Cancer CRCdb

TF information

TF name:	RUNX2
TF family:	Runt
Ensembl gene ID:	ENSG00000124813
Ensembl protein ID:	ENSP00000496517, ENSP00000495497, ENSP00000460188, ENSP00000360491, ENSP00000458178, ENSP00000485863, ENSP00000360486, ENSP00000352514, ENSP00000360493, ENSP00000420707
Entrez gene ID:	860

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of RUNX2 in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_02_006	Other	Cervical	cervical-cancer_parental	0.5
Sample_02_021	Cell line	Colon	V429	0.18276160276737
Sample_02_069	Cell line	Brain	SF268	0.12977099236641
Sample_02_095	Cell line	Mammary Gland	MDA-MB-468	0.45992217898833
Sample_02_182	Cell line	Human melanoma	LOX-IMVI	0.30459770114943
Sample_02_196	Cell line	Stomach	NCC59	0.21428571428571
Sample_02_204	Cell line	Stomach	IM95	0.13636363636364
Sample_02_219	Cell line	Mammary Gland	MDA-MB-231	0.32352941176471
Sample_02_242	Cell line	Colon	V481	0.070979939755175
Sample_02_258	Other	Lung	NCI-H1299_EGFP-NEO_reporter_cells_DMSO	0.16
Sample_02_267	Cell line	Kidney	786-O	0.5
Sample_02_268	Cell line	Kidney	A-498	0.43695772567842
Sample_02_280	Cell line	Mammary Gland	SUM159_DMSO_24h	0.13333333333333
Sample_02_323	Cell line	Colon	RKO	0.5
Sample_02_358	Cell line	Colon	LS180	0.24881516587678

RUNX2 distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name
Sample_02_267	Kidney	Cell line	786-O
Sample_02_323	Colon	Cell line	RKO

