Cancer CRCdb

TF information

TF name:	HIF1A
TF family:	Others
Ensembl gene ID:	ENSG00000100644
Ensembl protein ID:	-
Entrez gene ID:	3091

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of HIF1A in all biosamples

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Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_01_046	Cell line	Mammary Gland	MCF-7	0.2
Sample_02_095	Cell line	Mammary Gland	MDA-MB-468	0.066147859922179
Sample_02_166	Cell line	Mammary Gland	HCC1954_Parental	0.232
Sample_02_219	Cell line	Mammary Gland	MDA-MB-231	0.18627450980392

HIF1A distribution in samples’ most representative CRC

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Sample ID	Tissue type	Biosample type	Biosample name

HIF1A distribution in all CRCs

Genomic distribution of SEs associated with HIF1A

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Mutation of HIF1A

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Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of HIF1A

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr14	62193429	62193429	G	A	exonic	HIF1A	nonsynonymous	PRAD\|1\|499\|0.00200
-	chr14	62193436	62193436	A	G	exonic	HIF1A	nonsynonymous	TGCT\|1\|155\|0.00645
-	chr14	62207863	62207863	C	G	exonic	HIF1A	nonsynonymous	CESC\|1\|194\|0.00515
rs774872613	chr14	62207751	62207751	C	T	exonic	HIF1A	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr14	62193410	62193410	C	T	intronic	HIF1A	unknown	CESC\|1\|194\|0.00515
-	chr14	62207234	62207234	C	A	exonic	HIF1A	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr14	62187153	62187153	G	A	exonic	HIF1A	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,SKCM\|1\|368\|0.00272
rs376459372	chr14	62207545	62207545	G	A	exonic	HIF1A	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr14	62162532	62162532	G	T	exonic	HIF1A	nonsynonymous	TGCT\|1\|155\|0.00645
rs199775054	chr14	62207590	62207590	G	A	exonic	HIF1A	nonsynonymous	TGCT\|1\|155\|0.00645
-	chr14	62200980	62200980	T	C	exonic	HIF1A	synonymous	UCEC\|1\|248\|0.00403
-	chr14	62200933	62200933	C	T	exonic	HIF1A	stopgain	BLCA\|1\|396\|0.00253
-	chr14	62194334	62194334	G	A	exonic	HIF1A	nonsynonymous	UCEC\|1\|248\|0.00403
rs776789375	chr14	62207880	62207880	C	T	exonic	HIF1A	synonymous	UCEC\|1\|248\|0.00403
-	chr14	62187161	62187161	G	T	exonic	HIF1A	stopgain	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr14	62199147	62199147	T	C	exonic	HIF1A	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr14	62188359	62188359	T	C	exonic	HIF1A	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr14	62187261	62187261	A	G	exonic	HIF1A	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr14	62203750	62203750	A	G	exonic	HIF1A	nonsynonymous	THCA\|1\|504\|0.00198
-	chr14	62187184	62187184	T	C	exonic	HIF1A	synonymous	BRCA\|1\|982\|0.00102
-	chr14	62211422	62211422	G	C	splicing	HIF1A	splicing	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr14	62207493	62207493	G	T	exonic	HIF1A	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr14	62194225	62194225	C	-	exonic	HIF1A	frameshift	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr14	62200971	62200971	A	G	exonic	HIF1A	synonymous	UCEC\|1\|248\|0.00403
-	chr14	62193502	62193502	G	T	exonic	HIF1A	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr14	62203800	62203800	A	G	exonic	HIF1A	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr14	62187119	62187119	A	C	exonic	HIF1A	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr14	62213706	62213706	T	C	exonic	HIF1A	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr14	62207599	62207599	C	G	exonic	HIF1A	nonsynonymous	HNSC\|1\|512\|0.00195
-	chr14	62193397	62193397	T	C	intronic	HIF1A	unknown	CESC\|1\|194\|0.00515
-	chr14	62187113	62187113	C	G	exonic	HIF1A	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr14	62193399	62193399	A	C	intronic	HIF1A	unknown	CESC\|1\|194\|0.00515
-	chr14	62200949	62200949	A	T	exonic	HIF1A	nonsynonymous	ESCA\|1\|185\|0.00541
rs781683603	chr14	62204929	62204929	G	A	exonic	HIF1A	synonymous	HNSC\|2\|512\|0.00391
-	chr14	62199183	62199183	C	A	exonic	HIF1A	stopgain	SKCM\|1\|368\|0.00272
-	chr14	62200988	62200988	T	C	exonic	HIF1A	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr14	62207603	62207603	G	A	exonic	HIF1A	nonsynonymous	SKCM\|1\|368\|0.00272
-	chr14	62207710	62207710	G	A	exonic	HIF1A	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr14	62200973	62200973	A	T	exonic	HIF1A	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr14	62212467	62212467	G	A	exonic	HIF1A	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr14	62203736	62203736	C	G	exonic	HIF1A	synonymous	BLCA\|1\|396\|0.00253
-	chr14	62187170	62187170	-	T	exonic	HIF1A	frameshift	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr14	62211509	62211509	C	A	exonic	HIF1A	stopgain	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr14	62193473	62193473	C	G	exonic	HIF1A	synonymous	BRCA\|1\|982\|0.00102
-	chr14	62203609	62203609	G	A	exonic	HIF1A	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr14	62205038	62205038	C	A	exonic	HIF1A	nonsynonymous	SKCM\|1\|368\|0.00272
