	SKCM\|1\|368\|0.00272
-	chr2	16082286	16082286	G	T	exonic	MYCN	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr2	16085650	16085650	G	T	exonic	MYCN	stopgain	SKCM\|1\|368\|0.00272
rs373661257	chr2	16085655	16085655	C	T	exonic	MYCN	synonymous	UCEC\|1\|248\|0.00403
-	chr2	16086010	16086010	G	C	exonic	MYCN	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
rs776847158	chr2	16085680	16085680	C	T	exonic	MYCN	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr2	16082411	16082411	G	T	exonic	MYCN	synonymous	LUSC\|1\|178\|0.00562
-	chr2	16082317	16082317	C	T	exonic	MYCN	nonsynonymous	UCEC\|2\|248\|0.00806
-	chr2	16082254	16082254	C	A	exonic	MYCN	stopgain	LUAD\|1\|543\|0.00184
-	chr2	16086030	16086030	C	T	exonic	MYCN	synonymous	LUSC\|1\|178\|0.00562
-	chr2	16086016	16086016	C	T	exonic	MYCN	nonsynonymous	HNSC\|1\|512\|0.00195,SKCM\|2\|368\|0.00543
-	chr2	16086019	16086019	T	A	exonic	MYCN	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr2	16082220	16082220	A	G	exonic	MYCN	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr2	16086130	16086130	G	A	exonic	MYCN	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr2	16085629	16085629	G	A	exonic	MYCN	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
rs775092426	chr2	16085897	16085897	C	T	exonic	MYCN	nonsynonymous	OV\|1\|469\|0.00213
rs140581169	chr2	16085729	16085729	G	A	exonic	MYCN	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr2	16082322	16082322	G	A	exonic	MYCN	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr2	16082801	16082801	G	T	exonic	MYCN	synonymous	BLCA\|1\|396\|0.00253
-	chr2	16082359	16082359	C	T	exonic	MYCN	nonsynonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr2	16085913	16085913	C	-	exonic	MYCN	frameshift	PRAD\|1\|499\|0.00200
-	chr2	16085979	16085979	C	A	exonic	MYCN	nonsynonymous	TGCT\|1\|155\|0.00645

Disease information of MYCN

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
MYCN	Autosome Abnormalities	C23	Cell or Molecular Dysfunction	CTD_human
MYCN	Basal cell carcinoma	C04	Neoplastic Process	CTD_human
MYCN	Neoplastic Cell Transformation	C04;C23	Neoplastic Process	CTD_human
MYCN	Chromosome Aberrations	C23	Cell or Molecular Dysfunction	CTD_human
MYCN	Adenoid Cystic Carcinoma	C04	Neoplastic Process	CTD_human
MYCN	Hyperplasia	C23	Pathologic Function	CTD_human
MYCN	Medulloblastoma	C04	Neoplastic Process	CTD_human
MYCN	Necrosis	C23	Organ or Tissue Function	CTD_human
MYCN	Nephroblastoma	C04;C12;C13;C16	Neoplastic Process	CTD_human
MYCN	Neuroblastoma	C04	Neoplastic Process	CGI;CTD_human;ORPHANET
MYCN	Medullomyoblastoma	C04	Neoplastic Process	CTD_human
MYCN	Childhood Medulloblastoma	C04	Neoplastic Process	CTD_human
MYCN	Adult Medulloblastoma	C04	Neoplastic Process	CTD_human
MYCN	Primary microcephaly		Congenital Abnormality	GENOMICS_ENGLAND
MYCN	Desmoplastic Medulloblastoma	C04	Neoplastic Process	CTD_human
MYCN	Familial Retinoblastoma	C04;C11	Neoplastic Process	ORPHANET
MYCN	Oculodigitoesophagoduodenal syndrome	C05;C06;C08;C10;C16;C23;F01;F03	Disease or Syndrome	CTD_human;ORPHANET;UNIPROT
MYCN	Melanotic medulloblastoma	C04	Neoplastic Process	CTD_human
MYCN	Pigmented Basal Cell Carcinoma	C04	Neoplastic Process	CTD_human
MYCN	Esophageal atresia with or without tracheoesophageal fistula	C06;C08;C16;C23	Disease or Syndrome	CTD_human
MYCN	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	C04;C15;C20	Neoplastic Process	CTD_human
MYCN	Bilateral Wilms Tumor	C04;C12;C13;C16	Disease or Syndrome	CTD_human
MYCN	Neural crest tumor	C04;C19	Disease or Syndrome	ORPHANET
MYCN	Intellectual Disability	C10;C23;F01;F03	Mental or Behavioral Dysfunction	GENOMICS_ENGLAND

Pathway associated with MYCN

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number
pathway0002757	Hs_Pathways_Affected_in_Adenoid_Cystic_Carcinoma_WP3651_89271	wikipathways	27	108

Go term information of MYCN

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GO_term_name	GO_term_type	TF_name
GO_EMBRYO_DEVELOPMENT_ENDING_IN_BIRTH_OR_EGG_HATCHING	BP	MYCN
GO_NEGATIVE_REGULATION_OF_CELL_DEVELOPMENT	BP	MYCN
GO_NEGATIVE_REGULATION_OF_KINASE_ACTIVITY	BP	MYCN
GO_EMBRYONIC_DIGIT_MORPHOGENESIS	BP	MYCN
GO_NEGATIVE_REGULATION_OF_GLIOGENESIS	BP	MYCN
GO_EMBRYONIC_SKELETAL_SYSTEM_DEVELOPMENT	BP	MYCN
GO_NEGATIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS	BP	MYCN
GO_REGULATION_OF_KINASE_ACTIVITY	BP	MYCN
GO_TISSUE_MORPHOGENESIS	BP	MYCN
GO_NEGATIVE_REGULATION_OF_GLIAL_CELL_DIFFERENTIATION	BP	MYCN
GO_NEGATIVE_REGULATION_OF_ASTROCYTE_DIFFERENTIATION	BP	MYCN
GO_REGULATION_OF_ASTROCYTE_DIFFERENTIATION	BP	MYCN
GO_REGULATION_OF_MESENCHYMAL_CELL_PROLIFERATION	BP	MYCN
GO_CELL_AGGREGATION	BP	MYCN
GO_POSITIVE_REGULATION_OF_CELL_DEATH	BP	MYCN
GO_REGULATION_OF_EPIDERMAL_CELL_DIFFERENTIATION	BP	MYCN
GO_CONNECTIVE_TISSUE_DEVELOPMENT	BP	MYCN
GO_REGULATION_OF_GLIAL_CELL_DIFFERENTIATION	BP	MYCN
GO_RESPIRATORY_SYSTEM_DEVELOPMENT	BP	MYCN
GO_POSITIVE_REGULATION_OF_MESENCHYMAL_CELL_PROLIFERATION	BP	MYCN
GO_POSITIVE_REGULATION_OF_STEM_CELL_PROLIFERATION	BP	MYCN
GO_REGULATION_OF_GLIOGENESIS	BP	MYCN
GO_BRANCHING_MORPHOGENESIS_OF_AN_EPITHELIAL_TUBE	BP	MYCN
GO_SKELETAL_SYSTEM_MORPHOGENESIS	BP	MYCN

Survival analysis of MYCN

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of MYCN

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)