RUNX2 distribution in all CRCs

Genomic distribution of SEs associated with RUNX2

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Mutation of RUNX2

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of RUNX2

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr6	45515018	45515018	T	G	exonic	RUNX2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	45480107	45480107	G	A	exonic	RUNX2	synonymous	LUSC\|1\|178\|0.00562
rs12173874	chr6	45459784	45459784	G	A	exonic	RUNX2	synonymous	SKCM\|1\|368\|0.00272
-	chr6	45514594	45514594	C	G	exonic	RUNX2	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr6	45405688	45405688	G	C	exonic	RUNX2	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr6	45390650	45390650	C	A	exonic	RUNX2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	45514809	45514809	C	A	exonic	RUNX2	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr6	45390498	45390498	C	A	exonic	RUNX2	nonsynonymous	TGCT\|1\|155\|0.00645
-	chr6	45515014	45515014	T	-	exonic	RUNX2	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	45514747	45514747	C	A	exonic	RUNX2	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr6	45405707	45405707	A	G	exonic	RUNX2	nonsynonymous	KICH\|1\|66\|0.01515,KIPAN\|1\|799\|0.00125
-	chr6	45390448	45390448	G	A	exonic	RUNX2	synonymous	BLCA\|1\|396\|0.00253,PAAD\|2\|185\|0.01081
-	chr6	45390488	45390504	GCGGCGGCGGCGGCTGC	-	exonic	RUNX2	frameshift	BLCA\|1\|396\|0.00253
-	chr6	45405785	45405785	A	C	exonic	RUNX2	synonymous	BLCA\|1\|396\|0.00253
rs775204103	chr6	45296446	45296446	A	-	UTR5	RUNX2	unknown	ESCA\|2\|185\|0.01081,LUAD\|1\|543\|0.00184,PAAD\|1\|185\|0.00541,STAD\|4\|395\|0.01013,STES\|4\|395\|0.01013
rs563987595	chr6	45390445	45390445	A	G	exonic	RUNX2	synonymous	KIPAN\|2\|799\|0.00250,KIRP\|2\|282\|0.00709,PAAD\|2\|185\|0.01081,PCPG\|1\|184\|0.00543,PRAD\|1\|499\|0.00200,SKCM\|1\|368\|0.00272,TGCT\|1\|155\|0.00645,THCA\|2\|504\|0.00397
-	chr6	45390427	45390427	G	A	exonic	RUNX2	synonymous	HNSC\|1\|512\|0.00195
rs746114073	chr6	45480082	45480082	C	T	exonic	RUNX2	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr6	45514821	45514821	A	G	exonic	RUNX2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr6	45480142	45480142	C	A	exonic	RUNX2	stopgain	BRCA\|1\|982\|0.00102
-	chr6	45515017	45515017	A	-	exonic	RUNX2	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	45399648	45399648	G	A	exonic	RUNX2	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr6	45480078	45480078	-	C	exonic	RUNX2	frameshift	CESC\|1\|194\|0.00515
rs377128508	chr6	45459753	45459753	A	G	exonic	RUNX2	nonsynonymous	KICH\|1\|66\|0.01515,KIPAN\|1\|799\|0.00125
-	chr6	45514984	45514984	C	A	exonic	RUNX2	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr6	45515041	45515041	G	T	exonic	RUNX2	stoploss	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
rs746700872	chr6	45514845	45514845	C	T	exonic	RUNX2	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr6	45390514	45390514	G	A	exonic	RUNX2	synonymous	ACC\|2\|90\|0.02222
-	chr6	45514903	45514903	C	T	exonic	RUNX2	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr6	45399653	45399653	T	-	exonic	RUNX2	frameshift	UCEC\|1\|248\|0.00403
rs770452837	chr6	45514681	45514681	C	T	exonic	RUNX2	nonsynonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr6	45514707	45514707	G	A	exonic	RUNX2	nonsynonymous	COADREAD\|1\|489\|0.00204,OV\|1\|469\|0.00213,READ\|1\|122\|0.00820
-	chr6	45390447	45390448	AG	-	exonic	RUNX2	frameshift	PAAD\|6\|185\|0.03243,SKCM\|1\|368\|0.00272,THYM\|1\|123\|0.00813
-	chr6	45399754	45399754	G	A	exonic	RUNX2	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr6	45514839	45514839	C	G	exonic	RUNX2	nonsynonymous	BLCA\|1\|396\|0.00253
rs776247579	chr6	45405709	45405709	C	T	exonic	RUNX2	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs746139832	chr6	45513000	45513000	C	T	exonic	RUNX2	synonymous	BRCA\|1\|982\|0.00102