rs776377120	chr14	62187188	62187188	C	T	exonic	HIF1A	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr14	62212433	62212433	G	A	exonic	HIF1A	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr14	62199237	62199237	A	G	exonic	HIF1A	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr14	62207246	62207246	T	C	exonic	HIF1A	synonymous	BLCA\|1\|396\|0.00253
-	chr14	62211442	62211442	G	T	exonic	HIF1A	stopgain	UCEC\|1\|248\|0.00403
-	chr14	62200986	62200986	T	A	exonic	HIF1A	stopgain	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
rs774190899	chr14	62204876	62204876	G	A	exonic	HIF1A	nonsynonymous	COADREAD\|1\|489\|0.00204,READ\|1\|122\|0.00820
-	chr14	62187241	62187241	G	A	exonic	HIF1A	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr14	62207716	62207716	A	T	exonic	HIF1A	nonsynonymous	LIHC\|2\|373\|0.00536
rs199845303	chr14	62207893	62207893	G	A	exonic	HIF1A	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr14	62207727	62207727	G	A	exonic	HIF1A	synonymous	BLCA\|1\|396\|0.00253
-	chr14	62207260	62207260	G	T	exonic	HIF1A	nonsynonymous	UCS\|1\|57\|0.01754
-	chr14	62200959	62200959	G	T	exonic	HIF1A	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr14	62207347	62207347	T	C	splicing	HIF1A	splicing	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr14	62194217	62194223	ACCAACC	-	exonic	HIF1A	frameshift	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr14	62162552	62162552	G	C	exonic	HIF1A	nonsynonymous	CESC\|1\|194\|0.00515
-	chr14	62207303	62207303	T	G	exonic	HIF1A	synonymous	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
rs761301966	chr14	62213681	62213681	A	G	exonic	HIF1A	nonsynonymous	HNSC\|1\|512\|0.00195,KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr14	62200950	62200950	T	C	exonic	HIF1A	synonymous	PRAD\|1\|499\|0.00200
-	chr14	62187197	62187197	C	-	exonic	HIF1A	frameshift	LUAD\|1\|543\|0.00184
-	chr14	62211492	62211492	A	C	exonic	HIF1A	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr14	62207257	62207257	A	G	exonic	HIF1A	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr14	62193491	62193491	A	G	exonic	HIF1A	synonymous	ESCA\|1\|185\|0.00541,UCEC\|1\|248\|0.00403
-	chr14	62204854	62204854	T	G	exonic	HIF1A	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr14	62204876	62204876	G	T	exonic	HIF1A	stopgain	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr14	62205023	62205023	A	G	exonic	HIF1A	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr14	62188361	62188361	G	T	exonic	HIF1A	stopgain	UCEC\|1\|248\|0.00403
-	chr14	62188501	62188501	T	C	exonic	HIF1A	synonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr14	62207856	62207856	A	T	exonic	HIF1A	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr14	62207904	62207904	A	G	exonic	HIF1A	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr14	62204942	62204942	C	T	exonic	HIF1A	stopgain	BLCA\|1\|396\|0.00253
-	chr14	62207503	62207503	C	G	exonic	HIF1A	nonsynonymous	CESC\|1\|194\|0.00515
-	chr14	62187187	62187187	T	G	exonic	HIF1A	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr14	62211508	62211508	T	C	exonic	HIF1A	nonsynonymous	COAD\|2\|367\|0.00545,COADREAD\|2\|489\|0.00409
-	chr14	62207888	62207888	C	A	exonic	HIF1A	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr14	62200959	62200959	G	A	exonic	HIF1A	synonymous	SKCM\|1\|368\|0.00272
-	chr14	62204914	62204914	A	G	exonic	HIF1A	synonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr14	62212426	62212426	G	T	exonic	HIF1A	nonsynonymous	ESCA\|1\|185\|0.00541
rs768145418	chr14	62187220	62187220	G	A	exonic	HIF1A	synonymous	SARC\|1\|247\|0.00405
rs755629700	chr14	62188256	62188256	G	A	exonic	HIF1A	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr14	62194217	62194225	ACCAACCTC	-	exonic	HIF1A	nonframeshift	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr14	62211433	62211433	C	A	exonic	HIF1A	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr14	62207832	62207832	A	G	exonic	HIF1A	synonymous	PRAD\|1\|499\|0.00200
-	chr14	62199167	62199167	G	T	exonic	HIF1A	stopgain	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,LUAD\|1\|543\|0.00184
rs142614329	chr14	62200996	62200996	G	A	exonic	HIF1A	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr14	62207581	62207581	C	T	exonic	HIF1A	nonsynonymous	ESCA\|1\|185\|0.00541
-	chr14	62207327	62207327	G	T	exonic	HIF1A	nonsynonymous	BRCA\|1\|982\|0.00102,UCEC\|1\|248\|0.00403
-	chr14	62203713	62203713	G	A	exonic	HIF1A	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr14	62187267	62187267	G	C	exonic	HIF1A	nonsynonymous	BLCA\|1\|396\|0.00253
rs761548161	chr14	62207881	62207881	G	A	exonic	HIF1A	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204,ESCA\|1\|185\|0.00541,STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr14	62187117	62187117	G	A	exonic	HIF1A	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr14	62205046	62205046	G	C	exonic	HIF1A	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr14	62207737	62207737	C	T	exonic	HIF1A	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr14	62187224	62187224	C	A	exonic	HIF1A	nonsynonymous	KIPAN\|1\|799\|0.00125,KIRC\|1\|451\|0.00222
-	chr14	62188340	62188340	G	C	exonic	HIF1A	nonsynonymous	CESC\|1\|194\|0.00515
rs755825658	chr14	62203827	62203827	G	A	exonic	HIF1A	nonsynonymous	CESC\|1\|194\|0.00515
rs61755644	chr14	62199180	62199180	G	A	exonic	HIF1A	nonsynonymous	HNSC\|1\|512\|0.00195,PRAD\|1\|499\|0.00200

