Cancer CRCdb

TF information

TF name:	FOXC1
TF family:	Fork_head
Ensembl gene ID:	ENSG00000054598
Ensembl protein ID:	ENSP00000493906, ENSP00000370256
Entrez gene ID:	2296

Database name	Link	Database name	Link
NCBI Gene:		Genecards:
Uniprot:		Wikipedia:
Cosmic 3D:		Geneontology:
CCLE:

Frequency of FOXC1 in all biosamples

Download

Sample ID	Biosample type	Tissue type	Biosample name	TF Frequency
Sample_02_007	Other	Cervical	cervical-cancer_vector	0.62582781456954
Sample_02_095	Cell line	Mammary Gland	MDA-MB-468	1
Sample_02_395	Cell line	Mammary Gland	BT-549	0.5241958041958

FOXC1 distribution in samples’ most representative CRC

Download

Sample ID	Tissue type	Biosample type	Biosample name
Sample_02_007	Cervical	Other	cervical-cancer_vector
Sample_02_095	Mammary Gland	Cell line	MDA-MB-468

FOXC1 distribution in all CRCs

Genomic distribution of SEs associated with FOXC1

Download

Mutation of FOXC1

Download

Database name	Link
gnomAD:	gnomAD
ExAC:	ExAC
ICGC:

Database name	Link
Cosmic:
Cosmic cell lines:
Depmap:

TCGA somatic mutations and clinical variants of FOXC1

rsID	Chr	Start	Stop	Ref	Alt	Gene_region	Gene_symble	Effect	TCGA_Occurrence
-	chr6	1611345	1611345	G	T	exonic	FOXC1	nonsynonymous	ACC\|1\|90\|0.01111
-	chr6	1612143	1612144	CG	-	exonic	FOXC1	frameshift	PCPG\|1\|184\|0.00543,SARC\|1\|247\|0.00405
-	chr6	1611193	1611193	G	A	exonic	FOXC1	synonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr6	1612242	1612242	C	T	exonic	FOXC1	nonsynonymous	LIHC\|1\|373\|0.00268
rs773527470	chr6	1611181	1611181	C	T	exonic	FOXC1	synonymous	LUSC\|1\|178\|0.00562
-	chr6	1610942	1610942	A	G	exonic	FOXC1	nonsynonymous	GBMLGG\|1\|820\|0.00122,LGG\|1\|530\|0.00189
-	chr6	1611204	1611204	A	C	exonic	FOXC1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
-	chr6	1611076	1611076	C	G	exonic	FOXC1	synonymous	CESC\|1\|194\|0.00515
-	chr6	1611582	1611582	C	G	exonic	FOXC1	nonsynonymous	LIHC\|1\|373\|0.00268
-	chr6	1611802	1611802	-	GC	exonic	FOXC1	frameshift	BLCA\|1\|396\|0.00253
-	chr6	1612341	1612341	G	A	exonic	FOXC1	synonymous	BLCA\|1\|396\|0.00253
rs2230096	chr6	1611085	1611085	C	T	exonic	FOXC1	synonymous	DLBC\|1\|48\|0.02083
-	chr6	1612318	1612318	C	T	exonic	FOXC1	synonymous	BLCA\|1\|396\|0.00253
-	chr6	1611464	1611465	AG	-	exonic	FOXC1	frameshift	HNSC\|2\|512\|0.00391,LUAD\|1\|543\|0.00184
-	chr6	1611120	1611120	G	T	exonic	FOXC1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr6	1610970	1610971	AG	-	exonic	FOXC1	frameshift	ESCA\|1\|185\|0.00541
-	chr6	1612199	1612199	G	A	exonic	FOXC1	nonsynonymous	CESC\|1\|194\|0.00515
rs372857241	chr6	1610821	1610821	C	G	exonic	FOXC1	stopgain	DLBC\|1\|48\|0.02083
-	chr6	1610993	1610993	T	C	exonic	FOXC1	nonsynonymous	PAAD\|1\|185\|0.00541
-	chr6	1612017	1612017	-	GG	exonic	FOXC1	frameshift	ESCA\|1\|185\|0.00541
-	chr6	1612042	1612042	G	C	exonic	FOXC1	synonymous	LIHC\|3\|373\|0.00804
-	chr6	1610867	1610867	G	A	exonic	FOXC1	nonsynonymous	BLCA\|1\|396\|0.00253
-	chr6	1610903	1610903	G	A	exonic	FOXC1	nonsynonymous	DLBC\|1\|48\|0.02083
rs768160181	chr6	1612231	1612231	-	T	exonic	FOXC1	frameshift	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs542630440	chr6	1612173	1612173	C	T	exonic	FOXC1	nonsynonymous	PRAD\|1\|499\|0.00200
-	chr6	1610983	1610983	G	A	exonic	FOXC1	synonymous	HNSC\|1\|512\|0.00195
-	chr6	1610938	1610938	C	A	exonic	FOXC1	synonymous	BRCA\|1\|982\|0.00102
-	chr6	1612301	1612301	C	T	exonic	FOXC1	nonsynonymous	LUSC\|1\|178\|0.00562
-	chr6	1612302	1612302	G	A	exonic	FOXC1	nonsynonymous	PRAD\|1\|499\|0.00200,UVM\|1\|80\|0.01250
rs772118724	chr6	1610801	1610801	C	T	exonic	FOXC1	nonsynonymous	TGCT\|1\|155\|0.00645
-	chr6	1610746	1610746	G	T	exonic	FOXC1	nonsynonymous	TGCT\|1\|155\|0.00645
rs73406891	chr6	1612243	1612243	T	G	exonic	FOXC1	synonymous	DLBC\|1\|48\|0.02083
-	chr6	1611233	1611233	G	A	exonic	FOXC1	nonsynonymous	SARC\|1\|247\|0.00405
-	chr6	1610914	1610914	G	T	exonic	FOXC1	nonsynonymous	STAD\|1\|395\|0.00253,STES\|1\|395\|0.00253
rs376255999	chr6	1611121	1611121	C	T	exonic	FOXC1	synonymous	OV\|1\|469\|0.00213
-	chr6	1612016	1612016	C	G	exonic	FOXC1	nonsynonymous	LIHC\|1\|373\|0.00268
rs369346224	chr6	1611154	1611154	C	T	exonic	FOXC1	synonymous	PRAD\|2\|499\|0.00401
-	chr6	1611149	1611149	G	T	exonic	FOXC1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr6	1611915	1611915	-	G	exonic	FOXC1	frameshift	KIPAN\|1\|799\|0.00125,KIRP\|1\|282\|0.00355
-	chr6	1611205	1611205	G	A	exonic	FOXC1	synonymous	LUAD\|1\|543\|0.00184
-	chr6	1611214	1611214	C	G	exonic	FOXC1	nonsynonymous	LUAD\|1\|543\|0.00184
-	chr6	1611048	1611048	A	C	exonic	FOXC1	nonsynonymous	UCEC\|1\|248\|0.00403
-	chr6	1611053	1611053	A	G	exonic	FOXC1	nonsynonymous	BRCA\|1\|982\|0.00102
-	chr6	1611195	1611195	G	A	exonic	FOXC1	nonsynonymous	COAD\|1\|367\|0.00272,COADREAD\|1\|489\|0.00204
-	chr6	1610937	1610937	-	A	exonic	FOXC1	frameshift	BRCA\|1\|982\|0.00102
-	chr6	1611183	1611183	T	A	exonic	FOXC1	nonsynonymous	LUSC\|1\|178\|0.00562
rs776663624	chr6	1612237	1612237	C	A	exonic	FOXC1	nonsynonymous	ACC\|1\|90\|0.01111