rs104893995	chr6	45399682	45399682	G	A	exonic	RUNX2	nonsynonymous	BRCA\|1\|982\|0.00102,SKCM\|1\|368\|0.00272
-	chr6	45480048	45480048	C	G	exonic	RUNX2	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr6	45405777	45405777	G	T	exonic	RUNX2	nonsynonymous	HNSC\|1\|512\|0.00195
rs114654066	chr6	45390356	45390356	C	A	exonic	RUNX2	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr6	45514992	45514992	G	T	exonic	RUNX2	nonsynonymous	SARC\|1\|247\|0.00405
-	chr6	45480058	45480058	C	T	exonic	RUNX2	nonsynonymous	CESC\|1\|194\|0.00515
-	chr6	45480128	45480128	G	A	exonic	RUNX2	synonymous	SKCM\|1\|368\|0.00272
-	chr6	45390504	45390505	CG	-	exonic	RUNX2	frameshift	ESCA\|1\|185\|0.00541
rs397515538	chr6	45390354	45390354	-	C	exonic	RUNX2	frameshift	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr6	45399750	45399750	G	T	exonic	RUNX2	stopgain	BRCA\|1\|982\|0.00102
-	chr6	45514801	45514801	C	G	exonic	RUNX2	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr6	45514577	45514577	G	-	exonic	RUNX2	frameshift	BLCA\|1\|396\|0.00253
-	chr6	45399733	45399733	G	T	exonic	RUNX2	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr6	45514679	45514679	C	T	exonic	RUNX2	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr6	45399640	45399640	C	T	exonic	RUNX2	nonsynonymous	CESC\|1\|194\|0.00515,UCEC\|1\|248\|0.00403
-	chr6	45480097	45480097	G	A	exonic	RUNX2	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr6	45459688	45459688	G	A	exonic	RUNX2	synonymous	PAAD\|1\|185\|0.00541
-	chr6	45514719	45514719	A	G	exonic	RUNX2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	45296430	45296430	G	T	UTR5	RUNX2	unknown	BLCA\|1\|396\|0.00253
-	chr6	45399649	45399649	C	T	exonic	RUNX2	nonsynonymous	UCEC\|1\|248\|0.00403
rs776156260	chr6	45296521	45296521	G	A	exonic	RUNX2	nonsynonymous	SKCM\|1\|368\|0.00272
rs147009083	chr6	45405710	45405710	G	A	exonic	RUNX2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	45480092	45480092	C	A	exonic	RUNX2	synonymous	OV\|1\|469\|0.00213
-	chr6	45390463	45390463	G	A	exonic	RUNX2	synonymous	CHOL\|2\|35\|0.05714,GBMLGG\|4\|820\|0.00488,HNSC\|1\|512\|0.00195,KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355,LGG\|4\|530\|0.00755,PAAD\|11\|185\|0.05946,PRAD\|3\|499\|0.00601,THCA\|3\|504\|0.00595
rs756718952	chr6	45514856	45514856	G	A	exonic	RUNX2	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr6	45480007	45480007	C	T	exonic	RUNX2	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr6	45514873	45514873	C	A	exonic	RUNX2	nonsynonymous	KIPAN\|2\|799\|0.00250,KIRC\|2\|451\|0.00443
rs768569177	chr6	45390457	45390457	G	A	exonic	RUNX2	synonymous	TGCT\|1\|155\|0.00645
-	chr6	45514563	45514563	G	A	splicing	RUNX2	splicing	SKCM\|1\|368\|0.00272
rs376891808	chr6	45459744	45459744	G	A	exonic	RUNX2	nonsynonymous	HNSC\|1\|512\|0.00195,PRAD\|1\|499\|0.00200
-	chr6	45514855	45514855	-	G	exonic	RUNX2	frameshift	KIPAN\|2\|799\|0.00250,KIRC\|2\|451\|0.00443,LUAD\|2\|543\|0.00368
-	chr6	45515026	45515026	T	C	exonic	RUNX2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs751811026	chr6	45514872	45514872	C	T	exonic	RUNX2	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr6	45515008	45515008	G	A	exonic	RUNX2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr6	45390499	45390499	G	T	exonic	RUNX2	synonymous	SARC\|1\|247\|0.00405
-	chr6	45480133	45480133	G	T	exonic	RUNX2	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr6	45390604	45390604	C	T	exonic	RUNX2	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs756072084	chr6	45390520	45390520	T	G	exonic	RUNX2	synonymous	LIHC\|1\|373\|0.00268
-	chr6	45480115	45480115	C	T	exonic	RUNX2	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr6	45480097	45480097	G	C	exonic	RUNX2	nonsynonymous	SKCM\|1\|368\|0.00272
rs781003025	chr6	45390460	45390460	G	A	exonic	RUNX2	synonymous	ESCA\|1\|185\|0.00541,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs776221631	chr6	45480063	45480063	T	C	exonic	RUNX2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr6	45514591	45514591	A	T	exonic	RUNX2	nonsynonymous	ESCA\|1\|185\|0.00541