Disease information of HIF1A

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TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
HIF1A	Anaplasia	C04;C23	Neoplastic Process	CTD_human
HIF1A	Astrocytoma	C04	Neoplastic Process	CTD_human
HIF1A	Bipolar Disorder	F03	Mental or Behavioral Dysfunction	PSYGENET
HIF1A	Malignant neoplasm of breast	C04;C17	Neoplastic Process	CTD_human
HIF1A	Carcinoma	C04	Neoplastic Process	CTD_human
HIF1A	Malignant neoplasm of skin	C04;C17	Neoplastic Process	CTD_human
HIF1A	Noninfiltrating Intraductal Carcinoma	C04	Neoplastic Process	CTD_human
HIF1A	Brain Ischemia	C10;C14	Disease or Syndrome	CTD_human
HIF1A	Primary biliary cirrhosis	C06	Disease or Syndrome	CTD_human
HIF1A	Cholangitis, Sclerosing	C06	Disease or Syndrome	CTD_human
HIF1A	Mental Depression	F01	Mental or Behavioral Dysfunction	PSYGENET
HIF1A	Glioblastoma	C04	Neoplastic Process	CTD_human
HIF1A	Congenital Heart Defects	C14;C16	Congenital Abnormality	CTD_human
HIF1A	Cardiomegaly	C14;C23	Finding	CTD_human
HIF1A	Heart failure	C14	Disease or Syndrome	CTD_human
HIF1A	Congestive heart failure	C14	Disease or Syndrome	CTD_human
HIF1A	Hyperplasia	C23	Pathologic Function	CTD_human
HIF1A	Hypertensive disease	C14	Disease or Syndrome	CTD_human
HIF1A	Pulmonary Hypertension	C08	Pathologic Function	CTD_human
HIF1A	Left-Sided Heart Failure	C14	Disease or Syndrome	CTD_human
HIF1A	Biliary cirrhosis	C06	Disease or Syndrome	CTD_human
HIF1A	Lung diseases	C08	Disease or Syndrome	CTD_human
HIF1A	Myocardial Reperfusion Injury	C14;C23	Pathologic Function	CTD_human
HIF1A	Neoplasm Invasiveness	C04;C23	Pathologic Function	CTD_human
HIF1A	Pancreatic Neoplasm	C04;C06;C19	Neoplastic Process	CTD_human
HIF1A	Prostatic Neoplasms	C04;C12	Neoplastic Process	CTD_human
HIF1A	Radiation Injuries, Experimental	C26	Injury or Poisoning	CTD_human
HIF1A	Skin Neoplasms	C04;C17	Neoplastic Process	CTD_human
HIF1A	Spinal Cord Injuries	C10;C26	Injury or Poisoning	CTD_human
HIF1A	Thyroid Neoplasm	C04;C19	Neoplastic Process	CTD_human
HIF1A	Unipolar Depression	F03	Mental or Behavioral Dysfunction	PSYGENET
HIF1A	Thyroid Gland Follicular Adenoma	C04;C19	Neoplastic Process	CTD_human
HIF1A	Familial erythrocytosis	C15	Disease or Syndrome	GENOMICS_ENGLAND
HIF1A	Cerebral Hypoxia-Ischemia	C10;C14	Disease or Syndrome	CTD_human
HIF1A	Anaplastic carcinoma	C04	Neoplastic Process	CTD_human
HIF1A	Carcinoma, Spindle-Cell	C04	Neoplastic Process	CTD_human
HIF1A	Undifferentiated carcinoma	C04	Neoplastic Process	CTD_human
HIF1A	Carcinomatosis	C04	Neoplastic Process	CTD_human
HIF1A	Subependymal Giant Cell Astrocytoma	C04	Neoplastic Process	CTD_human
HIF1A	Hemangioblastoma	C04	Neoplastic Process	CTD_human
HIF1A	Heart Failure, Right-Sided	C14	Disease or Syndrome	CTD_human
HIF1A	Biliary Cirrhosis, Secondary	C06	Disease or Syndrome	CTD_human
HIF1A	Squamous cell carcinoma of esophagus	C04;C06	Neoplastic Process	CTD_human
HIF1A	Juvenile Pilocytic Astrocytoma	C04	Neoplastic Process	CTD_human
HIF1A	Diffuse Astrocytoma	C04	Neoplastic Process	CTD_human
HIF1A	Anaplastic astrocytoma	C04	Neoplastic Process	CTD_human
HIF1A	Protoplasmic astrocytoma	C04	Neoplastic Process	CTD_human
HIF1A	Gemistocytic astrocytoma	C04	Neoplastic Process	CTD_human
HIF1A	Fibrillary Astrocytoma	C04	Neoplastic Process	CTD_human
HIF1A	Pilocytic Astrocytoma	C04	Neoplastic Process	CTD_human
HIF1A	Giant Cell Glioblastoma	C04	Neoplastic Process	CTD_human
HIF1A	Childhood Cerebral Astrocytoma	C04	Neoplastic Process	CTD_human
HIF1A	Complications of Diabetes Mellitus	C19	Disease or Syndrome	CTD_human
HIF1A	Malignant neoplasm of pancreas	C04;C06;C19	Neoplastic Process	CTD_human
