Cancer CRCdb

Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_02_095	Cell line	Mammary Gland	MDA-MB-468	0.44902723735409

Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of GRHL1

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr2	10136458	10136458	C	T	exonic	GRHL1	stopgain	UCEC\|2\|248\|0.00806
-	chr2	10139097	10139097	C	T	exonic	GRHL1	nonsynonymous	BLCA\|1\|396\|0.00253
rs752155021	chr2	10126392	10126392	C	T	exonic	GRHL1	synonymous	BLCA\|1\|396\|0.00253
-	chr2	10140759	10140759	A	G	exonic	GRHL1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr2	10130874	10130874	A	G	exonic	GRHL1	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs141487705	chr2	10101440	10101440	C	T	exonic	GRHL1	nonsynonymous	PAAD\|1\|185\|0.00541
rs868069554	chr2	10102621	10102621	G	A	exonic	GRHL1	nonsynonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr2	10098918	10098918	C	G	exonic	GRHL1	nonsynonymous	BRCA\|1\|982\|0.00102
rs371814208	chr2	10105499	10105499	G	A	exonic	GRHL1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr2	10136520	10136520	G	C	exonic	GRHL1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr2	10095163	10095163	C	T	exonic	GRHL1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr2	10095050	10095050	G	C	exonic	GRHL1	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr2	10136041	10136041	G	T	exonic	GRHL1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr2	10101349	10101349	G	A	exonic	GRHL1	synonymous	LUAD\|1\|543\|0.00184
-	chr2	10095062	10095062	T	C	exonic	GRHL1	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr2	10136059	10136059	C	T	exonic	GRHL1	nonsynonymous	HNSC\|1\|512\|0.00195,SKCM\|1\|368\|0.00272
rs140008573	chr2	10105420	10105420	C	A	exonic	GRHL1	nonsynonymous	CESC\|1\|194\|0.00515
rs766376962	chr2	10101458	10101458	C	T	exonic	GRHL1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr2	10098938	10098938	A	G	exonic	GRHL1	synonymous	UCEC\|1\|248\|0.00403
rs755804402	chr2	10136028	10136028	G	A	exonic	GRHL1	synonymous	SKCM\|1\|368\|0.00272
-	chr2	10140748	10140748	T	C	exonic	GRHL1	synonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr2	10095208	10095208	G	A	exonic	GRHL1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs568011556	chr2	10136032	10136032	G	A	exonic	GRHL1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr2	10102641	10102641	-	T	exonic	GRHL1	frameshift	HNSC\|1\|512\|0.00195
-	chr2	10104439	10104439	C	G	exonic	GRHL1	nonsynonymous	OV\|1\|469\|0.00213
-	chr2	10136026	10136026	C	A	exonic	GRHL1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr2	10105483	10105483	C	T	exonic	GRHL1	synonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr2	10105464	10105464	C	T	exonic	GRHL1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr2	10130840	10130840	T	C	exonic	GRHL1	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr2	10104169	10104169	C	T	exonic	GRHL1	stopgain	SKCM\|1\|368\|0.00272
-	chr2	10104149	10104149	A	C	exonic	GRHL1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr2	10132262	10132262	G	A	exonic	GRHL1	synonymous	LIHC\|1\|373\|0.00268
rs746451999	chr2	10105471	10105471	C	T	exonic	GRHL1	synonymous	ACC\|1\|90\|0.01111
-	chr2	10101265	10101265	C	T	exonic	GRHL1	synonymous	SKCM\|1\|368\|0.00272
-	chr2	10101473	10101473	G	C	exonic	GRHL1	nonsynonymous	KIPAN\|2\|799\|0.00250,KIRC\|2\|451\|0.00443
-	chr2	10132140	10132140	G	C	exonic	GRHL1	nonsynonymous	BLCA\|1\|396\|0.00253
rs752756443	chr2	10140799	10140799	-	G	exonic	GRHL1	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr2	10101228	10101228	G	T	exonic	GRHL1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr2	10105480	10105480	C	T	exonic	GRHL1	synonymous	SKCM\|1\|368\|0.00272
-	chr2	10132201	10132201	T	C	exonic	GRHL1	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr2	10132275	10132275	G	A	splicing	GRHL1	splicing	LUAD\|1\|543\|0.00184
-	chr2	10095215	10095215	C	G	exonic	GRHL1	synonymous	BLCA\|1\|396\|0.00253
-	chr2	10136044	10136044	G	A	exonic	GRHL1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr2	10136062	10136062	T	G	exonic	GRHL1	nonsynonymous	PRAD\|1\|499\|0.00200
-	chr2	10104067	10104067	G	A	exonic	GRHL1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr2	10136085	10136090	AGAACC	-	exonic	GRHL1	nonframeshift	LUAD\|1\|543\|0.00184
rs548450490	chr2	10130834	10130834	G	A	exonic	GRHL1	nonsynonymous	LUAD\|1\|543\|0.00184,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr2	10095217	10095217	A	G	exonic	GRHL1	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr2	10104363	10104363	G	A	splicing	GRHL1	splicing	BLCA\|1\|396\|0.00253