rs545654311	chr6	45390430	45390430	A	G	exonic	RUNX2	synonymous	HNSC\|1\|512\|0.00195
rs575896136	chr6	45390466	45390466	A	G	exonic	RUNX2	synonymous	BLCA\|1\|396\|0.00253,GBMLGG\|6\|820\|0.00732,HNSC\|1\|512\|0.00195,LGG\|6\|530\|0.01132,LIHC\|3\|373\|0.00804,PAAD\|13\|185\|0.07027,PCPG\|1\|184\|0.00543,PRAD\|5\|499\|0.01002,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253,THCA\|2\|504\|0.00397,UCS\|1\|57\|0.01754
-	chr6	45390432	45390432	A	C	exonic	RUNX2	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr6	45399659	45399659	T	A	exonic	RUNX2	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr6	45514906	45514906	C	T	exonic	RUNX2	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr6	45514837	45514837	A	G	exonic	RUNX2	nonsynonymous	LIHC\|1\|373\|0.00268
rs774631263	chr6	45390482	45390482	C	G	exonic	RUNX2	nonsynonymous	DLBC\|2\|48\|0.04167,GBMLGG\|2\|820\|0.00244,HNSC\|1\|512\|0.00195,LGG\|2\|530\|0.00377,PAAD\|7\|185\|0.03784,PRAD\|1\|499\|0.00200,SKCM\|1\|368\|0.00272,TGCT\|4\|155\|0.02581,UCS\|1\|57\|0.01754
-	chr6	45390581	45390581	G	T	exonic	RUNX2	stopgain	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs748951752	chr6	45296445	45296445	-	A	UTR5	RUNX2	unknown	PAAD\|4\|185\|0.02162,PCPG\|1\|184\|0.00543
-	chr6	45399665	45399665	T	G	exonic	RUNX2	nonsynonymous	UCEC\|1\|248\|0.00403
rs200992166	chr6	45514682	45514682	G	A	exonic	RUNX2	synonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
-	chr6	45459775	45459775	C	A	exonic	RUNX2	synonymous	HNSC\|1\|512\|0.00195
-	chr6	45515016	45515016	G	A	exonic	RUNX2	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr6	45459774	45459774	T	C	exonic	RUNX2	nonsynonymous	UCEC\|1\|248\|0.00403
rs745887977	chr6	45296155	45296155	A	G	UTR5	RUNX2	unknown	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	45390685	45390685	G	A	exonic	RUNX2	synonymous	GBM\|1\|290\|0.00345,GBMLGG\|1\|820\|0.00122
rs369481795	chr6	45514825	45514825	C	T	exonic	RUNX2	nonsynonymous	BLCA\|1\|396\|0.00253,ESCA\|1\|185\|0.00541
-	chr6	45514706	45514706	C	A	exonic	RUNX2	synonymous	LUAD\|1\|543\|0.00184
-	chr6	45459812	45459812	C	T	exonic	RUNX2	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr6	45399744	45399744	C	T	exonic	RUNX2	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr6	45405763	45405763	A	C	exonic	RUNX2	synonymous	LUSC\|1\|178\|0.00562
-	chr6	45514572	45514572	G	T	exonic	RUNX2	stopgain	LUSC\|1\|178\|0.00562
-	chr6	45514918	45514918	-	G	exonic	RUNX2	frameshift	UCEC\|1\|248\|0.00403
rs377403216	chr6	45514961	45514961	C	T	exonic	RUNX2	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	45405767	45405767	G	C	exonic	RUNX2	nonsynonymous	STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr6	45390355	45390355	C	-	exonic	RUNX2	frameshift	COAD\|5\|367\|0.01362,COADREAD\|5\|489\|0.01022,STAD\|2\|395\|0.00506,STES\|2\|395\|0.00506
-	chr6	45390468	45390469	AG	-	exonic	RUNX2	frameshift	PAAD\|1\|185\|0.00541
-	chr6	45480080	45480080	C	A	exonic	RUNX2	synonymous	LUSC\|1\|178\|0.00562
rs748186399	chr6	45390469	45390469	G	A	exonic	RUNX2	synonymous	BLCA\|1\|396\|0.00253,LIHC\|1\|373\|0.00268,PAAD\|1\|185\|0.00541,THCA\|1\|504\|0.00198
-	chr6	45480144	45480144	G	T	exonic	RUNX2	nonsynonymous	UCEC\|1\|248\|0.00403
rs749565421	chr6	45480055	45480055	C	T	exonic	RUNX2	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	45514854	45514854	C	T	exonic	RUNX2	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr6	45390610	45390610	C	G	exonic	RUNX2	synonymous	CESC\|1\|194\|0.00515
-	chr6	45296404	45296404	G	A	UTR5	RUNX2	unknown	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs535268603	chr6	45296101	45296101	C	T	UTR5	RUNX2	unknown	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	45459726	45459726	G	T	exonic	RUNX2	nonsynonymous	LUAD\|1\|543\|0.00184