HIF1A	Malignant neoplasm of prostate	C04;C12	Neoplastic Process	CTD_human
HIF1A	Spinal Cord Contusion	C10;C26	Injury or Poisoning	CTD_human
HIF1A	Spinal Cord Laceration	C10;C26	Injury or Poisoning	CTD_human
HIF1A	Spinal Cord transection injury	C10;C26	Injury or Poisoning	CTD_human
HIF1A	Mood Disorders	F03	Mental or Behavioral Dysfunction	PSYGENET
HIF1A	Mixed oligoastrocytoma	C04	Neoplastic Process	CTD_human
HIF1A	Thyroid carcinoma	C04;C19	Neoplastic Process	CTD_human
HIF1A	Primary sclerosing cholangitis	C06	Disease or Syndrome	CTD_human
HIF1A	Breast Carcinoma	C04;C17	Neoplastic Process	CTD_human
HIF1A	Cerebral Astrocytoma	C04	Neoplastic Process	CTD_human
HIF1A	Intracranial Astrocytoma	C04	Neoplastic Process	CTD_human
HIF1A	Post-Traumatic Myelopathy	C10;C26	Injury or Poisoning	CTD_human
HIF1A	Multiple Hemangioblastomas	C04	Neoplastic Process	CTD_human
HIF1A	Hypoxic-Ischemic Encephalopathy	C10;C14	Disease or Syndrome	CTD_human
HIF1A	Anoxic-Ischemic Encephalopathy	C10;C14	Disease or Syndrome	CTD_human
HIF1A	Anoxia-Ischemia, Brain	C10;C14	Disease or Syndrome	CTD_human
HIF1A	Anoxia-Ischemia, Cerebral	C10;C14	Disease or Syndrome	CTD_human
HIF1A	Hypoxia-Ischemia, Brain	C10;C14	Disease or Syndrome	CTD_human
HIF1A	Cerebral Ischemia	C10;C14	Disease or Syndrome	CTD_human
HIF1A	Ductal Carcinoma	C04	Neoplastic Process	CTD_human
HIF1A	Mammary Neoplasms, Human	C04;C17	Neoplastic Process	CTD_human
HIF1A	Major Depressive Disorder	F03	Mental or Behavioral Dysfunction	PSYGENET
HIF1A	Atypical Ductal Breast Hyperplasia	C04	Neoplastic Process	CTD_human
HIF1A	Cardiac Hypertrophy	C14;C23	Pathologic Function	CTD_human
HIF1A	Mammary Neoplasms	C04;C17	Neoplastic Process	CTD_human
HIF1A	Glioblastoma Multiforme	C04	Neoplastic Process	CTD_human
HIF1A	Grade I Astrocytoma	C04	Neoplastic Process	CTD_human
HIF1A	Idiopathic Pulmonary Fibrosis	C08	Disease or Syndrome	CTD_human
HIF1A	Myocardial Failure	C14	Disease or Syndrome	CTD_human
HIF1A	Heart Decompensation	C14	Pathologic Function	CTD_human

Pathway associated with HIF1A

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pathway_ID	pathway_name	pathway_source	gene_number	edge_number
pathway0000177	Angiogenesis	panther	141	2497
pathway0000187	AP-1 transcription factor network	pid	71	659
pathway0000316	BMAL1:CLOCK,NPAS2 activates circadian gene expression	reactome	42	282
pathway0000430	Circadian Clock	reactome	49	389
pathway0001021	HIF-1-alpha transcription factor network	pid	67	420
pathway0001022	HIF-2-alpha transcription factor network	pid	34	119
pathway0001071	Hypoxia response via HIF activation	panther	16	37
pathway0001072	Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	pid	19	73
pathway0001516	Notch-mediated HES/HEY network	pid	48	337
pathway0001524	NOTCH1 Intracellular Domain Regulates Transcription	reactome	47	463
pathway0001564	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	reactome	18	112
pathway0001594	Parkinson disease	panther	85	658
pathway0001744	PTK6 Expression	reactome	5	9
pathway0001745	PTK6 promotes HIF1A stabilization	reactome	6	17
pathway0001833	Regulation of gene expression by Hypoxia-inducible Factor	reactome	10	40
pathway0002408	VEGF signaling pathway	panther	54	637
pathway0002410	VEGFR1 specific signals	pid	29	191
pathway0002583	mTOR signaling pathway	kegg	50	342
pathway0002658	Renal cell carcinoma	kegg	65	609
pathway0002717	Hs_Hepatitis_C_and_Hepatocellular_Carcinoma_WP3646_88640	wikipathways	36	226
pathway0002852	Hs_Focal_Adhesion-PI3K-Akt-mTOR-signaling_pathway_WP3932_91101	wikipathways	8	14
pathway0002862	Hs_AGE-RAGE_pathway_WP2324_89798	wikipathways	27	130
pathway0002873	Hs_Notch_Signaling_Pathway_WP61_78592	wikipathways	16	52