-	chr2	10102598	10102598	G	C	exonic	GRHL1	synonymous	LUAD\|1\|543\|0.00184
-	chr2	10126310	10126310	G	A	exonic	GRHL1	nonsynonymous	BRCA\|1\|982\|0.00102
rs754495603	chr2	10101289	10101289	C	T	exonic	GRHL1	synonymous	DLBC\|1\|48\|0.02083
-	chr2	10104143	10104143	G	A	exonic	GRHL1	nonsynonymous	HNSC\|1\|512\|0.00195
rs140278187	chr2	10101557	10101557	G	A	exonic	GRHL1	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs370119892	chr2	10095093	10095093	C	T	exonic	GRHL1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr2	10132152	10132152	C	T	exonic	GRHL1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs367582209	chr2	10105453	10105453	C	T	exonic	GRHL1	synonymous	BLCA\|1\|396\|0.00253,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253,UCEC\|1\|248\|0.00403
-	chr2	10132193	10132193	C	G	exonic	GRHL1	nonsynonymous	HNSC\|2\|512\|0.00391
rs143356570	chr2	10140825	10140825	C	T	exonic	GRHL1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr2	10126281	10126281	A	G	exonic	GRHL1	synonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr2	10126289	10126289	C	T	exonic	GRHL1	nonsynonymous	BLCA\|2\|396\|0.00505
rs575432176	chr2	10132241	10132241	C	T	exonic	GRHL1	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr2	10105488	10105488	G	A	exonic	GRHL1	stopgain	SKCM\|1\|368\|0.00272
-	chr2	10104056	10104056	G	A	exonic	GRHL1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr2	10105479	10105479	C	T	exonic	GRHL1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr2	10101494	10101494	C	T	exonic	GRHL1	stopgain	BLCA\|1\|396\|0.00253
rs773330664	chr2	10101455	10101455	G	A	exonic	GRHL1	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820,UCEC\|1\|248\|0.00403
-	chr2	10098920	10098920	-	G	exonic	GRHL1	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
rs747569983	chr2	10101324	10101324	C	T	exonic	GRHL1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr2	10130832	10130832	G	A	exonic	GRHL1	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr2	10101410	10101410	C	A	exonic	GRHL1	nonsynonymous	LUAD\|1\|543\|0.00184
rs748306312	chr2	10102611	10102611	C	T	exonic	GRHL1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr2	10126264	10126264	G	T	exonic	GRHL1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr2	10101464	10101464	C	G	exonic	GRHL1	nonsynonymous	BLCA\|1\|396\|0.00253,LUSC\|1\|178\|0.00562
-	chr2	10098951	10098951	G	-	exonic	GRHL1	frameshift	ESCA\|1\|185\|0.00541
rs369646093	chr2	10098934	10098934	C	T	exonic	GRHL1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr2	10101555	10101555	G	A	exonic	GRHL1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr2	10098922	10098922	G	A	exonic	GRHL1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr2	10132227	10132227	C	T	exonic	GRHL1	nonsynonymous	SKCM\|2\|368\|0.00543
-	chr2	10104081	10104081	G	A	exonic	GRHL1	nonsynonymous	LUAD\|1\|543\|0.00184
rs766799953	chr2	10104084	10104084	G	A	exonic	GRHL1	synonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr2	10139100	10139100	A	G	exonic	GRHL1	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr2	10104055	10104055	C	T	exonic	GRHL1	stopgain	UCS\|1\|57\|0.01754
-	chr2	10098918	10098918	C	T	exonic	GRHL1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr2	10126376	10126376	G	C	exonic	GRHL1	nonsynonymous	SKCM\|1\|368\|0.00272
rs773457452	chr2	10091971	10091971	G	A	exonic	GRHL1	synonymous	SKCM\|1\|368\|0.00272
-	chr2	10101374	10101374	G	C	exonic	GRHL1	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr2	10091972	10091972	G	A	exonic	GRHL1	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr2	10132199	10132199	C	T	exonic	GRHL1	synonymous	SKCM\|2\|368\|0.00543
-	chr2	10105481	10105481	T	C	exonic	GRHL1	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr2	10139116	10139116	C	A	exonic	GRHL1	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204

TF name:	GRHL1
TF family:	CP2
Ensembl gene ID:	ENSG00000134317
Ensembl protein ID:	ENSP00000418275, ENSP00000384209, ENSP00000324693
Entrez gene ID:	29841

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

GO_term_name	GO_term_type	TF_name
GO_CHROMATIN_DNA_BINDING	MF	GRHL1
GO_TRANSCRIPTIONAL_ACTIVATOR_ACTIVITY_RNA_POLYMERASE_II_CORE_PROMOTER_PROXIMAL_REGION_SEQUENCE_SPECIFIC_BINDING	MF	GRHL1
GO_STRUCTURE_SPECIFIC_DNA_BINDING	MF	GRHL1

TF information

TCGA somatic mutations and clinical variants of GRHL1

Survival analysis of GRHL1

Expression of GRHL1