Disease information of FOXC1

Download

TF_name	Disease_name	Disease_class	Disease_semantic_type	TF_disease_source
FOXC1	Aniridia	C11;C16	Congenital Abnormality	ORPHANET
FOXC1	Dandy-Walker Syndrome	C10;C16	Disease or Syndrome	CTD_human
FOXC1	Glaucoma, Open-Angle	C11	Disease or Syndrome	CTD_human
FOXC1	Prostatic Neoplasms	C04;C12	Neoplastic Process	CTD_human
FOXC1	Tetralogy of Fallot	C14;C16	Congenital Abnormality	CTD_human
FOXC1	Cataract	C11	Acquired Abnormality	GENOMICS_ENGLAND
FOXC1	Ataxia, Spinocerebellar	C10;C16	Disease or Syndrome	CTD_human
FOXC1	Rieger syndrome	C11;C16	Disease or Syndrome	ORPHANET
FOXC1	Axenfeld anomaly (disorder)	C11;C16	Congenital Abnormality	ORPHANET
FOXC1	Secondary Open Angle Glaucoma	C11	Disease or Syndrome	CTD_human
FOXC1	Glaucoma, Primary Open Angle	C11	Disease or Syndrome	CTD_human
FOXC1	Irido-corneo-trabecular dysgenesis (disorder)	C11;C16	Congenital Abnormality	ORPHANET
FOXC1	Malignant neoplasm of prostate	C04;C12	Neoplastic Process	CTD_human
FOXC1	Spinocerebellar Ataxia Type 1	C10;C16	Disease or Syndrome	CTD_human
FOXC1	Spinocerebellar Ataxia Type 2	C10;C16	Disease or Syndrome	CTD_human
FOXC1	Spinocerebellar Ataxia Type 4	C10;C16	Disease or Syndrome	CTD_human
FOXC1	Spinocerebellar Ataxia Type 5	C10;C16	Disease or Syndrome	CTD_human
FOXC1	Spinocerebellar Ataxia Type 6 (disorder)	C10;C16	Disease or Syndrome	CTD_human
FOXC1	Spinocerebellar Ataxia Type 7	C10;C16	Disease or Syndrome	CTD_human
FOXC1	IRIS HYPOPLASIA WITH GLAUCOMA	C11	Disease or Syndrome	UNIPROT
FOXC1	IRIDOGONIODYSGENESIS, TYPE 1 (disorder)	C11;C16	Disease or Syndrome	CTD_human;UNIPROT
FOXC1	Glaucoma Iridogoniodysplasia, Familial	C11	Disease or Syndrome	UNIPROT
FOXC1	Cakut	C12;C13;C16	Disease or Syndrome	GENOMICS_ENGLAND
FOXC1	AXENFELD-RIEGER SYNDROME, TYPE 3	C11;C16	Disease or Syndrome	CTD_human;UNIPROT
FOXC1	Axenfeld-Rieger syndrome	C11;C16	Disease or Syndrome	ORPHANET
FOXC1	Rieger eye malformation sequence		Disease or Syndrome	ORPHANET
FOXC1	Intellectual Disability	C10;C23;F01;F03	Mental or Behavioral Dysfunction	GENOMICS_ENGLAND
FOXC1	Axenfeld-Rieger Syndrome, Type 1	C11;C16	Disease or Syndrome	CTD_human
FOXC1	Dandy-Walker Syndrome, Familial	C10;C16	Disease or Syndrome	CTD_human

Pathway associated with FOXC1

Download

pathway_ID	pathway_name	pathway_source	gene_number	edge_number
pathway0002768	Hs_Heart_Development_WP1591_90186	wikipathways	28	78
pathway0002826	Hs_Mesodermal_Commitment_Pathway_WP2857_87780	wikipathways	47	175