Go term information of HIF1A

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GO_term_name	GO_term_type	TF_name
GO_ANATOMICAL_STRUCTURE_FORMATION_INVOLVED_IN_MORPHOGENESIS	BP	HIF1A
GO_HEMOGLOBIN_METABOLIC_PROCESS	BP	HIF1A
GO_REGULATION_OF_VASCULOGENESIS	BP	HIF1A
GO_REGULATION_OF_CELLULAR_RESPONSE_TO_GROWTH_FACTOR_STIMULUS	BP	HIF1A
GO_EMBRYONIC_HEMOPOIESIS	BP	HIF1A
GO_RESPONSE_TO_IONIZING_RADIATION	BP	HIF1A
GO_AXO_DENDRITIC_TRANSPORT	BP	HIF1A
GO_B_CELL_HOMEOSTASIS	BP	HIF1A
GO_POSITIVE_REGULATION_OF_ERYTHROCYTE_DIFFERENTIATION	BP	HIF1A
GO_POSITIVE_REGULATION_OF_HEMOPOIESIS	BP	HIF1A
GO_RESPONSE_TO_ELECTRICAL_STIMULUS	BP	HIF1A
GO_RESPONSE_TO_STEROID_HORMONE	BP	HIF1A
GO_CARDIAC_CHAMBER_MORPHOGENESIS	BP	HIF1A
GO_REGULATION_OF_LEUKOCYTE_APOPTOTIC_PROCESS	BP	HIF1A
GO_REGULATION_OF_MONOOXYGENASE_ACTIVITY	BP	HIF1A
GO_NEGATIVE_REGULATION_OF_BIOMINERAL_TISSUE_DEVELOPMENT	BP	HIF1A
GO_CELLULAR_RESPONSE_TO_LIGHT_STIMULUS	BP	HIF1A
GO_ASSOCIATIVE_LEARNING	BP	HIF1A
GO_NEGATIVE_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS	BP	HIF1A
GO_MAMMARY_GLAND_EPITHELIUM_DEVELOPMENT	BP	HIF1A
GO_LYMPHOCYTE_HOMEOSTASIS	BP	HIF1A
GO_TISSUE_MORPHOGENESIS	BP	HIF1A
GO_POSITIVE_REGULATION_OF_VASCULATURE_DEVELOPMENT	BP	HIF1A
GO_CELLULAR_IRON_ION_HOMEOSTASIS	BP	HIF1A
GO_MULTICELLULAR_ORGANISMAL_MACROMOLECULE_METABOLIC_PROCESS	BP	HIF1A
GO_RESPONSE_TO_FUNGICIDE	BP	HIF1A
GO_MAMMARY_GLAND_EPITHELIAL_CELL_DIFFERENTIATION	BP	HIF1A
GO_SKELETAL_SYSTEM_DEVELOPMENT	BP	HIF1A
GO_NEGATIVE_REGULATION_OF_RESPONSE_TO_OXIDATIVE_STRESS	BP	HIF1A
GO_NEGATIVE_REGULATION_OF_NOTCH_SIGNALING_PATHWAY	BP	HIF1A
GO_POSITIVE_REGULATION_OF_NEUROBLAST_PROLIFERATION	BP	HIF1A
GO_MORPHOGENESIS_OF_EMBRYONIC_EPITHELIUM	BP	HIF1A
GO_POSITIVE_REGULATION_OF_HORMONE_METABOLIC_PROCESS	BP	HIF1A
GO_REGULATION_OF_NUCLEOTIDE_CATABOLIC_PROCESS	BP	HIF1A
GO_EPITHELIAL_TO_MESENCHYMAL_TRANSITION	BP	HIF1A
GO_POSITIVE_REGULATION_OF_NUCLEOSIDE_METABOLIC_PROCESS	BP	HIF1A
GO_CELLULAR_RESPONSE_TO_INSULIN_STIMULUS	BP	HIF1A
GO_RESPONSE_TO_METAL_ION	BP	HIF1A
GO_NEGATIVE_REGULATION_OF_LEUKOCYTE_APOPTOTIC_PROCESS	BP	HIF1A
GO_REGULATION_OF_EPITHELIAL_CELL_PROLIFERATION	BP	HIF1A
GO_REGULATION_OF_NITRIC_OXIDE_SYNTHASE_ACTIVITY	BP	HIF1A
GO_POSITIVE_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS	BP	HIF1A
GO_CELLULAR_RESPONSE_TO_ELECTRICAL_STIMULUS	BP	HIF1A
GO_DIGESTIVE_SYSTEM_DEVELOPMENT	BP	HIF1A
GO_REGULATION_OF_NUCLEOSIDE_METABOLIC_PROCESS	BP	HIF1A
GO_EMBRYONIC_PLACENTA_DEVELOPMENT	BP	HIF1A
GO_REGULATION_OF_MITOCHONDRION_ORGANIZATION	BP	HIF1A
GO_POSITIVE_REGULATION_OF_MITOCHONDRION_ORGANIZATION	BP	HIF1A
GO_REGULATION_OF_MYOBLAST_DIFFERENTIATION	BP	HIF1A
GO_NEURAL_CREST_CELL_MIGRATION	BP	HIF1A