Disease information of RUNX2

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
RUNX2	Arthritis, Psoriatic	C05;C17	Disease or Syndrome	CTD_human
RUNX2	Rheumatoid Arthritis	C05;C17;C20	Disease or Syndrome	CTD_human
RUNX2	Cleidocranial Dysplasia	C05;C16	Disease or Syndrome	CTD_human;ORPHANET;UNIPROT
RUNX2	Craniosynostosis	C05;C16	Disease or Syndrome	GENOMICS_ENGLAND
RUNX2	Degenerative polyarthritis	C05	Disease or Syndrome	CTD_human
RUNX2	Osteogenesis Imperfecta	C05;C16;C17	Congenital Abnormality; Disease or Syndrome	GENOMICS_ENGLAND
RUNX2	Osteosarcoma	C04	Neoplastic Process	CTD_human
RUNX2	Tooth Abnormalities	C07;C16	Anatomical Abnormality	CTD_human
RUNX2	Uremia	C12;C13	Disease or Syndrome	CTD_human
RUNX2	Osteoarthrosis Deformans	C05	Disease or Syndrome	CTD_human
RUNX2	Stomatognathic System Abnormalities	C07;C16	Congenital Abnormality	CTD_human
RUNX2	Craniofacial Abnormalities	C05;C16	Congenital Abnormality	CTD_human
RUNX2	Odontome	C07;C16	Congenital Abnormality	CTD_human
RUNX2	Spondylarthritis	C05	Disease or Syndrome	CTD_human
RUNX2	Metaphyseal Dysplasia with Maxillary Hypoplasia and Brachydactyly	C05;C16;C23	Disease or Syndrome	CTD_human
RUNX2	CLEIDOCRANIAL DYSPLASIA, FORME FRUSTE, DENTAL ANOMALIES ONLY	C05;C07;C16	Disease or Syndrome	UNIPROT
RUNX2	Cleidocranial Dysplasia, Forme Fruste, With Brachydactyly	C05;C16	Disease or Syndrome	UNIPROT
RUNX2	METAPHYSEAL DYSPLASIA WITH MAXILLARY HYPOPLASIA WITH OR WITHOUT BRACHYDACTYLY		Disease or Syndrome	ORPHANET
RUNX2	Intellectual Disability	C10;C23;F01;F03	Mental or Behavioral Dysfunction	GENOMICS_ENGLAND

Pathway associated with RUNX2

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number
pathway0000780	FGF signaling pathway	pid	55	600
pathway0001516	Notch-mediated HES/HEY network	pid	48	337
pathway0002460	YAP1- and WWTR1 (TAZ)-stimulated gene expression	reactome	29	144
pathway0002725	Hs_Endochondral_Ossification_WP474_87977	wikipathways	43	117
pathway0002726	Hs_Role_of_Osx_and_miRNAs_in_tooth_development_WP3971_91525	wikipathways	9	11
pathway0002770	Hs_Bone_Morphogenic_Protein_(BMP)_Signalling_and_Regulation_WP1425_86082	wikipathways	6	10
pathway0002852	Hs_Focal_Adhesion-PI3K-Akt-mTOR-signaling_pathway_WP3932_91101	wikipathways	8	14