Go term information of FOXC1

Download

GO_term_name	GO_term_type	TF_name
GO_NEGATIVE_REGULATION_OF_CELL_DEVELOPMENT	BP	FOXC1
GO_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_SIGNALING_PATHWAY	BP	FOXC1
GO_POSITIVE_REGULATION_OF_HEMOPOIESIS	BP	FOXC1
GO_COLLAGEN_FIBRIL_ORGANIZATION	BP	FOXC1
GO_CARDIAC_CHAMBER_MORPHOGENESIS	BP	FOXC1
GO_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_RECEPTOR_SIGNALING_PATHWAY	BP	FOXC1
GO_MUSCLE_CELL_PROLIFERATION	BP	FOXC1
GO_OVARIAN_FOLLICLE_DEVELOPMENT	BP	FOXC1
GO_EMBRYONIC_HEART_TUBE_DEVELOPMENT	BP	FOXC1
GO_ARTERY_MORPHOGENESIS	BP	FOXC1
GO_VENTRICULAR_CARDIAC_MUSCLE_TISSUE_DEVELOPMENT	BP	FOXC1
GO_IN_UTERO_EMBRYONIC_DEVELOPMENT	BP	FOXC1
GO_REGULATION_OF_HEART_MORPHOGENESIS	BP	FOXC1
GO_ANTERIOR_POSTERIOR_PATTERN_SPECIFICATION	BP	FOXC1
GO_SOMITOGENESIS	BP	FOXC1
GO_CARDIAC_VENTRICLE_MORPHOGENESIS	BP	FOXC1
GO_CARDIAC_MUSCLE_TISSUE_MORPHOGENESIS	BP	FOXC1
GO_MUSCLE_ORGAN_MORPHOGENESIS	BP	FOXC1
GO_EXOCRINE_SYSTEM_DEVELOPMENT	BP	FOXC1
GO_AMINOGLYCAN_METABOLIC_PROCESS	BP	FOXC1
GO_ORGAN_GROWTH	BP	FOXC1
GO_MESODERM_MORPHOGENESIS	BP	FOXC1
GO_TUBE_DEVELOPMENT	BP	FOXC1
GO_BLOOD_VESSEL_REMODELING	BP	FOXC1
GO_REGULATION_OF_HEMATOPOIETIC_PROGENITOR_CELL_DIFFERENTIATION	BP	FOXC1
GO_ORGANONITROGEN_COMPOUND_METABOLIC_PROCESS	BP	FOXC1
GO_STRIATED_MUSCLE_CELL_PROLIFERATION	BP	FOXC1
GO_PARAXIAL_MESODERM_DEVELOPMENT	BP	FOXC1
GO_ODONTOGENESIS_OF_DENTIN_CONTAINING_TOOTH	BP	FOXC1
GO_HEART_GROWTH	BP	FOXC1
GO_LYMPH_VESSEL_DEVELOPMENT	BP	FOXC1
GO_MESENCHYME_MORPHOGENESIS	BP	FOXC1
GO_SOMITE_DEVELOPMENT	BP	FOXC1
GO_MESONEPHROS_DEVELOPMENT	BP	FOXC1
GO_CELLULAR_RESPONSE_TO_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_STIMULUS	BP	FOXC1
GO_NEURAL_CREST_CELL_DIFFERENTIATION	BP	FOXC1
GO_DEVELOPMENTAL_GROWTH	BP	FOXC1
GO_REGULATION_OF_STEM_CELL_DIFFERENTIATION	BP	FOXC1
GO_CHROMATIN	CC	FOXC1
GO_NUCLEAR_HETEROCHROMATIN	CC	FOXC1
GO_DNA_BINDING_BENDING	MF	FOXC1
GO_TRANSCRIPTIONAL_ACTIVATOR_ACTIVITY_RNA_POLYMERASE_II_TRANSCRIPTION_REGULATORY_REGION_SEQUENCE_SPECIFIC_BINDING	MF	FOXC1
GO_TRANSCRIPTION_FACTOR_ACTIVITY_RNA_POLYMERASE_II_DISTAL_ENHANCER_SEQUENCE_SPECIFIC_BINDING	MF	FOXC1

Survival analysis of FOXC1

Methods

Overall Survival

Disease Free Survival (RFS)

Group Cutoff

Median

Quartile

Custom

Cutoff-High(%)

Hazards Ratio (HR) Calculate the hazards ratio based on Cox PH Model.

95% Confidence Interval Add the 95% CI as dotted line.

Axis Units

Expression of FOXC1

Pan cancer (TCGA) Cell line (ENCODE) In vitro differentiated cell (ENCODE) Primary cell (ENCODE) Tissue (NCBI) Normal tissue (GTEx) Cell line (CCLE)