GO_REGULATION_OF_BIOMINERAL_TISSUE_DEVELOPMENT	BP	HIF1A
GO_MORPHOGENESIS_OF_AN_EPITHELIAL_FOLD	BP	HIF1A
GO_EMBRYONIC_HEART_TUBE_DEVELOPMENT	BP	HIF1A
GO_POSITIVE_REGULATION_OF_SMOOTH_MUSCLE_CELL_PROLIFERATION	BP	HIF1A
GO_NEGATIVE_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY	BP	HIF1A
GO_REGULATION_OF_T_CELL_APOPTOTIC_PROCESS	BP	HIF1A
GO_IN_UTERO_EMBRYONIC_DEVELOPMENT	BP	HIF1A
GO_NEGATIVE_REGULATION_OF_BLOOD_CIRCULATION	BP	HIF1A
GO_TRANSITION_METAL_ION_HOMEOSTASIS	BP	HIF1A
GO_CELL_MATURATION	BP	HIF1A
GO_CELLULAR_RESPONSE_TO_TOXIC_SUBSTANCE	BP	HIF1A
GO_REGULATION_OF_MESENCHYMAL_CELL_APOPTOTIC_PROCESS	BP	HIF1A
GO_ACUTE_INFLAMMATORY_RESPONSE	BP	HIF1A
GO_REGULATION_OF_CELLULAR_RESPONSE_TO_HYPOXIA	BP	HIF1A
GO_REGULATION_OF_THYMOCYTE_APOPTOTIC_PROCESS	BP	HIF1A
GO_CELLULAR_RESPONSE_TO_HYDROGEN_PEROXIDE	BP	HIF1A
GO_CEREBRAL_CORTEX_DEVELOPMENT	BP	HIF1A
GO_POSITIVE_REGULATION_OF_PRI_MIRNA_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER	BP	HIF1A
GO_REGULATION_OF_TRANSFORMING_GROWTH_FACTOR_BETA_PRODUCTION	BP	HIF1A
GO_REGULATION_OF_MUSCLE_CELL_DIFFERENTIATION	BP	HIF1A
GO_INTESTINAL_EPITHELIAL_CELL_DEVELOPMENT	BP	HIF1A
GO_LEARNING	BP	HIF1A
GO_REGULATION_OF_CELLULAR_LOCALIZATION	BP	HIF1A
GO_NEGATIVE_REGULATION_OF_TOR_SIGNALING	BP	HIF1A
GO_REGULATION_OF_RECEPTOR_BIOSYNTHETIC_PROCESS	BP	HIF1A
GO_RESPONSE_TO_SALT_STRESS	BP	HIF1A
GO_POSITIVE_REGULATION_OF_RECEPTOR_BIOSYNTHETIC_PROCESS	BP	HIF1A
GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_IN_RESPONSE_TO_STRESS	BP	HIF1A
GO_DIGESTIVE_TRACT_MORPHOGENESIS	BP	HIF1A
GO_REGULATION_OF_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY	BP	HIF1A
GO_REGULATION_OF_CHEMOKINE_PRODUCTION	BP	HIF1A
GO_NEGATIVE_REGULATION_OF_T_CELL_APOPTOTIC_PROCESS	BP	HIF1A
GO_RESPONSE_TO_ORGANIC_CYCLIC_COMPOUND	BP	HIF1A
GO_POSITIVE_REGULATION_OF_NEURAL_PRECURSOR_CELL_PROLIFERATION	BP	HIF1A
GO_POSITIVE_REGULATION_OF_NUCLEOTIDE_CATABOLIC_PROCESS	BP	HIF1A
GO_RESPONSE_TO_INTERLEUKIN_1	BP	HIF1A
GO_REGULATION_OF_REACTIVE_OXYGEN_SPECIES_METABOLIC_PROCESS	BP	HIF1A
GO_RESPONSE_TO_ESTROGEN	BP	HIF1A
GO_REGULATION_OF_NEUROBLAST_PROLIFERATION	BP	HIF1A
GO_HOMEOSTASIS_OF_NUMBER_OF_CELLS	BP	HIF1A
GO_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_IN_RESPONSE_TO_HYPOXIA	BP	HIF1A
GO_POSITIVE_REGULATION_OF_CHEMOKINE_PRODUCTION	BP	HIF1A
GO_RESPONSE_TO_AUDITORY_STIMULUS	BP	HIF1A
GO_INTESTINAL_EPITHELIAL_CELL_DIFFERENTIATION	BP	HIF1A
GO_REGULATION_OF_HORMONE_BIOSYNTHETIC_PROCESS	BP	HIF1A
GO_POSITIVE_REGULATION_OF_CELL_DEATH	BP	HIF1A
GO_NEGATIVE_REGULATION_OF_CELL_DEATH	BP	HIF1A
GO_REGULATION_OF_ERYTHROCYTE_DIFFERENTIATION	BP	HIF1A
GO_NEGATIVE_REGULATION_OF_LYMPHOCYTE_APOPTOTIC_PROCESS	BP	HIF1A