Go term information of RUNX2

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GO_term_name	GO_term_type	TF_name
GO_REGULATION_OF_CELLULAR_RESPONSE_TO_GROWTH_FACTOR_STIMULUS	BP	RUNX2
GO_REGULATION_OF_CARTILAGE_DEVELOPMENT	BP	RUNX2
GO_EMBRYONIC_SKELETAL_SYSTEM_DEVELOPMENT	BP	RUNX2
GO_FORELIMB_MORPHOGENESIS	BP	RUNX2
GO_CHONDROCYTE_DEVELOPMENT	BP	RUNX2
GO_LEUKOCYTE_DIFFERENTIATION	BP	RUNX2
GO_REPLACEMENT_OSSIFICATION	BP	RUNX2
GO_BONE_DEVELOPMENT	BP	RUNX2
GO_EMBRYONIC_FORELIMB_MORPHOGENESIS	BP	RUNX2
GO_CELL_MATURATION	BP	RUNX2
GO_REGULATION_OF_FIBROBLAST_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY	BP	RUNX2
GO_REGULATION_OF_CHONDROCYTE_DIFFERENTIATION	BP	RUNX2
GO_REGULATION_OF_ODONTOGENESIS	BP	RUNX2
GO_NEGATIVE_REGULATION_OF_SMOOTHENED_SIGNALING_PATHWAY	BP	RUNX2
GO_CRANIAL_SKELETAL_SYSTEM_DEVELOPMENT	BP	RUNX2
GO_POSITIVE_REGULATION_OF_CARTILAGE_DEVELOPMENT	BP	RUNX2
GO_REGULATION_OF_SMOOTHENED_SIGNALING_PATHWAY	BP	RUNX2
GO_RESPONSE_TO_BMP	BP	RUNX2
GO_REGULATION_OF_OSTEOBLAST_DIFFERENTIATION	BP	RUNX2
GO_CELL_FATE_COMMITMENT	BP	RUNX2
GO_CONNECTIVE_TISSUE_DEVELOPMENT	BP	RUNX2
GO_ODONTOGENESIS_OF_DENTIN_CONTAINING_TOOTH	BP	RUNX2
GO_POSITIVE_REGULATION_OF_OSTEOBLAST_DIFFERENTIATION	BP	RUNX2
GO_OSTEOBLAST_DEVELOPMENT	BP	RUNX2
GO_BONE_MORPHOGENESIS	BP	RUNX2
GO_ENDOCHONDRAL_BONE_MORPHOGENESIS	BP	RUNX2
GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_INVOLVED_IN_CELLULAR_RESPONSE_TO_CHEMICAL_STIMULUS	BP	RUNX2
GO_POSITIVE_REGULATION_OF_CHONDROCYTE_DIFFERENTIATION	BP	RUNX2
GO_DEVELOPMENTAL_MATURATION	BP	RUNX2
GO_REGULATION_OF_ODONTOGENESIS_OF_DENTIN_CONTAINING_TOOTH	BP	RUNX2
GO_EMBRYONIC_CRANIAL_SKELETON_MORPHOGENESIS	BP	RUNX2
GO_TRANSCRIPTION_FACTOR_COMPLEX	CC	RUNX2
GO_BHLH_TRANSCRIPTION_FACTOR_BINDING	MF	RUNX2
GO_CORE_PROMOTER_BINDING	MF	RUNX2
GO_DOUBLE_STRANDED_DNA_BINDING	MF	RUNX2
GO_RNA_POLYMERASE_II_CORE_PROMOTER_SEQUENCE_SPECIFIC_DNA_BINDING	MF	RUNX2
GO_REPRESSING_TRANSCRIPTION_FACTOR_BINDING	MF	RUNX2
GO_CORE_PROMOTER_SEQUENCE_SPECIFIC_DNA_BINDING	MF	RUNX2

Survival analysis of RUNX2

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of RUNX2

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)