GO_REGULATION_OF_INSULIN_SECRETION_INVOLVED_IN_CELLULAR_RESPONSE_TO_GLUCOSE_STIMULUS	BP	HIF1A
GO_COLUMNAR_CUBOIDAL_EPITHELIAL_CELL_DEVELOPMENT	BP	HIF1A
GO_REGULATION_OF_MITOPHAGY	BP	HIF1A
GO_POSITIVE_REGULATION_OF_RESPONSE_TO_EXTRACELLULAR_STIMULUS	BP	HIF1A
GO_COLUMNAR_CUBOIDAL_EPITHELIAL_CELL_DIFFERENTIATION	BP	HIF1A
GO_NEGATIVE_REGULATION_OF_GROWTH	BP	HIF1A
GO_REGULATION_OF_SYSTEM_PROCESS	BP	HIF1A
GO_REGULATION_OF_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_PRODUCTION	BP	HIF1A
GO_POSITIVE_REGULATION_OF_OXIDOREDUCTASE_ACTIVITY	BP	HIF1A
GO_REGULATION_OF_SMOOTH_MUSCLE_CELL_PROLIFERATION	BP	HIF1A
GO_POSITIVE_REGULATION_OF_RESPONSE_TO_CYTOKINE_STIMULUS	BP	HIF1A
GO_MRNA_TRANSCRIPTION	BP	HIF1A
GO_RESPONSE_TO_MUSCLE_ACTIVITY	BP	HIF1A
GO_POSITIVE_REGULATION_OF_MYOBLAST_DIFFERENTIATION	BP	HIF1A
GO_NEGATIVE_REGULATION_OF_APOPTOTIC_SIGNALING_PATHWAY	BP	HIF1A
GO_MATERNAL_PROCESS_INVOLVED_IN_FEMALE_PREGNANCY	BP	HIF1A
GO_POSITIVE_REGULATION_OF_CELL_SIZE	BP	HIF1A
GO_REGULATION_OF_OXIDATIVE_STRESS_INDUCED_CELL_DEATH	BP	HIF1A
GO_BODY_FLUID_SECRETION	BP	HIF1A
GO_POSITIVE_REGULATION_OF_EPITHELIAL_CELL_MIGRATION	BP	HIF1A
GO_MUSCLE_CELL_CELLULAR_HOMEOSTASIS	BP	HIF1A
GO_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_IN_RESPONSE_TO_STRESS	BP	HIF1A
GO_CONNECTIVE_TISSUE_DEVELOPMENT	BP	HIF1A
GO_MAMMARY_GLAND_LOBULE_DEVELOPMENT	BP	HIF1A
GO_REGULATION_OF_GENERATION_OF_PRECURSOR_METABOLITES_AND_ENERGY	BP	HIF1A
GO_VISUAL_BEHAVIOR	BP	HIF1A
GO_RETINA_VASCULATURE_DEVELOPMENT_IN_CAMERA_TYPE_EYE	BP	HIF1A
GO_MICROTUBULE_BASED_MOVEMENT	BP	HIF1A
GO_SENSORY_ORGAN_MORPHOGENESIS	BP	HIF1A
GO_DOPAMINERGIC_NEURON_DIFFERENTIATION	BP	HIF1A
GO_REGULATION_OF_CELLULAR_RESPIRATION	BP	HIF1A
GO_RESPONSE_TO_X_RAY	BP	HIF1A
GO_OUTFLOW_TRACT_MORPHOGENESIS	BP	HIF1A
GO_REGULATION_OF_OXIDATIVE_STRESS_INDUCED_NEURON_DEATH	BP	HIF1A
GO_NEGATIVE_REGULATION_OF_OSSIFICATION	BP	HIF1A
GO_CELLULAR_TRANSITION_METAL_ION_HOMEOSTASIS	BP	HIF1A
GO_PLACENTA_DEVELOPMENT	BP	HIF1A
GO_REGULATION_OF_HORMONE_METABOLIC_PROCESS	BP	HIF1A
GO_REGULATION_OF_RESPONSE_TO_OXIDATIVE_STRESS	BP	HIF1A
GO_MITOCHONDRION_LOCALIZATION	BP	HIF1A
GO_REGULATION_OF_PRI_MIRNA_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER	BP	HIF1A
GO_POSITIVE_REGULATION_OF_MONOOXYGENASE_ACTIVITY	BP	HIF1A
GO_PEPTIDYL_ASPARAGINE_MODIFICATION	BP	HIF1A
GO_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_PROLIFERATION	BP	HIF1A
GO_POSITIVE_REGULATION_OF_AUTOPHAGY	BP	HIF1A
GO_POSITIVE_REGULATION_OF_STEM_CELL_PROLIFERATION	BP	HIF1A
GO_EPITHELIAL_CELL_DIFFERENTIATION	BP	HIF1A
GO_CELLULAR_RESPONSE_TO_REACTIVE_NITROGEN_SPECIES	BP	HIF1A
GO_POSITIVE_REGULATION_OF_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY	BP	HIF1A
GO_ESTABLISHMENT_OF_MITOCHONDRION_LOCALIZATION	BP	HIF1A
GO_POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER_INVOLVED_IN_CELLULAR_RESPONSE_TO_CHEMICAL_STIMULUS	BP	HIF1A
GO_RESPONSE_TO_COBALT_ION	BP	HIF1A
GO_NEGATIVE_REGULATION_OF_OXIDATIVE_STRESS_INDUCED_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY	BP	HIF1A
GO_NEGATIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_PROCESS	BP	HIF1A
GO_REGULATION_OF_NEURAL_PRECURSOR_CELL_PROLIFERATION	BP	HIF1A
GO_PROTEIN_HYDROXYLATION	BP	HIF1A
GO_EPITHELIAL_CELL_MATURATION	BP	HIF1A
GO_REGULATION_OF_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY	BP	HIF1A
GO_NEGATIVE_REGULATION_OF_NEURON_DEATH	BP	HIF1A
GO_POSITIVE_REGULATION_OF_NITRIC_OXIDE_SYNTHASE_ACTIVITY	BP	HIF1A
GO_EMBRYONIC_HEART_TUBE_MORPHOGENESIS	BP	HIF1A
GO_POSITIVE_REGULATION_OF_INSULIN_SECRETION_INVOLVED_IN_CELLULAR_RESPONSE_TO_GLUCOSE_STIMULUS	BP	HIF1A
GO_REGULATION_OF_CARBOHYDRATE_CATABOLIC_PROCESS	BP	HIF1A
GO_RESPONSE_TO_MECHANICAL_STIMULUS	BP	HIF1A
GO_CYTOSKELETON_DEPENDENT_INTRACELLULAR_TRANSPORT	BP	HIF1A
GO_DEVELOPMENTAL_MATURATION	BP	HIF1A
GO_CELLULAR_RESPONSE_TO_DRUG	BP	HIF1A
GO_RESPONSE_TO_PURINE_CONTAINING_COMPOUND	BP	HIF1A
GO_CELLULAR_RESPONSE_TO_REACTIVE_OXYGEN_SPECIES	BP	HIF1A
GO_NEURAL_CREST_CELL_DIFFERENTIATION	BP	HIF1A
GO_RESPONSE_TO_HYDROGEN_PEROXIDE	BP	HIF1A
GO_REGULATION_OF_OXIDATIVE_STRESS_INDUCED_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY	BP	HIF1A
GO_LEUKOCYTE_HOMEOSTASIS	BP	HIF1A
GO_POSITIVE_REGULATION_OF_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_PRODUCTION	BP	HIF1A
GO_RESPONSE_TO_ACTIVITY	BP	HIF1A
GO_ACUTE_PHASE_RESPONSE	BP	HIF1A
GO_LACTATION	BP	HIF1A
GO_MRNA_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER	BP	HIF1A
GO_EYE_MORPHOGENESIS	BP	HIF1A
GO_CELL_PROJECTION_CYTOPLASM	CC	HIF1A
GO_MOTILE_CILIUM	CC	HIF1A
GO_AXON_CYTOPLASM	CC	HIF1A
GO_TRANSCRIPTIONAL_ACTIVATOR_ACTIVITY_RNA_POLYMERASE_II_TRANSCRIPTION_REGULATORY_REGION_SEQUENCE_SPECIFIC_BINDING	MF	HIF1A
GO_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_PAIRED_DONORS_WITH_INCORPORATION_OR_REDUCTION_OF_MOLECULAR_OXYGEN_2_OXOGLUTARATE_AS_ONE_DONOR_AND_INCORPORATION_OF_ONE_ATOM_EACH_OF_OXYGEN_INTO_BOTH_DONORS	MF	HIF1A
GO_TRANSCRIPTION_FACTOR_ACTIVITY_RNA_POLYMERASE_II_DISTAL_ENHANCER_SEQUENCE_SPECIFIC_BINDING	MF	HIF1A
GO_HSP90_PROTEIN_BINDING	MF	HIF1A
GO_OXYGEN_BINDING	MF	HIF1A
GO_ORGANIC_ACID_BINDING	MF	HIF1A
GO_TRANSCRIPTION_FACTOR_ACTIVITY_PROTEIN_BINDING	MF	HIF1A
GO_NF_KAPPAB_BINDING	MF	HIF1A
GO_IRON_ION_BINDING	MF	HIF1A
GO_HISTONE_ACETYLTRANSFERASE_BINDING	MF	HIF1A
GO_NOTCH_BINDING	MF	HIF1A

Survival analysis of HIF1A

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of HIF1A

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)